NO323059B1 - Antitrombotisk forbindelse, samt fremstilling og anvendelse derav og farmasoytisk preparat. - Google Patents

Antitrombotisk forbindelse, samt fremstilling og anvendelse derav og farmasoytisk preparat. Download PDF

Info

Publication number: NO323059B1
Authority: NO; Norway
Prior art keywords: compound; mmol; solution; water; concentrated
Prior art date: 1999-12-07

Application number

NO20022689A

Other languages

English (en)

Norwegian (no)

Other versions

NO20022689D0 (no

NO20022689L (no

Inventor

Constant Adriaan Anton Van Boeckel

Cornelia Maria Tromp

Tamara Theodora Maria Geertsen

Original Assignee

Organon Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-07

Filing date

2002-06-06

Publication date

2006-12-27

2002-06-06 Application filed by Organon Nv filed Critical Organon Nv

2002-06-06 Publication of NO20022689D0 publication Critical patent/NO20022689D0/no

2002-06-06 Publication of NO20022689L publication Critical patent/NO20022689L/no

2006-12-27 Publication of NO323059B1 publication Critical patent/NO323059B1/no

Links

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108090000190 Thrombin Proteins 0.000 claims description 13
229960004072 thrombin Drugs 0.000 claims description 13
PXXJHWLDUBFPOL-UHFFFAOYSA-N benzamidine Chemical group NC(=N)C1=CC=CC=C1 PXXJHWLDUBFPOL-UHFFFAOYSA-N 0.000 claims description 7
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238000001356 surgical procedure Methods 0.000 description 1
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239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
238000010998 test method Methods 0.000 description 1
229960003766 thrombin (human) Drugs 0.000 description 1
230000002537 thrombolytic effect Effects 0.000 description 1
201000005060 thrombophlebitis Diseases 0.000 description 1
230000001732 thrombotic effect Effects 0.000 description 1
230000009466 transformation Effects 0.000 description 1
ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
FTVLMFQEYACZNP-UHFFFAOYSA-N trimethylsilyl trifluoromethanesulfonate Chemical compound C[Si](C)(C)OS(=O)(=O)C(F)(F)F FTVLMFQEYACZNP-UHFFFAOYSA-N 0.000 description 1
229910021642 ultra pure water Inorganic materials 0.000 description 1
239000012498 ultrapure water Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Biophysics (AREA)
Hematology (AREA)
Diabetes (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Peptides Or Proteins (AREA)

NO20022689A 1999-12-07 2002-06-06 Antitrombotisk forbindelse, samt fremstilling og anvendelse derav og farmasoytisk preparat. NO323059B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP99204172		1999-12-07
PCT/EP2000/012155 WO2001042262A2 (en)	1999-12-07	2000-12-01	Antithrombotic compound

Publications (3)

Publication Number	Publication Date
NO20022689D0 NO20022689D0 (no)	2002-06-06
NO20022689L NO20022689L (no)	2002-06-06
NO323059B1 true NO323059B1 (no)	2006-12-27

Family

ID=8240976

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20022689A NO323059B1 (no)	1999-12-07	2002-06-06	Antitrombotisk forbindelse, samt fremstilling og anvendelse derav og farmasoytisk preparat.

Country Status (23)

