NO323616B1 - Immunogent konjugat av gruppe C meningokokkisk polysakarid anvendelig i vaksiner mot Neisseria Meningtidis, samt fremstilling derav - Google Patents

Immunogent konjugat av gruppe C meningokokkisk polysakarid anvendelig i vaksiner mot Neisseria Meningtidis, samt fremstilling derav Download PDF

Info

Publication number: NO323616B1
Authority: NO; Norway
Prior art keywords: channel; hydrogen; electrolysis; electrolysis chamber; electrolyte
Prior art date: 1992-08-31

Application number

NO19950739A

Other languages

English (en)

Norwegian (no)

Other versions

NO950739L (no

NO950739D0 (no

Inventor

Joseph Y Tai

Lucjan J Hronowski

Sharon Mates

Francis Michon

Harold Jennings

Original Assignee

Baxter Healthcare Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-08-31

Filing date

1995-02-27

Publication date

2007-06-18

1992-08-31 Priority claimed from US07/938,367 external-priority patent/US5425946A/en

1995-02-27 Application filed by Baxter Healthcare Sa filed Critical Baxter Healthcare Sa

1995-02-27 Publication of NO950739D0 publication Critical patent/NO950739D0/no

1995-04-26 Publication of NO950739L publication Critical patent/NO950739L/no

2007-06-18 Publication of NO323616B1 publication Critical patent/NO323616B1/no

Links

150000004676 glycans Chemical class 0.000 title abstract 3
229920001282 polysaccharide Polymers 0.000 title abstract 3
239000005017 polysaccharide Substances 0.000 title abstract 3
230000002163 immunogen Effects 0.000 title abstract 2
241000588653 Neisseria Species 0.000 title 1
229960005486 vaccine Drugs 0.000 title 1
238000005868 electrolysis reaction Methods 0.000 claims description 55
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 44
239000001257 hydrogen Substances 0.000 claims description 43
229910052739 hydrogen Inorganic materials 0.000 claims description 43
239000003792 electrolyte Substances 0.000 claims description 38
239000007789 gas Substances 0.000 claims description 36
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 26
229910052760 oxygen Inorganic materials 0.000 claims description 26
239000001301 oxygen Substances 0.000 claims description 26
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 25
150000002430 hydrocarbons Chemical class 0.000 claims description 14
229930195733 hydrocarbon Natural products 0.000 claims description 11
238000000034 method Methods 0.000 claims description 9
239000003054 catalyst Substances 0.000 claims description 5
230000001105 regulatory effect Effects 0.000 claims description 5
PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims description 4
239000000126 substance Substances 0.000 claims description 4
239000004020 conductor Substances 0.000 claims description 3
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 2
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 2
229910052802 copper Inorganic materials 0.000 claims description 2
239000010949 copper Substances 0.000 claims description 2
229910052759 nickel Inorganic materials 0.000 claims description 2
229910052725 zinc Inorganic materials 0.000 claims description 2
239000011701 zinc Substances 0.000 claims description 2
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 1
229910001882 dioxygen Inorganic materials 0.000 claims 1
230000000844 anti-bacterial effect Effects 0.000 abstract 1
238000003381 deacetylation reaction Methods 0.000 abstract 1
230000003053 immunization Effects 0.000 abstract 1
238000002649 immunization Methods 0.000 abstract 1
230000009851 immunogenic response Effects 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 description 6
239000004215 Carbon black (E152) Substances 0.000 description 5
239000000654 additive Substances 0.000 description 5
238000010438 heat treatment Methods 0.000 description 5
150000002431 hydrogen Chemical class 0.000 description 4
239000007788 liquid Substances 0.000 description 4
239000000463 material Substances 0.000 description 4
239000012530 fluid Substances 0.000 description 3
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
229910002092 carbon dioxide Inorganic materials 0.000 description 2
230000005611 electricity Effects 0.000 description 2
VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 2
238000005192 partition Methods 0.000 description 2
-1 steam Substances 0.000 description 2
UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
238000009835 boiling Methods 0.000 description 1
150000003842 bromide salts Chemical class 0.000 description 1
239000006227 byproduct Substances 0.000 description 1
239000001569 carbon dioxide Substances 0.000 description 1
229910002091 carbon monoxide Inorganic materials 0.000 description 1
239000000919 ceramic Substances 0.000 description 1
239000002131 composite material Substances 0.000 description 1
238000010276 construction Methods 0.000 description 1
238000002425 crystallisation Methods 0.000 description 1
230000008025 crystallization Effects 0.000 description 1
230000000694 effects Effects 0.000 description 1
238000010891 electric arc Methods 0.000 description 1
125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
150000004694 iodide salts Chemical class 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
230000005012 migration Effects 0.000 description 1
238000013508 migration Methods 0.000 description 1
239000000203 mixture Substances 0.000 description 1
239000003345 natural gas Substances 0.000 description 1
239000000047 product Substances 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
238000002407 reforming Methods 0.000 description 1
238000007789 sealing Methods 0.000 description 1
238000000926 separation method Methods 0.000 description 1
239000007787 solid Substances 0.000 description 1
230000003068 static effect Effects 0.000 description 1
238000000629 steam reforming Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Immunology (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Microbiology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
Urology & Nephrology (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Physics & Mathematics (AREA)
Communicable Diseases (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Mycology (AREA)
Analytical Chemistry (AREA)
Epidemiology (AREA)
Food Science & Technology (AREA)
Biotechnology (AREA)
Cell Biology (AREA)
Biochemistry (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicinal Preparation (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Peptides Or Proteins (AREA)

