NO324694B1 - Anvendelse av endotelinreseptor-antagonister for fremstilling av medikamenter for a kontrollere hyperlipidemi. - Google Patents

Anvendelse av endotelinreseptor-antagonister for fremstilling av medikamenter for a kontrollere hyperlipidemi. Download PDF

Info

Publication number: NO324694B1
Authority: NO; Norway
Prior art keywords: receptor antagonists; endothelin receptor; medications; manufacture; endothelin
Prior art date: 1997-12-05

Application number

NO20002777A

Other languages

English (en)

Norwegian (no)

Other versions

NO20002777D0 (no

NO20002777L (no

Inventor

Michael Kirchengast

Klaus Muenter

Original Assignee

Abbott Gmbh & Co Kg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-05

Filing date

2000-05-30

Publication date

2007-12-03

2000-05-30 Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg

2000-05-30 Publication of NO20002777D0 publication Critical patent/NO20002777D0/no

2000-06-02 Publication of NO20002777L publication Critical patent/NO20002777L/no

2007-12-03 Publication of NO324694B1 publication Critical patent/NO324694B1/no

Links

229940118365 Endothelin receptor antagonist Drugs 0.000 title abstract description 9
239000002308 endothelin receptor antagonist Substances 0.000 title abstract description 9
208000031226 Hyperlipidaemia Diseases 0.000 title abstract description 5
239000003814 drug Substances 0.000 title description 10
229940079593 drug Drugs 0.000 title description 10
238000004519 manufacturing process Methods 0.000 title description 3
238000002483 medication Methods 0.000 title 1
208000008589 Obesity Diseases 0.000 abstract description 6
235000020824 obesity Nutrition 0.000 abstract description 6
201000010099 disease Diseases 0.000 abstract description 3
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 3
201000005569 Gout Diseases 0.000 abstract description 2
206010020772 Hypertension Diseases 0.000 abstract description 2
208000020832 chronic kidney disease Diseases 0.000 abstract description 2
208000022831 chronic renal failure syndrome Diseases 0.000 abstract description 2
208000001072 type 2 diabetes mellitus Diseases 0.000 abstract description 2
206010003210 Arteriosclerosis Diseases 0.000 abstract 1
208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
239000007903 gelatin capsule Substances 0.000 description 6
108050009340 Endothelin Proteins 0.000 description 5
102000002045 Endothelin Human genes 0.000 description 5
239000000654 additive Substances 0.000 description 5
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 description 5
210000004185 liver Anatomy 0.000 description 4
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
229920005862 polyol Polymers 0.000 description 4
150000003077 polyols Chemical class 0.000 description 4
239000000243 solution Substances 0.000 description 4
239000000126 substance Substances 0.000 description 4
239000003826 tablet Substances 0.000 description 4
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
241001465754 Metazoa Species 0.000 description 3
239000008298 dragée Substances 0.000 description 3
239000007788 liquid Substances 0.000 description 3
229940044551 receptor antagonist Drugs 0.000 description 3
239000002464 receptor antagonist Substances 0.000 description 3
239000007940 sugar coated tablet Substances 0.000 description 3
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
241000699670 Mus sp. Species 0.000 description 2
KGNDCEVUMONOKF-UGPLYTSKSA-N benzyl n-[(2r)-1-[(2s,4r)-2-[[(2s)-6-amino-1-(1,3-benzoxazol-2-yl)-1,1-dihydroxyhexan-2-yl]carbamoyl]-4-[(4-methylphenyl)methoxy]pyrrolidin-1-yl]-1-oxo-4-phenylbutan-2-yl]carbamate Chemical compound C1=CC(C)=CC=C1CO[C@H]1CN(C(=O)[C@@H](CCC=2C=CC=CC=2)NC(=O)OCC=2C=CC=CC=2)[C@H](C(=O)N[C@@H](CCCCN)C(O)(O)C=2OC3=CC=CC=C3N=2)C1 KGNDCEVUMONOKF-UGPLYTSKSA-N 0.000 description 2
230000037396 body weight Effects 0.000 description 2
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
229940125833 compound 23 Drugs 0.000 description 2
239000003925 fat Substances 0.000 description 2
239000008187 granular material Substances 0.000 description 2
238000002347 injection Methods 0.000 description 2
239000007924 injection Substances 0.000 description 2
239000008101 lactose Substances 0.000 description 2
235000019359 magnesium stearate Nutrition 0.000 description 2
239000000203 mixture Substances 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
150000003839 salts Chemical class 0.000 description 2
239000000829 suppository Substances 0.000 description 2
239000000454 talc Substances 0.000 description 2
229910052623 talc Inorganic materials 0.000 description 2
235000015112 vegetable and seed oil Nutrition 0.000 description 2
239000008158 vegetable oil Substances 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
239000001993 wax Substances 0.000 description 2
YSUIQYOGTINQIN-UZFYAQMZSA-N 2-amino-9-[(1S,6R,8R,9S,10R,15R,17R,18R)-8-(6-aminopurin-9-yl)-9,18-difluoro-3,12-dihydroxy-3,12-bis(sulfanylidene)-2,4,7,11,13,16-hexaoxa-3lambda5,12lambda5-diphosphatricyclo[13.2.1.06,10]octadecan-17-yl]-1H-purin-6-one Chemical compound NC1=NC2=C(N=CN2[C@@H]2O[C@@H]3COP(S)(=O)O[C@@H]4[C@@H](COP(S)(=O)O[C@@H]2[C@@H]3F)O[C@H]([C@H]4F)N2C=NC3=C2N=CN=C3N)C(=O)N1 YSUIQYOGTINQIN-UZFYAQMZSA-N 0.000 description 1
101150037123 APOE gene Proteins 0.000 description 1
