NO328363B1 - Camptothecinderivater som har antitumoraktivitet, fremgangsmate for fremstilling derav, anvendelse derav samt farmasoytisk preparat - Google Patents

Camptothecinderivater som har antitumoraktivitet, fremgangsmate for fremstilling derav, anvendelse derav samt farmasoytisk preparat Download PDF

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Publication number
NO328363B1
NO328363B1 NO20014128A NO20014128A NO328363B1 NO 328363 B1 NO328363 B1 NO 328363B1 NO 20014128 A NO20014128 A NO 20014128A NO 20014128 A NO20014128 A NO 20014128A NO 328363 B1 NO328363 B1 NO 328363B1
Authority
NO
Norway
Prior art keywords
group
formula
iminomethylcamptothecin
cpt
linear
Prior art date
Application number
NO20014128A
Other languages
English (en)
Norwegian (no)
Other versions
NO20014128D0 (no
NO20014128L (no
Inventor
Sergio Penco
Lucio Merlini
Franco Zunino
Paolo Carminati
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of NO20014128D0 publication Critical patent/NO20014128D0/no
Publication of NO20014128L publication Critical patent/NO20014128L/no
Publication of NO328363B1 publication Critical patent/NO328363B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO20014128A 1999-03-09 2001-08-24 Camptothecinderivater som har antitumoraktivitet, fremgangsmate for fremstilling derav, anvendelse derav samt farmasoytisk preparat NO328363B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99830124A EP1044977B1 (en) 1999-03-09 1999-03-09 Camptothecin derivatives having antitumor activity
PCT/EP2000/001570 WO2000053607A1 (en) 1999-03-09 2000-03-08 Camptothecin derivatives having antitumor activity

Publications (3)

Publication Number Publication Date
NO20014128D0 NO20014128D0 (no) 2001-08-24
NO20014128L NO20014128L (no) 2001-08-24
NO328363B1 true NO328363B1 (no) 2010-02-01

Family

ID=8243303

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20014128A NO328363B1 (no) 1999-03-09 2001-08-24 Camptothecinderivater som har antitumoraktivitet, fremgangsmate for fremstilling derav, anvendelse derav samt farmasoytisk preparat

Country Status (38)

Country Link
US (2) US6242457B1 (sr)
EP (1) EP1044977B1 (sr)
JP (1) JP4610743B2 (sr)
KR (1) KR100702085B1 (sr)
CN (1) CN1139592C (sr)
AR (1) AR022860A1 (sr)
AT (1) ATE216998T1 (sr)
AU (1) AU774174B2 (sr)
BG (1) BG65032B1 (sr)
BR (1) BR0008840B1 (sr)
CA (1) CA2362760C (sr)
CO (1) CO5180590A1 (sr)
CZ (1) CZ304465B6 (sr)
DE (1) DE69901379T2 (sr)
DK (1) DK1044977T3 (sr)
EA (1) EA003605B1 (sr)
EE (1) EE04679B1 (sr)
EG (1) EG23999A (sr)
ES (1) ES2175919T3 (sr)
HR (1) HRP20010667B1 (sr)
HU (1) HU229506B1 (sr)
IL (2) IL144958A0 (sr)
IS (1) IS2003B (sr)
ME (2) ME00017B (sr)
MX (1) MXPA01009081A (sr)
NO (1) NO328363B1 (sr)
NZ (1) NZ513393A (sr)
PE (1) PE20001485A1 (sr)
PL (1) PL222208B1 (sr)
PT (1) PT1044977E (sr)
RS (1) RS50405B (sr)
SI (1) SI1044977T1 (sr)
SK (1) SK287561B6 (sr)
TN (1) TNSN00045A1 (sr)
TR (1) TR200102603T2 (sr)
TW (1) TWI272272B (sr)
WO (1) WO2000053607A1 (sr)
ZA (1) ZA200107408B (sr)

Families Citing this family (40)