NO19950739A 1992-08-31 1995-02-27 Immunogent konjugat av gruppe C meningokokkisk polysakarid anvendelig i vaksiner mot Neisseria Meningtidis, samt fremstilling derav NO323616B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US07/938,367 US5425946A (en)	1992-08-31	1992-08-31	Vaccines against group C Neisseria meningitidis
US6450193A	1993-05-19	1993-05-19
PCT/US1993/008155 WO1994005325A1 (en)	1992-08-31	1993-08-30	Vaccines against group c neisseria meningitidis

Publications (3)

Publication Number	Publication Date
NO950739D0 NO950739D0 (no)	1995-02-27
NO950739L NO950739L (no)	1995-04-26
NO323616B1 true NO323616B1 (no)	2007-06-18

Family

ID=26744584

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19950739A NO323616B1 (no)	1992-08-31	1995-02-27	Immunogent konjugat av gruppe C meningokokkisk polysakarid anvendelig i vaksiner mot Neisseria Meningtidis, samt fremstilling derav

Country Status (12)

Country	Link
EP (1)	EP0658118B1 (de)
JP (2)	JP4097691B2 (de)
AT (1)	ATE212233T1 (de)
AU (1)	AU4841693A (de)
CA (1)	CA2142981C (de)
DE (1)	DE69331495T2 (de)
DK (1)	DK0658118T3 (de)
ES (1)	ES2171418T3 (de)
NO (1)	NO323616B1 (de)
PL (1)	PL175595B1 (de)
PT (1)	PT658118E (de)
WO (1)	WO1994005325A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5780606A (en) *	1995-06-07	1998-07-14	Connaught Laboratories Limited	Neisseria meningitidis capsular polysaccharide conjugates
GB9713156D0 (en) *	1997-06-20	1997-08-27	Microbiological Res Authority	Vaccines
WO1998058670A1 (en) *	1997-06-24	1998-12-30	Chiron Corporation	Methods of immunizing adults using anti-meningococcal vaccine compositions
WO2001078787A2 (en) *	2000-04-18	2001-10-25	Endobiologics, Incorporated	Lipopolysaccharide-conjugate vaccine for sepsis treatment
US7749511B2 (en)	2000-04-18	2010-07-06	Endobiologics, Incorporated	Anti-sepsis conjugate vaccine
SI21352A (sl) *	2001-01-23	2004-06-30	Aventis Pasteur	Multivalentno meningokokno cepivo iz konjugata polisaharida-proteina
CA2530364C (en) *	2003-06-23	2014-03-18	Baxter International Inc.	Vaccines against group y neisseria meningitidis and meningococcal combinations thereof
GB0323103D0 (en)	2003-10-02	2003-11-05	Chiron Srl	De-acetylated saccharides
NZ546430A (en)	2003-10-02	2009-04-30	Novartis Vaccines & Diagnostic	Liquid vaccines for multiple meningococcal serogroups
GB0406013D0 (en)	2004-03-17	2004-04-21	Chiron Srl	Analysis of saccharide vaccines without interference
NZ550533A (en)	2004-04-30	2010-02-26	Novartis Vaccines & Diagnostic	Meningococcal conjugate vaccination comprising N. meningitidis and diphtheria toxin
GB0409745D0 (en)	2004-04-30	2004-06-09	Chiron Srl	Compositions including unconjugated carrier proteins
GB0500787D0 (en)	2005-01-14	2005-02-23	Chiron Srl	Integration of meningococcal conjugate vaccination