101710095339 Apolipoprotein E Proteins 0.000 description 1
102100029470 Apolipoprotein E Human genes 0.000 description 1
229920002261 Corn starch Polymers 0.000 description 1
101100216294 Danio rerio apoeb gene Proteins 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
206010020710 Hyperphagia Diseases 0.000 description 1
241000700159 Rattus Species 0.000 description 1
206010038372 Renal arteriosclerosis Diseases 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
235000021355 Stearic acid Nutrition 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
108010047918 TAK 044 Proteins 0.000 description 1
206010045261 Type IIa hyperlipidaemia Diseases 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
238000010171 animal model Methods 0.000 description 1
230000003579 anti-obesity Effects 0.000 description 1
239000003963 antioxidant agent Substances 0.000 description 1
MOTJMGVDPWRKOC-QPVYNBJUSA-N atrasentan Chemical compound C1([C@H]2[C@@H]([C@H](CN2CC(=O)N(CCCC)CCCC)C=2C=C3OCOC3=CC=2)C(O)=O)=CC=C(OC)C=C1 MOTJMGVDPWRKOC-QPVYNBJUSA-N 0.000 description 1
LFYJSSARVMHQJB-QIXNEVBVSA-N bakuchiol Chemical compound CC(C)=CCC[C@@](C)(C=C)\C=C\C1=CC=C(O)C=C1 LFYJSSARVMHQJB-QIXNEVBVSA-N 0.000 description 1
GJPICJJJRGTNOD-UHFFFAOYSA-N bosentan Chemical compound COC1=CC=CC=C1OC(C(=NC(=N1)C=2N=CC=CN=2)OCCO)=C1NS(=O)(=O)C1=CC=C(C(C)(C)C)C=C1 GJPICJJJRGTNOD-UHFFFAOYSA-N 0.000 description 1
229960003065 bosentan Drugs 0.000 description 1
239000000872 buffer Substances 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
235000012000 cholesterol Nutrition 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
239000003086 colorant Substances 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
239000008120 corn starch Substances 0.000 description 1
230000007850 degeneration Effects 0.000 description 1
UWHBIISPHYTOGL-PFSAEEMXSA-L disodium;2-[(2r,5s,8s,11s,14s,17r)-8-(carboxylatomethyl)-17-(1h-indol-3-ylmethyl)-14-(2-methylpropyl)-3,6,9,12,15,18-hexaoxo-5-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]-11-thiophen-2-yl-1,4,7,10,13,16-hexazacyclooctadec-2-yl]acetate Chemical compound [Na+].[Na+].C([C@H]1C(=O)N[C@@H](CC([O-])=O)C(=O)N[C@@H](C(=O)N[C@H](C(N[C@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@H](CC([O-])=O)C(=O)N1)=O)CC(C)C)C=1SC=CC=1)C(=O)N(CC1)CCN1C1=CC=CC=C1 UWHBIISPHYTOGL-PFSAEEMXSA-L 0.000 description 1
230000002526 effect on cardiovascular system Effects 0.000 description 1
230000000694 effects Effects 0.000 description 1
239000003995 emulsifying agent Substances 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
235000013305 food Nutrition 0.000 description 1
235000013355 food flavoring agent Nutrition 0.000 description 1
235000003599 food sweetener Nutrition 0.000 description 1
239000008103 glucose Substances 0.000 description 1
235000009200 high fat diet Nutrition 0.000 description 1
-1 invert sugar Substances 0.000 description 1
229960004903 invert sugar Drugs 0.000 description 1
LJGUZUROJOJEMI-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C=CC(=CC=2)C=2OC=CN=2)=C1C LJGUZUROJOJEMI-UHFFFAOYSA-N 0.000 description 1
ORJRYNKVKJAJPY-UHFFFAOYSA-N n-[[2-[2-[(4,5-dimethyl-1,2-oxazol-3-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n,3,3-trimethylbutanamide Chemical compound CC(C)(C)CC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC1=NOC(C)=C1C ORJRYNKVKJAJPY-UHFFFAOYSA-N 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
239000003921 oil Substances 0.000 description 1
235000019198 oils Nutrition 0.000 description 1
239000006259 organic additive Substances 0.000 description 1
230000003204 osmotic effect Effects 0.000 description 1
235000020830 overeating Nutrition 0.000 description 1
230000001575 pathological effect Effects 0.000 description 1
230000007170 pathology Effects 0.000 description 1
239000000813 peptide hormone Substances 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
229960002578 sitaxentan Drugs 0.000 description 1
PHWXUGHIIBDVKD-UHFFFAOYSA-N sitaxentan Chemical compound CC1=NOC(NS(=O)(=O)C2=C(SC=C2)C(=O)CC=2C(=CC=3OCOC=3C=2)C)=C1Cl PHWXUGHIIBDVKD-UHFFFAOYSA-N 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
COKFAUSKNMGISZ-BMGIYVBOSA-M sodium;(z)-2-(2,1,3-benzothiadiazol-5-yl)-4-(4-methoxyphenyl)-4-oxo-3-[(3,4,5-trimethoxyphenyl)methyl]but-2-enoate Chemical compound [Na+].C1=CC(OC)=CC=C1C(=O)C(\CC=1C=C(OC)C(OC)=C(OC)C=1)=C(/C([O-])=O)C1=CC2=NSN=C2C=C1 COKFAUSKNMGISZ-BMGIYVBOSA-M 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000002966 varnish Substances 0.000 description 1
239000005526 vasoconstrictor agent Substances 0.000 description 1
238000005303 weighing Methods 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Hematology (AREA)
Epidemiology (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Child & Adolescent Psychology (AREA)
Vascular Medicine (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Plant Substances (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO20002777A 1997-12-05 2000-05-30 Anvendelse av endotelinreseptor-antagonister for fremstilling av medikamenter for a kontrollere hyperlipidemi. NO324694B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19754082A DE19754082A1 (de)	1997-12-05	1997-12-05	Methode zur Bekämpfung der Fettleibigkeit
PCT/EP1998/007501 WO1999029308A2 (de)	1997-12-05	1998-11-21	Methode zur bekämpfung der fettleibigkeit

