NO320588B1 - 5-pyridyl-1,3-azolforbindelser, fremgangsmate for fremstilling av disse, farmasoytisk preparat omfattende disse og anvendelse av disse. - Google Patents

5-pyridyl-1,3-azolforbindelser, fremgangsmate for fremstilling av disse, farmasoytisk preparat omfattende disse og anvendelse av disse. Download PDF

Info

Publication number: NO320588B1
Authority: NO; Norway
Prior art keywords: pyridyl; thiazol; methylphenyl; compound; formula
Prior art date: 1999-04-23

Application number

NO20015156A

Other languages

English (en)

Norwegian (no)

Other versions

NO20015156L (no

NO20015156D0 (no

Inventor

Shigenori Ohkawa

Naoyuki Kanzaki

Seiji Miwatashi

Original Assignee

Takeda Pharmaceutical

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-04-23

Filing date

2001-10-22

Publication date

2005-12-27

2001-10-22 Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical

2001-10-22 Publication of NO20015156D0 publication Critical patent/NO20015156D0/no

2001-12-18 Publication of NO20015156L publication Critical patent/NO20015156L/no

2005-12-27 Publication of NO320588B1 publication Critical patent/NO320588B1/no

Links

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239000008194 pharmaceutical composition Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 claims description 457
238000006243 chemical reaction Methods 0.000 claims description 191
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 80
150000003839 salts Chemical class 0.000 claims description 76
-1 alkyl hydrogen peroxide Chemical compound 0.000 claims description 59
125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 52
229910052736 halogen Inorganic materials 0.000 claims description 43
125000004076 pyridyl group Chemical group 0.000 claims description 42
239000003795 chemical substances by application Substances 0.000 claims description 41
229910052717 sulfur Inorganic materials 0.000 claims description 38
125000000217 alkyl group Chemical group 0.000 claims description 37
230000002401 inhibitory effect Effects 0.000 claims description 33
125000004434 sulfur atom Chemical group 0.000 claims description 32
125000003277 amino group Chemical group 0.000 claims description 31
125000002252 acyl group Chemical group 0.000 claims description 24
125000005843 halogen group Chemical group 0.000 claims description 23
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LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
IHIXIJGXTJIKRB-UHFFFAOYSA-N trisodium vanadate Chemical compound [Na+].[Na+].[Na+].[O-][V]([O-])([O-])=O IHIXIJGXTJIKRB-UHFFFAOYSA-N 0.000 description 1
ZNOKGRXACCSDPY-UHFFFAOYSA-N tungsten trioxide Chemical compound O=[W](=O)=O ZNOKGRXACCSDPY-UHFFFAOYSA-N 0.000 description 1
230000007306 turnover Effects 0.000 description 1
241001529453 unidentified herpesvirus Species 0.000 description 1
241000712461 unidentified influenza virus Species 0.000 description 1
125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
239000008215 water for injection Substances 0.000 description 1
238000005303 weighing Methods 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
239000008096 xylene Substances 0.000 description 1
239000002076 α-tocopherol Substances 0.000 description 1
235000004835 α-tocopherol Nutrition 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Hematology (AREA)
Pulmonology (AREA)
Immunology (AREA)
Cardiology (AREA)
Oncology (AREA)
Rheumatology (AREA)
Obesity (AREA)
Communicable Diseases (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Virology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Psychology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)

NO20015156A 1999-04-23 2001-10-22 5-pyridyl-1,3-azolforbindelser, fremgangsmate for fremstilling av disse, farmasoytisk preparat omfattende disse og anvendelse av disse. NO320588B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP11668699		1999-04-23
JP22465099		1999-08-06
PCT/JP2000/002575 WO2000064894A1 (en)	1999-04-23	2000-04-20	5-pyridyl-1,3-azole compounds, process for producing the same and use thereof

Publications (3)

Publication Number	Publication Date
NO20015156D0 NO20015156D0 (no)	2001-10-22
NO20015156L NO20015156L (no)	2001-12-18
NO320588B1 true NO320588B1 (no)	2005-12-27

Family

ID=26454974

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20015156A NO320588B1 (no)	1999-04-23	2001-10-22	5-pyridyl-1,3-azolforbindelser, fremgangsmate for fremstilling av disse, farmasoytisk preparat omfattende disse og anvendelse av disse.

Country Status (24)

Country	Link
US (3)	US7101899B1 (da)
EP (1)	EP1180518B1 (da)
KR (2)	KR100558123B1 (da)
CN (1)	CN1156471C (da)
AU (1)	AU765473B2 (da)
BR (1)	BR0009952A (da)
CA (1)	CA2370264A1 (da)
CZ (1)	CZ300709B6 (da)
DE (1)	DE60033028T2 (da)
DK (1)	DK1180518T3 (da)
ES (1)	ES2275500T3 (da)
HK (1)	HK1044338B (da)
HU (1)	HUP0203766A3 (da)
IL (1)	IL146105A (da)
MX (1)	MXPA01010675A (da)
MY (1)	MY126736A (da)
NO (1)	NO320588B1 (da)
NZ (1)	NZ515215A (da)
PL (1)	PL351148A1 (da)
PT (1)	PT1180518E (da)
RU (1)	RU2237062C2 (da)
SI (1)	SI1180518T1 (da)
SK (1)	SK286666B6 (da)
WO (1)	WO2000064894A1 (da)

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2000
- 2000-04-20 DE DE60033028T patent/DE60033028T2/de not_active Expired - Fee Related
- 2000-04-20 KR KR1020027008313A patent/KR100558123B1/ko not_active Expired - Fee Related
- 2000-04-20 US US09/959,356 patent/US7101899B1/en not_active Expired - Fee Related
- 2000-04-20 IL IL14610500A patent/IL146105A/xx unknown
- 2000-04-20 WO PCT/JP2000/002575 patent/WO2000064894A1/ja not_active Ceased
- 2000-04-20 CA CA002370264A patent/CA2370264A1/en not_active Abandoned
- 2000-04-20 PL PL00351148A patent/PL351148A1/xx not_active Application Discontinuation
- 2000-04-20 SK SK1495-2001A patent/SK286666B6/sk not_active IP Right Cessation
- 2000-04-20 AU AU38401/00A patent/AU765473B2/en not_active Ceased
- 2000-04-20 DK DK00917375T patent/DK1180518T3/da active
- 2000-04-20 CZ CZ20013805A patent/CZ300709B6/cs not_active IP Right Cessation
- 2000-04-20 HU HU0203766A patent/HUP0203766A3/hu unknown
- 2000-04-20 RU RU2001131556/04A patent/RU2237062C2/ru active
- 2000-04-20 HK HK02105924.8A patent/HK1044338B/en not_active IP Right Cessation
- 2000-04-20 BR BR0009952-0A patent/BR0009952A/pt not_active Application Discontinuation
- 2000-04-20 CN CNB008085498A patent/CN1156471C/zh not_active Expired - Fee Related
- 2000-04-20 SI SI200030940T patent/SI1180518T1/sl unknown
- 2000-04-20 ES ES00917375T patent/ES2275500T3/es not_active Expired - Lifetime
- 2000-04-20 NZ NZ515215A patent/NZ515215A/en unknown
- 2000-04-20 EP EP00917375A patent/EP1180518B1/en not_active Expired - Lifetime
- 2000-04-20 MX MXPA01010675A patent/MXPA01010675A/es active IP Right Grant
- 2000-04-20 PT PT00917375T patent/PT1180518E/pt unknown
- 2000-04-20 KR KR10-2001-7013493A patent/KR100449215B1/ko not_active Expired - Fee Related
- 2000-10-20 MY MYPI20004966A patent/MY126736A/en unknown
2001
- 2001-10-22 NO NO20015156A patent/NO320588B1/no not_active IP Right Cessation
2006
- 2006-02-16 US US11/354,897 patent/US7276527B2/en not_active Expired - Fee Related
2007
- 2007-08-29 US US11/896,072 patent/US20090048307A1/en not_active Abandoned

