NO321841B1 - Anvendelse av selektive antagonister for den a1b-adrenerge reseptor for forbedring av seksuell dysfunksjon - Google Patents

Anvendelse av selektive antagonister for den a1b-adrenerge reseptor for forbedring av seksuell dysfunksjon Download PDF

Info

Publication number: NO321841B1
Authority: NO; Norway
Prior art keywords: compound; quinazoline; dimethoxy; amino; group
Prior art date: 1999-05-07

Application number

NO20015428A

Other languages

English (en)

Norwegian (no)

Other versions

NO20015428L (no

NO20015428D0 (no

Inventor

Amedo Leonardi

Gianni Motta

Rodolfo Testa

Giorgio Sironi

Original Assignee

Recordati Ireland Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-05-07

Filing date

2001-11-06

Publication date

2006-07-10

2001-11-06 Application filed by Recordati Ireland Ltd filed Critical Recordati Ireland Ltd

2001-11-06 Publication of NO20015428L publication Critical patent/NO20015428L/no

2001-11-06 Publication of NO20015428D0 publication Critical patent/NO20015428D0/no

2006-07-10 Publication of NO321841B1 publication Critical patent/NO321841B1/no

Links

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Classifications

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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9406—Neurotransmitters
- G01N33/9433—(Nor)adrenaline
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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NO20015428A 1999-05-07 2001-11-06 Anvendelse av selektive antagonister for den a1b-adrenerge reseptor for forbedring av seksuell dysfunksjon NO321841B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT1999MI000995A IT1312310B1 (it)	1999-05-07	1999-05-07	Uso di antagonisti selettivi del recettore adrenergico a 1b per ilmiglioramento della disfunzione sessuale
PCT/EP2000/004308 WO2000067735A2 (en)	1999-05-07	2000-05-08	USE OF SELECTIVE ANTAGONISTS OF THE α1b-ADRENERGIC RECEPTOR FOR IMPROVEMENT OF SEXUAL DYSFUNCTION

Publications (3)

Publication Number	Publication Date
NO20015428L NO20015428L (no)	2001-11-06
NO20015428D0 NO20015428D0 (no)	2001-11-06
NO321841B1 true NO321841B1 (no)	2006-07-10

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ID=11382912

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Application Number	Title	Priority Date	Filing Date
NO20015428A NO321841B1 (no)	1999-05-07	2001-11-06	Anvendelse av selektive antagonister for den a1b-adrenerge reseptor for forbedring av seksuell dysfunksjon

Country Status (25)

Country	Link
US (2)	US6303606B1 (de)
EP (1)	EP1177190B1 (de)
JP (1)	JP2002544158A (de)
KR (1)	KR100696755B1 (de)
CN (1)	CN1150187C (de)
AT (1)	ATE308538T1 (de)
AU (1)	AU765487B2 (de)
BR (1)	BR0010348A (de)
CA (1)	CA2366201A1 (de)
DE (1)	DE60023686T2 (de)
DK (1)	DK1177190T3 (de)
ES (1)	ES2250130T3 (de)
HK (1)	HK1039900B (de)
HU (1)	HUP0201184A3 (de)
IL (1)	IL146003A0 (de)
IT (1)	IT1312310B1 (de)
MX (1)	MXPA01011261A (de)
NO (1)	NO321841B1 (de)
NZ (1)	NZ515240A (de)
PL (1)	PL196708B1 (de)
RU (1)	RU2239633C2 (de)
SI (1)	SI1177190T1 (de)
TW (1)	TWI224503B (de)
WO (1)	WO2000067735A2 (de)
ZA (1)	ZA200110042B (de)