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Publication number Priority date Publication date Assignee Title
DE60036915T2 (de) 1999-01-13 2008-08-07 Alchemia Oncology Pty Ltd., Hawthorn Verwendung von hyaluronan zur herstellung eines medikaments zur erhöhung der wirksamkeit von zytotoxischen arzneimitteln
US7105492B2 (en) * 1999-03-09 2006-09-12 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Camptothecin derivatives having antitumor activity
FR2794123B1 (fr) * 1999-05-28 2001-07-27 Aventis Pharma Sa Preparation de derives de la camptothecine et de la nothapodytine
US6352996B1 (en) * 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US9066919B2 (en) * 2000-07-14 2015-06-30 Alchemia Oncology Pty Limited Hyaluronan as a chemo-sensitizer in the treatment of cancer
AUPQ879500A0 (en) * 2000-07-14 2000-08-10 Meditech Research Limited Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease
US20040029906A1 (en) * 2001-07-31 2004-02-12 Michael Christman Inhibitors of dna polymerase sigma
US20050042303A1 (en) * 2001-08-27 2005-02-24 Brown Tracey Jean Therapeutic protocols
WO2003033525A1 (en) * 2001-10-12 2003-04-24 Debio Recherche Pharmacuetique S.A. Amino-substituted camptothecin polymer derivatives and use of the same for the manufacture of a medicament
ITRM20020305A1 (it) * 2002-05-31 2003-12-01 Sigma Tau Ind Farmaceuti Camptotecine con anello lattonico modificato.
ITRM20020306A1 (it) * 2002-05-31 2003-12-01 Sigma Tau Ind Farmaceuti Esteri in posizione 20 di camptotecine.
FR2852606A1 (fr) * 2003-03-18 2004-09-24 Inst Nat Sante Rech Med Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie
US20040204435A1 (en) * 2003-04-09 2004-10-14 Joachim Liehr Alternating treatment with topoisomerase I and topoisomerase II inhibitors
ITRM20030344A1 (it) * 2003-07-14 2005-01-15 Ist Naz Stud Cura Dei Tumori 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi.
CA2559532A1 (en) * 2004-03-26 2005-10-06 Novartis Ag Use of camptothecin derivates for the treatment of proliferative diseases in a fixed dosing regimen
CN1946421B (zh) 2004-04-27 2013-07-17 威尔斯达特生物制剂公司 使用病毒和喜树碱进行的癌症治疗
ITRM20040242A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori "7-t-butossiimminometilcamptotecina coniugata in posizione 20 con antagonisti delle integrine.
ITRM20040241A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori Camptotecine coniugate in posizione 20 con antagonisti delle integrine.
ITRM20040240A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori Camptotecine coniugate in posizione 7 con antagonisti delle integrine.
ITRM20040288A1 (it) * 2004-06-11 2004-09-11 Sigma Tau Ind Farmaceuti Uso della 7-t-butossiimminometilcamptotecina per la preparazione di un medicamento per il trattamento delle neoplasie dell'utero.
CN100334089C (zh) * 2004-07-21 2007-08-29 王洋 一种9－硝基喜树碱的生产方法
GT200500310A (es) * 2004-11-19 2006-06-19 Compuestos organicos
MX2007007212A (es) * 2004-12-15 2007-11-07 Novartis Ag Combinaciones de agentes terapeuticos para el tratamiento del cancer.
JP5491699B2 (ja) * 2004-12-21 2014-05-14 シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ 立体選択的方法およびカンプトテシンの結晶形態
SA06270147B1 (ar) 2005-06-09 2009-12-22 نوفارتيس ايه جي عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين
NZ562951A (en) 2005-07-14 2011-09-30 Wellstat Biologics Corp Cancer treatment using a Newcastle disease virus, a fluoropyrimidine and a camptothecin combination
AU2006274509B2 (en) * 2005-07-27 2012-01-19 Alchemia Oncology Pty Limited Therapeutic protocols using hyaluronan
ITRM20050418A1 (it) * 2005-08-04 2007-02-05 Sigma Tau Ind Farmaceuti Sistemi terapeutici a rilascio immediato per il migliorato assorbimento orale di 7-[(e)-t-butilossimminometil] camptotecina.
RU2008108894A (ru) * 2005-08-10 2009-09-20 Новартис АГ (CH) Композиции 7-(трет-бутокси)иминометилкамптотецина
CN101287475B (zh) * 2005-09-07 2012-11-14 阿尔卡米亚肿瘤学股份有限公司 包含透明质酸和治疗抗体的治疗组合物以及制药用途
