NO320429B1 - Farmasoytisk blanding for forokning av motstanden mot sykdommer forarsaket av patogene mikroorganismer og anvendelse av glukan for fremstilling av en farmasoytisk blanding. - Google Patents
Farmasoytisk blanding for forokning av motstanden mot sykdommer forarsaket av patogene mikroorganismer og anvendelse av glukan for fremstilling av en farmasoytisk blanding. Download PDFInfo
- Publication number
- NO320429B1 NO320429B1 NO20032494A NO20032494A NO320429B1 NO 320429 B1 NO320429 B1 NO 320429B1 NO 20032494 A NO20032494 A NO 20032494A NO 20032494 A NO20032494 A NO 20032494A NO 320429 B1 NO320429 B1 NO 320429B1
- Authority
- NO
- Norway
- Prior art keywords
- glucan
- larvae
- pharmaceutical composition
- diatoms
- diseases caused
- Prior art date
Links
- 229920001503 Glucan Polymers 0.000 title claims abstract description 64
- 201000010099 disease Diseases 0.000 title claims abstract description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 13
- 244000000010 microbial pathogen Species 0.000 title claims abstract description 9
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 6
- 230000000069 prophylactic effect Effects 0.000 claims abstract description 5
- 230000001717 pathogenic effect Effects 0.000 claims abstract description 4
- 241000251468 Actinopterygii Species 0.000 claims description 15
- 229920002498 Beta-glucan Polymers 0.000 claims description 14
- 241000206761 Bacillariophyta Species 0.000 claims description 12
- 241000206745 Nitzschia alba Species 0.000 claims description 10
- 235000015170 shellfish Nutrition 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 8
- 206010052804 Drug tolerance Diseases 0.000 claims description 4
- 230000026781 habituation Effects 0.000 claims description 4
- 241000894007 species Species 0.000 claims description 2
- 230000012010 growth Effects 0.000 abstract description 11
- 230000002708 enhancing effect Effects 0.000 abstract 2
- 241000276438 Gadus morhua Species 0.000 description 21
- 230000003308 immunostimulating effect Effects 0.000 description 17
- 235000019688 fish Nutrition 0.000 description 13
- 230000002519 immonomodulatory effect Effects 0.000 description 10
- 230000004083 survival effect Effects 0.000 description 10
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 8
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 8
- 229960001438 immunostimulant agent Drugs 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 7
- 230000001580 bacterial effect Effects 0.000 description 7
- 235000005911 diet Nutrition 0.000 description 7
- 230000037213 diet Effects 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 7
- 239000003022 immunostimulating agent Substances 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
- 241000195493 Cryptophyta Species 0.000 description 6
- 229920001543 Laminarin Polymers 0.000 description 6
- 210000001035 gastrointestinal tract Anatomy 0.000 description 6
- 230000012447 hatching Effects 0.000 description 6
- 210000000987 immune system Anatomy 0.000 description 6
- DBTMGCOVALSLOR-VPNXCSTESA-N laminarin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)OC1O[C@@H]1[C@@H](O)C(O[C@H]2[C@@H]([C@@H](CO)OC(O)[C@@H]2O)O)O[C@H](CO)[C@H]1O DBTMGCOVALSLOR-VPNXCSTESA-N 0.000 description 6
- 241000607284 Vibrio sp. Species 0.000 description 5
- 230000008092 positive effect Effects 0.000 description 5
- 238000011282 treatment Methods 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 241000607598 Vibrio Species 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 210000002540 macrophage Anatomy 0.000 description 4
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 241000287828 Gallus gallus Species 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 241000277263 Salmo Species 0.000 description 3
- 229940072056 alginate Drugs 0.000 description 3
- 229920000615 alginic acid Polymers 0.000 description 3
- 235000010443 alginic acid Nutrition 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 229940088710 antibiotic agent Drugs 0.000 description 3
- 238000009360 aquaculture Methods 0.000 description 3
- 244000144974 aquaculture Species 0.000 description 3
- 150000004676 glycans Chemical class 0.000 description 3
- 238000003306 harvesting Methods 0.000 description 3
- 230000001418 larval effect Effects 0.000 description 3
- 239000004005 microsphere Substances 0.000 description 3
- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- 229960005486 vaccine Drugs 0.000 description 3
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 description 2
- 241000238582 Artemia Species 0.000 description 2
- 241000972773 Aulopiformes Species 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 2
- 241001474374 Blennius Species 0.000 description 2
- 241000227752 Chaetoceros Species 0.000 description 2
- 241000199919 Phaeophyceae Species 0.000 description 2
- 241000700141 Rotifera Species 0.000 description 2
- 206010047400 Vibrio infections Diseases 0.000 description 2
- 230000003698 anagen phase Effects 0.000 description 2
- 208000022362 bacterial infectious disease Diseases 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 238000002518 distortionless enhancement with polarization transfer Methods 0.000 description 2
- 235000013601 eggs Nutrition 0.000 description 2
- 208000010824 fish disease Diseases 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000009571 larval growth Effects 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 235000019515 salmon Nutrition 0.000 description 2
- 239000013535 sea water Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- JCLFHZLOKITRCE-UHFFFAOYSA-N 4-pentoxyphenol Chemical compound CCCCCOC1=CC=C(O)C=C1 JCLFHZLOKITRCE-UHFFFAOYSA-N 0.000 description 1
- 241000607528 Aeromonas hydrophila Species 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 241001467606 Bacillariophyceae Species 0.000 description 1
- 208000034309 Bacterial disease carrier Diseases 0.000 description 1
- 241000700104 Brachionus plicatilis Species 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 241000030251 Chelmon muelleri Species 0.000 description 1
- 241000195628 Chlorophyta Species 0.000 description 1
- 241001147476 Cyclotella Species 0.000 description 1
- AEMOLEFTQBMNLQ-VANFPWTGSA-N D-mannopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H]1O AEMOLEFTQBMNLQ-VANFPWTGSA-N 0.000 description 1
- 241001646657 Detonula confervacea Species 0.000 description 1
- 208000035240 Disease Resistance Diseases 0.000 description 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- 241000296380 Laminaria hyperborea Species 0.000 description 1
- 241000489861 Maximus Species 0.000 description 1
- 239000012901 Milli-Q water Substances 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- 206010057249 Phagocytosis Diseases 0.000 description 1
- 235000014676 Phragmites communis Nutrition 0.000 description 1
- 241000589774 Pseudomonas sp. Species 0.000 description 1
- 241000157468 Reinhardtius hippoglossoides Species 0.000 description 1
- 241000277289 Salmo salar Species 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 241000385219 Trichopodus trichopterus Species 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 229920001222 biopolymer Polymers 0.000 description 1
- 244000144987 brood Species 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 235000019621 digestibility Nutrition 0.000 description 1
- 235000014105 formulated food Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000015788 innate immune response Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 210000004347 intestinal mucosa Anatomy 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000009364 mariculture Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000008782 phagocytosis Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 238000009372 pisciculture Methods 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 108010001062 polysaccharide-K Proteins 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fodder In General (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO20032494A NO320429B1 (no) | 2003-06-03 | 2003-06-03 | Farmasoytisk blanding for forokning av motstanden mot sykdommer forarsaket av patogene mikroorganismer og anvendelse av glukan for fremstilling av en farmasoytisk blanding. |
| ES04735831T ES2349411T3 (es) | 2003-06-03 | 2004-06-02 | Composición farmaceutica que comprende glucano derivado de microalgas. |
| DE602004028236T DE602004028236D1 (de) | 2003-06-03 | 2004-06-02 | Pharmazeutische zusammensetzung enthaltend glucan aus mikroalgen |
| DK04735831.2T DK1633373T3 (da) | 2003-06-03 | 2004-06-02 | Farmaceutisk sammensætning indeholdende glucan hidrørende fra mikroalger |
| CL200401348A CL2004001348A1 (es) | 2003-06-03 | 2004-06-02 | Composicion farmaceutica o alimenticia que comprende glucano derivado de microalgas o microalgas que lo contienen, la cual tiene efectos inmunoestimulantes, profilacticos y/o de crecimiento aumentando la resistencia contra enfermedades causadas por m |