Also Published As

Publication number	Publication date
HUP0203766A3 (en)	2008-01-28
NZ515215A (en)	2003-07-25
EP1180518A4 (en)	2004-09-15
AU3840100A (en)	2000-11-10
CZ300709B6 (cs)	2009-07-22
RU2237062C2 (ru)	2004-09-27
IL146105A (en)	2005-09-25
US20060135566A1 (en)	2006-06-22
SK286666B6 (sk)	2009-03-05
US7276527B2 (en)	2007-10-02
MXPA01010675A (es)	2002-06-04
SK14952001A3 (sk)	2002-04-04
DE60033028D1 (de)	2007-03-08
KR100449215B1 (ko)	2004-09-18
US20090048307A1 (en)	2009-02-19
KR20020059453A (ko)	2002-07-12
DK1180518T3 (da)	2007-05-21
SI1180518T1 (sl)	2007-06-30
CA2370264A1 (en)	2000-11-02
WO2000064894A1 (en)	2000-11-02
US7101899B1 (en)	2006-09-05
EP1180518A1 (en)	2002-02-20
PT1180518E (pt)	2007-02-28
CN1353710A (zh)	2002-06-12
MY126736A (en)	2006-10-31
CN1156471C (zh)	2004-07-07
PL351148A1 (en)	2003-03-24
HK1044338A1 (en)	2002-10-18
CZ20013805A3 (cs)	2002-04-17
NO20015156L (no)	2001-12-18
KR20010111314A (ko)	2001-12-17
NO20015156D0 (no)	2001-10-22
BR0009952A (pt)	2002-03-26
IL146105A0 (en)	2002-07-25
HK1044338B (en)	2007-06-29
ES2275500T3 (es)	2007-06-16
EP1180518B1 (en)	2007-01-17
DE60033028T2 (de)	2007-11-15
AU765473B2 (en)	2003-09-18
KR100558123B1 (ko)	2006-03-07
HUP0203766A2 (hu)	2003-03-28

Legal Events

Date	Code	Title	Description
2010-11-29	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO320588B1 (no)	2005-12-27	5-pyridyl-1,3-azolforbindelser, fremgangsmate for fremstilling av disse, farmasoytisk preparat omfattende disse og anvendelse av disse.
US6962933B1 (en)	2005-11-08	Method for inhibiting p38 MAP kinase or TNF-α production using a 1,3-thiazole
JP2010526869A (ja)	2010-08-05	２−シクロプロピル−チアゾール誘導体
US20040248950A1 (en)	2004-12-09	Apo ai expression accelerating agent
WO2001074811A2 (en)	2001-10-11	Substituted 1,3-thiazole compounds, their production and use
JP2010531871A (ja)	2010-09-30	３−アザ−ビシクロ［３．３．０］オクタン化合物
WO2002062792A9 (fr)	2002-12-12	Inhibiteur de jnk
JP2010534646A (ja)	2010-11-11	トランス−３−アザ−ビシクロ［３．１．０］ヘキサン誘導体
JP2010522737A (ja)	2010-07-08	オレキシン受容体拮抗薬としてのチアゾリジン誘導体
JP2006515013A (ja)	2006-05-18	グリコーゲン合成酵素キナーゼ３β活性抑制剤、組成物及びその製造方法
MXPA05001328A (es)	2005-04-28	Derivados de tiazol.
JP3333774B2 (ja)	2002-10-15	５−ピリジル−１，３−アゾール化合物、その製造法及び用途
JP4310079B2 (ja)	2009-08-05	５−ピリジル−１，３−アゾール化合物、その製造法及び用途
ZA200108996B (en)	2003-01-31	5-pyridyl-1,3-azole compounds, process for producing the same and use thereof.
JPWO2000064894A1 (ja)	2002-07-30	５−ピリジル−１，３−アゾール化合物、その製造法および用途