PL1962850T3 (pl) * 2005-12-21 2012-07-31 Sigma Tau Ind Farmaceuti Leczenie lekoopornych nowotworów
JP5596924B2 (ja) 2006-02-17 2014-09-24 カスケード プロドラッグ インコーポレイテッド ビンカアルカロイドｎ酸化物および類似体による過剰増殖疾患の処置
US8410045B2 (en) 2006-03-30 2013-04-02 Drais Pharmaceuticals, Inc. Camptothecin-peptide conjugates and pharmaceutical compositions containing the same
WO2008094959A1 (en) * 2007-02-01 2008-08-07 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Pharmaceutical composition comprising a campothecin derivative
WO2008098701A1 (en) * 2007-02-13 2008-08-21 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Broad-spectrum anti-cancer treatment based on iminocamptothecin derivatives
WO2009015981A2 (en) * 2007-08-01 2009-02-05 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Treatment of pediatric tumors
EP2096113A1 (en) 2008-02-05 2009-09-02 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. 9-substituted camptothecin derivatives as antitumor compounds
TWI482621B (zh) 2009-12-23 2015-05-01 Sigma Tau Ind Farmaceuti 青蒿素基藥物與其他化學治療劑的抗癌組合物
CA2995029C (en) 2015-09-25 2022-10-25 Zy Therapeutics Inc. Drug formulation based on particulates comprising polysaccharide-vitamin conjugate
WO2025252101A1 (zh) * 2024-06-05 2025-12-11 荣昌生物制药(烟台)股份有限公司 一种喜树碱类化合物及其用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399276A (en) * 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
WO1993009782A1 (en) * 1991-11-15 1993-05-27 Smithkline Beecham Corporation Combination chemotherapy
US5614529A (en) * 1994-09-22 1997-03-25 Research Triangle Institute Inhibition of plasmodia parasites by camptothecin compounds
US5972955A (en) * 1995-06-06 1999-10-26 Dr. Reddy's Research Foundation Water soluble C-ring analogues of 20(S)-camptothecin
GB9512670D0 (en) * 1995-06-21 1995-08-23 Sod Conseils Rech Applic Camptothecin analogues
IT1282673B1 (it) * 1996-02-23 1998-03-31 Ist Naz Stud Cura Dei Tumori Derivati della camptotecina e loro uso come agenti antitumorali
IL127800A (en) * 1996-08-19 2005-11-20 Bionumerik Pharmaceuticals Inc Highly lipophilic 7-substituted camptothecin derivatives and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
IS6031A (is) 2001-07-31
BG105810A (en) 2002-06-28
US6242457B1 (en) 2001-06-05
ZA200107408B (en) 2002-05-29
CA2362760C (en) 2009-08-18
AR022860A1 (es) 2002-09-04
CN1139592C (zh) 2004-02-25
RS50405B (sr) 2009-12-31
HK1031222A1 (en) 2001-06-08
NZ513393A (en) 2003-04-29
HU229506B1 (en) 2014-01-28
TWI272272B (en) 2007-02-01
JP2002539128A (ja) 2002-11-19
SK11642001A3 (sk) 2002-01-07
TR200102603T2 (tr) 2002-01-21
KR100702085B1 (ko) 2007-04-02
EA003605B1 (ru) 2003-06-26
ATE216998T1 (de) 2002-05-15
ES2175919T3 (es) 2002-11-16
IS2003B (is) 2005-04-15
MEP4008A (xx) 2010-02-10
US20010008939A1 (en) 2001-07-19
HUP0200210A3 (en) 2004-03-29
YU64301A (sh) 2005-07-19
NO20014128D0 (no) 2001-08-24
DK1044977T3 (da) 2002-07-08
ME00017B (me) 2010-06-10
PL222208B1 (pl) 2016-07-29
EA200100954A1 (ru) 2002-04-25
PL355094A1 (en) 2004-03-22
KR20010102519A (ko) 2001-11-15
EG23999A (en) 2008-03-19
CN1343209A (zh) 2002-04-03
HRP20010667A2 (en) 2002-08-31
BG65032B1 (bg) 2006-12-29
HRP20010667B1 (en) 2003-06-30
CA2362760A1 (en) 2000-09-14
BR0008840A (pt) 2002-01-08
EP1044977B1 (en) 2002-05-02
CZ20013077A3 (cs) 2002-01-16
IL144958A0 (en) 2002-06-30
HUP0200210A2 (hu) 2002-05-29
CZ304465B6 (cs) 2014-05-21
IL144958A (en) 2009-08-03
EE200100466A (et) 2002-12-16
SI1044977T1 (en) 2002-08-31
AU3160400A (en) 2000-09-28
US6589939B2 (en) 2003-07-08
EP1044977A1 (en) 2000-10-18
DE69901379T2 (de) 2002-11-07
PT1044977E (pt) 2002-09-30
DE69901379D1 (de) 2002-06-06
EE04679B1 (et) 2006-08-15
PE20001485A1 (es) 2000-12-07
TNSN00045A1 (fr) 2005-11-10
CO5180590A1 (es) 2002-07-30
MXPA01009081A (es) 2002-08-30
WO2000053607A1 (en) 2000-09-14
BR0008840B1 (pt) 2011-12-27
NO20014128L (no) 2001-08-24
JP4610743B2 (ja) 2011-01-12
SK287561B6 (sk) 2011-02-04
AU774174B2 (en) 2004-06-17

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