NO319982B1 - Human telomerase katalytisk subenhet - Google Patents

Human telomerase katalytisk subenhet Download PDF

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Publication number
NO319982B1
NO319982B1 NO19991588A NO991588A NO319982B1 NO 319982 B1 NO319982 B1 NO 319982B1 NO 19991588 A NO19991588 A NO 19991588A NO 991588 A NO991588 A NO 991588A NO 319982 B1 NO319982 B1 NO 319982B1
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NO
Norway
Prior art keywords
telomerase
htrt
cell
sequence
polynucleotide
Prior art date
Application number
NO19991588A
Other languages
English (en)
Norwegian (no)
Other versions
NO991588L (no
NO991588D0 (no
Inventor
Thomas R Cech
William H Andrews
Joachim Lingner
Toru Nakamura
Karen B Chapman
Gregg B Morin
Calvin B Harley
Original Assignee
Geron Corp
Univ Technology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27575511&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO319982(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/851,843 external-priority patent/US6093809A/en
Priority claimed from US08/854,050 external-priority patent/US6261836B1/en
Priority claimed from US08/912,951 external-priority patent/US6475789B1/en
Application filed by Geron Corp, Univ Technology Corp filed Critical Geron Corp
Publication of NO991588D0 publication Critical patent/NO991588D0/no
Publication of NO991588L publication Critical patent/NO991588L/no
Publication of NO319982B1 publication Critical patent/NO319982B1/no

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NO19991588A 1996-10-01 1999-03-31 Human telomerase katalytisk subenhet NO319982B1 (no)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US72464396A 1996-10-01 1996-10-01
US84441997A 1997-04-18 1997-04-18
US84601797A 1997-04-25 1997-04-25
US08/851,843 US6093809A (en) 1996-10-01 1997-05-06 Telomerase
US08/854,050 US6261836B1 (en) 1996-10-01 1997-05-09 Telomerase
US91131297A 1997-08-14 1997-08-14
US91550397A 1997-08-14 1997-08-14
US08/912,951 US6475789B1 (en) 1996-10-01 1997-08-14 Human telomerase catalytic subunit: diagnostic and therapeutic methods
PCT/US1997/017885 WO1998014593A2 (fr) 1996-10-01 1997-10-01 Sous-unite catalytique de la telomerase d'origine humaine

Publications (3)

Publication Number Publication Date
NO991588D0 NO991588D0 (no) 1999-03-31
NO991588L NO991588L (no) 1999-05-31
NO319982B1 true NO319982B1 (no) 2005-10-10

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ID=27575511

Family Applications (2)

Application Number Title Priority Date Filing Date
NO19991588A NO319982B1 (no) 1996-10-01 1999-03-31 Human telomerase katalytisk subenhet
NO20053120A NO332085B1 (no) 1996-10-01 2005-06-24 Immunogent peptid av hTRT samt fragment derav, sammensetning, isolert eller rekombinant polynukleotid, vektor og farmasoytisk sammensetning.

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20053120A NO332085B1 (no) 1996-10-01 2005-06-24 Immunogent peptid av hTRT samt fragment derav, sammensetning, isolert eller rekombinant polynukleotid, vektor og farmasoytisk sammensetning.

Country Status (20)

Country Link
US (4) US6166178A (fr)
EP (6) EP0932686A2 (fr)
JP (7) JP2001523947A (fr)
KR (2) KR20000048820A (fr)
CN (3) CN1291231B (fr)
AT (3) ATE552341T1 (fr)
AU (2) AU4803697A (fr)
BR (3) BR9712254A (fr)
CA (3) CA2266752A1 (fr)
DE (5) DE69739675D1 (fr)
EA (2) EA199900349A1 (fr)
ES (1) ES2205132T5 (fr)
FI (1) FI990655A7 (fr)
FR (1) FR2757177A1 (fr)
GB (2) GB2317891C (fr)
IL (2) IL129222A0 (fr)
NO (2) NO319982B1 (fr)
NZ (1) NZ334709A (fr)
SG (1) SG94355A1 (fr)
WO (2) WO1998014592A2 (fr)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5958680A (en) 1994-07-07 1999-09-28 Geron Corporation Mammalian telomerase
US6545133B1 (en) 1995-08-04 2003-04-08 Geron Corporation Methods for purifying telomerase
US6517834B1 (en) * 1995-08-04 2003-02-11 Geron Corporation Purified telomerase
DE19681033D2 (de) 1995-11-16 1999-03-18 Michael W Dahm Verfahren zur Quantifizierung von Tumorzellen in einer Körperflüssigkeit und dazu geeignete Testkits
US6881571B1 (en) * 1998-03-11 2005-04-19 Exonhit Therapeutics S.A. Qualitative differential screening
US6607898B1 (en) 1996-03-26 2003-08-19 Oncomedx, Inc. Method for detection of hTR and hTERT telomerase-associated RNA in plasma or serum
US6808880B2 (en) 1996-10-01 2004-10-26 Geron Corporation Method for detecting polynucleotides encoding telomerase
US6444650B1 (en) * 1996-10-01 2002-09-03 Geron Corporation Antisense compositions for detecting and inhibiting telomerase reverse transcriptase
US6475789B1 (en) 1996-10-01 2002-11-05 University Technology Corporation Human telomerase catalytic subunit: diagnostic and therapeutic methods
US6777203B1 (en) 1997-11-19 2004-08-17 Geron Corporation Telomerase promoter driving expression of therapeutic gene sequences
US6610839B1 (en) 1997-08-14 2003-08-26 Geron Corporation Promoter for telomerase reverse transcriptase
US6261836B1 (en) 1996-10-01 2001-07-17 Geron Corporation Telomerase
EP0932686A2 (fr) * 1996-10-01 1999-08-04 Geron Corporation Transcriptase inverse de la telomerase
US7585622B1 (en) 1996-10-01 2009-09-08 Geron Corporation Increasing the proliferative capacity of cells using telomerase reverse transcriptase
US6093809A (en) 1996-10-01 2000-07-25 University Technology Corporation Telomerase
US7390891B1 (en) * 1996-11-15 2008-06-24 Amgen Inc. Polynucleotides encoding a telomerase component TP2
