NO320099B1 - 3-fenylpyridinderivater,fremgangsmate for fremstilling og anvendelse derav, samt medikament. - Google Patents

3-fenylpyridinderivater,fremgangsmate for fremstilling og anvendelse derav, samt medikament. Download PDF

Info

Publication number: NO320099B1
Authority: NO; Norway
Prior art keywords: formula; compound; methyl; trifluoromethyl; phenyl
Prior art date: 1999-02-24

Application number

NO20014098A

Other languages

English (en)

Norwegian (no)

Other versions

NO20014098L (no

NO20014098D0 (no

Inventor

Heinz Stadler

Walter Hunkeler

Thierry Godel

Michael Bos

Torsten Hoffmann

Patrick Schnider

Guido Galley

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-02-24

Filing date

2001-08-23

Publication date

2005-10-24

2001-08-23 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2001-08-23 Publication of NO20014098L publication Critical patent/NO20014098L/no

2001-08-23 Publication of NO20014098D0 publication Critical patent/NO20014098D0/no

2005-10-24 Publication of NO320099B1 publication Critical patent/NO320099B1/no

Links

238000000034 method Methods 0.000 title claims description 26
238000002360 preparation method Methods 0.000 title claims description 18
239000003814 drug Substances 0.000 title claims description 9
229940079593 drug Drugs 0.000 title claims description 6
150000005361 3-phenylpyridines Chemical class 0.000 title description 2
150000001875 compounds Chemical class 0.000 claims description 112
150000003839 salts Chemical class 0.000 claims description 16
238000006243 chemical reaction Methods 0.000 claims description 15
125000001424 substituent group Chemical group 0.000 claims description 12
239000000654 additive Substances 0.000 claims description 7
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229910052736 halogen Inorganic materials 0.000 claims description 4
150000002367 halogens Chemical class 0.000 claims description 4
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
229940044551 receptor antagonist Drugs 0.000 claims description 4
239000002464 receptor antagonist Substances 0.000 claims description 4
WRKCFWQULJFVBO-UHFFFAOYSA-N 2-[3,5-bis(trifluoromethyl)phenyl]-n,2-dimethyl-n-[3-(2-methylphenyl)pyridin-4-yl]propanamide Chemical group C=1C=NC=C(C=2C(=CC=CC=2)C)C=1N(C)C(=O)C(C)(C)C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 WRKCFWQULJFVBO-UHFFFAOYSA-N 0.000 claims description 3
230000008569 process Effects 0.000 claims description 3
SFMWMKZRUGYFBA-UHFFFAOYSA-N 2-[3,5-bis(trifluoromethyl)phenyl]-n,2-dimethyl-n-(3-naphthalen-1-ylpyridin-4-yl)propanamide Chemical compound C=1C=NC=C(C=2C3=CC=CC=C3C=CC=2)C=1N(C)C(=O)C(C)(C)C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 SFMWMKZRUGYFBA-UHFFFAOYSA-N 0.000 claims description 2
DMOOMKYJDBINDF-UHFFFAOYSA-N 2-[3,5-bis(trifluoromethyl)phenyl]-n-[3-(4-fluoro-2-methylphenyl)pyridin-4-yl]-n,2-dimethylpropanamide Chemical compound C=1C=NC=C(C=2C(=CC(F)=CC=2)C)C=1N(C)C(=O)C(C)(C)C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 DMOOMKYJDBINDF-UHFFFAOYSA-N 0.000 claims description 2
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230000004048 modification Effects 0.000 claims description 2
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QOQSAUOBLCCCRM-UHFFFAOYSA-N n-[(3,5-dichlorophenyl)methyl]-5-(2-methoxyphenyl)-n-methyl-2-(4-methylpiperazin-1-yl)pyridine-4-carboxamide Chemical compound COC1=CC=CC=C1C1=CN=C(N2CCN(C)CC2)C=C1C(=O)N(C)CC1=CC(Cl)=CC(Cl)=C1 QOQSAUOBLCCCRM-UHFFFAOYSA-N 0.000 claims description 2
HJBXFIIMRLNJEP-UHFFFAOYSA-N n-[[3,5-bis(trifluoromethyl)phenyl]methyl]-5-(2-methoxyphenyl)-n-methyl-2-(4-methylpiperazin-1-yl)pyridine-4-carboxamide Chemical compound COC1=CC=CC=C1C1=CN=C(N2CCN(C)CC2)C=C1C(=O)N(C)CC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 HJBXFIIMRLNJEP-UHFFFAOYSA-N 0.000 claims description 2
229910052739 hydrogen Inorganic materials 0.000 claims 6
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125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 1
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NFHFRUOZVGFOOS-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 description 8
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Classifications

- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides

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Health & Medical Sciences (AREA)
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Organic Chemistry (AREA)
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Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Addiction (AREA)
Rheumatology (AREA)
Ophthalmology & Optometry (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

NO20014098A 1999-02-24 2001-08-23 3-fenylpyridinderivater,fremgangsmate for fremstilling og anvendelse derav, samt medikament. NO320099B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP99103503		1999-02-24
PCT/EP2000/001223 WO2000050401A1 (fr)	1999-02-24	2000-02-15	Derives de 3-phenylpyridine et utilisation de ces derniers comme antagonistes de recepteur nk-1

Publications (3)

Publication Number	Publication Date
NO20014098L NO20014098L (no)	2001-08-23
NO20014098D0 NO20014098D0 (no)	2001-08-23
NO320099B1 true NO320099B1 (no)	2005-10-24

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ID=8237624

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20014098A NO320099B1 (no)	1999-02-24	2001-08-23	3-fenylpyridinderivater,fremgangsmate for fremstilling og anvendelse derav, samt medikament.

Country Status (33)

Country	Link
US (1)	US6225316B1 (fr)
EP (1)	EP1157005B1 (fr)
JP (1)	JP4068305B2 (fr)
KR (1)	KR100437587B1 (fr)
CN (1)	CN1134417C (fr)
AR (1)	AR029616A1 (fr)
AT (1)	ATE280158T1 (fr)
AU (1)	AU772446B2 (fr)
BR (1)	BR0008494A (fr)
CA (1)	CA2364662C (fr)
CO (1)	CO5140087A1 (fr)
CZ (1)	CZ20013047A3 (fr)
DE (1)	DE60015089T2 (fr)
DK (1)	DK1157005T3 (fr)
ES (1)	ES2230070T3 (fr)
GC (1)	GC0000183A (fr)
HK (1)	HK1044942B (fr)
HR (1)	HRP20010604A2 (fr)
HU (1)	HUP0200139A3 (fr)
IL (2)	IL144851A0 (fr)
JO (1)	JO2254B1 (fr)
MA (1)	MA26773A1 (fr)
MY (1)	MY122630A (fr)
NO (1)	NO320099B1 (fr)
NZ (1)	NZ513370A (fr)
PL (1)	PL350428A1 (fr)
PT (1)	PT1157005E (fr)
RU (1)	RU2236402C2 (fr)
SI (1)	SI1157005T1 (fr)
TR (1)	TR200102489T2 (fr)
WO (1)	WO2000050401A1 (fr)
YU (1)	YU59901A (fr)
ZA (1)	ZA200106371B (fr)

