NO329385B1 - Fremgangsmate for opparbeidelse av celler - Google Patents

Fremgangsmate for opparbeidelse av celler Download PDF

Info

Publication number: NO329385B1
Authority: NO; Norway
Prior art keywords: cells; production; production batch; bioreactor; batch
Prior art date: 1997-12-24

Application number

NO20003215A

Other languages

English (en)

Norwegian (no)

Other versions

NO20003215L (no

NO20003215D0 (no

Inventor

Rudi Brands

Original Assignee

Solvay Biolog Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-24

Filing date

2000-06-21

Publication date

2010-10-11

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8229133&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO329385(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2000-06-21 Application filed by Solvay Biolog Bv filed Critical Solvay Biolog Bv

2000-06-21 Publication of NO20003215L publication Critical patent/NO20003215L/no

2000-06-21 Publication of NO20003215D0 publication Critical patent/NO20003215D0/no

2010-10-11 Publication of NO329385B1 publication Critical patent/NO329385B1/no

Links

238000000034 method Methods 0.000 title claims abstract description 41
238000002360 preparation method Methods 0.000 title claims abstract description 11
238000004519 manufacturing process Methods 0.000 claims abstract description 69
239000000758 substrate Substances 0.000 claims description 16
239000012620 biological material Substances 0.000 claims description 14
230000001419 dependent effect Effects 0.000 claims description 11
238000012546 transfer Methods 0.000 claims description 9
238000012545 processing Methods 0.000 claims description 8
241000700605 Viruses Species 0.000 claims description 6
229960000074 biopharmaceutical Drugs 0.000 abstract 2
210000004027 cell Anatomy 0.000 description 129
238000000855 fermentation Methods 0.000 description 24
230000004151 fermentation Effects 0.000 description 24
239000000969 carrier Substances 0.000 description 10
239000001963 growth medium Substances 0.000 description 9
238000013341 scale-up Methods 0.000 description 6
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 5
238000013411 master cell bank Methods 0.000 description 4
239000000463 material Substances 0.000 description 4
239000007787 solid Substances 0.000 description 4
239000006228 supernatant Substances 0.000 description 4
239000000725 suspension Substances 0.000 description 4
108091005804 Peptidases Proteins 0.000 description 3
239000000047 product Substances 0.000 description 3
238000000926 separation method Methods 0.000 description 3
102000004190 Enzymes Human genes 0.000 description 2
108090000790 Enzymes Proteins 0.000 description 2
102000035195 Peptidases Human genes 0.000 description 2
102000004142 Trypsin Human genes 0.000 description 2
108090000631 Trypsin Proteins 0.000 description 2
238000004113 cell culture Methods 0.000 description 2
230000000694 effects Effects 0.000 description 2
238000005516 engineering process Methods 0.000 description 2
238000011081 inoculation Methods 0.000 description 2
239000002609 medium Substances 0.000 description 2
239000000203 mixture Substances 0.000 description 2
238000001556 precipitation Methods 0.000 description 2
239000012588 trypsin Substances 0.000 description 2
241000283690 Bos taurus Species 0.000 description 1
241000466177 Cansumys canus Species 0.000 description 1
241000282693 Cercopithecidae Species 0.000 description 1
241000353621 Eilat virus Species 0.000 description 1
241000287828 Gallus gallus Species 0.000 description 1
108010044467 Isoenzymes Proteins 0.000 description 1
239000004365 Protease Substances 0.000 description 1
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
238000013019 agitation Methods 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
210000004102 animal cell Anatomy 0.000 description 1
230000022131 cell cycle Effects 0.000 description 1
239000006285 cell suspension Substances 0.000 description 1
239000007795 chemical reaction product Substances 0.000 description 1
230000003750 conditioning effect Effects 0.000 description 1
238000011109 contamination Methods 0.000 description 1
238000010924 continuous production Methods 0.000 description 1
230000002338 cryopreservative effect Effects 0.000 description 1
239000002577 cryoprotective agent Substances 0.000 description 1
229940124642 endogenous agent Drugs 0.000 description 1
230000002255 enzymatic effect Effects 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
230000008014 freezing Effects 0.000 description 1
238000007710 freezing Methods 0.000 description 1
238000003306 harvesting Methods 0.000 description 1
239000012510 hollow fiber Substances 0.000 description 1
210000005260 human cell Anatomy 0.000 description 1
238000011534 incubation Methods 0.000 description 1
239000002054 inoculum Substances 0.000 description 1
210000003734 kidney Anatomy 0.000 description 1
238000011031 large-scale manufacturing process Methods 0.000 description 1
238000007747 plating Methods 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
230000002797 proteolythic effect Effects 0.000 description 1
239000011343 solid material Substances 0.000 description 1
239000007858 starting material Substances 0.000 description 1
238000013190 sterility testing Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
238000012360 testing method Methods 0.000 description 1
230000035899 viability Effects 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Virology (AREA)
Immunology (AREA)
Cell Biology (AREA)
Medicinal Chemistry (AREA)
Sustainable Development (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Apparatus Associated With Microorganisms And Enzymes (AREA)