Publications (3)

Publication Number	Publication Date
NO20002777D0 NO20002777D0 (no)	2000-05-30
NO20002777L NO20002777L (no)	2000-06-02
NO324694B1 true NO324694B1 (no)	2007-12-03

Family

ID=7850913

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO20002777A NO324694B1 (no)	1997-12-05	2000-05-30	Anvendelse av endotelinreseptor-antagonister for fremstilling av medikamenter for a kontrollere hyperlipidemi.
NO20074419A NO20074419L (no)	1997-12-05	2007-08-30	Anvendelse av endotelinreseptorantagonister for fremstilling av medikamenter for a bekjempe sykdom

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
NO20074419A NO20074419L (no)	1997-12-05	2007-08-30	Anvendelse av endotelinreseptorantagonister for fremstilling av medikamenter for a bekjempe sykdom

Country Status (16)

Country	Link
US (1)	US6197780B1 (cs)
EP (1)	EP1035851B1 (cs)
JP (1)	JP2002512173A (cs)
KR (1)	KR20010032779A (cs)
CN (1)	CN1152685C (cs)
AT (1)	ATE204172T1 (cs)
AU (1)	AU751053B2 (cs)
BR (1)	BR9815335A (cs)
CA (1)	CA2311423C (cs)
CZ (1)	CZ300442B6 (cs)
DE (2)	DE19754082A1 (cs)
ES (1)	ES2162493T3 (cs)
HU (1)	HUP0100171A3 (cs)
NO (2)	NO324694B1 (cs)
RU (1)	RU2292891C2 (cs)
WO (1)	WO1999029308A2 (cs)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19533023B4 (de) *	1994-10-14	2007-05-16	Basf Ag	Neue Carbonsäurederivate, ihre Herstellung und Verwendung
EP1130027A1 (de) *	2000-02-29	2001-09-05	Aventis Pharma Deutschland GmbH	Memno-Peptide, Verfahren zu ihrer Herstellung und Verwendung derselben
US20050175667A1 (en) *	2004-02-10	2005-08-11	Wenda Carlyle	Use of endothelin antagonists to prevent restenosis
EP2545920A1 (en)	2007-08-22	2013-01-16	Abbott GmbH & Co. KG	Therapy for complications of diabetes
RS57157B1 (sr)	2011-11-11	2018-07-31	Gilead Apollo Llc	Acc inhibitori i njihove primene
WO2016099233A2 (ru) *	2014-10-20	2016-06-23	Товарищество С Ограниченной Ответственностью "Фармацевтическая Компания "Ромат"	Фармацевтическая композиция для лечения туберкулеза
AR106472A1 (es)	2015-10-26	2018-01-17	Gilead Apollo Llc	Inhibidores de acc y usos de los mismos
PL3380479T3 (pl)	2015-11-25	2023-05-08	Gilead Apollo, Llc	Triazolowe inhibitory acc i ich zastosowania
EA201890949A1 (ru)	2015-11-25	2018-12-28	Джилид Аполло, Ллс	СЛОЖНОЭФИРНЫЕ ИНГИБИТОРЫ АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ И ВАРИАНТЫ ИХ ПРИМЕНЕНИЯ
AU2016361412A1 (en)	2015-11-25	2018-05-24	Gilead Apollo, Llc	Pyrazole ACC inhibitors and uses thereof
BR112018009212B1 (pt)	2015-11-25	2022-06-14	Gilead Apollo, Llc	Método para controlar patógenos fúngicos agrícolas
SG11201807077RA (en)	2016-03-02	2018-09-27	Gilead Apollo Llc	Solid forms of a thienopyrimidinedione acc inhibitor and methods for production thereof