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KR20070094666A (ko)	2005-02-25	2007-09-20	에프. 호프만-라 로슈 아게	약제 물질 분산성이 향상된 정제
EP1945632B1 (fr)	2005-11-08	2013-09-18	Vertex Pharmaceuticals Incorporated	Modulateurs hétérocycliques de transporteurs à cassette liant l' atp
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US7671221B2 (en)	2005-12-28	2010-03-02	Vertex Pharmaceuticals Incorporated	Modulators of ATP-Binding Cassette transporters
US7754739B2 (en)	2007-05-09	2010-07-13	Vertex Pharmaceuticals Incorporated	Modulators of CFTR
PE20090277A1 (es) *	2007-04-24	2009-04-06	Takeda Pharmaceutical	Derivados de piperidina como antagonistas de taquiquininas
US8969386B2 (en)	2007-05-09	2015-03-03	Vertex Pharmaceuticals Incorporated	Modulators of CFTR
EP2639224B1 (fr)	2007-12-07	2016-08-24	Vertex Pharmaceuticals Incorporated	Procédés de fabrication d'acides cycloalkylcarboxamido-pyridine benzoïques
SI2225230T1 (sl)	2007-12-07	2017-03-31	Vertex Pharmaceuticals Incorporated	Trdne oblike 3-(6-(1-2,2-difluorobenzo(d)(1,3)dioxol-5-il)ciklopropan- karboksamido)-3-metilpiridin-2-il) benzojske kisline
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KR100943878B1 (ko) *	2008-07-11	2010-02-24	오토스테크 주식회사	디지털방식 눈부심 방지 장치 및 그 제어 방법
MX2011004551A (es) *	2008-10-30	2011-05-25	Merck Sharp & Dohme	Antagonistas del receptor de orexina de isonicotinamida.
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HRP20211752T1 (hr)	2010-04-07	2022-02-18	Vertex Pharmaceuticals Incorporated	Farmaceutski pripravci 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-il)ciklopropankarboksamido)-3-metilpiridin-2-il)benzojeve kiseline i njihova primjena
US8410107B2 (en) *	2010-10-15	2013-04-02	Hoffmann-La Roche Inc.	N-pyridin-3-yl or N-pyrazin-2-yl carboxamides
WO2013112804A1 (fr)	2012-01-25	2013-08-01	Vertex Pharmaceuticals Incorporated	Formulations d'acide 3-(6-(1-(2,2-difluorobenzo [d] [1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-méthylpyridin-2-yl) benzoïque
CA2930008A1 (fr)	2013-11-08	2015-05-14	Kissei Pharmaceutical Co., Ltd.	Derive de carboxymethylpiperidine
JP6963896B2 (ja)	2013-11-12	2021-11-10	バーテックスファーマシューティカルズインコーポレイテッドVertex Pharmaceuticals Incorporated	Ｃｆｔｒ媒介性疾患の処置のための医薬組成物を調製する方法
TWI649307B (zh)	2014-05-07	2019-02-01	日商橘生藥品工業股份有限公司	Cyclohexylpyridine derivative
PT3221692T (pt)	2014-11-18	2021-09-10	Vertex Pharma	Processo de realização de testagem de alta produtividade por cromatografia líquida de alta eficiência
CN115531553A (zh)	2015-12-22	2022-12-30	武田药品工业株式会社	内体g蛋白-偶联的受体的三部分调节剂
EP4146628A1 (fr)	2020-05-06	2023-03-15	Bayer Aktiengesellschaft	Pyridine (thio)amides en tant que composés fongicides
BR112022024405A2 (pt)	2020-06-04	2023-01-31	Bayer Ag	Heterociclil piridinas como novos fungicidas
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2000
- 2000-02-15 KR KR10-2001-7010731A patent/KR100437587B1/ko not_active Expired - Fee Related
- 2000-02-15 WO PCT/EP2000/001223 patent/WO2000050401A1/fr not_active Ceased
- 2000-02-15 TR TR2001/02489T patent/TR200102489T2/xx unknown
- 2000-02-15 SI SI200030546T patent/SI1157005T1/xx unknown
- 2000-02-15 DK DK00909174T patent/DK1157005T3/da active
- 2000-02-15 HR HR20010604A patent/HRP20010604A2/hr not_active Application Discontinuation
- 2000-02-15 EP EP00909174A patent/EP1157005B1/fr not_active Expired - Lifetime
- 2000-02-15 PL PL00350428A patent/PL350428A1/xx not_active Application Discontinuation
- 2000-02-15 DE DE60015089T patent/DE60015089T2/de not_active Expired - Lifetime
- 2000-02-15 AU AU31549/00A patent/AU772446B2/en not_active Ceased
- 2000-02-15 HU HU0200139A patent/HUP0200139A3/hu unknown
- 2000-02-15 AT AT00909174T patent/ATE280158T1/de not_active IP Right Cessation
- 2000-02-15 IL IL14485100A patent/IL144851A0/xx active IP Right Grant
- 2000-02-15 PT PT00909174T patent/PT1157005E/pt unknown
- 2000-02-15 YU YU59901A patent/YU59901A/sh unknown
- 2000-02-15 HK HK02106317.1A patent/HK1044942B/zh not_active IP Right Cessation
- 2000-02-15 JP JP2000600984A patent/JP4068305B2/ja not_active Expired - Fee Related
- 2000-02-15 CA CA002364662A patent/CA2364662C/fr not_active Expired - Fee Related
- 2000-02-15 BR BR0008494-8A patent/BR0008494A/pt not_active Application Discontinuation
- 2000-02-15 CN CNB008042322A patent/CN1134417C/zh not_active Expired - Fee Related
- 2000-02-15 CZ CZ20013047A patent/CZ20013047A3/cs unknown
- 2000-02-15 RU RU2001125893/04A patent/RU2236402C2/ru not_active IP Right Cessation
- 2000-02-15 NZ NZ513370A patent/NZ513370A/xx unknown
- 2000-02-15 ES ES00909174T patent/ES2230070T3/es not_active Expired - Lifetime
- 2000-02-16 US US09/505,359 patent/US6225316B1/en not_active Expired - Fee Related
- 2000-02-22 JO JO200015A patent/JO2254B1/en active
- 2000-02-22 MY MYPI20000647A patent/MY122630A/en unknown
- 2000-02-22 CO CO00012321A patent/CO5140087A1/es unknown
- 2000-02-23 GC GCP2000535 patent/GC0000183A/en active
- 2000-02-23 AR ARP000100756A patent/AR029616A1/es not_active Application Discontinuation
2001
- 2001-08-02 ZA ZA200106371A patent/ZA200106371B/en unknown
- 2001-08-09 IL IL144851A patent/IL144851A/en not_active IP Right Cessation
- 2001-08-23 NO NO20014098A patent/NO320099B1/no unknown
- 2001-08-23 MA MA26301A patent/MA26773A1/fr unknown