GB0605757D0 (en)	2006-03-22	2006-05-03	Chiron Srl	Separation of conjugated and unconjugated components
PL2004225T3 (pl)	2006-03-22	2012-09-28	Novartis Ag	Schematy immunizacji koniugatami meningokokowymi
ES2555786T3 (es)	2007-06-04	2016-01-08	Glaxosmithkline Biologicals Sa	Formulación de vacunas contra la meningitis
BR122016015627A2 (pt)	2007-10-19	2018-10-30	Novartis Ag	kit, composição antigênica liofilizada e método para preparação de uma composição imunogênica
GB0822633D0 (en)	2008-12-11	2009-01-21	Novartis Ag	Formulation
GB0822634D0 (en)	2008-12-11	2009-01-21	Novartis Ag	Meningitis vaccines
WO2010070453A2 (en)	2008-12-17	2010-06-24	Novartis Ag	Meningococcal vaccines including hemoglobin receptor
EP2373333A1 (de) *	2008-12-22	2011-10-12	Children's Hospital & Research Center at Oakland	Ex-vivo-bakteriämietest mit passivem schutz
EP2411048B1 (de)	2009-03-24	2020-05-06	GlaxoSmithKline Biologicals SA	Adjuvantierendes meningokokken-faktor-h-bindungsprotein
EP3017826A1 (de)	2009-03-24	2016-05-11	Novartis AG	Kombinationen von meningokkoken-faktor-h-bindenden proteinen und pneumokokken-saccharid-konjugaten
GB201003922D0 (en)	2010-03-09	2010-04-21	Glaxosmithkline Biolog Sa	Conjugation process
AU2011268507B2 (en)	2010-06-25	2014-08-14	Novartis Ag	Combinations of meningococcal factor H binding proteins
WO2012117377A1 (en)	2011-03-02	2012-09-07	Novartis Ag	Combination vaccines with lower doses of antigen and/or adjuvant
EP2729178A1 (de)	2011-07-08	2014-05-14	Novartis AG	Tyrosinverbindungsverfahren
RU2636350C2 (ru)	2011-11-07	2017-11-22	Новартис Аг	МОЛЕКУЛА, СОДЕРЖАЩАЯ SPR0096 и SPR2021
JP2015505309A (ja)	2011-12-29	2015-02-19	ノバルティスアーゲー	髄膜炎菌ｈ因子結合タンパク質のアジュバントされた組み合わせ
EP2822584A1 (de)	2012-03-08	2015-01-14	Novartis AG	Kombinationsimpfstoffe mit tlr4-agonisten
JP6324961B2 (ja)	2012-09-06	2018-05-16	ノバルティスアーゲー	血清群ｂ髄膜炎菌とｄ／ｔ／ｐとの組み合わせワクチン
US20150320852A1 (en)	2012-12-18	2015-11-12	Glaxosmithkline Biologicals Sa	Conjugates for protecting against diphtheria and/or tetanus
AU2014286990A1 (en)	2013-07-11	2016-02-11	Novartis Ag	Lysine-specific chemoenzymatic protein modifications using microbial transglutaminase
MY186874A (en) *	2014-02-25	2021-08-26	Msd Wellcome Trust Hilleman Laboratories Pvt Ltd	A novel downstream process for purifying polysaccharides
US12109259B2 (en)	2016-09-02	2024-10-08	Glaxosmithkline Biologicals Sa	Vaccines for Neisseria gonorrhoeae
BR112019003992A2 (pt) *	2016-09-02	2019-05-28	Sanofi Pasteur Inc	vacina contra neisseria meningitidis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5097020A (en) *	1983-07-05	1992-03-17	The University Of Rochester	Immunogenic conjugates
FR2682388B1 (fr) *	1991-10-10	1995-06-09	Pasteur Merieux Serums Vacc	Procede de preparation d'un oligoside par depolymerisation d'un polyoside issu d'un agent pathogene, oligoside ainsi obtenu et son utilisation notamment comme agent vaccinal.