WO1998023759A2 (fr) * 1996-11-26 1998-06-04 Baylor College Of Medicine Identification d'inhibiteurs empechant l'acces de la telomerase aux terminaisons chromosomiques
WO1998037181A2 (fr) * 1997-02-20 1998-08-27 Whitehead Institute For Biomedical Research Gene de sous-unite catalytique de telomerase et proteine codee
US20050013825A1 (en) * 1997-04-18 2005-01-20 Geron Corporation Vaccine containing the catalytic subunit of telomerase for treating cancer
US7622549B2 (en) 1997-04-18 2009-11-24 Geron Corporation Human telomerase reverse transcriptase polypeptides
US7413864B2 (en) 1997-04-18 2008-08-19 Geron Corporation Treating cancer using a telomerase vaccine
JP2002508662A (ja) * 1997-06-20 2002-03-19 バイエル・アクチエンゲゼルシヤフト ヒトテロメラーゼの触媒サブユニット並びにその診断的及び治療的使用
EP1571215A3 (fr) * 1997-07-01 2007-10-31 Cambia Biosystems LLC Gènes et protéines de télomérases de vertèbres et leurs utilisations
KR100581990B1 (ko) 1997-07-01 2006-05-23 캄비아 바이오시스템즈 엘엘씨 척추 동물 텔로머라제 유전자 및 단백질과 이의 용도
US7378244B2 (en) * 1997-10-01 2008-05-27 Geron Corporation Telomerase promoters sequences for screening telomerase modulators
AU1606999A (en) * 1997-11-26 1999-06-15 Albert Einstein College Of Medicine Of Yeshiva University Mouse telomerase reverse transcriptase
DE19757984A1 (de) * 1997-12-24 1999-07-01 Bayer Ag Regulatorische DNA-Sequenzen aus der 5'-Region vom Gen der humanen katalytischen Telomerase-Untereinheit udn deren diagnostische und therapeutische Verwendung
DE19804372A1 (de) 1998-02-04 1999-08-05 Michael W Dr Dr Dahm Verfahren zur quantitativen Bestimmung von Tumorzellen in einer Körperflüssigkeit und dazu geeignete Testkits
US6639057B1 (en) 1998-03-26 2003-10-28 Kyowa Hakko Kogyo Co., Ltd. Monoclonal antibody against human telomerase catalytic subunit
US7402307B2 (en) 1998-03-31 2008-07-22 Geron Corporation Method for identifying and killing cancer cells
US6337200B1 (en) * 1998-03-31 2002-01-08 Geron Corporation Human telomerase catalytic subunit variants
CA2347067C (fr) 1998-03-31 2013-09-17 Geron Corporation Vaccin a base de cellule dendritique contenant de la transcriptase inverse de la telomarase pour le traitement du cancer
US20030105315A1 (en) * 1998-04-09 2003-06-05 Metagen Pharmaceuticals Gmbh Human nucleic acid sequences from ovarian tumor tissue
US7030211B1 (en) * 1998-07-08 2006-04-18 Gemvax As Antigenic peptides derived from telomerase
US6900049B2 (en) 1998-09-10 2005-05-31 Cell Genesys, Inc. Adenovirus vectors containing cell status-specific response elements and methods of use thereof
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
AU1331100A (en) 1998-10-29 2000-05-22 Dana-Farber Cancer Institute Cancer immunotheraphy and diagnosis using universal tumor associated antigens, including htert
GB9900298D0 (en) * 1999-01-07 1999-02-24 Medical Res Council Optical sorting method
DE10003356A1 (de) * 1999-01-22 2000-07-27 Humboldt Uni Zu Berlin Univers Gegen die katalytische Untereinheit der humanen Telomerase (hTERT)gerichtete Ribozyme
CA2362367C (fr) * 1999-02-04 2004-08-03 Geron Corporation Sequences regulatoires transcriptionnelle de la transcriptase inversee de la telomerase
US7960540B2 (en) 1999-04-08 2011-06-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
EP1181304B1 (fr) 1999-04-08 2007-10-10 Antisoma Research Limited Procede inhibant la proliferation d'oligonucleotides riches en guanosine et procede de liaison desdits oligonucleotides a la nucleoline
US8114850B2 (en) 1999-04-08 2012-02-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
CA2368967A1 (fr) * 1999-04-09 2000-10-19 Biomira, Inc. Vaccin anticancereux specifique de la telomerase
US6358739B1 (en) * 1999-04-12 2002-03-19 Modex Therapeutiques, S.A. Transiently immortalized cells
DE19916929A1 (de) 1999-04-15 2000-10-19 Bayer Ag Ein automatisierbarer Schnelltest zum Nachweis von Krebserkrankungen auf der Basis von Telomerase(hTC) mRNA mit spezifischen Primern und Sonden
US6995145B1 (en) 1999-06-04 2006-02-07 Au Jessie L-S Methods and compositions for modulating drug activity through telomere damage
US20050255596A1 (en) * 1999-09-07 2005-11-17 West Michael D Methods of repairing tandemly repeated DNA sequences and extending cell life-span nuclear transfer
CN1317291C (zh) 1999-09-10 2007-05-23 杰龙公司 寡核苷酸n3′→p5′硫代氨基磷酸酯,其合成及应用
FR2798673B1 (fr) * 1999-09-16 2004-05-28 Exonhit Therapeutics Sa Methodes et compositions pour la detection d'evenements pathologiques
US6399384B1 (en) 1999-09-17 2002-06-04 Reneuron Limited Conditional immortalization of cells
AU1309101A (en) * 1999-11-16 2001-05-30 Kyowa Hakko Kogyo Co. Ltd. Method of searching for substance inhibiting binding between telomerase subunits
GB9927353D0 (en) * 1999-11-19 2000-01-19 Cantab Pharma Res Virus preparation and use
US7074983B2 (en) 1999-11-19 2006-07-11 Kirin Beer Kabushiki Kaisha Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin
US7414170B2 (en) 1999-11-19 2008-08-19 Kirin Beer Kabushiki Kaisha Transgenic bovines capable of human antibody production
US6664046B1 (en) * 1999-12-16 2003-12-16 Roche Molecular Systems, Inc. Quantitation of hTERT mRNA expression
KR20010096991A (ko) * 2000-04-19 2001-11-08 임정빈 텔로머레이즈의 프로모터에 특정하게 결합하는더블유티이1 절편, 그 유전자, 발현벡터 및 그것을 이용한세포성장 억제 방법
US6458589B1 (en) 2000-04-27 2002-10-01 Geron Corporation Hepatocyte lineage cells derived from pluripotent stem cells
IT1318504B1 (it) * 2000-05-08 2003-08-27 Talent Srl Metodo e apparecchiatura per la diagnosi precoce di tumori vescicalisu campioni di urina.
