NO318146B1 - Fremgangsmate for fremstilling av semisyntetiske statiner samt nye mellomprodukter ved fremgangsmaten - Google Patents

Fremgangsmate for fremstilling av semisyntetiske statiner samt nye mellomprodukter ved fremgangsmaten Download PDF

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Publication number
NO318146B1
NO318146B1 NO19993644A NO993644A NO318146B1 NO 318146 B1 NO318146 B1 NO 318146B1 NO 19993644 A NO19993644 A NO 19993644A NO 993644 A NO993644 A NO 993644A NO 318146 B1 NO318146 B1 NO 318146B1
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NO
Norway
Prior art keywords
group
compound
formula
hydrogen
alkyl
Prior art date
Application number
NO19993644A
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English (en)
Norwegian (no)
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NO993644D0 (no
NO993644L (no
Inventor
Hans Wijnberg
Wijnand Sjourd Faber
Venetka Ivanove Kalkman-Agayn
Mieke Sibeyn
Ton Rene Vries
Original Assignee
Plus Chemicals Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Plus Chemicals Bv filed Critical Plus Chemicals Bv
Publication of NO993644D0 publication Critical patent/NO993644D0/no
Publication of NO993644L publication Critical patent/NO993644L/no
Publication of NO318146B1 publication Critical patent/NO318146B1/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
NO19993644A 1997-01-28 1999-07-27 Fremgangsmate for fremstilling av semisyntetiske statiner samt nye mellomprodukter ved fremgangsmaten NO318146B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP97200223 1997-01-28
EP97306809 1997-09-03
PCT/EP1998/000519 WO1998032751A1 (en) 1997-01-28 1998-01-27 Process for the production of semi synthetic statins via novel intermediates

Publications (3)

Publication Number Publication Date
NO993644D0 NO993644D0 (no) 1999-07-27
NO993644L NO993644L (no) 1999-09-28
NO318146B1 true NO318146B1 (no) 2005-02-07

Family

ID=26146080

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19993644A NO318146B1 (no) 1997-01-28 1999-07-27 Fremgangsmate for fremstilling av semisyntetiske statiner samt nye mellomprodukter ved fremgangsmaten

Country Status (16)