Country	Link
US (1)	US6875755B2 (cs)
EP (1)	EP1237897B1 (cs)
JP (1)	JP4820517B2 (cs)
KR (1)	KR100776607B1 (cs)
CN (1)	CN1195767C (cs)
AR (1)	AR026726A1 (cs)
AU (1)	AU781846B2 (cs)
BR (1)	BR0016217A (cs)
CA (1)	CA2393042C (cs)
CO (1)	CO5251449A1 (cs)
CZ (1)	CZ303385B6 (cs)
HK (1)	HK1047593A1 (cs)
HU (1)	HUP0203471A3 (cs)
IL (2)	IL149628A0 (cs)
NO (1)	NO323059B1 (cs)
NZ (1)	NZ519100A (cs)
PE (1)	PE20010935A1 (cs)
PL (1)	PL202840B1 (cs)
RU (1)	RU2266913C2 (cs)
SK (1)	SK287682B6 (cs)
TW (1)	TWI289566B (cs)
WO (1)	WO2001042262A2 (cs)
ZA (1)	ZA200203799B (cs)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2557086A3 (en) *	2001-09-07	2014-11-05	Alchemia Limited	Synthetic heparin pentasaccharides
WO2004007468A1 (en)	2002-07-15	2004-01-22	Merck & Co., Inc.	Piperidino pyrimidine dipeptidyl peptidase inhibitors for the treatment of diabetes
WO2004032836A2 (en)	2002-10-07	2004-04-22	Merck & Co., Inc.	Antidiabetic beta-amino heterocylcic dipeptidyl peptidase inhibitors
JP4413863B2 (ja)	2002-11-07	2010-02-10	メルクエンドカムパニーインコーポレーテッド	糖尿病の治療又は予防のためのジペチジルペプチダーゼ阻害剤としてのフェニルアラニン誘導体
CA2512546A1 (en)	2003-01-17	2004-08-05	Merck & Co., Inc.	3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
JP2006516573A (ja)	2003-01-31	2006-07-06	メルク　エンド　カムパニー　インコーポレーテッド	糖尿病の治療および予防のためのジペプチジルペプチダーゼ阻害薬としての３−アミノ−４−フェニルブタン酸誘導体
WO2004103276A2 (en)	2003-05-14	2004-12-02	Merck & Co., Inc.	3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
WO2004110436A1 (en)	2003-06-06	2004-12-23	Merck & Co., Inc.	Fused indoles as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
US7456204B2 (en)	2003-06-17	2008-11-25	Merck & Co., Inc.	Cyclohexylglycine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
CN1882551A (zh)	2003-07-31	2006-12-20	麦克公司	用作用于治疗或预防糖尿病的二肽基肽酶－iv酶抑制剂的六氢二氮杂吖庚因酮
EP1574516A1 (en)	2004-03-05	2005-09-14	Sanofi-Aventis	Antithrombotic compound
TW200621794A (en) *	2004-10-06	2006-07-01	Akzo Nobel Nv	Pulmonary administration of an antithrombotic compound
TWI403334B (zh) *	2004-12-23	2013-08-01	Merck Sharp & Dohme	包含生物素殘基之抗血栓雙重抑制劑
TWI376234B (en)	2005-02-01	2012-11-11	Msd Oss Bv	Conjugates of a polypeptide and an oligosaccharide
HRP20110331T1 (hr) *	2005-10-10	2011-06-30	N.V. Organon	Antikoagulantno-antitrombotski dvojni inhibitori, koji sadrže biotinski biljeg
CN102892411B (zh)	2009-12-18	2015-01-21	恩多提斯药业公司	含有合成的低聚糖的药物口服剂型

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4115468A1 (de) *	1991-05-11	1992-11-12	Behringwerke Ag	Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel als antikoagulantien
DE4206858A1 (de) *	1992-03-05	1993-09-09	Behringwerke Ag	Glycopeptid-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel
FR2704226B1 (fr) *	1993-04-22	1995-07-21	Sanofi Elf	3-desoxy oligosaccharides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
ES2147216T3 (es) *	1993-09-01	2000-09-01	Akzo Nobel Nv	Bisconjugados que comprenden dos sacaridos y un grupo de union.
IL126893A (en) *	1997-11-19	2003-05-29	Akzo Nobel Nv	Sulfated pentasaccharide derivatives and pharmaceutical compositions containing them
NZ508623A (en) *	1998-06-17	2002-11-26	Akzo Nobel Nv	Antithrombotic peptide compounds with saccharide radicals