SI4122464T1 (sl)	2017-03-28	2024-07-31	Gilead Sciences, Inc.	Terapevtske kombinacije za zdravljenje bolezni jeter

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1994012499A1 (fr) *	1992-12-01	1994-06-09	The Green Cross Corporation	Derive de 1,8-naphthyridin-2-one et utilisation de ce derive
US5998468A (en)	1995-08-24	1999-12-07	Warner-Lambert Company	Furanone endothelin antagonists
JP3116347B2 (ja) *	1996-11-13	2000-12-11	田辺製薬株式会社	医薬組成物

1997
- 1997-12-05 DE DE19754082A patent/DE19754082A1/de not_active Withdrawn
1998
- 1998-11-21 JP JP2000523980A patent/JP2002512173A/ja active Pending
- 1998-11-21 CN CNB988118327A patent/CN1152685C/zh not_active Expired - Fee Related
- 1998-11-21 EP EP98965685A patent/EP1035851B1/de not_active Expired - Lifetime
- 1998-11-21 ES ES98965685T patent/ES2162493T3/es not_active Expired - Lifetime
- 1998-11-21 KR KR1020007006075A patent/KR20010032779A/ko not_active Ceased
- 1998-11-21 AU AU21535/99A patent/AU751053B2/en not_active Ceased
- 1998-11-21 CZ CZ20002006A patent/CZ300442B6/cs not_active IP Right Cessation
- 1998-11-21 BR BR9815335-8A patent/BR9815335A/pt not_active Application Discontinuation
- 1998-11-21 US US09/530,131 patent/US6197780B1/en not_active Expired - Lifetime
- 1998-11-21 HU HU0100171A patent/HUP0100171A3/hu unknown
- 1998-11-21 WO PCT/EP1998/007501 patent/WO1999029308A2/de not_active Ceased
- 1998-11-21 CA CA002311423A patent/CA2311423C/en not_active Expired - Fee Related
- 1998-11-21 AT AT98965685T patent/ATE204172T1/de active
- 1998-11-21 DE DE59801230T patent/DE59801230D1/de not_active Expired - Lifetime
2000
- 2000-05-30 NO NO20002777A patent/NO324694B1/no not_active IP Right Cessation
2003
- 2003-12-29 RU RU2003138080/15A patent/RU2292891C2/ru not_active IP Right Cessation
2007
- 2007-08-30 NO NO20074419A patent/NO20074419L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
AU2153599A (en)	1999-06-28
CZ300442B6 (cs)	2009-05-20
HK1037141A1 (en)	2002-02-01
DE19754082A1 (de)	1999-06-10
AU751053B2 (en)	2002-08-08
CZ20002006A3 (cs)	2000-11-15
WO1999029308A2 (de)	1999-06-17
HUP0100171A3 (en)	2003-10-28
CA2311423A1 (en)	1999-06-17
ES2162493T3 (es)	2001-12-16
US6197780B1 (en)	2001-03-06
CA2311423C (en)	2008-01-29
NO20002777D0 (no)	2000-05-30
WO1999029308A3 (de)	1999-09-30
JP2002512173A (ja)	2002-04-23
RU2292891C2 (ru)	2007-02-10
HUP0100171A2 (hu)	2003-02-28
CN1152685C (zh)	2004-06-09
NO20002777L (no)	2000-06-02
RU2003138080A (ru)	2005-06-10
EP1035851B1 (de)	2001-08-16
BR9815335A (pt)	2000-10-17
DE59801230D1 (de)	2001-09-20
ATE204172T1 (de)	2001-09-15
CN1301162A (zh)	2001-06-27
KR20010032779A (ko)	2001-04-25
NO20074419L (no)	2000-06-02
EP1035851A2 (de)	2000-09-20