NO20003215A 1997-12-24 2000-06-21 Fremgangsmate for opparbeidelse av celler NO329385B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP97204110		1997-12-24
PCT/EP1998/008522 WO1999033955A1 (en)	1997-12-24	1998-12-17	Preparation of cells for production of biologicals

Publications (3)

Publication Number	Publication Date
NO20003215L NO20003215L (no)	2000-06-21
NO20003215D0 NO20003215D0 (no)	2000-06-21
NO329385B1 true NO329385B1 (no)	2010-10-11

Family

ID=8229133

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20003215A NO329385B1 (no)	1997-12-24	2000-06-21	Fremgangsmate for opparbeidelse av celler

Country Status (25)

Country	Link
US (1)	US20070148753A1 (de)
EP (2)	EP1801201B1 (de)
JP (1)	JP4478328B2 (de)
KR (1)	KR100683429B1 (de)
CN (1)	CN1185339C (de)
AT (2)	ATE507284T1 (de)
AU (1)	AU758209B2 (de)
BR (1)	BR9814490A (de)
CA (1)	CA2316739C (de)
CZ (1)	CZ299719B6 (de)
DE (2)	DE69842245D1 (de)
DK (2)	DK1060241T4 (de)
ES (2)	ES2281148T5 (de)
HU (1)	HUP0100538A3 (de)
ID (1)	ID26784A (de)
IL (1)	IL136736A (de)
NO (1)	NO329385B1 (de)
NZ (1)	NZ505371A (de)
PL (1)	PL196042B1 (de)
PT (2)	PT1060241E (de)
RU (1)	RU2230784C2 (de)
SK (1)	SK285971B6 (de)
TR (1)	TR200001960T2 (de)
UA (1)	UA72732C2 (de)
WO (1)	WO1999033955A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN102782121A (zh)	2009-12-23	2012-11-14	赛诺菲巴斯德有限公司	用于培养贴壁细胞的方法
US11338020B2 (en)	2018-01-09	2022-05-24	Synthetic Biologics, Inc.	Alkaline phosphatase agents for treatment of neurodevelopmental disorders
ES3032290T3 (en)	2018-03-20	2025-07-16	Theriva Biologics Inc	Intestinal alkaline phosphatase formulations
US11654184B2 (en)	2018-03-20	2023-05-23	Theriva Biologics, Inc.	Alkaline phosphatase agents for treatment of radiation disorders
US12071607B2 (en) *	2018-06-01	2024-08-27	Lonza Ltd.	Midscale model for organic growth and phasing
JP7660523B2 (ja)	2019-05-06	2025-04-11	セリバ・バイオロジクス・インコーポレイテッド	アルカリリン酸塩に基づいた癌治療
JP7680418B2 (ja) *	2019-07-16	2025-05-20	イノベントバイオロジクス（スーチョウ）カンパニー，リミティド	高密度連続接種の細胞培養方法及びその応用
EP4339274B1 (de)	2022-09-13	2025-03-26	Sartorius Stedim Biotech GmbH	Verfahren zum betreiben einer bioprozessanlage zur herstellung eines bioprodukts
CN116064409A (zh) *	2023-01-06	2023-05-05	四川阿思科力生物科技有限公司	一种大规模高产量细胞连续培养和收获的生产工艺

