NO325148B1 - Farmasoytisk preparat og anvendelse av en sammensetning ved fremstilling av et medikament for behandling av allergiske reaksjoner - Google Patents

Farmasoytisk preparat og anvendelse av en sammensetning ved fremstilling av et medikament for behandling av allergiske reaksjoner Download PDF

Info

Publication number: NO325148B1
Authority: NO; Norway
Prior art keywords: peg; acid; glycoprotein; antihistamine; fexofenadine
Prior art date: 1997-08-14

Application number

NO20000706A

Other languages

English (en)

Norwegian (no)

Other versions

NO20000706D0 (no

NO20000706L (no

Inventor

Kin-Kai Hwang

Dennis H Giesing

Gail H Hurst

Original Assignee

Aventis Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-08-14

Filing date

2000-02-11

Publication date

2008-02-11

2000-02-11 Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc

2000-02-11 Publication of NO20000706D0 publication Critical patent/NO20000706D0/no

2000-04-13 Publication of NO20000706L publication Critical patent/NO20000706L/no

2008-02-11 Publication of NO325148B1 publication Critical patent/NO325148B1/no

Links

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229940075614 colloidal silicon dioxide Drugs 0.000 description 1
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238000005886 esterification reaction Methods 0.000 description 1
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238000009472 formulation Methods 0.000 description 1
239000001530 fumaric acid Substances 0.000 description 1
235000011087 fumaric acid Nutrition 0.000 description 1
239000000499 gel Substances 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
239000011521 glass Substances 0.000 description 1
229940093915 gynecological organic acid Drugs 0.000 description 1
210000003494 hepatocyte Anatomy 0.000 description 1
125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
235000001050 hortel pimenta Nutrition 0.000 description 1
206010021247 idiopathic urticaria Diseases 0.000 description 1
239000012729 immediate-release (IR) formulation Substances 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
150000007529 inorganic bases Chemical class 0.000 description 1
125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
239000004310 lactic acid Substances 0.000 description 1
235000014655 lactic acid Nutrition 0.000 description 1
239000008101 lactose Substances 0.000 description 1
XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 1
239000011344 liquid material Substances 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
210000004072 lung Anatomy 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
239000011976 maleic acid Substances 0.000 description 1
239000001630 malic acid Substances 0.000 description 1
235000011090 malic acid Nutrition 0.000 description 1
229960002510 mandelic acid Drugs 0.000 description 1
239000000463 material Substances 0.000 description 1
230000001404 mediated effect Effects 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
150000002739 metals Chemical class 0.000 description 1
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239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
229960001047 methyl salicylate Drugs 0.000 description 1
229960002216 methylparaben Drugs 0.000 description 1
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235000019813 microcrystalline cellulose Nutrition 0.000 description 1
239000008108 microcrystalline cellulose Substances 0.000 description 1
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239000007968 orange flavor Substances 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
150000007530 organic bases Chemical class 0.000 description 1
125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
-1 peppermint Chemical compound 0.000 description 1
230000035699 permeability Effects 0.000 description 1
235000021317 phosphate Nutrition 0.000 description 1
150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
239000006187 pill Substances 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
239000004033 plastic Substances 0.000 description 1
231100000614 poison Toxicity 0.000 description 1
229940068918 polyethylene glycol 400 Drugs 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
229940068968 polysorbate 80 Drugs 0.000 description 1
229920000053 polysorbate 80 Polymers 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
150000003141 primary amines Chemical class 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
235000019260 propionic acid Nutrition 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
235000013772 propylene glycol Nutrition 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
210000000512 proximal kidney tubule Anatomy 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
229940107700 pyruvic acid Drugs 0.000 description 1
IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
229940081974 saccharin Drugs 0.000 description 1
235000019204 saccharin Nutrition 0.000 description 1
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
229960004889 salicylic acid Drugs 0.000 description 1
125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
150000003335 secondary amines Chemical class 0.000 description 1
238000010956 selective crystallization Methods 0.000 description 1
239000012056 semi-solid material Substances 0.000 description 1
238000000926 separation method Methods 0.000 description 1
229940113147 shellac Drugs 0.000 description 1
ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
239000004208 shellac Substances 0.000 description 1
235000013874 shellac Nutrition 0.000 description 1
210000003491 skin Anatomy 0.000 description 1
206010041232 sneezing Diseases 0.000 description 1
235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
239000000243 solution Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008223 sterile water Substances 0.000 description 1
210000000352 storage cell Anatomy 0.000 description 1
239000000758 substrate Substances 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
150000003460 sulfonic acids Chemical class 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
150000003512 tertiary amines Chemical class 0.000 description 1
239000003440 toxic substance Substances 0.000 description 1
230000007723 transport mechanism Effects 0.000 description 1
230000004614 tumor growth Effects 0.000 description 1
230000002485 urinary effect Effects 0.000 description 1
230000036325 urinary excretion Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/745—Polymers of hydrocarbons
- A61K31/75—Polymers of hydrocarbons of ethene
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
- A61K31/77—Polymers containing oxygen of oxiranes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pulmonology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Inorganic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)