Country Link
US (1) US6294680B1 (de)
EP (2) EP0971913B1 (de)
JP (1) JP2001508782A (de)
KR (1) KR100538674B1 (de)
AR (1) AR011780A1 (de)
AT (2) ATE237605T1 (de)
AU (1) AU747219C (de)
CA (1) CA2278603A1 (de)
DE (2) DE69834279T2 (de)
DK (1) DK0971913T3 (de)
ES (2) ES2266671T3 (de)
IL (1) IL131044A (de)
NO (1) NO318146B1 (de)
NZ (1) NZ336993A (de)
PT (1) PT971913E (de)
WO (1) WO1998032751A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0940395A1 (de) * 1998-03-05 1999-09-08 Synthon B.V. Verfahren zur Erzeugung von Simvatarin in und/oder deren Derivate
NO991045L (no) 1998-03-05 1999-09-06 Synthon Bv FremgangsmÕte ved fremstilling av simvastatin og/eller dets derivater
CN1122029C (zh) * 1998-12-10 2003-09-24 钟渊化学工业株式会社 制备辛伐他汀的方法
CO5140104A1 (es) 1999-02-16 2002-03-22 Novartis Ag Derivados de mevinolina y preparacion farmaceuticas que los contienen
KR20010009846A (ko) * 1999-07-14 2001-02-05 구광시 심바스타틴 제조에 유용한 중간체 및 그의 제조방법
AU2127500A (en) 1999-11-11 2001-06-06 Biocon India Limited Process for manufacturing simvastatin and the novel intermediates
US6573385B1 (en) 1999-11-11 2003-06-03 Biocon India Limited Process for manufacturing simvastatin and novel intermediates thereof
CZ2003554A3 (cs) * 2000-07-27 2003-08-13 Plus Chemicals, B. V. Vysoce přečištěný simvastatin
NL1017548C2 (nl) 2001-03-09 2002-09-10 Synthon Bv Een lactonisatie proces.
KR20040026705A (ko) 2001-08-16 2004-03-31 테바 파마슈티컬 인더스트리즈 리미티드 스타틴의 칼슘 염 형태의 제조 방법
US6472542B1 (en) 2001-11-29 2002-10-29 Fermic S.A. De C.V. Method for alkylating the alpha carbon of the 2-methylbutyrate secondary chain of lovastatin
KR100423892B1 (ko) * 2001-12-03 2004-03-22 씨제이 주식회사 스타틴의 제조에 있어서 새로운 락톤화 방법
SI21187A (sl) 2002-03-26 2003-10-31 Krka, Tovarna Zdravil D.D., Novo Mesto Postopek za pripravo 4-oksitetrahidropiran-2-onov
US6603022B1 (en) 2002-05-10 2003-08-05 Biocon India Limited Process for manufacturing Simvastatin and novel intermediates thereof
WO2004071456A2 (en) 2003-02-11 2004-08-26 Plus Chemicals, B.V. Process for preparing simvastatin having controlled ranges of simvastatin dimer content
CN102703539A (zh) * 2003-10-21 2012-10-03 维莱尼姆公司 制备新伐他汀及中间体的方法
JP4621451B2 (ja) 2004-08-11 2011-01-26 富士フイルム株式会社 液浸露光用保護膜形成組成物及びそれを用いたパターン形成方法
EP1919393A2 (de) * 2005-09-01 2008-05-14 Prescient Medical, Inc. Auf eine vorrichtung beschichtete arzneimittel zur behandlung von empfindlichem plaque
EP2024341B1 (de) 2006-05-03 2015-12-02 MSN Laboratories Private Limited Neue verfahren für statine und deren pharmazeutisch unbedenkliche salze
US8404841B2 (en) 2006-10-09 2013-03-26 Msn Laboratories Limited Process for the preparation of statins and their pharmaceutically acceptable salts thereof
WO2010089770A2 (en) 2009-01-19 2010-08-12 Msn Laboratories Limited Improved process for the preparation of highly pure (3r,5s)-7-[2-cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl]-3,5-dihydroxy-6(e)-heptenoic acid and pharmaceutically acceptable salts thereof
US8470805B2 (en) * 2009-04-30 2013-06-25 Kaohsiung Medical University Processes for preparing piperazinium salts of KMUP and use thereof
US8987444B2 (en) 2010-01-18 2015-03-24 Msn Laboratories Private Limited Process for the preparation of amide intermediates and their use thereof
HU229260B1 (en) * 2010-11-29 2013-10-28 Egis Gyogyszergyar Nyrt Process for preparation of rosuvastatin salts
CN110483459A (zh) * 2019-09-10 2019-11-22 山东罗欣药业集团恒欣药业有限公司 一种辛伐他汀的合成方法
CN110563680A (zh) * 2019-09-10 2019-12-13 山东罗欣药业集团恒欣药业有限公司 一种治疗高脂血症药物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820850A (en) * 1987-07-10 1989-04-11 Merck & Co., Inc. Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
EP0415488B1 (de) * 1989-08-31 1994-04-20 Merck & Co. Inc. 7-Subsituierte HMG-CoA-Reduktase-Inhibitoren
US5393893A (en) * 1993-11-08 1995-02-28 Apotex, Inc. Process for producing simvastatin and analogs thereof
EP0940395A1 (de) 1998-03-05 1999-09-08 Synthon B.V. Verfahren zur Erzeugung von Simvatarin in und/oder deren Derivate

Also Published As

Publication number Publication date
US6294680B1 (en) 2001-09-25
KR100538674B1 (ko) 2005-12-26
NO993644D0 (no) 1999-07-27
DE69834279T2 (de) 2007-01-04
JP2001508782A (ja) 2001-07-03
AU747219B2 (en) 2002-05-09
AU6618398A (en) 1998-08-18
IL131044A (en) 2003-07-31
ATE237605T1 (de) 2003-05-15
DE69813538T2 (de) 2004-04-01
ES2197465T3 (es) 2004-01-01
IL131044A0 (en) 2001-01-28
DK0971913T3 (da) 2003-08-04
EP1340752A1 (de) 2003-09-03
ES2266671T3 (es) 2007-03-01
DE69813538D1 (de) 2003-05-22
AR011780A1 (es) 2000-09-13
EP0971913B1 (de) 2003-04-16
EP1340752B1 (de) 2006-04-19
CA2278603A1 (en) 1998-07-30
NO993644L (no) 1999-09-28
ATE323689T1 (de) 2006-05-15
WO1998032751A1 (en) 1998-07-30
KR20000070501A (ko) 2000-11-25
EP0971913A1 (de) 2000-01-19
AU747219C (en) 2003-11-20
NZ336993A (en) 2000-05-26
PT971913E (pt) 2003-08-29
DE69834279D1 (de) 2006-05-24

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