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AU2005296719B2 (en) *	2004-10-18	2011-02-03	Polymun Scientific Immunbiologische Forschung Gmbh	Liposomal composition comprising an active ingredient for relaxing smooth muscle production and therapeutically use of said composition
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JP2009541443A (ja)	2006-06-30	2009-11-26	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	尿失禁及び関連疾患の治療のためのフリバンセリン
GB0613333D0 (en)	2006-07-05	2006-08-16	Controlled Therapeutics Sct	Hydrophilic polyurethane compositions
GB0613638D0 (en)	2006-07-08	2006-08-16	Controlled Therapeutics Sct	Polyurethane elastomers
EP2054041A2 (de)	2006-08-14	2009-05-06	Boehringer Ingelheim International GmbH	Formulierungen von flibanserin und herstellungsverfahren dafür
IL197129A (en)	2006-08-25	2014-08-31	Boehringer Ingelheim Int	Controlled release system and method for production
GB0620685D0 (en)	2006-10-18	2006-11-29	Controlled Therapeutics Sct	Bioresorbable polymers
CL2008002693A1 (es)	2007-09-12	2009-10-16	Boehringer Ingelheim Int	Uso de flibanserina para el tratamiento de sintomas vasomotores seleccionados de sofocos, sudores nocturnos, cambios de estado de animo e irritabilidad
CN101592613B (zh) *	2009-07-06	2011-12-21	广东省药品检验所	一种中成药、保健食品和食品中添加pde5型抑制剂的检测方法
DK2616460T3 (en) *	2010-09-13	2016-01-18	Otsuka Pharma Co Ltd	HETEROCYCLIC COMPOUNDS FOR TREATMENT OR PREVENTION OF DISEASES CAUSED BY decreased neurotransmission of serotonin, norepinephrine or dopamine
JP6415982B2 (ja) *	2012-03-12	2018-10-31	大塚製薬株式会社	複素環化合物
US20130315891A1 (en)	2012-05-25	2013-11-28	Matthew Charles	Formulations of human tissue kallikrein-1 for parenteral delivery and related methods
EP2854841B1 (de)	2012-06-04	2017-02-22	Diamedica Inc.	Kallikrein-1-glycosylierungsisoformen aus menschlichem gewebe
WO2017168174A1 (en)	2016-04-02	2017-10-05	N4 Pharma Uk Limited	New pharmaceutical forms of sildenafil
RU2018145364A (ru)	2016-06-27	2020-07-28	Ачиллион Фармасьютикалс, Инк.	Хиназолиновые и индольные соединения для лечения медицинских нарушений
CN110446501A (zh)	2017-03-09	2019-11-12	代阿麦迪卡股份有限公司	组织激肽释放酶1的剂型

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1999
- 1999-05-07 IT IT1999MI000995A patent/IT1312310B1/it active
2000
- 2000-04-27 TW TW089108045A patent/TWI224503B/zh not_active IP Right Cessation
- 2000-05-05 US US09/565,842 patent/US6303606B1/en not_active Expired - Fee Related
- 2000-05-08 DK DK00927199T patent/DK1177190T3/da active
- 2000-05-08 WO PCT/EP2000/004308 patent/WO2000067735A2/en not_active Ceased
- 2000-05-08 MX MXPA01011261A patent/MXPA01011261A/es active IP Right Grant
- 2000-05-08 NZ NZ515240A patent/NZ515240A/en unknown
- 2000-05-08 AU AU45654/00A patent/AU765487B2/en not_active Ceased
- 2000-05-08 IL IL14600300A patent/IL146003A0/xx unknown
- 2000-05-08 JP JP2000616762A patent/JP2002544158A/ja active Pending
- 2000-05-08 BR BR0010348-9A patent/BR0010348A/pt not_active Application Discontinuation
- 2000-05-08 KR KR1020017014073A patent/KR100696755B1/ko not_active Expired - Fee Related
- 2000-05-08 PL PL351624A patent/PL196708B1/pl unknown
- 2000-05-08 SI SI200030764T patent/SI1177190T1/sl unknown
- 2000-05-08 RU RU2001133004/04A patent/RU2239633C2/ru not_active IP Right Cessation
- 2000-05-08 DE DE60023686T patent/DE60023686T2/de not_active Expired - Fee Related
- 2000-05-08 CN CNB008071764A patent/CN1150187C/zh not_active Expired - Fee Related
- 2000-05-08 CA CA002366201A patent/CA2366201A1/en not_active Abandoned
- 2000-05-08 HK HK02101448.4A patent/HK1039900B/en not_active IP Right Cessation
- 2000-05-08 ES ES00927199T patent/ES2250130T3/es not_active Expired - Lifetime
- 2000-05-08 EP EP00927199A patent/EP1177190B1/de not_active Expired - Lifetime
- 2000-05-08 AT AT00927199T patent/ATE308538T1/de not_active IP Right Cessation
- 2000-05-08 HU HU0201184A patent/HUP0201184A3/hu unknown
2001
- 2001-08-22 US US09/935,288 patent/US6953800B2/en not_active Expired - Fee Related
- 2001-11-06 NO NO20015428A patent/NO321841B1/no unknown
- 2001-12-06 ZA ZA200110042A patent/ZA200110042B/xx unknown