NO20000706A 1997-08-14 2000-02-11 Farmasoytisk preparat og anvendelse av en sammensetning ved fremstilling av et medikament for behandling av allergiske reaksjoner NO325148B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US91156397A	1997-08-14	1997-08-14
PCT/US1998/015098 WO1999008690A1 (en)	1997-08-14	1998-07-21	Method of enhancing bioavailability of fexofenadine and its derivatives

Publications (3)

Publication Number	Publication Date
NO20000706D0 NO20000706D0 (no)	2000-02-11
NO20000706L NO20000706L (no)	2000-04-13
NO325148B1 true NO325148B1 (no)	2008-02-11

Family

ID=25430473

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20000706A NO325148B1 (no)	1997-08-14	2000-02-11	Farmasoytisk preparat og anvendelse av en sammensetning ved fremstilling av et medikament for behandling av allergiske reaksjoner

Country Status (29)

Country	Link
EP (1)	EP1003528B1 (pl)
JP (1)	JP4295913B2 (pl)
KR (1)	KR100522985B1 (pl)
CN (1)	CN1143680C (pl)
AR (1)	AR018505A1 (pl)
AT (1)	ATE224721T1 (pl)
AU (1)	AU725965C (pl)
BR (1)	BR9811937A (pl)
CA (1)	CA2301267C (pl)
CZ (1)	CZ293666B6 (pl)
DE (1)	DE69808303T2 (pl)
DK (1)	DK1003528T3 (pl)
EE (1)	EE04263B1 (pl)
ES (1)	ES2179523T3 (pl)
HU (1)	HU226823B1 (pl)
ID (1)	ID24463A (pl)
IL (1)	IL134521A (pl)
NO (1)	NO325148B1 (pl)
NZ (1)	NZ502133A (pl)
OA (1)	OA11287A (pl)
PL (1)	PL191607B1 (pl)
PT (1)	PT1003528E (pl)
RU (1)	RU2197967C2 (pl)
SK (1)	SK283868B6 (pl)
TR (1)	TR200000419T2 (pl)
TW (1)	TWI240633B (pl)
UA (1)	UA64765C2 (pl)
WO (1)	WO1999008690A1 (pl)
ZA (1)	ZA987221B (pl)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0812195B1 (en)	1995-02-28	2002-10-30	Aventis Pharmaceuticals Inc.	Pharmaceutical composition for piperidinoalkanol compounds
NZ501248A (en) *	1997-08-26	2001-06-29	Aventis Pharma Inc	Pharmaceutical composition for combination of piperidinoalkanol-decongestant
GB9822170D0 (en) *	1998-10-13	1998-12-02	Danbioyst Uk Ltd	Novel formulations of fexofenadine
BR0306329A (pt) *	2002-05-29	2005-04-26	Aventis Pharmaceuticals Holdin	Método de tratamento de asma
GB0319935D0 (en) *	2003-08-26	2003-09-24	Cipla Ltd	Polymorphs