Legal Events

Date	Code	Title	Description
2014-06-02	CHAD	Change of the owner's name or address (par. 44 patent law, par. patentforskriften)	Owner name: ABBVIE DEUTSCHLAND GMBH & CO AG, DE
2015-06-22	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO324694B1 (no)	2007-12-03	Anvendelse av endotelinreseptor-antagonister for fremstilling av medikamenter for a kontrollere hyperlipidemi.
Neuschwander-Tetri et al.	2003	Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-γ ligand rosiglitazone
Martin et al.	1996	Acarbose: An α-glucosidase inhibitor
Henriksen et al.	2013	The role of the renin-angiotensin system in the development of insulin resistance in skeletal muscle
Lam et al.	1998	Acarbose in NIDDM patients with poor control on conventional oral agents: a 24-week placebo-controlled study
Shan et al.	2020	Vitamin B6 inhibits macrophage activation to prevent lipopolysaccharide‐induced acute pneumonia in mice
US20080300217A1 (en)	2008-12-04	Combination Therapy with Fumaric Acid Esters for the Treatment of Autoimmune and/or Inflammatory Disorders
Hou et al.	2023	Overview of the pharmacokinetics and pharmacodynamics of URAT1 inhibitors for the treatment of hyperuricemia and gout
Lang et al.	2014	Chronic alcohol consumption disrupts myocardial protein balance and function in aged, but not adult, female F344 rats
EP3142655B1 (en)	2020-12-02	Compositions and methods of treating cardiac fibrosis with ifetroban
NO315595B1 (no)	2003-09-29	Preparat inneholdende en kombinasjon av 5-metylisoksazol-4- karboksylsyre-(4-trifluormetyl)-anilid og N-(4-trifluormetylfenyl)2-cyano-3-hydroksykrotin
Rosenthal et al.	2002	Effects on blood pressure of the α-glucosidase inhibitor acarbose compared with the insulin enhancer glibenclamide in patients with hypertension and type 2 diabetes mellitus
US20160243082A1 (en)	2016-08-25	4-Methylpyrazole Formulations for Inhibiting Ethanol Intolerance
JiXiong et al.	2003	− 429T/C and− 374T/A polymorphisms of RAGE gene promoter are not associated with diabetic retinopathy in Chinese patients with type 2 diabetes
Vary et al.	2007	Sex-dependent differences in the regulation of myocardial protein synthesis following long-term ethanol consumption
Kassab et al.	2006	The angiotensin type 1 receptor antagonist valsartan attenuates pathological ventricular hypertrophy induced by hyperhomocysteinemia in rats
Hasler et al.	2004	Safety profile of tegaserod, a 5-HT4 receptor agonist, for the treatment of irritable bowel syndrome
Jaffe	1979	Penicillamine in rheumatoid arthritis: clinical pharmacology and biochemical properties
JP2025531309A (ja)	2025-09-19	腸透過性を改善するための組成物及び方法
MXPA00004989A (en)	2001-07-31	Method for combating obesity
Nelson et al.	2020	SAT-572 Extremely Elevated Plasma Lipoprotein X Level Secondary to Alcoholic Cholestasis
Dubey et al.	2023	Molecular docking studies of potent and selective orally bioavailable dihydro-pyrazole Gpr-40 agonists as Alpha-Glucosidase Inhibitors (AGIS)
JP2010111581A (ja)	2010-05-20	ドーパミンｄ２様受容体アゴニストを有効成分とする医薬及びスクリーニング方法
CN108938591A (zh)	2018-12-07	一种含有非布司他的固体药物组合物
CN107714699A (zh)	2018-02-23	盐酸石蒜碱用于制备药物的医药用途