1993
- 1993-08-30 PL PL93307745A patent/PL175595B1/pl unknown
- 1993-08-30 DE DE69331495T patent/DE69331495T2/de not_active Expired - Lifetime
- 1993-08-30 ES ES93921251T patent/ES2171418T3/es not_active Expired - Lifetime
- 1993-08-30 AU AU48416/93A patent/AU4841693A/en not_active Abandoned
- 1993-08-30 CA CA002142981A patent/CA2142981C/en not_active Expired - Lifetime
- 1993-08-30 EP EP93921251A patent/EP0658118B1/de not_active Expired - Lifetime
- 1993-08-30 JP JP50737294A patent/JP4097691B2/ja not_active Expired - Lifetime
- 1993-08-30 PT PT93921251T patent/PT658118E/pt unknown
- 1993-08-30 AT AT93921251T patent/ATE212233T1/de active
- 1993-08-30 WO PCT/US1993/008155 patent/WO1994005325A1/en not_active Ceased
- 1993-08-30 DK DK93921251T patent/DK0658118T3/da active
1995
- 1995-02-27 NO NO19950739A patent/NO323616B1/no not_active IP Right Cessation
2007
- 2007-09-19 JP JP2007242721A patent/JP2008044955A/ja active Pending

Also Published As

Publication number	Publication date
AU4841693A (en)	1994-03-29
ES2171418T3 (es)	2002-09-16
DK0658118T3 (da)	2002-05-06
JP2008044955A (ja)	2008-02-28
WO1994005325A1 (en)	1994-03-17
JPH08500607A (ja)	1996-01-23
PT658118E (pt)	2002-05-31
NO950739L (no)	1995-04-26
EP0658118A4 (de)	1995-09-13
DE69331495D1 (de)	2002-03-14
CA2142981C (en)	2007-10-23
ATE212233T1 (de)	2002-02-15
EP0658118A1 (de)	1995-06-21
PL307745A1 (en)	1995-06-12
JP4097691B2 (ja)	2008-06-11
NO950739D0 (no)	1995-02-27
DE69331495T2 (de)	2002-10-31
EP0658118B1 (de)	2002-01-23
PL175595B1 (pl)	1999-01-29
CA2142981A1 (en)	1994-03-17

Legal Events

Date	Code	Title	Description
2013-10-07	MK1K	Patent expired

Publication	Publication Date	Title
NO323616B1 (no)	2007-06-18	Immunogent konjugat av gruppe C meningokokkisk polysakarid anvendelig i vaksiner mot Neisseria Meningtidis, samt fremstilling derav
CA2752698C (en)	2014-01-28	Apparatus and method for gas capture during electrolysis
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