PE20060416A1 (es) *	2004-08-03	2006-06-09	Novartis Ag	Composicion de inhibidores de renina e inhibidores de proteinas de efusion
JP2008120684A (ja) *	2005-03-07	2008-05-29	Kumamoto Univ	抗アレルギー薬
KR101106374B1 (ko)	2009-06-05	2012-01-19	민병욱	고체연료에 의한 가연성 가스 발생 장치
KR101117014B1 (ko) *	2009-09-09	2012-06-14	민병욱	부패성 폐기물의 바이오매스 처리에 의한 폐자원 재활용 방법 및 장치
CN101843616B (zh) *	2010-06-04	2011-07-27	西安万隆制药有限责任公司	一种盐酸非索非那定与微晶纤维素组合物及其制备方法
RU2453315C2 (ru) *	2010-08-17	2012-06-20	Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН")	Фармацевтическая композиция для лечения аллергических заболеваний
SG195015A1 (en)	2011-05-20	2013-12-30	Aventis Pharma Inc	Pharmaceutical composition comprising fexofenadine
RU2504018C1 (ru) *	2012-05-28	2014-01-10	Государственное бюджетное образовательное учреждение высшего профессионального образования "Рязанский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения и социального развития Российской Федерации	Способ моделирования состояния индукции функциональной активности гликопротеина-р финастеридом в эксперименте
RU2553362C1 (ru) *	2014-01-09	2015-06-10	Государственное бюджетное образовательное учреждение высшего профессионального образования "Рязанский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации	Способ моделирования состояния ингибирования функциональной активности гликопротеина-р линестренолом в эксперименте
CN104188998A (zh) *	2014-09-18	2014-12-10	中山大学	一种柚皮苷与盐酸非索非那丁药物组合物及其制剂

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4254129A (en) *	1979-04-10	1981-03-03	Richardson-Merrell Inc.	Piperidine derivatives
HU205850B (en) *	1989-01-31	1992-07-28	Int Pharma Agentur	Systhem of erosion-regulated release of the active components and process for producing it
US5567592A (en) *	1994-02-02	1996-10-22	Regents Of The University Of California	Screening method for the identification of bioenhancers through the inhibition of P-glycoprotein transport in the gut of a mammal
US5916566A (en) *	1995-06-07	1999-06-29	Avmax, Inc.	Use of benzoin gum to inhibit P-glycoprotein-mediated resistance of pharmaceutical compounds
AU5893796A (en) *	1995-06-07	1996-12-30	Novo Nordisk A/S	Modification of polypeptides