US6331399B1 (en) 2000-05-16 2001-12-18 Isis Pharmaceuticals, Inc. Antisense inhibition of tert expression
US6492171B2 (en) * 2000-05-16 2002-12-10 Isis Pharmaceuticals, Inc. Antisense modulation of TERT expression
US7250294B2 (en) 2000-05-17 2007-07-31 Geron Corporation Screening small molecule drugs using neural cells differentiated from human embryonic stem cells
EP1158055A1 (fr) 2000-05-26 2001-11-28 Xu Qi University of Teaxs Laboratoire de Leucémie Chen Méthode pour le diagnostic de cancers
US7078491B1 (en) 2000-09-21 2006-07-18 Amgen Inc. Selective binding agents of telomerase
WO2002042468A2 (fr) 2000-11-27 2002-05-30 Geron Corporation Vecteurs de glycosyltransferase pour traitement du cancer
US6576464B2 (en) 2000-11-27 2003-06-10 Geron Corporation Methods for providing differentiated stem cells
WO2002048319A1 (fr) * 2000-12-14 2002-06-20 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Lignees cellulaires humaines de foie immortalisees au moyen de la telomerase
US7491534B2 (en) 2000-12-22 2009-02-17 Kirin Holdings Kabushiki Kaisha Methods for altering cell fate to generate T-cells specific for an antigen of interest
DE60144248D1 (de) 2000-12-22 2011-04-28 Kyowa Hakko Kirin Co Ltd Verfahren zur klonierung von nichtmenschliche säugern unter verwendung von reprogrammiertem donorchromatin oder donorzellen
US6906237B2 (en) * 2001-02-27 2005-06-14 G. Scott Herron Vivo assay for anti angiogenic compounds
US20040063922A1 (en) * 2001-04-17 2004-04-01 Conrad Charles A. Methods and compositions for catalytic DNA exchange in a sequence specific manner
US7262174B2 (en) * 2001-05-09 2007-08-28 Geron Corporation Treatment for wounds
GB0112342D0 (en) * 2001-05-21 2001-07-11 Norsk Hydro As Polypeptides
JPWO2003008577A1 (ja) 2001-07-16 2004-11-11 冬木 石川 新規の形質転換細胞、抗老化剤のスクリーニング方法および抗老化剤
AU2002327433A1 (en) * 2001-08-10 2003-02-24 Cornell Research Foundation, Inc. Telomerase immortalized human neutral stem cells and phenotypically-restricted progenitor cells
AUPR769701A0 (en) * 2001-09-14 2001-10-11 Li, He Telomerase inhibitory peptides and uses thereof
DK1440085T3 (da) * 2001-10-18 2010-08-09 Medicyte Gmbh Transient immortalisering af celler af onkogene proteiner eller telomerase
EP1480992A4 (fr) * 2001-10-22 2007-02-07 Univ Rochester Interference par telomerase
JPWO2003038076A1 (ja) * 2001-10-31 2005-02-24 株式会社レノメディクス研究所 不死化間葉系細胞及びその利用
CA2470539C (fr) 2001-12-07 2011-10-04 Geron Corporation Cellules d'ilots pancreatiques provenant de cellules souches embryonnaires humaines
US20030153082A1 (en) 2001-12-07 2003-08-14 The John P. Robarts Research Institute Hematopoietic cells from human embryonic stem cells
DE10163130B4 (de) * 2001-12-20 2009-05-14 Cyto Tools Gmbh Apoptotisch wirksame Peptide und diese umfassende pharmazeutische Zusammensetzungen
JPWO2003054545A1 (ja) * 2001-12-21 2005-04-28 清史 村上 抗テロメラーゼ抗体の検出方法
GB0200929D0 (en) * 2002-01-16 2002-03-06 Univ Glasgow Tissue rejection
ATE548461T1 (de) * 2002-01-18 2012-03-15 Morphotek Inc Verfahren zur erzeugung manipulierter zellen zur locus-spezifischen genregulation und analyse
US20030175961A1 (en) * 2002-02-26 2003-09-18 Herron G. Scott Immortal micorvascular endothelial cells and uses thereof
US20050106729A1 (en) * 2002-05-03 2005-05-19 Mark Irvin Rosenblatt Gene transfer methods and compositions
CA2487419A1 (fr) * 2002-05-28 2003-12-04 Regents Of The University Of Minnesota Utilisation de polyppetides crisp comme contaceptifs et inhibiteurs de capacitation du sperme
US7294708B2 (en) * 2002-05-31 2007-11-13 Beijing Institute Of Biotechnology Telomerase reverse transcriptase fragments and uses thereof
AU2003267967B2 (en) * 2002-06-18 2008-11-20 Zymogenetics, Inc. Hybrid vector having a cytomegalovirus enhancer and myeloproliferative sarcoma virus promoter
US7285415B2 (en) 2002-07-11 2007-10-23 The Regents Of The University Of California Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury
WO2004044156A2 (fr) 2002-11-08 2004-05-27 Hematech, Llc Ongules transgeniques presentant une activite de la proteine prion reduite et leurs utilisations
US7166692B2 (en) 2003-03-04 2007-01-23 Canbrex Bio Science Walkersville, Inc. Intracellular delivery of small molecules, proteins, and nucleic acids
WO2004099385A2 (fr) * 2003-04-30 2004-11-18 Duke University Allongement de telomere
PL1644009T3 (pl) 2003-06-23 2018-07-31 Telomerase Activation Sciences, Inc. Kompozycje do zwiększania aktywności telomerazy i leczenia zakażenia hiv
JP4423428B2 (ja) * 2003-09-12 2010-03-03 リニューロン・リミテッド 細胞療法
EP1522858A1 (fr) * 2003-10-10 2005-04-13 Jean-Christophe Roegel Procédé de sélection de composés utilisant des anticorps agissant comme agoniste, antagoniste ou modulateur allostériques
