NO325810B1 - Isoindolin-1-onderivater, farmasoytiske forbindelser inneholdende slike, fremgangsmate for fremstilling av disse, slike forbindelser for anvendelse som legemiddel samt anvendelse av disse for fremstilling av medikament for behandling av diabetes - Google Patents

Isoindolin-1-onderivater, farmasoytiske forbindelser inneholdende slike, fremgangsmate for fremstilling av disse, slike forbindelser for anvendelse som legemiddel samt anvendelse av disse for fremstilling av medikament for behandling av diabetes Download PDF

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Publication number
NO325810B1
NO325810B1 NO20032674A NO20032674A NO325810B1 NO 325810 B1 NO325810 B1 NO 325810B1 NO 20032674 A NO20032674 A NO 20032674A NO 20032674 A NO20032674 A NO 20032674A NO 325810 B1 NO325810 B1 NO 325810B1
Authority
NO
Norway
Prior art keywords
oxo
cyclohexyl
dihydro
isoindol
propionamide
Prior art date
Application number
NO20032674A
Other languages
English (en)
Norwegian (no)
Other versions
NO20032674L (no
NO20032674D0 (no
Inventor
Kevin Richard Guertin
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20032674L publication Critical patent/NO20032674L/no
Publication of NO20032674D0 publication Critical patent/NO20032674D0/no
Publication of NO325810B1 publication Critical patent/NO325810B1/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
NO20032674A 2000-12-13 2003-06-12 Isoindolin-1-onderivater, farmasoytiske forbindelser inneholdende slike, fremgangsmate for fremstilling av disse, slike forbindelser for anvendelse som legemiddel samt anvendelse av disse for fremstilling av medikament for behandling av diabetes NO325810B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25527300P 2000-12-13 2000-12-13
US31871501P 2001-09-13 2001-09-13
PCT/EP2001/014404 WO2002048106A2 (en) 2000-12-13 2001-12-07 Isoindolin-1-one glucokinase activators

Publications (3)

Publication Number Publication Date
NO20032674L NO20032674L (no) 2003-06-12
NO20032674D0 NO20032674D0 (no) 2003-06-12
NO325810B1 true NO325810B1 (no) 2008-07-21

Family

ID=26944583

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20032674A NO325810B1 (no) 2000-12-13 2003-06-12 Isoindolin-1-onderivater, farmasoytiske forbindelser inneholdende slike, fremgangsmate for fremstilling av disse, slike forbindelser for anvendelse som legemiddel samt anvendelse av disse for fremstilling av medikament for behandling av diabetes

Country Status (35)

Country Link
US (1) US6482951B2 (sr)
EP (1) EP1349856B1 (sr)
JP (1) JP4021766B2 (sr)
KR (1) KR100520651B1 (sr)
CN (1) CN1247574C (sr)
AT (1) ATE297922T1 (sr)
AU (2) AU3841502A (sr)
BG (1) BG107903A (sr)
BR (1) BR0116169A (sr)
CA (1) CA2430579C (sr)
CY (1) CY1105587T1 (sr)
CZ (1) CZ20031882A3 (sr)
DE (1) DE60111570T2 (sr)
DK (1) DK1349856T3 (sr)
EG (1) EG24358A (sr)
ES (1) ES2243578T3 (sr)
HR (1) HRP20030450B1 (sr)
HU (1) HUP0400587A3 (sr)
IL (2) IL156264A0 (sr)
MA (1) MA26973A1 (sr)
MX (1) MXPA03005170A (sr)
MY (1) MY136741A (sr)
NO (1) NO325810B1 (sr)
NZ (1) NZ526236A (sr)
PA (1) PA8534601A1 (sr)
PE (1) PE20020593A1 (sr)
PL (1) PL366006A1 (sr)
PT (1) PT1349856E (sr)
RS (1) RS50933B (sr)
RU (1) RU2249590C2 (sr)
SI (1) SI1349856T1 (sr)
SK (1) SK8732003A3 (sr)
TW (1) TWI294876B (sr)
UY (1) UY27069A1 (sr)
WO (1) WO2002048106A2 (sr)

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AU2005229415B2 (en) * 2004-04-02 2009-05-14 Novartis Ag Thiazolopyridine derivatives, pharmaceutical conditions containing them and methods of treating glucokinase mediated conditions
CA2614746C (en) 2005-07-09 2011-05-10 Astrazeneca Ab Heteroaryl benzamide derivatives for use as glk activators in the treatment of diabetes
CA2621227A1 (en) * 2005-08-31 2007-03-08 Astellas Pharma Inc. Thiazole derivative
JP2007063225A (ja) * 2005-09-01 2007-03-15 Takeda Chem Ind Ltd イミダゾピリジン化合物
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JP2009515997A (ja) * 2005-11-18 2009-04-16 タケダ サン ディエゴ インコーポレイテッド グルコキナーゼ活性剤
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US8173645B2 (en) * 2007-03-21 2012-05-08 Takeda San Diego, Inc. Glucokinase activators
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BRPI0912802A2 (pt) * 2008-05-16 2015-10-13 Takeda San Diego Inc ativadores de glicoquinase
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Also Published As

Publication number Publication date
PT1349856E (pt) 2005-09-30
CY1105587T1 (el) 2010-07-28
CN1481382A (zh) 2004-03-10
HUP0400587A2 (hu) 2004-06-28
IL156264A0 (en) 2004-01-04
PE20020593A1 (es) 2002-07-06
MY136741A (en) 2008-11-28
NO20032674L (no) 2003-06-12
YU47703A (sh) 2006-05-25
MA26973A1 (fr) 2004-12-20
JP2004521095A (ja) 2004-07-15
EG24358A (en) 2009-03-04
IL156264A (en) 2010-11-30
KR100520651B1 (ko) 2005-10-11
RU2249590C2 (ru) 2005-04-10
HUP0400587A3 (en) 2011-03-28
UY27069A1 (es) 2002-07-31
DK1349856T3 (da) 2005-10-17
WO2002048106A2 (en) 2002-06-20
EP1349856A2 (en) 2003-10-08
EP1349856B1 (en) 2005-06-15
DE60111570D1 (de) 2005-07-21
BR0116169A (pt) 2003-12-23
HRP20030450A2 (en) 2005-04-30
TWI294876B (en) 2008-03-21
PL366006A1 (en) 2005-01-24
US6482951B2 (en) 2002-11-19
DE60111570T2 (de) 2006-05-11
WO2002048106A3 (en) 2002-11-28
HK1063314A1 (en) 2004-12-24
CA2430579A1 (en) 2002-06-20
CA2430579C (en) 2010-01-26
SI1349856T1 (en) 2005-10-31
SK8732003A3 (en) 2004-04-06
MXPA03005170A (es) 2003-09-22
NZ526236A (en) 2004-12-24
US20020082260A1 (en) 2002-06-27
CZ20031882A3 (cs) 2003-12-17
CN1247574C (zh) 2006-03-29
ES2243578T3 (es) 2005-12-01
NO20032674D0 (no) 2003-06-12
RS50933B (sr) 2010-08-31
ATE297922T1 (de) 2005-07-15
AU2002238415B2 (en) 2007-01-04
KR20030064817A (ko) 2003-08-02
AU3841502A (en) 2002-06-24
BG107903A (bg) 2004-02-27
PA8534601A1 (es) 2002-08-26
JP4021766B2 (ja) 2007-12-12
HRP20030450B1 (en) 2006-02-28

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