NO328022B1 - Faktor XΔ-analog, rekombinant DNA som koder for denne, celler inneholdende slikt DNA samt preparat, anvendelse av preparatet og fremgangsmate for fremstilling av slike preparater inneholdende XΔ-analogene - Google Patents

Faktor XΔ-analog, rekombinant DNA som koder for denne, celler inneholdende slikt DNA samt preparat, anvendelse av preparatet og fremgangsmate for fremstilling av slike preparater inneholdende XΔ-analogene Download PDF

Info

Publication number: NO328022B1
Authority: NO; Norway
Prior art keywords: factor; analogue; preparation; amino acid; chain
Prior art date: 1997-02-27

Application number

NO19994136A

Other languages

English (en)

Norwegian (no)

Other versions

NO994136D0 (no

NO994136L (no

Inventor

Friedrich Dorner

Johann Eibl

Uwe Schlokat

Falko-Guenter Falkner

Michele Himmelspach

Michael Pfleiderer

Original Assignee

Baxter Innovations Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-02-27

Filing date

1999-08-26

Publication date

2009-11-09

1999-08-26 Application filed by Baxter Innovations Gmbh filed Critical Baxter Innovations Gmbh

1999-08-26 Publication of NO994136D0 publication Critical patent/NO994136D0/no

1999-10-27 Publication of NO994136L publication Critical patent/NO994136L/no

2009-11-09 Publication of NO328022B1 publication Critical patent/NO328022B1/no

Links

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Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6432—Coagulation factor Xa (3.4.21.6)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21006—Coagulation factor Xa (3.4.21.6)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
General Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Biotechnology (AREA)
Diabetes (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Microbiology (AREA)
Pharmacology & Pharmacy (AREA)
Molecular Biology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)

NO19994136A 1997-02-27 1999-08-26 Faktor XΔ-analog, rekombinant DNA som koder for denne, celler inneholdende slikt DNA samt preparat, anvendelse av preparatet og fremgangsmate for fremstilling av slike preparater inneholdende XΔ-analogene NO328022B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
AT0033697A AT405517B (de)	1997-02-27	1997-02-27	Faktor x-deletionsmutanten und analoge davon
PCT/AT1998/000046 WO1998038318A1 (de)	1997-02-27	1998-02-27	Faktor x-deletionsmutanten und analoge davon

Publications (3)

Publication Number	Publication Date
NO994136D0 NO994136D0 (no)	1999-08-26
NO994136L NO994136L (no)	1999-10-27
NO328022B1 true NO328022B1 (no)	2009-11-09

Family

ID=3487892

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19994136A NO328022B1 (no)	1997-02-27	1999-08-26	Faktor XΔ-analog, rekombinant DNA som koder for denne, celler inneholdende slikt DNA samt preparat, anvendelse av preparatet og fremgangsmate for fremstilling av slike preparater inneholdende XΔ-analogene

Country Status (17)

Country	Link
US (2)	US6562598B1 (pl)
EP (1)	EP1012303B1 (pl)
JP (1)	JP4108761B2 (pl)
AR (1)	AR010119A1 (pl)
AT (2)	AT405517B (pl)
AU (1)	AU732953B2 (pl)
BR (1)	BR9807618A (pl)
CA (1)	CA2282728A1 (pl)
CZ (1)	CZ298296B6 (pl)
DE (1)	DE59813745D1 (pl)
ES (1)	ES2273405T3 (pl)
HU (1)	HU225247B1 (pl)
IL (2)	IL131171A0 (pl)
NO (1)	NO328022B1 (pl)
PL (1)	PL191778B1 (pl)
SK (1)	SK282369B6 (pl)
WO (1)	WO1998038318A1 (pl)