US7473418B2 (en) 2004-03-25 2009-01-06 Cell Genesys, Inc. Pan cancer oncolytic vectors and methods of use thereof
NZ550106A (en) 2004-04-22 2009-06-26 Kyowa Hakko Kirin Co Ltd Transgenic animals and uses thereof
JP4814875B2 (ja) 2004-05-11 2011-11-16 アキシオジェネシス エージー ｉｎｖｉｔｒｏ分化細胞に基づく薬物発見のための検定
EP1781337A4 (fr) * 2004-08-05 2010-06-23 Univ Leland Stanford Junior Procedes et compositions pour l'activation de cellules
US8697139B2 (en) 2004-09-21 2014-04-15 Frank M. Phillips Method of intervertebral disc treatment using articular chondrocyte cells
JP2006242618A (ja) * 2005-03-01 2006-09-14 Univ Of Tokyo 組織ｆｉｓｈ法によるテロメア量を指標とした癌の診断
JP4635196B2 (ja) * 2005-03-04 2011-02-16 国立大学法人広島大学 遺伝子導入細胞、及びそれを用いたテロメラーゼ誘導物質の検出方法
AU2006220500A1 (en) * 2005-03-09 2006-09-14 Board Of Regents, The University Of Texas System Novel hTMC promoter and vectors for the tumor-selective and high-efficient expression of cancer therapeutic genes
CA2651367A1 (fr) * 2005-05-11 2006-11-16 Genetic Technologies Limited Procedes d'enrichissement de cellules foetales
EP1748067A1 (fr) * 2005-07-29 2007-01-31 Institut Pasteur Polynucleotides codant pour des épitopes de la hTERT restreints au CMH de classe I, analogues et polyépitopes
ATE498005T1 (de) 2005-12-21 2011-02-15 Univ Catholique Louvain Isolierte leberstammzellen
US8415153B2 (en) 2006-06-19 2013-04-09 Geron Corporation Differentiation and enrichment of islet-like cells from human pluripotent stem cells
WO2008002285A1 (fr) * 2006-06-26 2008-01-03 Science Applications International Corporation Anticorps igy contre la transcriptase inverse de la télomérase humaine
US20080131442A1 (en) * 2006-06-26 2008-06-05 Science Applications International Corporation IgY antibodies to human telomerase reverse transcriptase
AU2007278831B2 (en) * 2006-07-28 2013-03-21 The Trustees Of The University Of Pennsylvania Improved vaccines and methods for using the same
AU2013203229C1 (en) * 2006-07-28 2015-10-29 The Trustees Of The University Of Pennsylvania Improved vaccines and methods for using the same
EP2076531B1 (fr) 2006-10-12 2011-11-23 Istituto di Ricerche di Biologia Molecolare P. Angeletti S.R.L. Protéine de fusion de transcriptase inverse de la télomérase, nucléotides qui codent pour elle et ses utilisations
ES2882360T3 (es) 2006-11-03 2021-12-01 Univ Leland Stanford Junior Inmunoempobrecimiento selectivo de un nicho de células madre endógenas para injerto
EP1994942A1 (fr) * 2007-05-25 2008-11-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Compositions pharmaceutiques comprenant de la télomérase et leurs utilisations
EP2249718B1 (fr) 2008-01-14 2019-09-18 Conventus Orthopaedics, Inc. Appareil de réparation des fractures
US9186128B2 (en) 2008-10-01 2015-11-17 Covidien Lp Needle biopsy device
US9782565B2 (en) 2008-10-01 2017-10-10 Covidien Lp Endoscopic ultrasound-guided biliary access system
US9332973B2 (en) 2008-10-01 2016-05-10 Covidien Lp Needle biopsy device with exchangeable needle and integrated needle protection
US11298113B2 (en) 2008-10-01 2022-04-12 Covidien Lp Device for needle biopsy with integrated needle protection
US8968210B2 (en) 2008-10-01 2015-03-03 Covidien LLP Device for needle biopsy with integrated needle protection
US9447467B2 (en) 2009-04-21 2016-09-20 Genetic Technologies Limited Methods for obtaining fetal genetic material
SG176806A1 (en) * 2009-07-09 2012-01-30 Centocor Ortho Biotech Inc Cardiac tissue-derived cells
WO2011088172A1 (fr) 2010-01-15 2011-07-21 Brenzel Michael P Tige orthopédique tournante rigide
CN102821707B (zh) 2010-01-20 2016-02-03 康文图斯整形外科公司 用于骨接近和骨腔准备的装置及方法
EP2536830B1 (fr) 2010-02-16 2019-07-17 Ultimovacs AS Polypeptides
WO2011106671A1 (fr) * 2010-02-26 2011-09-01 Geron Corporation Dosage de l'activité de la télomérase
CN108125714A (zh) 2010-03-08 2018-06-08 康文图斯整形外科公司 用于固定骨植入物的装置及方法
US9029145B2 (en) 2010-04-08 2015-05-12 The University Court Of The University Of Edinburgh Chondrogenic progenitor cells, protocol for derivation of cells and uses thereof
WO2012026309A1 (fr) * 2010-08-23 2012-03-01 公立大学法人横浜市立大学 Création d'un médicament anticorps anti-pad4
CN102093980B (zh) * 2010-12-10 2013-04-17 梁伟国 永生化人椎间盘髓核细胞体系的制备方法
US8420617B2 (en) * 2011-03-11 2013-04-16 Biocell Laboratories Multiantivirus compound, composition and method for treatment of virus diseases
CN102676518B (zh) * 2012-02-27 2013-09-18 华侨大学 一种新型抗肿瘤amiRNA序列及其应用
EP2639299A1 (fr) 2012-03-16 2013-09-18 Invectys Peptides universels du cancer dérivés de la télomérase
JP6262721B2 (ja) * 2012-05-11 2018-01-17 ジェムバックス アンド カエル カンパニー，リミティド 敗血症の予防用または治療用の組成物
WO2013167298A1 (fr) * 2012-05-11 2013-11-14 Kael-Gemvax Co., Ltd. Peptides anti-inflammatoires et composition comprenant ceux-ci