Also Published As

Publication number	Publication date
PL196708B1 (pl)	2008-01-31
KR20020002494A (ko)	2002-01-09
ES2250130T3 (es)	2006-04-16
IT1312310B1 (it)	2002-04-15
MXPA01011261A (es)	2002-08-12
ZA200110042B (en)	2002-07-02
DE60023686D1 (de)	2005-12-08
ITMI990995A1 (it)	2000-11-07
TWI224503B (en)	2004-12-01
HUP0201184A3 (en)	2003-05-28
ATE308538T1 (de)	2005-11-15
DE60023686T2 (de)	2006-07-20
CN1354749A (zh)	2002-06-19
CN1150187C (zh)	2004-05-19
US6303606B1 (en)	2001-10-16
SI1177190T1 (sl)	2006-02-28
HK1039900A1 (en)	2002-05-17
NO20015428L (no)	2001-11-06
PL351624A1 (en)	2003-05-19
NZ515240A (en)	2003-09-26
HUP0201184A2 (en)	2002-10-28
IL146003A0 (en)	2002-07-25
HK1039900B (en)	2006-02-03
WO2000067735A2 (en)	2000-11-16
WO2000067735A3 (en)	2001-02-01
AU765487B2 (en)	2003-09-18
US20020161009A1 (en)	2002-10-31
NO20015428D0 (no)	2001-11-06
KR100696755B1 (ko)	2007-03-19
DK1177190T3 (da)	2006-02-20
CA2366201A1 (en)	2000-11-16
BR0010348A (pt)	2002-02-13
RU2239633C2 (ru)	2004-11-10
JP2002544158A (ja)	2002-12-24
AU4565400A (en)	2000-11-21
EP1177190B1 (de)	2005-11-02
EP1177190A2 (de)	2002-02-06
US6953800B2 (en)	2005-10-11

Publication	Publication Date	Title
NO321841B1 (no)	2006-07-10	Anvendelse av selektive antagonister for den a1b-adrenerge reseptor for forbedring av seksuell dysfunksjon
US6172060B1 (en)	2001-01-09	Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
US6930113B2 (en)	2005-08-16	Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
JP4318744B2 (ja)	2009-08-26	シクロペンタピリジンおよびテトラヒドロキノリン誘導体
WO2000012075A1 (en)	2000-03-09	Nitrosated and nitrosylated alpha-adrenergic receptor antagonists, compositions and methods of use
JP2009504693A (ja)	2009-02-05	Ａｍｐｋ活性化物質としてのチエノピリドン誘導体の使用およびこれを含む医薬組成物
JP5697800B2 (ja)	2015-04-08	複素環置換ピリミジン化合物
US6469065B1 (en)	2002-10-22	Nitrosated and nitrosylated α-adrenergic receptor antagonist, compositions and methods of use
KR20030078962A (ko)	2003-10-08	Ｉｐ 길항제인 알콕시카보닐아미노 헤테로아릴 카복실산유도체
US20020061879A1 (en)	2002-05-23	Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses
JP2007504263A (ja)	2007-03-01	オキシトシン作働薬としてのピペラジン類
US20050065161A1 (en)	2005-03-24	Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses
US20040106629A1 (en)	2004-06-03	Compouds in the form of homodimeric, heterodimeric and/or homo and heteromultimeric pro-drugs; process for obtaining these pro-drugs and their acceptable pharmaceutical salts and use of compounds in the treatment of phosphodiesterasis-mediated deseases or dysfunction
JP2002255937A (ja)	2002-09-11	新規化合物
JP2003506379A (ja)	2003-02-18	チエノピランカルボキサミド誘導体
AU2004201585B2 (en)	2007-01-18	Nitrosated and nitrosylated alpha-adrenergic receptor antagonists, compositions and methods of use
TWI254638B (en)	2006-05-11	An enantiomerically pure opioid diarylmethylpiperazine and methods of using same