Also Published As

Publication number	Publication date
HUP0200139A2 (en)	2002-06-29
ES2230070T3 (es)	2005-05-01
KR100437587B1 (ko)	2004-06-30
CN1134417C (zh)	2004-01-14
HUP0200139A3 (en)	2003-01-28
HK1044942A1 (en)	2002-11-08
TR200102489T2 (tr)	2002-04-22
CA2364662C (fr)	2009-10-20
CZ20013047A3 (cs)	2002-02-13
CA2364662A1 (fr)	2000-08-31
PT1157005E (pt)	2005-02-28
NO20014098L (no)	2001-08-23
AR029616A1 (es)	2003-07-10
MA26773A1 (fr)	2004-12-20
NO20014098D0 (no)	2001-08-23
IL144851A0 (en)	2002-06-30
PL350428A1 (en)	2002-12-16
AU772446B2 (en)	2004-04-29
DE60015089D1 (de)	2004-11-25
ATE280158T1 (de)	2004-11-15
HRP20010604A2 (en)	2002-08-31
IL144851A (en)	2006-08-20
EP1157005B1 (fr)	2004-10-20
MY122630A (en)	2006-04-29
NZ513370A (en)	2004-02-27
US6225316B1 (en)	2001-05-01
ZA200106371B (en)	2002-11-04
BR0008494A (pt)	2002-02-05
CO5140087A1 (es)	2002-03-22
GC0000183A (en)	2006-03-29
JP4068305B2 (ja)	2008-03-26
AU3154900A (en)	2000-09-14
KR20010102347A (ko)	2001-11-15
RU2236402C2 (ru)	2004-09-20
JO2254B1 (en)	2004-10-07
DK1157005T3 (da)	2005-02-14
JP2002537382A (ja)	2002-11-05
YU59901A (sh)	2005-07-19
DE60015089T2 (de)	2006-02-16
EP1157005A1 (fr)	2001-11-28
SI1157005T1 (en)	2005-02-28
CN1341100A (zh)	2002-03-20
HK1044942B (zh)	2004-05-28
WO2000050401A1 (fr)	2000-08-31

Publication	Publication Date	Title
NO320099B1 (no)	2005-10-24	3-fenylpyridinderivater,fremgangsmate for fremstilling og anvendelse derav, samt medikament.
EP1035115B1 (fr)	2004-09-29	Dérivés de 4-phenylpyridine et leur utilisation comme antagonistes du recepteur NK-1
CA2416874C (fr)	2011-01-18	Derives de 4-phenyle-pyridine utilises en tant qu'antagonistes du recepteur de la neurokinine-1
AU2001282005A1 (en)	2002-05-02	4-phenyl-pyridine derivatives as neurokinin-1 receptor antagonists
AU2006218179B2 (en)	2010-12-23	NK1 antagonists
MXPA01008511A (es)	2002-05-09	Derivados de 3-fenilpiridina y su uso como antagonistas del receptor de la neuroquinina (nk-1)
MXPA00001849A (en)	2002-06-05	4-phenylpyridine derivatives and their use as nk-1 receptor antagonists