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS60151458A (ja)	1984-01-20	1985-08-09	Nippon Piston Ring Co Ltd	カムシヤフト
US4664912A (en) *	1984-10-01	1987-05-12	Wiktor Tadeusz J	Process for the large scale production of rabies vaccine
DE3833925A1 (de) *	1988-03-11	1989-09-21	Inst Angewandte Biotechnologie	Verfahren und herstellung von virus und viralem antigen und vorrichtung hierzu
US5017490A (en)	1989-03-10	1991-05-21	Baxter International Inc.	Method for in vitro reproduction and growth of cells in culture medium
DE3930140A1 (de) *	1989-09-09	1991-03-21	Bayer Ag	Verfahren zur herstellung von biologischen materialien in zellkulturen und vorrichtungen
WO1992010564A1 (en) *	1990-12-13	1992-06-25	The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce	Sustained and continuous production of high titers of recombinant viral vectors and transduced target cells for use in gene therapy
DE19612966B4 (de)	1996-04-01	2009-12-10	Novartis Vaccines And Diagnostics Gmbh & Co. Kg	MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren
KR100669716B1 (ko) *	2004-07-14	2007-01-16	삼성에스디아이 주식회사	페닐카르바졸 화합물 및 이를 이용한 유기 전계 발광 소자
KR100787425B1 (ko) *	2004-11-29	2007-12-26	삼성에스디아이 주식회사	페닐카바졸계 화합물 및 이를 이용한 유기 전계 발광 소자
KR100573137B1 (ko) *	2004-04-02	2006-04-24	삼성에스디아이 주식회사	플루오렌계 화합물 및 이를 이용한 유기 전계 발광 소자
US8188315B2 (en) *	2004-04-02	2012-05-29	Samsung Mobile Display Co., Ltd.	Organic light emitting device and flat panel display device comprising the same
JP4184332B2 (ja) *	2004-11-22	2008-11-19	本田技研工業株式会社	可変気筒式内燃機関の制御装置

1998
- 1998-12-17 CA CA2316739A patent/CA2316739C/en not_active Expired - Fee Related
- 1998-12-17 ES ES98966693T patent/ES2281148T5/es not_active Expired - Lifetime
- 1998-12-17 UA UA2000074455A patent/UA72732C2/uk unknown
- 1998-12-17 AU AU24179/99A patent/AU758209B2/en not_active Ceased
- 1998-12-17 EP EP07103139A patent/EP1801201B1/de not_active Expired - Lifetime
- 1998-12-17 AT AT07103139T patent/ATE507284T1/de active
- 1998-12-17 DE DE69842245T patent/DE69842245D1/de not_active Expired - Lifetime
- 1998-12-17 AT AT98966693T patent/ATE356197T1/de active
- 1998-12-17 DK DK98966693.8T patent/DK1060241T4/da active
- 1998-12-17 BR BR9814490-1A patent/BR9814490A/pt not_active IP Right Cessation
- 1998-12-17 ES ES07103139T patent/ES2365631T3/es not_active Expired - Lifetime
- 1998-12-17 WO PCT/EP1998/008522 patent/WO1999033955A1/en not_active Ceased
- 1998-12-17 PL PL98341401A patent/PL196042B1/pl not_active IP Right Cessation
- 1998-12-17 PT PT98966693T patent/PT1060241E/pt unknown
- 1998-12-17 ID IDW20001431A patent/ID26784A/id unknown
- 1998-12-17 DK DK07103139.7T patent/DK1801201T3/da active
- 1998-12-17 CZ CZ20002343A patent/CZ299719B6/cs not_active IP Right Cessation
- 1998-12-17 SK SK965-2000A patent/SK285971B6/sk not_active IP Right Cessation
- 1998-12-17 PT PT07103139T patent/PT1801201E/pt unknown
- 1998-12-17 JP JP2000526613A patent/JP4478328B2/ja not_active Expired - Fee Related
- 1998-12-17 KR KR1020007007068A patent/KR100683429B1/ko not_active Expired - Fee Related
- 1998-12-17 EP EP98966693A patent/EP1060241B2/de not_active Expired - Lifetime
- 1998-12-17 HU HU0100538A patent/HUP0100538A3/hu not_active Application Discontinuation
- 1998-12-17 IL IL13673698A patent/IL136736A/en not_active IP Right Cessation
- 1998-12-17 NZ NZ505371A patent/NZ505371A/en not_active IP Right Cessation
- 1998-12-17 RU RU2000119783/13A patent/RU2230784C2/ru not_active IP Right Cessation
- 1998-12-17 CN CNB988126354A patent/CN1185339C/zh not_active Expired - Fee Related
- 1998-12-17 DE DE69837287T patent/DE69837287T3/de not_active Expired - Lifetime
- 1998-12-17 TR TR2000/01960T patent/TR200001960T2/xx unknown
2000
- 2000-06-21 NO NO20003215A patent/NO329385B1/no not_active IP Right Cessation
2007
- 2007-01-18 US US11/654,556 patent/US20070148753A1/en not_active Abandoned