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AT405517B (de) *	1997-02-27	1999-09-27	Immuno Ag	Faktor x-deletionsmutanten und analoge davon
AT405516B (de) *	1997-02-27	1999-09-27	Immuno Ag	Faktor x-analoge mit modifizierter proteasespaltstelle
GB9826747D0 (en) *	1998-12-05	1999-01-27	Zeneca Ltd	Chemical compounds
AT410216B (de)	1999-08-10	2003-03-25	Baxter Ag	Faktor x-analogon mit verbesserter aktivierbarkeit
US20040102388A1 (en) *	2000-03-22	2004-05-27	High Katherine A.	Modified blood clotting factors and methods of use
WO2004101598A2 (en) *	2003-05-09	2004-11-25	Research Development Foundation	Insertion of furin protease cleavage sites in membrane proteins and uses thereof
EP1728798A1 (en) *	2005-06-01	2006-12-06	ZLB Behring GmbH	Coagulation factor X polypeptides with modified activation properties
MX336958B (es)	2005-11-15	2016-02-05	Philadelphia Children Hospital	Metodos y composiciones para modular la hemostasia.
GB2433592A (en)	2005-12-23	2007-06-27	Pentapharm Ag	Assay for thrombin inhibitors
EP1820508A1 (en) *	2006-02-21	2007-08-22	CSL Behring GmbH	Coagulation factor X polypeptides with modified activation properties
US20080050776A1 (en) *	2006-05-26	2008-02-28	Kenneth Neet	Stable mutated pro nerve growth factors
EP2193196B1 (en)	2007-09-28	2016-07-13	Portola Pharmaceuticals, Inc.	Antidotes for factor xa inhibitors and methods of using the same
EP2364165B1 (en)	2008-11-14	2018-01-03	Portola Pharmaceuticals, Inc.	Antidotes for factor xa inhibitors and methods of using the same in combination with blood coagulating agents
LT3604510T (lt)	2009-03-30	2025-07-10	Alexion Pharmaceuticals, Inc.	Faktoriaus xa inhibitorius neutralizuojančios medžiagos ir jų naudojimo būdai
JP6163304B2 (ja)	2009-07-15	2017-07-12	ポートラファーマシューティカルズ，インコーポレイテッド	第Ｘａ因子インヒビターの解毒剤の単位用量処方物およびその使用方法
US9371522B2 (en)	2011-09-30	2016-06-21	The Children's Hospital Of Philadelphia	Compositions and methods for modulating hemostasis
HK1205188A1 (en) *	2012-02-14	2015-12-11	Portola Pharmaceuticals, Inc.	Process for making recombinant antidote to factor xa inhibitor
SG11201500579SA (en)	2012-07-25	2015-02-27	Catalyst Biosciences Inc	Modified factor x polypeptides and uses thereof
KR20150103205A (ko)	2013-01-31	2015-09-09	화이자 인코포레이티드	인자 Xa 억제를 길항하기 위한 조성물 및 방법
SG11201601221XA (en)	2013-09-24	2016-04-28	Pfizer	Compositions comprising heterogeneous populations of recombinant human clotting factor xa proteins
US10676731B2 (en)	2014-08-19	2020-06-09	The Children's Hospital Of Philadelphia	Compositions and methods for modulating factor IX function
CA3082043A1 (en)	2017-11-07	2019-05-16	Rani Therapeutics, Llc	Clotting factor preparations for delivery into tissue of the intestinal tract using a swallowable drug delivery device
KR20220004148A (ko)	2019-05-03	2022-01-11	라니 테라퓨틱스, 엘엘씨	삼킬 수 있는 약물 전달 장치를 사용하여 장관 조직으로 전달하기 위한 응고인자 제제

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AT366916B (de)	1980-04-02	1982-05-25	Immuno Ag	Vorrichtung zur applikation eines gewebeklebstoffes auf basis von menschlichen oder tierischenproteinen
US4501731A (en)	1983-06-27	1985-02-26	Tishkoff Garson H	Treatment of disparate bleeding disorders with factor X zymogen
AT382783B (de) *	1985-06-20	1987-04-10	Immuno Ag	Vorrichtung zur applikation eines gewebeklebstoffes
US5028424A (en)	1987-10-16	1991-07-02	University Of Georgia Research Foundation	Antibodies to receptor and antigen for natural killer and non-specific cytotoxic cells
US5597799A (en) *	1990-09-04	1997-01-28	Cor Therapeutics, Inc.	Recombinant agents affecting thrombosis
EP0785273A1 (en)	1990-11-26	1997-07-23	Genetics Institute, Inc.	Paired basic amino acid converting enzyme and DNA sequence encoding it
US5621039A (en)	1993-06-08	1997-04-15	Hallahan; Terrence W.	Factor IX- polymeric conjugates
DE4325872C1 (de)	1993-08-02	1994-08-04	Immuno Ag	Virusinaktivierte Faktor Xa-Präparation
AT401270B (de) *	1994-09-26	1996-07-25	Immuno Ag	Verfahren zur quantifizierung von genomischer dna
AT404838B (de)	1995-11-24	1999-03-25	Immuno Ag	Herstellung von proteinen aus pro-proteinen durch fusionsproteine abgeleitet von furin oder furinanalogen
AT405516B (de) *	1997-02-27	1999-09-27	Immuno Ag	Faktor x-analoge mit modifizierter proteasespaltstelle
AT405517B (de) *	1997-02-27	1999-09-27	Immuno Ag	Faktor x-deletionsmutanten und analoge davon
US6582598B2 (en) *	2000-12-14	2003-06-24	Hubert Patrovsky	Wave filter for rotary filter

