NO329064B1 - Syreaddisjonssalter, fremstilling av slike, farmasoytiske preparater omfattende slike samt slike forbindelser for behandling av sykdom - Google Patents

Syreaddisjonssalter, fremstilling av slike, farmasoytiske preparater omfattende slike samt slike forbindelser for behandling av sykdom Download PDF

Info

Publication number: NO329064B1
Authority: NO; Norway
Prior art keywords: acid; compound; acid addition; addition salt; salt
Prior art date: 2002-05-31

Application number

NO20044867A

Other languages

English (en)

Norwegian (no)

Other versions

NO20044867L (no

Inventor

Tord Inghardt

Anita Lundblad

Martin Bohlin

Carl-Gustaf Sigfridsson

Matti Ahlqvist

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-05-31

Filing date

2004-11-09

Publication date

2010-08-09

2004-11-09 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2004-12-23 Publication of NO20044867L publication Critical patent/NO20044867L/no

2010-08-09 Publication of NO329064B1 publication Critical patent/NO329064B1/no

Links

150000001875 compounds Chemical class 0.000 title claims abstract description 254
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239000002253 acid Substances 0.000 title claims abstract description 70
238000011282 treatment Methods 0.000 title claims abstract description 19
238000002360 preparation method Methods 0.000 title claims description 60
239000000825 pharmaceutical preparation Substances 0.000 title claims description 8
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract description 16
201000010099 disease Diseases 0.000 title description 2
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125000001153 fluoro group Chemical group F* 0.000 claims abstract description 8
230000005764 inhibitory process Effects 0.000 claims abstract description 6
238000000034 method Methods 0.000 claims description 73
238000002425 crystallisation Methods 0.000 claims description 41
230000008025 crystallization Effects 0.000 claims description 41
230000008569 process Effects 0.000 claims description 39
238000000634 powder X-ray diffraction Methods 0.000 claims description 27
CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 claims description 22
SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 claims description 19
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238000004519 manufacturing process Methods 0.000 claims description 15
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239000012267 brine Substances 0.000 description 14
238000000113 differential scanning calorimetry Methods 0.000 description 14
CCIVGXIOQKPBKL-UHFFFAOYSA-N ethanesulfonic acid Chemical compound CCS(O)(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-N 0.000 description 14
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150000007513 acids Chemical class 0.000 description 13
239000000741 silica gel Substances 0.000 description 13
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239000000047 product Substances 0.000 description 11
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230000015572 biosynthetic process Effects 0.000 description 9
238000002844 melting Methods 0.000 description 9
230000008018 melting Effects 0.000 description 9
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NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 8
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239000012074 organic phase Substances 0.000 description 8
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- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
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Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)

NO20044867A 2002-05-31 2004-11-09 Syreaddisjonssalter, fremstilling av slike, farmasoytiske preparater omfattende slike samt slike forbindelser for behandling av sykdom NO329064B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE0201661A SE0201661D0 (sv)	2002-05-31	2002-05-31	New salts
PCT/SE2003/000859 WO2003101957A1 (en)	2002-05-31	2003-05-27	New salts

Publications (2)

Publication Number	Publication Date
NO20044867L NO20044867L (no)	2004-12-23
NO329064B1 true NO329064B1 (no)	2010-08-09

Family

ID=20288039

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20044867A NO329064B1 (no)	2002-05-31	2004-11-09	Syreaddisjonssalter, fremstilling av slike, farmasoytiske preparater omfattende slike samt slike forbindelser for behandling av sykdom

Country Status (30)

Country	Link
US (2)	US7273858B2 (is)
EP (2)	EP1513806B1 (is)
JP (1)	JP4541140B2 (is)
KR (1)	KR20050009726A (is)
CN (2)	CN101735131A (is)
AR (1)	AR039937A1 (is)
AT (1)	ATE425963T1 (is)
AU (1)	AU2003232871B2 (is)
BR (1)	BR0311365A (is)
CA (1)	CA2487509A1 (is)
CY (1)	CY1109085T1 (is)
DE (1)	DE60326720D1 (is)
DK (1)	DK1513806T3 (is)
ES (1)	ES2322048T3 (is)
IL (1)	IL165295A0 (is)
IS (1)	IS7598A (is)
MX (1)	MXPA04011912A (is)
MY (1)	MY133333A (is)
NO (1)	NO329064B1 (is)
NZ (2)	NZ554323A (is)
PL (1)	PL373794A1 (is)
PT (1)	PT1513806E (is)
RU (2)	RU2345064C2 (is)
SA (1)	SA03240440B1 (is)
SE (1)	SE0201661D0 (is)
SI (1)	SI1513806T1 (is)
TW (2)	TWI313173B (is)
UA (1)	UA81246C2 (is)
WO (1)	WO2003101957A1 (is)
ZA (1)	ZA200409228B (is)