EP3828278A1 (fr) * 2012-06-27 2021-06-02 Rutgers, the State University of New Jersey Analyses rapides pour l'activation des cellules t par mesures d'arn à l'aide de la cytométrie de flux
US20150125438A1 (en) * 2012-07-20 2015-05-07 Sang Jae Kim Anti-Inflammatory Peptides and Composition Comprising the Same
JP6510410B2 (ja) * 2012-09-19 2019-05-08 ジェムバックス アンド カエル カンパニー，リミティド 細胞透過性ペプチド、それを含んだコンジュゲート、及びそれを含んだ組成物
WO2014046478A1 (fr) * 2012-09-19 2014-03-27 주식회사 카엘젬백스 Peptide de pénétration cellulaire, conjugué le comprenant, et composition comprenant le conjugué
KR102038487B1 (ko) 2012-09-19 2019-10-30 주식회사 젬백스앤카엘 텔로머라제 펩티드를 포함하는 항균 또는 항진균용 조성물
KR102166542B1 (ko) 2012-09-28 2020-10-16 주식회사 젬백스앤카엘 줄기세포 검출을 위한 텔로머라제 유래 펩티드 및 조영물질의 컨쥬게이트 및 이를 포함하는 조영제
KR102106756B1 (ko) 2012-12-13 2020-05-06 주식회사 젬백스앤카엘 자외선에 의한 피부 손상 예방 또는 치료용 조성물
KR102093093B1 (ko) 2012-12-13 2020-03-25 주식회사 젬백스앤카엘 피부 노화 개선용 조성물
ES3047667T3 (en) 2013-02-22 2025-12-04 Univ Leland Stanford Junior Methods relating to telomere extension
EP2978445B1 (fr) 2013-03-28 2018-07-04 Invectys Vaccin contre le cancer pour chats
CA2908143C (fr) 2013-03-28 2021-08-31 Invectys Vaccin contre le cancer destine a des chiens
SG11201510177WA (en) 2013-06-11 2016-01-28 Harvard College SC-β CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME
US10183065B2 (en) 2013-10-28 2019-01-22 Invectys Telomerase encoding DNA vaccine
DK3063280T3 (da) 2013-10-28 2019-11-11 Invectys Genelektrooverførsel ind i hudceller
EP2871235A1 (fr) 2013-11-07 2015-05-13 Centre National de la Recherche Scientifique (CNRS) Nouveaux procédés pour produire un hTERT actif
CA2969316A1 (fr) 2013-12-12 2015-06-18 Conventus Orthopaedics, Inc. Outils et methodes de deplacement de tissu
KR102166549B1 (ko) 2014-01-10 2020-10-16 주식회사 젬백스앤카엘 혈뇌장벽 투과성 펩티드 및 이를 포함하는 컨쥬게이트
FI3656869T4 (fi) 2014-08-26 2025-06-04 Univ Leland Stanford Junior Kantasolujen siirrostaminen kantasoluihin kohdentuvan aineen ja immunoregulatorista signaalia moduloivan aineen yhdistelmän kanssa
WO2017079419A1 (fr) 2015-11-05 2017-05-11 The Regents Of The University Of California Cellules marquées par des conjugués lipidiques et méthodes d'utilisation de ces dernières
TWI709647B (zh) 2016-01-19 2020-11-11 美商輝瑞股份有限公司 癌症疫苗
JP7321934B2 (ja) 2017-01-30 2023-08-07 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 幹細胞移植のための非遺伝毒性移植前処置レジメン
US10631881B2 (en) 2017-03-09 2020-04-28 Flower Orthopedics Corporation Plating depth gauge and countersink instrument
US11351246B2 (en) 2017-05-09 2022-06-07 Invectys SAS Recombinant measles vaccine expressing hTERT
WO2019010252A2 (fr) 2017-07-04 2019-01-10 Conventus Orthopaedics, Inc. Appareil et méthodes de traitement d'os
WO2019070740A2 (fr) 2017-10-02 2019-04-11 Fred Hutchinson Cancer Research Center Agents de liaison aux récepteurs de l'hormone lutéinisante et agonistes de l'hormone lutéinisante utilisés pour identifier, multiplier, retirer et modifier des populations de cellules souches primitives
CN108715863B (zh) * 2018-05-30 2020-09-11 吉林大学 一种肿瘤靶向性载体pcTERT及其构建方法及其应用
CN110827920B (zh) * 2018-08-14 2022-11-22 武汉华大医学检验所有限公司 测序数据分析方法和设备及高通量测序方法
CN112930404A (zh) * 2018-09-05 2021-06-08 瑞德库尔有限责任公司 用于治疗剂分析的方法和系统
EP3846621A4 (fr) * 2018-09-06 2022-07-06 The Board Of Regents Of The University Of Texas System Complexe holoenzyme de télomérase et ses procédés d'utilisation
WO2020076976A1 (fr) 2018-10-10 2020-04-16 Readcoor, Inc. Indexation moléculaire spatiale tridimensionnelle
CN109545039A (zh) * 2019-01-15 2019-03-29 苏州大学 一种核孔复合体结构模型教具及其使用方法
AU2020311877B2 (en) 2019-07-05 2024-01-04 Case Western Reserve University Priming media and methods for stem cell culture and therapy
WO2021155063A1 (fr) 2020-01-29 2021-08-05 Readcoor, Llc Compositions et procédés pour la détection d'analytes
JP2021151979A (ja) * 2020-03-24 2021-09-30 均 石井 再生医療薬
US20220049303A1 (en) 2020-08-17 2022-02-17 Readcoor, Llc Methods and systems for spatial mapping of genetic variants
CN112063601B (zh) * 2020-09-22 2023-06-02 浙江愈方生物科技有限公司 一种灭活性端粒酶、具有其的腺病毒和人造mRNA及应用
JP2022119144A (ja) * 2021-02-03 2022-08-16 均 石井 パーキンソン病治療薬
JP2022151412A (ja) * 2021-03-23 2022-10-07 均 石井 脳卒中治療薬
CN113355303B (zh) * 2021-06-07 2023-06-16 中元汇吉生物技术股份有限公司 一种m-mlv逆转录酶突变体及其应用
EP4463151A4 (fr) 2022-01-19 2025-10-01 Univ Northwestern Agents ciblant la transcriptase inverse de la télomérase (tert) pour traiter le cancer et sensibiliser des cellules cancéreuses à une thérapie génotoxique
CN114920802B (zh) * 2022-05-16 2023-05-23 中国地质大学（武汉） 调节端粒酶限速蛋白运动的多肽探针及其复合物和方法
CN116364195B (zh) * 2023-05-10 2023-10-13 浙大城市学院 一种基于预训练模型的微生物遗传序列表型预测方法

Family Cites Families (151)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US912629A (en) 1908-08-29 1909-02-16 Conrad L Stueber Foundation-top for pipe-carriers.
