NO318628B1 - Pyrano-, piperidino- og tiopyranoforbindelser, farmasoytiske sammensetninger inneholdende det samme og anvendelse av forbindelsene - Google Patents

Pyrano-, piperidino- og tiopyranoforbindelser, farmasoytiske sammensetninger inneholdende det samme og anvendelse av forbindelsene Download PDF

Info

Publication number: NO318628B1
Authority: NO; Norway
Prior art keywords: hydrogen; compound according; dione; fluorophenyl; bromo
Prior art date: 1998-10-28

Application number

NO20012100A

Other languages

English (en)

Norwegian (no)

Other versions

NO20012100D0 (no

NO20012100L (no

Inventor

Robert J Altenbach

William A Carroll

Michael E Kort

Konstantinos A Agrios

Irene Drizin

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-28

Filing date

2001-04-27

Publication date

2005-04-18

2001-04-27 Application filed by Abbott Lab filed Critical Abbott Lab

2001-04-27 Publication of NO20012100D0 publication Critical patent/NO20012100D0/no

2001-06-14 Publication of NO20012100L publication Critical patent/NO20012100L/no

2005-04-18 Publication of NO318628B1 publication Critical patent/NO318628B1/no

Links

150000001875 compounds Chemical class 0.000 title claims description 335
239000008194 pharmaceutical composition Substances 0.000 title claims description 14
125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 title description 2
229910052739 hydrogen Inorganic materials 0.000 claims description 151
239000001257 hydrogen Substances 0.000 claims description 151
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 113
-1 benzoxadiazolyl Chemical group 0.000 claims description 43
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 32
150000003839 salts Chemical class 0.000 claims description 30
150000001408 amides Chemical class 0.000 claims description 28
150000002148 esters Chemical class 0.000 claims description 28
238000002360 preparation method Methods 0.000 claims description 23
125000005843 halogen group Chemical group 0.000 claims description 21
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 18
239000003814 drug Substances 0.000 claims description 15
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 13
229940079593 drug Drugs 0.000 claims description 12
238000011282 treatment Methods 0.000 claims description 11
229910052736 halogen Inorganic materials 0.000 claims description 10
229910052760 oxygen Inorganic materials 0.000 claims description 10
208000035475 disorder Diseases 0.000 claims description 9
229910052717 sulfur Inorganic materials 0.000 claims description 9