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SE0201661D0 (sv)	2002-05-31	2002-05-31	Astrazeneca Ab	New salts
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2002
- 2002-05-31 SE SE0201661A patent/SE0201661D0/xx unknown
2003
- 2003-05-27 RU RU2004133388/04A patent/RU2345064C2/ru not_active IP Right Cessation
- 2003-05-27 WO PCT/SE2003/000859 patent/WO2003101957A1/en not_active Ceased
- 2003-05-27 DK DK03728206T patent/DK1513806T3/da active
- 2003-05-27 EP EP03728206A patent/EP1513806B1/en not_active Expired - Lifetime
- 2003-05-27 UA UA20041109441A patent/UA81246C2/uk unknown
- 2003-05-27 US US10/516,422 patent/US7273858B2/en not_active Expired - Fee Related
- 2003-05-27 AU AU2003232871A patent/AU2003232871B2/en not_active Ceased
- 2003-05-27 DE DE60326720T patent/DE60326720D1/de not_active Expired - Lifetime
- 2003-05-27 PT PT03728206T patent/PT1513806E/pt unknown
- 2003-05-27 PL PL03373794A patent/PL373794A1/xx not_active Application Discontinuation
- 2003-05-27 IL IL16529503A patent/IL165295A0/xx unknown
- 2003-05-27 CN CN200910260483A patent/CN101735131A/zh active Pending
- 2003-05-27 AT AT03728206T patent/ATE425963T1/de not_active IP Right Cessation
- 2003-05-27 CA CA002487509A patent/CA2487509A1/en not_active Abandoned
- 2003-05-27 JP JP2004509651A patent/JP4541140B2/ja not_active Expired - Fee Related
- 2003-05-27 MX MXPA04011912A patent/MXPA04011912A/es active IP Right Grant
- 2003-05-27 BR BR0311365-5A patent/BR0311365A/pt not_active IP Right Cessation
- 2003-05-27 EP EP09151657A patent/EP2055696A1/en not_active Withdrawn
- 2003-05-27 NZ NZ554323A patent/NZ554323A/en not_active IP Right Cessation
- 2003-05-27 KR KR10-2004-7019439A patent/KR20050009726A/ko not_active Ceased
- 2003-05-27 ES ES03728206T patent/ES2322048T3/es not_active Expired - Lifetime
- 2003-05-27 NZ NZ536738A patent/NZ536738A/en not_active IP Right Cessation
- 2003-05-27 SI SI200331578T patent/SI1513806T1/sl unknown
- 2003-05-27 CN CNA038124912A patent/CN1656067A/zh active Pending
- 2003-05-29 MY MYPI20031981A patent/MY133333A/en unknown
- 2003-05-30 TW TW092114807A patent/TWI313173B/zh active
- 2003-05-30 AR ARP030101935A patent/AR039937A1/es unknown
- 2003-05-30 TW TW097151265A patent/TWI367754B/zh not_active IP Right Cessation
- 2003-12-10 SA SA3240440A patent/SA03240440B1/ar unknown
2004
- 2004-11-09 NO NO20044867A patent/NO329064B1/no not_active IP Right Cessation
- 2004-11-17 ZA ZA200409228A patent/ZA200409228B/en unknown
- 2004-12-15 IS IS7598A patent/IS7598A/is unknown
2007
- 2007-08-16 US US11/839,842 patent/US7763597B2/en not_active Expired - Fee Related
2008
- 2008-07-09 RU RU2008127541/04A patent/RU2008127541A/ru not_active Application Discontinuation
2009
- 2009-05-20 CY CY20091100535T patent/CY1109085T1/el unknown