1997
- 1997-02-27 AT AT0033697A patent/AT405517B/de not_active IP Right Cessation
1998
- 1998-02-25 AR ARP980100833A patent/AR010119A1/es unknown
- 1998-02-27 US US09/367,777 patent/US6562598B1/en not_active Expired - Lifetime
- 1998-02-27 CA CA002282728A patent/CA2282728A1/en not_active Abandoned
- 1998-02-27 WO PCT/AT1998/000046 patent/WO1998038318A1/de not_active Ceased
- 1998-02-27 AT AT98905134T patent/ATE340862T1/de active
- 1998-02-27 SK SK1170-99A patent/SK282369B6/sk not_active IP Right Cessation
- 1998-02-27 ES ES98905134T patent/ES2273405T3/es not_active Expired - Lifetime
- 1998-02-27 DE DE59813745T patent/DE59813745D1/de not_active Expired - Lifetime
- 1998-02-27 IL IL13117198A patent/IL131171A0/xx active IP Right Grant
- 1998-02-27 CZ CZ0303199A patent/CZ298296B6/cs not_active IP Right Cessation
- 1998-02-27 EP EP98905134A patent/EP1012303B1/de not_active Expired - Lifetime
- 1998-02-27 BR BR9807618-3A patent/BR9807618A/pt not_active IP Right Cessation
- 1998-02-27 PL PL335379A patent/PL191778B1/pl not_active IP Right Cessation
- 1998-02-27 HU HU0000826A patent/HU225247B1/hu not_active IP Right Cessation
- 1998-02-27 JP JP53706398A patent/JP4108761B2/ja not_active Expired - Lifetime
- 1998-02-27 AU AU60808/98A patent/AU732953B2/en not_active Ceased
1999
- 1999-07-29 IL IL131171A patent/IL131171A/en not_active IP Right Cessation
- 1999-08-26 NO NO19994136A patent/NO328022B1/no not_active IP Right Cessation
2003
- 2003-01-21 US US10/348,504 patent/US6905846B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AU6080898A (en)	1998-09-18
SK117099A3 (en)	2000-05-16
PL191778B1 (pl)	2006-07-31
NO994136D0 (no)	1999-08-26
DE59813745D1 (de)	2006-11-09
HUP0000826A3 (en)	2002-01-28
JP4108761B2 (ja)	2008-06-25
HUP0000826A1 (en)	2000-07-28
AR010119A1 (es)	2000-05-17
US6905846B2 (en)	2005-06-14
ES2273405T3 (es)	2007-05-01
HU225247B1 (en)	2006-08-28
BR9807618A (pt)	2000-02-15
AT405517B (de)	1999-09-27
US6562598B1 (en)	2003-05-13
CZ303199A3 (cs)	2000-01-12
EP1012303B1 (de)	2006-09-27
AU732953B2 (en)	2001-05-03
ATA33697A (de)	1999-01-15
SK282369B6 (sk)	2002-01-07
CZ298296B6 (cs)	2007-08-22
NO994136L (no)	1999-10-27
EP1012303A1 (de)	2000-06-28
JP2001513632A (ja)	2001-09-04
ATE340862T1 (de)	2006-10-15
WO1998038318A1 (de)	1998-09-03
US20030138914A1 (en)	2003-07-24
CA2282728A1 (en)	1998-09-03
IL131171A (en)	2007-05-15
PL335379A1 (en)	2000-04-25
IL131171A0 (en)	2001-01-28

Legal Events

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2010-09-27	MM1K	Lapsed by not paying the annual fees

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US6905846B2 (en)	2005-06-14	Nucleic acids encoding factor X deletion mutants and analogues thereof
US9249404B2 (en)	2016-02-02	Coagulation factor X polypeptides with modified activation properties
US6958322B1 (en)	2005-10-25	Factor X analog with an improved ability to be activated
MXPA99007817A (en)	2001-05-17	Factor x deletion mutants and analogues thereof
MXPA99007768A (en)	2000-08-01	Factor x analogues with a modified protease cleavage site