125000001544 thienyl group Chemical group 0.000 claims description 9
206010046543 Urinary incontinence Diseases 0.000 claims description 8
239000003937 drug carrier Substances 0.000 claims description 8
SVGVJFUHAFQBJW-UHFFFAOYSA-N 9-(3-bromo-4-fluorophenyl)-2,3,5,9-tetrahydro-4h-pyrano[3,4-b]thieno[2,3-e]pyridin-8(7h)-one 1,1-dioxide Chemical compound C1=C(Br)C(F)=CC=C1C1C(C(=O)COC2)=C2NC2=C1S(=O)(=O)CC2 SVGVJFUHAFQBJW-UHFFFAOYSA-N 0.000 claims description 7
GHKXQLMOLJUEMH-UHFFFAOYSA-N O=C1COCC(NC2=C3S(CC2)(=O)=O)=C1C3C1=CC=CC(C#N)=C1 Chemical compound O=C1COCC(NC2=C3S(CC2)(=O)=O)=C1C3C1=CC=CC(C#N)=C1 GHKXQLMOLJUEMH-UHFFFAOYSA-N 0.000 claims description 7
SSPWAVCEXCHHOU-UHFFFAOYSA-N 9-(3-bromo-4-fluorophenyl)-3,4,5,6,7,9-hexahydrofuro[3,4-b][1,7]naphthyridine-1,8-dione Chemical compound C1=C(Br)C(F)=CC=C1C1C(C(=O)CNC2)=C2NC2=C1C(=O)OC2 SSPWAVCEXCHHOU-UHFFFAOYSA-N 0.000 claims description 6
RTACIKQKDIPFHG-UHFFFAOYSA-N 9-(4-fluoro-3-iodophenyl)-2,3,5,9-tetrahydro-4h-pyrano[3,4-b]thieno[2,3-e]pyridin-8(7h)-one 1,1-dioxide Chemical compound C1=C(I)C(F)=CC=C1C1C(C(=O)COC2)=C2NC2=C1S(=O)(=O)CC2 RTACIKQKDIPFHG-UHFFFAOYSA-N 0.000 claims description 6
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BIUDHHGROGJSHN-UHFFFAOYSA-N 4-fluoro-3-(trifluoromethyl)benzaldehyde Chemical group FC1=CC=C(C=O)C=C1C(F)(F)F BIUDHHGROGJSHN-UHFFFAOYSA-N 0.000 claims description 4
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125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
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BFVJEPANUDHFNL-UHFFFAOYSA-N 5-(3-bromo-4-fluorophenyl)-7,7-dimethyl-5,8,9,10-tetrahydro-1h-pyrano[3,4-b]quinoline-4,6-dione Chemical compound O=C1C(C)(C)CCC(NC2=C3C(COC2)=O)=C1C3C1=CC=C(F)C(Br)=C1 BFVJEPANUDHFNL-UHFFFAOYSA-N 0.000 claims description 3
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ZGLWJIUBWJNBLH-UHFFFAOYSA-N chembl3138579 Chemical compound C1=C(Br)C(F)=CC=C1C1C(S(=O)(=O)CCC2)=C2NC2=C1C(=O)COC2 ZGLWJIUBWJNBLH-UHFFFAOYSA-N 0.000 claims description 3
201000001881 impotence Diseases 0.000 claims description 3
125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims description 3
XAXYWABWFVKQOX-UHFFFAOYSA-N 10-(3,4-dichlorophenyl)-2,3,4,5,6,10-hexahydropyrano[3,4-b][1,6]naphthyridine-1,9-dione Chemical compound C1=C(Cl)C(Cl)=CC=C1C1C(C(=O)NCC2)=C2NC2=C1C(=O)COC2 XAXYWABWFVKQOX-UHFFFAOYSA-N 0.000 claims description 2
SBSVMRKHPXQJIF-UHFFFAOYSA-N 10-(3-bromo-4-fluorophenyl)-2,3,4,5,6,10-hexahydropyrano[3,4-b][1,6]naphthyridine-1,9-dione Chemical compound C1=C(Br)C(F)=CC=C1C1C(C(=O)NCC2)=C2NC2=C1C(=O)COC2 SBSVMRKHPXQJIF-UHFFFAOYSA-N 0.000 claims description 2