| AT04735831T ATE474582T1 (de) | 2003-06-03 | 2004-06-02 | Pharmazeutische zusammensetzung enthaltend glucan aus mikroalgen |
| PCT/NO2004/000157 WO2004105775A1 (en) | 2003-06-03 | 2004-06-02 | Pharmaceutical composition comprising glucan derived from microalgae |
| EP04735831A EP1633373B1 (de) | 2003-06-03 | 2004-06-02 | Pharmazeutische zusammensetzung enthaltend glucan aus mikroalgen |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO20032494A NO320429B1 (no) | 2003-06-03 | 2003-06-03 | Farmasoytisk blanding for forokning av motstanden mot sykdommer forarsaket av patogene mikroorganismer og anvendelse av glukan for fremstilling av en farmasoytisk blanding. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20032494D0 NO20032494D0 (no) | 2003-06-03 |
| NO20032494L NO20032494L (no) | 2004-12-06 |
| NO320429B1 true NO320429B1 (no) | 2005-12-05 |
Family
ID=27607234
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20032494A NO320429B1 (no) | 2003-06-03 | 2003-06-03 | Farmasoytisk blanding for forokning av motstanden mot sykdommer forarsaket av patogene mikroorganismer og anvendelse av glukan for fremstilling av en farmasoytisk blanding. |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1633373B1 (de) |
| AT (1) | ATE474582T1 (de) |
| CL (1) | CL2004001348A1 (de) |
| DE (1) | DE602004028236D1 (de) |
| DK (1) | DK1633373T3 (de) |
| ES (1) | ES2349411T3 (de) |
| NO (1) | NO320429B1 (de) |
| WO (1) | WO2004105775A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1714673A1 (de) | 2005-04-21 | 2006-10-25 | Desol BV | Verfahren zur Verlängerung der Bewegungsperiode von Fischen |
| EP1714674A1 (de) | 2005-04-21 | 2006-10-25 | Desol BV | Verfahren zur Verbesserung der Fruchtbarkeit von Tieren |
| JP5572097B2 (ja) | 2007-11-26 | 2014-08-13 | ノバルティス アーゲー | 結合体化されたβ−1,3−結合グルカン |
| CN102153669B (zh) * | 2010-05-12 | 2013-01-16 | 北京雷力联合海洋生物科技有限公司 | 一种低分子褐藻葡聚糖的制备方法 |
| HK1205466A1 (en) | 2012-02-22 | 2015-12-18 | Algal Scientific Corporation | Animal feed compositions and methods of using the same |
| EP3288388A1 (de) * | 2015-04-30 | 2018-03-07 | Micoperi Blue Growth S.r.l. | Mikroalgenextrakt zur landwirtschaftlichen nutzung |
| US9901606B2 (en) | 2016-06-09 | 2018-02-27 | Algaeon, Inc. | Euglena lysate composition |
| CN116836807B (zh) * | 2023-08-03 | 2024-06-14 | 中科阿尔诺(深圳)生物科技有限公司 | 一株高葡聚糖含量的微藻突变株及其应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5815920A (ja) * | 1981-07-23 | 1983-01-29 | Kurorera Kogyo Kk | リンパ球増加剤 |
| US5084386A (en) * | 1989-03-31 | 1992-01-28 | Sri International | Production of beta-1,3-glucan in euglena |
| JP3034352B2 (ja) * | 1991-08-08 | 2000-04-17 | 生化学工業株式会社 | 安定な一重らせん構造の分子内架橋(1→3)−β−D−グルカン類及びその製造法 |
| DE19608563C2 (de) * | 1996-03-06 | 1999-08-05 | Greenpower International Natuu | Herstellung von Zubreitungen für oral zu verabreichende Arzneistoffe und/oder Nahrungsergänzungsstoffe |
| US5866150A (en) * | 1996-03-20 | 1999-02-02 | Aquaculture Technology Incorporated | Antibacterially active extracts from the marine algae chaetoceros and methods of use |
| CA2412600C (en) * | 2000-07-10 | 2011-09-27 | The University Of Mississippi | Potent immunostimulatory polysaccharides extracted from microalgae |
-
2003
- 2003-06-03 NO NO20032494A patent/NO320429B1/no not_active IP Right Cessation
-
2004
- 2004-06-02 EP EP04735831A patent/EP1633373B1/de not_active Expired - Lifetime
- 2004-06-02 AT AT04735831T patent/ATE474582T1/de not_active IP Right Cessation
- 2004-06-02 WO PCT/NO2004/000157 patent/WO2004105775A1/en not_active Ceased
- 2004-06-02 ES ES04735831T patent/ES2349411T3/es not_active Expired - Lifetime
- 2004-06-02 DK DK04735831.2T patent/DK1633373T3/da active
- 2004-06-02 CL CL200401348A patent/CL2004001348A1/es unknown
- 2004-06-02 DE DE602004028236T patent/DE602004028236D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1633373B1 (de) | 2010-07-21 |
| WO2004105775A8 (en) | 2005-01-27 |
| NO20032494D0 (no) | 2003-06-03 |
| ATE474582T1 (de) | 2010-08-15 |
| ES2349411T3 (es) | 2011-01-03 |
| DE602004028236D1 (de) | 2010-09-02 |
| CL2004001348A1 (es) | 2005-05-06 |
| EP1633373A1 (de) | 2006-03-15 |
| WO2004105775A1 (en) | 2004-12-09 |
| DK1633373T3 (da) | 2010-10-25 |
| NO20032494L (no) | 2004-12-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |