NO320498B1 - Oral sammensetning med modifisert frigjoring for behandling av inflammatoriske tarmsykdommer, samt anvendelse av 5-ASA eller et farmasoytisk akseptabelt salt eller ester derav for fremstilling av et medikament. - Google Patents

Oral sammensetning med modifisert frigjoring for behandling av inflammatoriske tarmsykdommer, samt anvendelse av 5-ASA eller et farmasoytisk akseptabelt salt eller ester derav for fremstilling av et medikament. Download PDF

Info

Publication number: NO320498B1
Authority: NO; Norway
Prior art keywords: range; asa; granules; minutes; composition
Prior art date: 1995-12-21

Application number

NO19982904A

Other languages

English (en)

Norwegian (no)

Other versions

NO982904D0 (no

NO982904L (no

Inventor

Soren Halskov

Svenn Kluever Jepsen

Original Assignee

Ferring Farma Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-21

Filing date

1998-06-22

Publication date

2005-12-12

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24302375&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO320498(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1998-06-22 Application filed by Ferring Farma Lab filed Critical Ferring Farma Lab

1998-06-22 Publication of NO982904D0 publication Critical patent/NO982904D0/no

1998-06-22 Publication of NO982904L publication Critical patent/NO982904L/no

2005-12-12 Publication of NO320498B1 publication Critical patent/NO320498B1/no

Links

KBOPZPXVLCULAV-UHFFFAOYSA-N mesalamine Chemical compound NC1=CC=C(O)C(C(O)=O)=C1 KBOPZPXVLCULAV-UHFFFAOYSA-N 0.000 title claims abstract description 103
229960004963 mesalazine Drugs 0.000 title claims abstract description 99
239000000203 mixture Substances 0.000 title claims abstract description 68
208000022559 Inflammatory bowel disease Diseases 0.000 title claims abstract description 17
150000003839 salts Chemical class 0.000 title claims description 16
150000002148 esters Chemical class 0.000 title claims description 12
239000003814 drug Substances 0.000 title claims description 7
238000004519 manufacturing process Methods 0.000 title claims description 7
208000011231 Crohn disease Diseases 0.000 claims abstract description 7
239000008187 granular material Substances 0.000 claims description 119
238000004090 dissolution Methods 0.000 claims description 17
210000000813 small intestine Anatomy 0.000 claims description 15
239000011248 coating agent Substances 0.000 claims description 11
238000000576 coating method Methods 0.000 claims description 11
230000000968 intestinal effect Effects 0.000 claims description 11
201000010099 disease Diseases 0.000 claims description 9
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 9
239000001856 Ethyl cellulose Substances 0.000 claims description 8
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 8
239000002552 dosage form Substances 0.000 claims description 8
235000019325 ethyl cellulose Nutrition 0.000 claims description 8
229920001249 ethyl cellulose Polymers 0.000 claims description 8
239000012530 fluid Substances 0.000 claims description 8
238000001727 in vivo Methods 0.000 claims description 8
206010009900 Colitis ulcerative Diseases 0.000 claims description 7
201000006704 Ulcerative Colitis Diseases 0.000 claims description 7
239000007931 coated granule Substances 0.000 claims description 7
210000001072 colon Anatomy 0.000 claims description 7
239000000463 material Substances 0.000 claims description 7
229920002678 cellulose Polymers 0.000 claims description 6
239000001913 cellulose Substances 0.000 claims description 6
235000010980 cellulose Nutrition 0.000 claims description 6
229940079593 drug Drugs 0.000 claims description 6
230000037406 food intake Effects 0.000 claims description 6
238000005563 spheronization Methods 0.000 claims description 6
229920000168 Microcrystalline cellulose Polymers 0.000 claims description 5
230000004888 barrier function Effects 0.000 claims description 5
238000000338 in vitro Methods 0.000 claims description 5
210000002429 large intestine Anatomy 0.000 claims description 5
235000019813 microcrystalline cellulose Nutrition 0.000 claims description 5
239000008108 microcrystalline cellulose Substances 0.000 claims description 5
229940016286 microcrystalline cellulose Drugs 0.000 claims description 5
230000030136 gastric emptying Effects 0.000 claims description 4
229920000642 polymer Polymers 0.000 claims description 4
238000003756 stirring Methods 0.000 claims description 4
229920000856 Amylose Polymers 0.000 claims description 3
210000002784 stomach Anatomy 0.000 claims description 3
239000002253 acid Substances 0.000 claims description 2
238000013019 agitation Methods 0.000 claims description 2
239000004615 ingredient Substances 0.000 abstract description 9
238000000034 method Methods 0.000 abstract description 7
230000000694 effects Effects 0.000 abstract description 5
239000008194 pharmaceutical composition Substances 0.000 abstract description 2
208000014997 Crohn colitis Diseases 0.000 abstract 1
239000008202 granule composition Substances 0.000 description 10
239000004480 active ingredient Substances 0.000 description 6
230000000052 comparative effect Effects 0.000 description 6
238000010191 image analysis Methods 0.000 description 6
238000010998 test method Methods 0.000 description 6
230000008901 benefit Effects 0.000 description 5
238000002156 mixing Methods 0.000 description 5
229940072223 pentasa Drugs 0.000 description 5
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
239000002775 capsule Substances 0.000 description 4
238000001035 drying Methods 0.000 description 4
-1 hydrochloric acid Chemical class 0.000 description 4
238000005259 measurement Methods 0.000 description 4
239000003960 organic solvent Substances 0.000 description 4
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
241000275031 Nica Species 0.000 description 3
238000004458 analytical method Methods 0.000 description 3
210000004534 cecum Anatomy 0.000 description 3
238000009826 distribution Methods 0.000 description 3
238000002474 experimental method Methods 0.000 description 3
239000002245 particle Substances 0.000 description 3
230000008569 process Effects 0.000 description 3
210000000664 rectum Anatomy 0.000 description 3
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
230000002411 adverse Effects 0.000 description 2
229910052791 calcium Inorganic materials 0.000 description 2
239000011575 calcium Substances 0.000 description 2
230000000112 colonic effect Effects 0.000 description 2
238000007906 compression Methods 0.000 description 2
230000006835 compression Effects 0.000 description 2
238000001704 evaporation Methods 0.000 description 2
230000008020 evaporation Effects 0.000 description 2
210000001035 gastrointestinal tract Anatomy 0.000 description 2
238000005469 granulation Methods 0.000 description 2
230000003179 granulation Effects 0.000 description 2
239000000314 lubricant Substances 0.000 description 2
231100000252 nontoxic Toxicity 0.000 description 2
230000003000 nontoxic effect Effects 0.000 description 2
239000008203 oral pharmaceutical composition Substances 0.000 description 2
230000010355 oscillation Effects 0.000 description 2
239000008188 pellet Substances 0.000 description 2
239000008363 phosphate buffer Substances 0.000 description 2
230000036470 plasma concentration Effects 0.000 description 2
229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
239000001267 polyvinylpyrrolidone Substances 0.000 description 2
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
238000012545 processing Methods 0.000 description 2
238000005070 sampling Methods 0.000 description 2
229910052708 sodium Inorganic materials 0.000 description 2
239000007787 solid Substances 0.000 description 2
239000002904 solvent Substances 0.000 description 2
238000013268 sustained release Methods 0.000 description 2
239000012730 sustained-release form Substances 0.000 description 2
230000001225 therapeutic effect Effects 0.000 description 2
238000002560 therapeutic procedure Methods 0.000 description 2
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 description 1
125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
WUBBRNOQWQTFEX-UHFFFAOYSA-N 4-aminosalicylic acid Chemical compound NC1=CC=C(C(O)=O)C(O)=C1 WUBBRNOQWQTFEX-UHFFFAOYSA-N 0.000 description 1
241000252983 Caecum Species 0.000 description 1
208000017667 Chronic Disease Diseases 0.000 description 1
206010012735 Diarrhoea Diseases 0.000 description 1
230000002159 abnormal effect Effects 0.000 description 1
125000002723 alicyclic group Chemical group 0.000 description 1
229910052783 alkali metal Inorganic materials 0.000 description 1
229910052784 alkaline earth metal Inorganic materials 0.000 description 1
125000003342 alkenyl group Chemical group 0.000 description 1
125000003710 aryl alkyl group Chemical group 0.000 description 1
150000007860 aryl ester derivatives Chemical class 0.000 description 1
210000001815 ascending colon Anatomy 0.000 description 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
229910000019 calcium carbonate Inorganic materials 0.000 description 1
125000002843 carboxylic acid group Chemical group 0.000 description 1
239000000969 carrier Substances 0.000 description 1
230000001684 chronic effect Effects 0.000 description 1
239000008199 coating composition Substances 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
125000000640 cyclooctyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
210000001731 descending colon Anatomy 0.000 description 1
238000009792 diffusion process Methods 0.000 description 1
125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
210000001198 duodenum Anatomy 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
230000001747 exhibiting effect Effects 0.000 description 1
238000001125 extrusion Methods 0.000 description 1
238000009472 formulation Methods 0.000 description 1
230000002496 gastric effect Effects 0.000 description 1
210000005095 gastrointestinal system Anatomy 0.000 description 1
239000003979 granulating agent Substances 0.000 description 1
125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
239000008240 homogeneous mixture Substances 0.000 description 1
238000010874 in vitro model Methods 0.000 description 1
210000000936 intestine Anatomy 0.000 description 1
125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
239000008141 laxative Substances 0.000 description 1
230000002475 laxative effect Effects 0.000 description 1
125000005644 linolenyl group Chemical group 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
238000012544 monitoring process Methods 0.000 description 1
125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
125000001624 naphthyl group Chemical group 0.000 description 1
125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
125000001117 oleyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
230000001575 pathological effect Effects 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
239000006187 pill Substances 0.000 description 1
239000011148 porous material Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
239000008213 purified water Substances 0.000 description 1
230000004044 response Effects 0.000 description 1
238000007873 sieving Methods 0.000 description 1
210000001599 sigmoid colon Anatomy 0.000 description 1
239000007921 spray Substances 0.000 description 1
125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
230000002459 sustained effect Effects 0.000 description 1
230000009747 swallowing Effects 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
238000012360 testing method Methods 0.000 description 1
238000011285 therapeutic regimen Methods 0.000 description 1
125000005425 toluyl group Chemical group 0.000 description 1
210000003384 transverse colon Anatomy 0.000 description 1
125000005065 undecenyl group Chemical group C(=CCCCCCCCCC)* 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
125000005023 xylyl group Chemical group 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/606—Salicylic acid; Derivatives thereof having amino groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Epidemiology (AREA)
Transplantation (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO19982904A 1995-12-21 1998-06-22 Oral sammensetning med modifisert frigjoring for behandling av inflammatoriske tarmsykdommer, samt anvendelse av 5-ASA eller et farmasoytisk akseptabelt salt eller ester derav for fremstilling av et medikament. NO320498B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US57595495A	1995-12-21	1995-12-21
PCT/DK1996/000551 WO1997023199A1 (en)	1995-12-21	1996-12-23	Modified release oral pharmaceutical composition containing 5-asa and method for the treatment of bowel diseases

Publications (3)

Publication Number	Publication Date
NO982904D0 NO982904D0 (no)	1998-06-22
NO982904L NO982904L (no)	1998-06-22
NO320498B1 true NO320498B1 (no)	2005-12-12

Family

ID=24302375

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19982904A NO320498B1 (no)	1995-12-21	1998-06-22	Oral sammensetning med modifisert frigjoring for behandling av inflammatoriske tarmsykdommer, samt anvendelse av 5-ASA eller et farmasoytisk akseptabelt salt eller ester derav for fremstilling av et medikament.

Country Status (27)

Country	Link
EP (1)	EP0871434B2 (is)
JP (1)	JP4714836B2 (is)
KR (2)	KR100542544B1 (is)
CN (1)	CN1155369C (is)
AT (1)	ATE205704T1 (is)
AU (1)	AU702934B2 (is)
BG (1)	BG63484B1 (is)
BR (1)	BR9612213A (is)
CA (1)	CA2240281C (is)
CZ (1)	CZ289290B6 (is)
DE (2)	DE69615400T3 (is)
DK (1)	DK0871434T4 (is)
EE (1)	EE03740B1 (is)
ES (1)	ES2149733T5 (is)
HU (1)	HU228856B1 (is)
IL (1)	IL124858A (is)
IS (1)	IS1834B (is)
NO (1)	NO320498B1 (is)
NZ (1)	NZ325201A (is)
PL (1)	PL186790B1 (is)
PT (1)	PT871434E (is)
RU (1)	RU2181043C2 (is)
SI (1)	SI0871434T2 (is)
SK (1)	SK282669B6 (is)
TR (1)	TR199801158T2 (is)
UA (1)	UA67721C2 (is)
WO (1)	WO1997023199A1 (is)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19732903A1 (de)	1997-07-30	1999-02-04	Falk Pharma Gmbh	Pellet-Formulierung zur Behandlung des Intestinaltraktes
AU764469B2 (en)	1999-01-29	2003-08-21	Disphar International B.V.	Pharmaceutical compositions
RU2191782C2 (ru) *	2000-09-21	2002-10-27	Институт нефтехимии и катализа АН РБ и УНЦ РАН	Способ получения модифицированной гиалуроновой кислоты
CA2359812C (en)	2000-11-20	2004-02-10	The Procter & Gamble Company	Pharmaceutical dosage form with multiple coatings for reduced impact of coating fractures
US8282955B2 (en) *	2001-10-15	2012-10-09	Ferring B.V.	Method for the preparation of a pharmaceutical composition comprising 5-aminosalicylic acid for use in treatment of ulcerative colitis and Crohn's disease
PT1441700E (pt) *	2001-10-15	2007-10-29	Ferring Bv	Método para a preparação de uma composição compreendendo ácido 5-aminosalicílico para uso em tratamento de colites ulcerosas ou da doença de crohn
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1996
- 1996-12-23 KR KR1019980704656A patent/KR100542544B1/ko not_active Expired - Lifetime
- 1996-12-23 RU RU98111765/14A patent/RU2181043C2/ru active
- 1996-12-23 SI SI9630388T patent/SI0871434T2/sl unknown
- 1996-12-23 IL IL12485896A patent/IL124858A/xx not_active IP Right Cessation
- 1996-12-23 WO PCT/DK1996/000551 patent/WO1997023199A1/en not_active Ceased
- 1996-12-23 PL PL96327323A patent/PL186790B1/pl unknown
- 1996-12-23 JP JP52323797A patent/JP4714836B2/ja not_active Expired - Lifetime
- 1996-12-23 DE DE69615400T patent/DE69615400T3/de not_active Expired - Lifetime
- 1996-12-23 ES ES96943884T patent/ES2149733T5/es not_active Expired - Lifetime
- 1996-12-23 HU HU0001084A patent/HU228856B1/hu unknown