PCVWZRUEHPBTRD-UHFFFAOYSA-N 10-(5-nitrothiophen-3-yl)-2,3,4,5,6,10-hexahydropyrano[3,4-b][1,6]naphthyridine-1,9-dione Chemical compound S1C([N+](=O)[O-])=CC(C2C3=C(CCNC3=O)NC3=C2C(COC3)=O)=C1 PCVWZRUEHPBTRD-UHFFFAOYSA-N 0.000 claims description 2
GNSUWSGMBWMSPA-UHFFFAOYSA-N 10-[4-chloro-3-(trifluoromethyl)phenyl]-2,3,4,5,6,10-hexahydropyrano[3,4-b][1,6]naphthyridine-1,9-dione Chemical compound C1=C(Cl)C(C(F)(F)F)=CC(C2C3=C(CCNC3=O)NC3=C2C(COC3)=O)=C1 GNSUWSGMBWMSPA-UHFFFAOYSA-N 0.000 claims description 2
GEIQGSRESAVZFB-UHFFFAOYSA-N 5-(3-bromo-4-fluorophenyl)-1,2,3,5,7,8,9,10-octahydropyrido[3,4-b][1,7]naphthyridine-4,6-dione Chemical compound C1=C(Br)C(F)=CC=C1C1C(C(=O)CNC2)=C2NC2=C1C(=O)CNC2 GEIQGSRESAVZFB-UHFFFAOYSA-N 0.000 claims description 2
CZNFHVVNAROKCU-UHFFFAOYSA-N 5-(3-bromo-4-fluorophenyl)-1,5,7,8,9,10-hexahydropyrano[3,4-b][1,7]naphthyridine-4,6-dione Chemical compound C1=C(Br)C(F)=CC=C1C1C(C(=O)COC2)=C2NC2=C1C(=O)CNC2 CZNFHVVNAROKCU-UHFFFAOYSA-N 0.000 claims description 2
RPPWFSAXVVNIKV-UHFFFAOYSA-N 9-(3-bromo-4-fluorophenyl)-2,3,5,9-tetrahydropyrano[3,4-b]pyrrolo[3,4-e]pyridine-1,8(4h,7h)-dione Chemical compound C1=C(Br)C(F)=CC=C1C1C(C(=O)COC2)=C2NC2=C1C(=O)NC2 RPPWFSAXVVNIKV-UHFFFAOYSA-N 0.000 claims description 2
QDTMVJADNZUMQR-UHFFFAOYSA-N 9-(3-bromo-4-fluorophenyl)-2-methyl-2,3,5,9-tetrahydropyrano[3,4-b]pyrrolo[3,4-e]pyridine-1,8(4h,7h)-dione Chemical compound O=C1N(C)CC(NC2=C3C(COC2)=O)=C1C3C1=CC=C(F)C(Br)=C1 QDTMVJADNZUMQR-UHFFFAOYSA-N 0.000 claims description 2
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125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
238000005303 weighing Methods 0.000 description 1
239000011787 zinc oxide Substances 0.000 description 1
235000014692 zinc oxide Nutrition 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
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- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/44—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
- C07C45/298—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with manganese derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/41—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrogenolysis or reduction of carboxylic groups or functional derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Gynecology & Obstetrics (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Hydrogenated Pyridines (AREA)
Pyrane Compounds (AREA)