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
US3817837A (en) 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3939350A (en) 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4277437A (en) 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4254082A (en) 1978-06-12 1981-03-03 Miles Laboratories, Inc. Specific binding-adsorbent assay test means
US4657760A (en) 1979-03-20 1987-04-14 Ortho Pharmaceutical Corporation Methods and compositions using monoclonal antibody to human T cells
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
WO1982001461A1 (fr) 1980-07-18 1982-05-13 Leland Stanford Junior Univ Hybridomes humains, precurseurs et produits
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4554101A (en) * 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US4517288A (en) 1981-01-23 1985-05-14 American Hospital Supply Corp. Solid phase system for ligand assay
US5055556A (en) 1981-10-06 1991-10-08 The Board Of Trustees Of The Leland Stanford Jr. Univ. Fluorescent conjugates for analysis of molecules and cells
JPS58215453A (ja) 1982-06-09 1983-12-14 Toray Silicone Co Ltd 室温硬化後塗装可能なオルガノポリシロキサン組成物
NZ207394A (en) 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
FR2542494B1 (fr) 1983-03-08 1985-08-16 Sevylor International Combinaison protectrice, utilisable notamment en atmosphere irradiee
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5272065A (en) 1983-10-20 1993-12-21 Research Foundation Of State University Of New York Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA
US5049386A (en) 1985-01-07 1991-09-17 Syntex (U.S.A.) Inc. N-ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US4897355A (en) 1985-01-07 1990-01-30 Syntex (U.S.A.) Inc. N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US4946787A (en) 1985-01-07 1990-08-07 Syntex (U.S.A.) Inc. N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US5034506A (en) 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US5206344A (en) 1985-06-26 1993-04-27 Cetus Oncology Corporation Interleukin-2 muteins and polymer conjugation thereof
CA1291031C (fr) 1985-12-23 1991-10-22 Nikolaas C.J. De Jaeger Methode pour la detection de liants specifiques et des substances liables par ceux-ci
GB8612087D0 (en) 1986-05-19 1986-06-25 Ici Plc Hybridisation probes
US5001225A (en) 1986-12-08 1991-03-19 Georgetown University Monoclonal antibodies to a pan-malarial antigen
US4889806A (en) 1987-04-15 1989-12-26 Washington University Large DNA cloning system based on yeast artificial chromosomes
US5017478A (en) 1987-07-16 1991-05-21 Berlex Laboratories, Inc. Transfected cells containing plasmids having genes oriented in opposing directions and methods of using
US5124246A (en) 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5093245A (en) 1988-01-26 1992-03-03 Applied Biosystems Labeling by simultaneous ligation and restriction
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5075227A (en) * 1989-03-07 1991-12-24 Zymogenetics, Inc. Directional cloning
JPH02307059A (ja) 1989-05-23 1990-12-20 Seiko Instr Inc 反応容器
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5399493A (en) 1989-06-15 1995-03-21 The Regents Of The University Of Michigan Methods and compositions for the optimization of human hematopoietic progenitor cell cultures
US5437994A (en) 1989-06-15 1995-08-01 Regents Of The University Of Michigan Method for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells
US5464764A (en) 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
US5545522A (en) 1989-09-22 1996-08-13 Van Gelder; Russell N. Process for amplifying a target polynucleotide sequence using a single primer-promoter complex
US5225212A (en) 1989-10-20 1993-07-06 Liposome Technology, Inc. Microreservoir liposome composition and method
AU647741B2 (en) 1989-12-01 1994-03-31 Regents Of The University Of California, The Methods and compositions for chromosome-specific staining
CA2075206C (fr) 1989-12-01 2006-05-23 Herbert L. Heyneker Production de polypeptides recombinants par des especes bovines et methodes transgeniques
RU2128227C1 (ru) 1989-12-22 1999-03-27 Апплайд Резеч Системз АРС Холдинг Н.В. (NL) (Антильские острова) Способ активации транскрипционно-молчащего гена
US5272071A (en) 1989-12-22 1993-12-21 Applied Research Systems Ars Holding N.V. Method for the modification of the expression characteristics of an endogenous gene of a given cell line
US5180940A (en) 1990-02-09 1993-01-19 Asulab S.A. Radial field electrostatic micromotor produced using a photolithographic micromanufacturing technique and a process for producing said micromotor
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
WO1991017424A1 (fr) 1990-05-03 1991-11-14 Vical, Inc. Acheminement intracellulaire de substances biologiquement actives effectue a l'aide de complexes de lipides s'auto-assemblant
SE468913B (sv) 1990-05-16 1993-04-05 Igesto Ab Saekerhetskrok
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
ATE300615T1 (de) 1990-08-29 2005-08-15 Genpharm Int Transgene mäuse fähig zur produktion heterologer antikörper
IL99552A0 (en) 1990-09-28 1992-08-18 Ixsys Inc Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof
KR100198659B1 (ko) 1996-05-16 1999-06-15 구본준 메모리 셀, 메모리 장치 및 그의 제조 방법
ES2097363T3 (es) 1991-10-11 1997-04-01 Promega Corp Transcripcion y traduccion acopladas en un extracto exento de celulas eucariotas.