- 1996-12-23 DK DK96943884T patent/DK0871434T4/da active
- 1996-12-23 AU AU13661/97A patent/AU702934B2/en not_active Expired
- 1996-12-23 AT AT96943884T patent/ATE205704T1/de active
- 1996-12-23 NZ NZ325201A patent/NZ325201A/en not_active IP Right Cessation
- 1996-12-23 EE EE9800191A patent/EE03740B1/xx unknown
- 1996-12-23 CN CNB96199679XA patent/CN1155369C/zh not_active Expired - Lifetime
- 1996-12-23 DE DE0871434T patent/DE871434T1/de active Pending
- 1996-12-23 CZ CZ19981946A patent/CZ289290B6/cs not_active IP Right Cessation
- 1996-12-23 TR TR1998/01158T patent/TR199801158T2/xx unknown
- 1996-12-23 SK SK834-98A patent/SK282669B6/sk not_active IP Right Cessation
- 1996-12-23 EP EP96943884A patent/EP0871434B2/en not_active Expired - Lifetime
- 1996-12-23 PT PT96943884T patent/PT871434E/pt unknown
- 1996-12-23 BR BR9612213-7A patent/BR9612213A/pt not_active IP Right Cessation
- 1996-12-23 UA UA98063228A patent/UA67721C2/uk unknown
- 1996-12-23 CA CA002240281A patent/CA2240281C/en not_active Expired - Lifetime
- 1996-12-23 KR KR1020057014255A patent/KR100598714B1/ko not_active Expired - Lifetime
1998
- 1998-06-15 IS IS4772A patent/IS1834B/is unknown
- 1998-06-18 BG BG102556A patent/BG63484B1/bg unknown
- 1998-06-22 NO NO19982904A patent/NO320498B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
PL186790B1 (pl)	2004-02-27
HU228856B1 (en)	2013-06-28
BG63484B1 (bg)	2002-03-29
DK0871434T4 (da)	2008-04-07
ES2149733T5 (es)	2008-05-01
NO982904D0 (no)	1998-06-22
KR100542544B1 (ko)	2006-05-10
DK0871434T3 (da)	2002-01-07
SI0871434T2 (sl)	2008-04-30
CN1207672A (zh)	1999-02-10
WO1997023199A1 (en)	1997-07-03
KR19990076584A (ko)	1999-10-15
EP0871434B1 (en)	2001-09-19
HK1017615A1 (en)	1999-11-26
EE03740B1 (et)	2002-06-17
IS1834B (is)	2002-11-15
JPH11510191A (ja)	1999-09-07
EP0871434A1 (en)	1998-10-21
SK282669B6 (sk)	2002-11-06
ES2149733T1 (es)	2000-11-16
AU702934B2 (en)	1999-03-11
UA67721C2 (en)	2004-07-15
NO982904L (no)	1998-06-22
BG102556A (en)	1999-02-26
KR20050087886A (ko)	2005-08-31
PL327323A1 (en)	1998-12-07
HUP0001084A2 (hu)	2000-11-28
IS4772A (is)	1998-06-15
DE69615400T2 (de)	2002-05-23
JP4714836B2 (ja)	2011-06-29
KR100598714B1 (ko)	2006-07-10
CA2240281A1 (en)	1997-07-03
HUP0001084A3 (en)	2000-12-28
IL124858A0 (en)	1999-01-26
IL124858A (en)	2003-03-12
ATE205704T1 (de)	2001-10-15
EE9800191A (et)	1998-12-15
DE871434T1 (de)	2001-04-05
BR9612213A (pt)	1999-12-28
ES2149733T3 (es)	2002-04-01
DE69615400D1 (de)	2001-10-25
EP0871434B2 (en)	2007-12-12
CN1155369C (zh)	2004-06-30
TR199801158T2 (xx)	1998-09-21
SI0871434T1 (en)	2002-04-30
RU2181043C2 (ru)	2002-04-10
CZ289290B6 (cs)	2001-12-12
SK83498A3 (en)	1999-01-11
CZ194698A3 (cs)	1998-10-14
NZ325201A (en)	1998-11-25
CA2240281C (en)	2007-02-27
DE69615400T3 (de)	2008-08-07
AU1366197A (en)	1997-07-17
PT871434E (pt)	2002-02-28

Legal Events

Date	Code	Title	Description
2017-01-09	MK1K	Patent expired

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