2000
- 2000-11-21 TW TW089124693A patent/TWI289566B/zh not_active IP Right Cessation
- 2000-12-01 NZ NZ519100A patent/NZ519100A/en not_active IP Right Cessation
- 2000-12-01 HU HU0203471A patent/HUP0203471A3/hu unknown
- 2000-12-01 US US10/148,868 patent/US6875755B2/en not_active Expired - Lifetime
- 2000-12-01 PL PL355484A patent/PL202840B1/pl not_active IP Right Cessation
- 2000-12-01 AU AU20038/01A patent/AU781846B2/en not_active Expired
- 2000-12-01 CA CA2393042A patent/CA2393042C/en not_active Expired - Lifetime
- 2000-12-01 JP JP2001543559A patent/JP4820517B2/ja not_active Expired - Lifetime
- 2000-12-01 KR KR1020027007186A patent/KR100776607B1/ko not_active Expired - Fee Related
- 2000-12-01 WO PCT/EP2000/012155 patent/WO2001042262A2/en not_active Ceased
- 2000-12-01 RU RU2002118117/04A patent/RU2266913C2/ru not_active IP Right Cessation
- 2000-12-01 BR BR0016217-5A patent/BR0016217A/pt active Search and Examination
- 2000-12-01 CN CNB008167753A patent/CN1195767C/zh not_active Expired - Fee Related
- 2000-12-01 EP EP00983209.8A patent/EP1237897B1/en not_active Expired - Lifetime
- 2000-12-01 HK HK02109170.1A patent/HK1047593A1/zh unknown
- 2000-12-01 IL IL14962800A patent/IL149628A0/xx unknown
- 2000-12-01 CZ CZ20021958A patent/CZ303385B6/cs not_active IP Right Cessation
- 2000-12-01 SK SK794-2002A patent/SK287682B6/sk not_active IP Right Cessation
- 2000-12-06 AR ARP000106443A patent/AR026726A1/es active IP Right Grant
- 2000-12-06 CO CO00093231A patent/CO5251449A1/es not_active Application Discontinuation
- 2000-12-06 PE PE2000001308A patent/PE20010935A1/es not_active Application Discontinuation
2002
- 2002-05-13 ZA ZA200203799A patent/ZA200203799B/xx unknown
- 2002-05-14 IL IL149628A patent/IL149628A/en not_active IP Right Cessation
- 2002-06-06 NO NO20022689A patent/NO323059B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
KR20020070988A (ko)	2002-09-11
NO20022689D0 (no)	2002-06-06
RU2266913C2 (ru)	2005-12-27
US20030114361A1 (en)	2003-06-19
PL202840B1 (pl)	2009-07-31
JP4820517B2 (ja)	2011-11-24
EP1237897B1 (en)	2015-01-14
NO20022689L (no)	2002-06-06
KR100776607B1 (ko)	2007-11-16
CA2393042C (en)	2011-06-28
CZ303385B6 (cs)	2012-08-29
BR0016217A (pt)	2002-09-10
PL355484A1 (en)	2004-05-04
CZ20021958A3 (cs)	2002-08-14
WO2001042262A3 (en)	2001-12-13
ZA200203799B (en)	2003-10-29
AU2003801A (en)	2001-06-18
CA2393042A1 (en)	2001-06-14
AR026726A1 (es)	2003-02-26
CN1195767C (zh)	2005-04-06
EP1237897A2 (en)	2002-09-11
SK287682B6 (sk)	2011-06-06
SK7942002A3 (en)	2002-09-10
NZ519100A (en)	2004-09-24
PE20010935A1 (es)	2001-09-20
WO2001042262A2 (en)	2001-06-14
AU781846B2 (en)	2005-06-16
HUP0203471A3 (en)	2003-03-28
CO5251449A1 (es)	2003-02-28
IL149628A0 (en)	2002-11-10
TWI289566B (en)	2007-11-11
HK1047593A1 (zh)	2003-02-28
US6875755B2 (en)	2005-04-05
CN1407989A (zh)	2003-04-02
JP2003520208A (ja)	2003-07-02
HUP0203471A2 (hu)	2003-02-28
IL149628A (en)	2010-04-29

Legal Events

Date	Code	Title	Description
2013-06-10	CHAD	Change of the owner's name or address (par. 44 patent law, par. patentforskriften)	Owner name: MERCK SHARP & DOHME BV, NL
2014-07-21	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
EP1237897B1 (en)	2015-01-14	Antithrombotic compound
JP4369052B2 (ja)	2009-11-18	抗血栓症化合物
JP5632886B2 (ja)	2014-11-26	ビオチン残基を含む抗血栓性デュアルインヒビター
MXPA02005278A (en)	2003-11-07	Antithrombotic compound
HK1034266B (en)	2008-10-24	Antithrombotic compounds