Also Published As

Publication number	Publication date
AU758209B2 (en)	2003-03-20
DK1801201T3 (da)	2011-07-11
EP1801201A1 (de)	2007-06-27
DE69837287T2 (de)	2007-07-05
CA2316739A1 (en)	1999-07-08
RU2230784C2 (ru)	2004-06-20
UA72732C2 (en)	2005-04-15
EP1060241B1 (de)	2007-03-07
WO1999033955A1 (en)	1999-07-08
JP4478328B2 (ja)	2010-06-09
EP1060241B2 (de)	2010-10-20
CZ299719B6 (cs)	2008-10-29
IL136736A0 (en)	2001-06-14
DK1060241T4 (da)	2011-01-24
DE69842245D1 (de)	2011-06-09
NZ505371A (en)	2001-11-30
PT1801201E (pt)	2011-07-05
SK285971B6 (sk)	2007-12-06
DE69837287T3 (de)	2011-06-22
DE69837287D1 (de)	2007-04-19
ID26784A (id)	2001-02-08
IL136736A (en)	2004-06-01
TR200001960T2 (tr)	2001-02-21
ATE507284T1 (de)	2011-05-15
PL196042B1 (pl)	2007-11-30
SK9652000A3 (en)	2000-12-11
ES2365631T3 (es)	2011-10-07
NO20003215L (no)	2000-06-21
NO20003215D0 (no)	2000-06-21
CN1283223A (zh)	2001-02-07
BR9814490A (pt)	2000-10-10
CN1185339C (zh)	2005-01-19
EP1060241A1 (de)	2000-12-20
AU2417999A (en)	1999-07-19
HUP0100538A3 (en)	2006-01-30
KR20010033558A (ko)	2001-04-25
DK1060241T3 (da)	2007-06-04
EP1801201B1 (de)	2011-04-27
JP2002500005A (ja)	2002-01-08
ES2281148T3 (es)	2007-09-16
PL341401A1 (en)	2001-04-09
PT1060241E (pt)	2007-04-30
CZ20002343A3 (cs)	2000-10-11
HK1030628A1 (en)	2001-05-11
HUP0100538A2 (hu)	2001-06-28
US20070148753A1 (en)	2007-06-28
ATE356197T1 (de)	2007-03-15
CA2316739C (en)	2011-06-21
KR100683429B1 (ko)	2007-02-20
ES2281148T5 (es)	2011-03-09

Legal Events

Date	Code	Title	Description
2012-08-27	CHAD	Change of the owner's name or address (par. 44 patent law, par. patentforskriften)	Owner name: ABBOTT BIOLOGICALS BV, NL
2014-07-21	MM1K	Lapsed by not paying the annual fees

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