NO20012100A 1998-10-28 2001-04-27 Pyrano-, piperidino- og tiopyranoforbindelser, farmasoytiske sammensetninger inneholdende det samme og anvendelse av forbindelsene NO318628B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US18169098A	1998-10-28	1998-10-28
US09/421,862 US6191140B1 (en)	1998-10-28	1999-10-20	Pyrano, piperidino, and thiopyrano compounds and methods of use
PCT/US1999/025373 WO2000024743A1 (en)	1998-10-28	1999-10-28	Pyrano, piperidino, and thiopyrano compounds and methods of use

Publications (3)

Publication Number	Publication Date
NO20012100D0 NO20012100D0 (no)	2001-04-27
NO20012100L NO20012100L (no)	2001-06-14
NO318628B1 true NO318628B1 (no)	2005-04-18

Family

ID=26877422

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20012100A NO318628B1 (no)	1998-10-28	2001-04-27	Pyrano-, piperidino- og tiopyranoforbindelser, farmasoytiske sammensetninger inneholdende det samme og anvendelse av forbindelsene

Country Status (21)

Country	Link
US (1)	US6191140B1 (de)
EP (1)	EP1124828B1 (de)
JP (1)	JP2002528454A (de)
KR (1)	KR20010085975A (de)
CN (1)	CN1335846A (de)
AT (1)	ATE382620T1 (de)
AU (1)	AU764163B2 (de)
BG (1)	BG105524A (de)
BR (1)	BR9914688A (de)
CA (1)	CA2348576A1 (de)
CZ (1)	CZ20011480A3 (de)
DE (1)	DE69937895T2 (de)
ES (1)	ES2299272T3 (de)
HK (1)	HK1041877A1 (de)
HU (1)	HUP0104146A3 (de)
NO (1)	NO318628B1 (de)
NZ (1)	NZ511041A (de)
PL (1)	PL347552A1 (de)
SK (1)	SK5242001A3 (de)
TR (1)	TR200101140T2 (de)
WO (1)	WO2000024743A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6593335B1 (en) *	1997-12-18	2003-07-15	Abbott Laboratories	Potassium channel openers
US6265417B1 (en)	1997-12-18	2001-07-24	Abbott Laboratories	Potassium channel openers
US6642222B2 (en) *	1998-10-28	2003-11-04	Abbott Laboratories	Pyrano, piperidino, and thiopyrano compounds and methods of use
ATE373642T1 (de) *	1999-08-03	2007-10-15	Abbott Lab	Kalium kanalaktivatoren
US6538004B2 (en) *	2000-03-03	2003-03-25	Abbott Laboratories	Tricyclic dihydropyrazolone and tricyclic dihydroisoxazolone potassium channel openers
US7074931B2 (en)	2000-08-02	2006-07-11	Astrazeneca Ab	Process for asymmetric synthesis of substituted 1,4 -dihydropyridines
WO2003011869A1 (en) *	2001-07-30	2003-02-13	Abbott Laboratories	Radioligands and their use for identifying potassium channel modulators
US6632418B2 (en) *	2001-07-30	2003-10-14	Abbott Laboratories	Radioligands and their use for identifying potassium channel modulators
US20030153773A1 (en) *	2002-02-14	2003-08-14	Wayne Gregory S.	Process for the production of dihydropyridines

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4321384A (en)	1981-02-27	1982-03-23	American Home Products Corporation	Antihypertensive agents
DE3169626D1 (en)	1981-02-27	1985-05-02	American Home Prod	Antihypertensive agents
US4551534A (en)	1984-03-30	1985-11-05	American Home Products Corporation	Aralkyl or aryloxyalkyl 1,7-naphthyridine-3-carboxylic acid esters
US4596873A (en)	1985-07-29	1986-06-24	American Home Products Corporation	1,4,5,6,7,8-Hexahydro-2-alkyl-4-aryl-5-oxo-1,7-naphthyridine-3-carboxylic acid aromatic esters and pharmaceutically acceptable acid addition salts thereof useful as antihypertensive agents
AU6042686A (en)	1985-07-29	1987-02-05	American Home Products Corporation	1,4,5,6,7,8-hexahydro-(substituted) phenyl-1,7- napthyridine-3-carboxylic acid derivatives
US4618678A (en)	1985-07-29	1986-10-21	American Home Products Corporation	4-(2,3-dichloro-6-fluorophenyl)-1,4,5,6,7,8-hexahydro-2-methyl-5-oxo-1,7-naphthyridine-3-carboxylic acid 2-(2,3-dichlorophenoxy)ethyl ester
CA2080949A1 (en)	1991-10-21	1993-04-22	Cyrus John Ohnmacht	Therapeutic agents
GB9220570D0 (en)	1991-10-21	1992-11-11	Ici Plc	Therapeutic agent
GB9318935D0 (en) *	1992-10-20	1993-10-27	Zeneca Ltd	Heterocyclic derivatives
DE4424678A1 (de) *	1994-07-13	1996-01-18	Bayer Ag	Dioxo-thiopyrano-pyridin-carbonsäure-derivate
US6593335B1 (en) *	1997-12-18	2003-07-15	Abbott Laboratories	Potassium channel openers
DK1040097T3 (da) *	1997-12-18	2004-08-02	Abbott Lab	Stoffer, som åbner kaliumkanaler
AU1459500A (en) *	1998-10-28	2000-05-15	Abbott Laboratories	Dihydropyridine compounds and methods of use