NZ245015A (en) 1991-11-05 1995-12-21 Transkaryotic Therapies Inc Delivery of human growth hormone through the administration of transfected cell lines encoding human growth hormone, which are physically protected from host immune response; the transfected cells and their production
US6270989B1 (en) 1991-11-05 2001-08-07 Transkaryotic Therapies, Inc. Protein production and delivery
US5641670A (en) 1991-11-05 1997-06-24 Transkaryotic Therapies, Inc. Protein production and protein delivery
EP0642589A4 (fr) 1992-05-11 1997-05-21 Ribozyme Pharm Inc Procede et reactif d'inhibition de la replication virale.
US5629154A (en) 1993-11-12 1997-05-13 Geron Corporation Telomerase activity assays
US5648215A (en) 1992-05-13 1997-07-15 Board Of Regents, The University Of Texas System Telomerase diagnostic methods
US5639613A (en) 1992-05-13 1997-06-17 Board Of Regents, University Of Texas System Methods for cancer diagnosis and prognosis
US5645986A (en) 1992-05-13 1997-07-08 Board Of Reagents, The University Of Texas System Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
US5489508A (en) * 1992-05-13 1996-02-06 University Of Texas System Board Of Regents Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
WO1994002595A1 (fr) 1992-07-17 1994-02-03 Ribozyme Pharmaceuticals, Inc. Procede et reactif pour le traitement de maladies chez les animaux
US6107062A (en) 1992-07-30 2000-08-22 Inpax, Inc. Antisense viruses and antisense-ribozyme viruses
GB2273932A (en) 1992-11-24 1994-07-06 Stiefel Laboratories Stable oligonucleotides
WO1994012629A1 (fr) 1992-12-02 1994-06-09 Baylor College Of Medicine Vecteurs episomiques pour therapie genique
TW402639B (en) 1992-12-03 2000-08-21 Transkaryotic Therapies Inc Protein production and protein delivery
AU680459B2 (en) 1992-12-03 1997-07-31 Genzyme Corporation Gene therapy for cystic fibrosis
JPH08508636A (ja) 1993-01-27 1996-09-17 オンコール インコーポレーテッド 核酸配列の増幅
US5919676A (en) 1993-06-24 1999-07-06 Advec, Inc. Adenoviral vector system comprising Cre-loxP recombination
US6120764A (en) 1993-06-24 2000-09-19 Advec, Inc. Adenoviruses for control of gene expression
US6140087A (en) 1993-06-24 2000-10-31 Advec, Inc. Adenovirus vectors for gene therapy
WO1995013382A1 (fr) * 1993-11-12 1995-05-18 Geron Corporation Diagnostic et traitement de desordres lies a la longueur de telomeres et/ou l'activite de la telomerase
US5578832A (en) 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
US5583016A (en) 1994-07-07 1996-12-10 Geron Corporation Mammalian telomerase
AU696702B2 (en) 1994-07-07 1998-09-17 Geron Corporation Mammalian telomerase
US5597697A (en) 1994-09-30 1997-01-28 Diamond; Paul Screening assay for inhibitors and activators of RNA and DNA-dependent nucleic acid polymerases
US5698686A (en) 1994-10-20 1997-12-16 Arch Development Corporation Yeast telomerase compositions
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
EP0799315A2 (fr) 1994-12-19 1997-10-08 Cold Spring Harbor Laboratory Fraction proteinique de la telomerase
US5741677A (en) 1995-06-07 1998-04-21 Geron Corporation Methods for measuring telomere length
US5722998A (en) 1995-06-07 1998-03-03 Intermedics, Inc. Apparatus and method for the control of an implantable medical device
JPH11507818A (ja) 1995-06-07 1999-07-13 コールド・スプリング・ハーバー・ラボラトリー 脊椎動物テロメラーゼの必須オリゴヌクレオチド
JPH11507839A (ja) 1995-06-07 1999-07-13 ジェロン コーポレイション テロメラーゼ活性検定
US6545133B1 (en) 1995-08-04 2003-04-08 Geron Corporation Methods for purifying telomerase
US5968506A (en) 1995-08-04 1999-10-19 Geron Corporation Purified telomerase
US6517834B1 (en) 1995-08-04 2003-02-11 Geron Corporation Purified telomerase
WO1997006012A1 (fr) 1995-08-04 1997-02-20 International Business Machines Corporation Tampon lithographique
JPH09154575A (ja) 1995-10-04 1997-06-17 Soosei:Kk テロメラーゼ
JPH09164575A (ja) 1995-12-13 1997-06-24 Japan Steel Works Ltd:The 流れ模様を有する樹脂板の製造方法およびその装置
US6015710A (en) 1996-04-09 2000-01-18 The University Of Texas System Modulation of mammalian telomerase by peptide nucleic acids
US5853719A (en) 1996-04-30 1998-12-29 Duke University Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA
US5770422A (en) 1996-07-08 1998-06-23 The Regents Of The University Of California Human telomerase
US5747317A (en) 1996-07-08 1998-05-05 Tularik Inc. Human telomerase RNA interacting protein gene
US5724021A (en) 1996-07-09 1998-03-03 Stephen C. Perrone Self-contained, programmable, time interval alarm reminder device for eyedrop medication administration and a means for affixing such to eyedrop/medication container
WO1998007838A1 (fr) 1996-08-21 1998-02-26 Mitsubishi Chemical Corporation Proteine de telomerase d'animaux superieurs et gene codant pour elle
AUPO181296A0 (en) 1996-08-21 1996-09-12 Commonwealth Scientific And Industrial Research Organisation Manipulation of proanthocyanidin biosynthesis
WO1998008938A1 (fr) 1996-08-28 1998-03-05 Shonen Yoshida Proteines ayant une activite de telomerase
DE19638482A1 (de) 1996-09-20 1998-04-02 Bosch Gmbh Robert Verfahren zur Auswahl einer Sendefrequenz
US6610839B1 (en) 1997-08-14 2003-08-26 Geron Corporation Promoter for telomerase reverse transcriptase
US6808880B2 (en) 1996-10-01 2004-10-26 Geron Corporation Method for detecting polynucleotides encoding telomerase