1998
- 1998-07-21 JP JP2000509429A patent/JP4295913B2/ja not_active Expired - Lifetime
- 1998-07-21 BR BR9811937-0A patent/BR9811937A/pt not_active Application Discontinuation
- 1998-07-21 SK SK184-2000A patent/SK283868B6/sk not_active IP Right Cessation
- 1998-07-21 ES ES98935892T patent/ES2179523T3/es not_active Expired - Lifetime
- 1998-07-21 RU RU2000106042/14A patent/RU2197967C2/ru active
- 1998-07-21 PL PL338579A patent/PL191607B1/pl unknown
- 1998-07-21 CZ CZ2000522A patent/CZ293666B6/cs not_active IP Right Cessation
- 1998-07-21 EE EEP200000069A patent/EE04263B1/xx unknown
- 1998-07-21 TR TR2000/00419T patent/TR200000419T2/xx unknown
- 1998-07-21 AU AU85050/98A patent/AU725965C/en not_active Expired
- 1998-07-21 CN CNB988081598A patent/CN1143680C/zh not_active Expired - Lifetime
- 1998-07-21 DE DE69808303T patent/DE69808303T2/de not_active Expired - Lifetime
- 1998-07-21 IL IL13452198A patent/IL134521A/xx not_active IP Right Cessation
- 1998-07-21 PT PT98935892T patent/PT1003528E/pt unknown
- 1998-07-21 UA UA2000031425A patent/UA64765C2/uk unknown
- 1998-07-21 EP EP98935892A patent/EP1003528B1/en not_active Expired - Lifetime
- 1998-07-21 AT AT98935892T patent/ATE224721T1/de active
- 1998-07-21 NZ NZ502133A patent/NZ502133A/xx not_active IP Right Cessation
- 1998-07-21 KR KR10-2000-7001447A patent/KR100522985B1/ko not_active Expired - Lifetime
- 1998-07-21 ID IDW20000262A patent/ID24463A/id unknown
- 1998-07-21 WO PCT/US1998/015098 patent/WO1999008690A1/en not_active Ceased
- 1998-07-21 HU HU0003189A patent/HU226823B1/hu unknown
- 1998-07-21 DK DK98935892T patent/DK1003528T3/da active
- 1998-07-21 CA CA002301267A patent/CA2301267C/en not_active Expired - Lifetime
- 1998-08-12 ZA ZA987221A patent/ZA987221B/xx unknown
- 1998-08-13 AR ARP980104005A patent/AR018505A1/es active IP Right Grant
- 1998-11-05 TW TW087113210A patent/TWI240633B/zh not_active IP Right Cessation
2000
- 2000-02-09 OA OA1200000032A patent/OA11287A/en unknown
- 2000-02-11 NO NO20000706A patent/NO325148B1/no not_active IP Right Cessation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Ingen mothold *

Also Published As

Publication number	Publication date
PL338579A1 (en)	2000-11-06
ZA987221B (en)	1999-02-15
KR100522985B1 (ko)	2005-10-21
BR9811937A (pt)	2000-09-05
NO20000706D0 (no)	2000-02-11
DK1003528T3 (da)	2003-02-03
PT1003528E (pt)	2003-02-28
JP4295913B2 (ja)	2009-07-15
SK283868B6 (sk)	2004-03-02
AU8505098A (en)	1999-03-08
WO1999008690A1 (en)	1999-02-25
CZ2000522A3 (cs)	2000-09-13
DE69808303D1 (de)	2002-10-31
RU2197967C2 (ru)	2003-02-10
HU226823B1 (hu)	2009-11-30
AR018505A1 (es)	2001-11-28
EE04263B1 (et)	2004-04-15
EE200000069A (et)	2000-10-16
CN1267221A (zh)	2000-09-20
OA11287A (en)	2003-10-22
SK1842000A3 (en)	2000-08-14
CN1143680C (zh)	2004-03-31
HUP0003189A3 (en)	2001-04-28
IL134521A (en)	2005-07-25
CA2301267C (en)	2004-07-13
JP2001515041A (ja)	2001-09-18
ES2179523T3 (es)	2003-01-16
NZ502133A (en)	2002-03-28
EP1003528A1 (en)	2000-05-31
UA64765C2 (uk)	2004-03-15
HUP0003189A2 (en)	2001-03-28
AU725965C (en)	2004-04-22
NO20000706L (no)	2000-04-13
EP1003528B1 (en)	2002-09-25
PL191607B1 (pl)	2006-06-30
IL134521A0 (en)	2001-04-30
KR20010022845A (ko)	2001-03-26
ATE224721T1 (de)	2002-10-15
HK1025901A1 (en)	2000-12-01
TWI240633B (en)	2005-10-01
DE69808303T2 (de)	2003-05-22
TR200000419T2 (tr)	2000-09-21
CA2301267A1 (en)	1999-02-25
ID24463A (id)	2000-07-20
AU725965B2 (en)	2000-10-26
CZ293666B6 (cs)	2004-06-16

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2016-08-01	CHAD	Change of the owner's name or address (par. 44 patent law, par. patentforskriften)	Owner name: AVENTISUB LLC, US
2018-08-13	MK1K	Patent expired

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