1999
- 1999-10-20 US US09/421,862 patent/US6191140B1/en not_active Expired - Fee Related
- 1999-10-28 PL PL99347552A patent/PL347552A1/xx not_active Application Discontinuation
- 1999-10-28 DE DE69937895T patent/DE69937895T2/de not_active Expired - Lifetime
- 1999-10-28 BR BR9914688-6A patent/BR9914688A/pt not_active IP Right Cessation
- 1999-10-28 TR TR2001/01140T patent/TR200101140T2/xx unknown
- 1999-10-28 KR KR1020017005347A patent/KR20010085975A/ko not_active Ceased
- 1999-10-28 NZ NZ511041A patent/NZ511041A/xx unknown
- 1999-10-28 HK HK02101208.4A patent/HK1041877A1/zh unknown
- 1999-10-28 CA CA002348576A patent/CA2348576A1/en not_active Abandoned
- 1999-10-28 WO PCT/US1999/025373 patent/WO2000024743A1/en not_active Ceased
- 1999-10-28 HU HU0104146A patent/HUP0104146A3/hu unknown
- 1999-10-28 ES ES99960168T patent/ES2299272T3/es not_active Expired - Lifetime
- 1999-10-28 EP EP99960168A patent/EP1124828B1/de not_active Expired - Lifetime
- 1999-10-28 JP JP2000578313A patent/JP2002528454A/ja active Pending
- 1999-10-28 CN CN99815020A patent/CN1335846A/zh active Pending
- 1999-10-28 AU AU17095/00A patent/AU764163B2/en not_active Ceased
- 1999-10-28 CZ CZ20011480A patent/CZ20011480A3/cs unknown
- 1999-10-28 AT AT99960168T patent/ATE382620T1/de not_active IP Right Cessation
- 1999-10-28 SK SK524-2001A patent/SK5242001A3/sk unknown
2001
- 2001-04-27 NO NO20012100A patent/NO318628B1/no not_active IP Right Cessation
- 2001-05-19 BG BG105524A patent/BG105524A/bg unknown

Also Published As

Publication number	Publication date
EP1124828B1 (de)	2008-01-02
AU1709500A (en)	2000-05-15
DE69937895T2 (de)	2009-01-02
NO20012100D0 (no)	2001-04-27
BG105524A (bg)	2001-12-29
ATE382620T1 (de)	2008-01-15
CZ20011480A3 (cs)	2001-08-15
ES2299272T3 (es)	2008-05-16
JP2002528454A (ja)	2002-09-03
US6191140B1 (en)	2001-02-20
CN1335846A (zh)	2002-02-13
KR20010085975A (ko)	2001-09-07
PL347552A1 (en)	2002-04-08
NZ511041A (en)	2003-03-28
HUP0104146A3 (en)	2002-10-28
TR200101140T2 (tr)	2002-07-22
CA2348576A1 (en)	2000-05-04
HK1041877A1 (zh)	2002-07-26
HUP0104146A2 (hu)	2002-04-29
SK5242001A3 (en)	2001-12-03
EP1124828A1 (de)	2001-08-22
DE69937895D1 (de)	2008-02-14
NO20012100L (no)	2001-06-14
WO2000024743A1 (en)	2000-05-04
BR9914688A (pt)	2001-10-02
AU764163B2 (en)	2003-08-14

Legal Events

Date	Code	Title	Description
2006-05-29	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
US6593335B1 (en)	2003-07-15	Potassium channel openers
US6265417B1 (en)	2001-07-24	Potassium channel openers
US20020007059A1 (en)	2002-01-17	Tricyclic dihydropyrazolone and tricyclic dihydroisoxazolone potassium channel openers
US6191140B1 (en)	2001-02-20	Pyrano, piperidino, and thiopyrano compounds and methods of use
EP1040097B1 (de)	2004-04-14	Kaliumkanalöffner
CA2407838C (en)	2010-01-12	Pyrano, piperidino, and thiopyrano compounds and methods of use
US20020099070A1 (en)	2002-07-25	Dihydronaphthyridine potassium channel openers
EP1131322A2 (de)	2001-09-12	Dihydropyridin verbindungen und ihre verwendung als kalium kanal öffner
MXPA01004248A (en)	2002-03-05	Pyrano, piperidino, and thiopyrano compounds and methods of use
EP1278746A2 (de)	2003-01-29	Dihydropyridin verbindungen und ihre verwendung
MXPA01004246A (en)	2002-03-05	Dihydropyridine compounds and methods of use
HK1032583B (en)	2005-02-18	Potassium channel openers