US6093809A (en) 1996-10-01 2000-07-25 University Technology Corporation Telomerase
US6475789B1 (en) 1996-10-01 2002-11-05 University Technology Corporation Human telomerase catalytic subunit: diagnostic and therapeutic methods
EP0932686A2 (fr) 1996-10-01 1999-08-04 Geron Corporation Transcriptase inverse de la telomerase
US6444650B1 (en) 1996-10-01 2002-09-03 Geron Corporation Antisense compositions for detecting and inhibiting telomerase reverse transcriptase
US7585622B1 (en) * 1996-10-01 2009-09-08 Geron Corporation Increasing the proliferative capacity of cells using telomerase reverse transcriptase
US6261836B1 (en) 1996-10-01 2001-07-17 Geron Corporation Telomerase
US6777203B1 (en) 1997-11-19 2004-08-17 Geron Corporation Telomerase promoter driving expression of therapeutic gene sequences
US6767719B1 (en) 1997-11-26 2004-07-27 Geron Corporation Mouse telomerase reverse transcriptase
US5890326A (en) 1996-11-06 1999-04-06 Hill-Rom, Inc. Head wall for a hospital room
US5919656A (en) 1996-11-15 1999-07-06 Amgen Canada Inc. Genes encoding telomerase protein 1
US7390891B1 (en) * 1996-11-15 2008-06-24 Amgen Inc. Polynucleotides encoding a telomerase component TP2
WO1998023759A2 (fr) 1996-11-26 1998-06-04 Baylor College Of Medicine Identification d'inhibiteurs empechant l'acces de la telomerase aux terminaisons chromosomiques
WO1998037181A2 (fr) * 1997-02-20 1998-08-27 Whitehead Institute For Biomedical Research Gene de sous-unite catalytique de telomerase et proteine codee
US6617119B2 (en) 1997-02-21 2003-09-09 The Regents Of The University Of California Assay for specific strains of multiple disease related conformations of a protein
JP2001509681A (ja) * 1997-04-04 2001-07-24 ジェロン コーポレイション 精製されたテロメラーゼ
US6485789B1 (en) 1997-04-14 2002-11-26 3M Innovative Properties Company Fluorochemical composition containing a condensation product of a fluorochemical polyether and a poly-isocyanate to impart stain release properties to a substrate
US7413864B2 (en) 1997-04-18 2008-08-19 Geron Corporation Treating cancer using a telomerase vaccine
US20050013825A1 (en) 1997-04-18 2005-01-20 Geron Corporation Vaccine containing the catalytic subunit of telomerase for treating cancer
US7622549B2 (en) 1997-04-18 2009-11-24 Geron Corporation Human telomerase reverse transcriptase polypeptides
US6201830B1 (en) 1997-06-11 2001-03-13 Texas Instruments Incorporated Low computation idle transmission method for DSL modems
JP2002508662A (ja) * 1997-06-20 2002-03-19 バイエル・アクチエンゲゼルシヤフト ヒトテロメラーゼの触媒サブユニット並びにその診断的及び治療的使用
KR100581990B1 (ko) 1997-07-01 2006-05-23 캄비아 바이오시스템즈 엘엘씨 척추 동물 텔로머라제 유전자 및 단백질과 이의 용도
US7378244B2 (en) 1997-10-01 2008-05-27 Geron Corporation Telomerase promoters sequences for screening telomerase modulators
AU1606999A (en) 1997-11-26 1999-06-15 Albert Einstein College Of Medicine Of Yeshiva University Mouse telomerase reverse transcriptase
DE19757984A1 (de) 1997-12-24 1999-07-01 Bayer Ag Regulatorische DNA-Sequenzen aus der 5'-Region vom Gen der humanen katalytischen Telomerase-Untereinheit udn deren diagnostische und therapeutische Verwendung
US6608188B1 (en) 1998-01-08 2003-08-19 Chugai Seiyaku Kabushiki Kaisha CRT-1 gene having reverse transcriptase motif
GB9801902D0 (en) 1998-01-29 1998-03-25 Cancer Res Campaign Tech A gene promoter
CA2347067C (fr) 1998-03-31 2013-09-17 Geron Corporation Vaccin a base de cellule dendritique contenant de la transcriptase inverse de la telomarase pour le traitement du cancer
US7402307B2 (en) 1998-03-31 2008-07-22 Geron Corporation Method for identifying and killing cancer cells
US6337200B1 (en) 1998-03-31 2002-01-08 Geron Corporation Human telomerase catalytic subunit variants
US6069471A (en) 1998-05-14 2000-05-30 Intel Corporation Dynamic set point switching regulator
CA2331378A1 (fr) 1998-06-12 1999-12-16 Sloan-Kettering Institute For Cancer Research Strategie de vaccination permettant de prevenir et de traiter les cancers
US7030211B1 (en) 1998-07-08 2006-04-18 Gemvax As Antigenic peptides derived from telomerase
CA2362367C (fr) 1999-02-04 2004-08-03 Geron Corporation Sequences regulatoires transcriptionnelle de la transcriptase inversee de la telomerase
CA2368967A1 (fr) 1999-04-09 2000-10-19 Biomira, Inc. Vaccin anticancereux specifique de la telomerase
WO2000073420A2 (fr) 1999-06-02 2000-12-07 Whitehead Institute For Biomedical Research Creation de cellules tumorigenes humaines et utilisations correspondante
US6354941B2 (en) 1999-11-03 2002-03-12 516 Holdings Electronic system for a game of chance
AU2001241533A1 (en) 2000-02-15 2001-08-27 The Regents Of The University Of California A universal vaccine and method for treating cancer employing telomerase reverse transcriptase
US7262174B2 (en) 2001-05-09 2007-08-28 Geron Corporation Treatment for wounds
JP2002348474A (ja) 2001-05-23 2002-12-04 Dow Corning Toray Silicone Co Ltd ポリオルガノシロキサンマイクロエマルジョン組成物および化粧料原料
AU2002363231A1 (en) 2001-10-29 2003-05-12 Baylor College Of Medicine Human telomerase reverse transcriptase as a class-ii restricted tumor-associated antigen
US7294708B2 (en) * 2002-05-31 2007-11-13 Beijing Institute Of Biotechnology Telomerase reverse transcriptase fragments and uses thereof
KR100705868B1 (ko) 2003-05-06 2007-04-10 후지 덴키 디바이스 테크놀로지 가부시키가이샤 반도체 장치 및 그 제조 방법

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