Also Published As

Publication number	Publication date
SE0201661D0 (sv)	2002-05-31
ATE425963T1 (de)	2009-04-15
CN1656067A (zh)	2005-08-17
NZ536738A (en)	2007-05-31
SI1513806T1 (sl)	2009-06-30
DE60326720D1 (de)	2009-04-30
IL165295A0 (en)	2005-12-18
TW200927094A (en)	2009-07-01
AR039937A1 (es)	2005-03-09
US7273858B2 (en)	2007-09-25
MXPA04011912A (es)	2005-03-31
TWI367754B (en)	2012-07-11
TW200402293A (en)	2004-02-16
RU2004133388A (ru)	2005-07-10
MY133333A (en)	2007-11-30
DK1513806T3 (da)	2009-06-15
CA2487509A1 (en)	2003-12-11
WO2003101957A1 (en)	2003-12-11
RU2345064C2 (ru)	2009-01-27
AU2003232871A1 (en)	2003-12-19
NO20044867L (no)	2004-12-23
TWI313173B (en)	2009-08-11
KR20050009726A (ko)	2005-01-25
PL373794A1 (en)	2005-09-19
IS7598A (is)	2004-12-15
UA81246C2 (en)	2007-12-25
EP1513806B1 (en)	2009-03-18
CN101735131A (zh)	2010-06-16
US7763597B2 (en)	2010-07-27
EP2055696A1 (en)	2009-05-06
JP4541140B2 (ja)	2010-09-08
US20050234035A1 (en)	2005-10-20
BR0311365A (pt)	2005-03-01
HK1073102A1 (en)	2005-09-23
NZ554323A (en)	2008-10-31
EP1513806A1 (en)	2005-03-16
JP2005532346A (ja)	2005-10-27
ZA200409228B (en)	2005-05-17
PT1513806E (pt)	2009-05-04
US20080269176A1 (en)	2008-10-30
ES2322048T3 (es)	2009-06-16
AU2003232871B2 (en)	2010-08-19
SA03240440B1 (ar)	2008-02-24
CY1109085T1 (el)	2012-05-23
RU2008127541A (ru)	2010-01-20

Legal Events

Date	Code	Title	Description
2011-12-27	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
US7763597B2 (en)	2010-07-27	Salts
EP2535337A1 (en)	2012-12-19	Crystalline forms of 4-methyl-n-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide sulfate and its amorphous form
JP2010209090A (ja)	2010-09-24	即時放出性医薬製剤
US6531622B1 (en)	2003-03-11	Crytalline form of (s)-2 ethoxy -3-[4-(2-{4- methanesulfonyloxyphenyl} ethoxy)phenyl]propanoic acid
RU2286993C2 (ru)	2006-11-10	3,7-диазабицикло[3.3.1]-препараты как антиаритмические соединения
KR20110135397A (ko)	2011-12-16	시타글립틴 염의 고체 상태 형태
US20150239890A1 (en)	2015-08-27	Crystal of n-[2-(amino)-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide
WO1995004043A1 (en)	1995-02-09	Optical resolution of gamma-(4-(((1,1-dimethylethoxy)carbonyl)methylamino)-piperidinyl-1)-gamma-oxo-alpha-(phenylmethyl)-butynic acid with (n,s-)cyclohexyl ethylamine
CN103781778B (zh)	2015-10-07	6-(哌啶-4-基氧基)-2h-异喹啉-1-酮盐酸盐的结晶性溶剂化物
KR102013567B1 (ko)	2019-08-23	６-(피페리딘-４-일옥시)-２ｈ-이소퀴놀린-１-온 하이드로클로라이드의 다형체
HK1073102B (en)	2009-09-11	Sulphonic acid salts of mandelic acid derivatives
HK1130479A (en)	2009-12-31	Acid addition salts of mandelic acid derivatives
KR20250147756A (ko)	2025-10-14	신규한 형태의 제미글립틴 말산염 결정형 및 이의 제조방법
ZA200203706B (en)	2003-10-29	Crystalline form of (S)-2ethoxy-3-[4-(2-4-methanesulfonyloxyphenyl} ethoxy)phenyl] propanoic acid.