NO330459B1 - Anvendelse av zoledronsyre for behandling av tilstander med okt benomsetning - Google Patents

Anvendelse av zoledronsyre for behandling av tilstander med okt benomsetning Download PDF

Info

Publication number: NO330459B1
Authority: NO; Norway
Prior art keywords: zoledronic acid; treatment; bone; pharmaceutically acceptable; period
Prior art date: 2000-06-20

Application number

NO20026117A

Other languages

English (en)

Norwegian (no)

Other versions

NO20026117L (no

NO20026117D0 (no

Inventor

Zebulun D Horowitz

Peter C Richardson

Ulrich Trechesel

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-20

Filing date

2002-12-19

Publication date

2011-04-18

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26952565&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO330459(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-12-19 Application filed by Novartis Ag filed Critical Novartis Ag

2002-12-19 Publication of NO20026117L publication Critical patent/NO20026117L/no

2002-12-19 Publication of NO20026117D0 publication Critical patent/NO20026117D0/no

2011-04-18 Publication of NO330459B1 publication Critical patent/NO330459B1/no

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SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
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230000003204 osmotic effect Effects 0.000 description 1
230000011164 ossification Effects 0.000 description 1
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XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
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239000003208 petroleum Substances 0.000 description 1
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OGBMKVWORPGQRR-UMXFMPSGSA-N teriparatide Chemical compound C([C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CNC=N1 OGBMKVWORPGQRR-UMXFMPSGSA-N 0.000 description 1
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238000002054 transplantation Methods 0.000 description 1
239000001069 triethyl citrate Substances 0.000 description 1
VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
235000013769 triethyl citrate Nutrition 0.000 description 1
HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Physical Education & Sports Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO20026117A 2000-06-20 2002-12-19 Anvendelse av zoledronsyre for behandling av tilstander med okt benomsetning NO330459B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US59713500A	2000-06-20	2000-06-20
US26768901P	2001-02-09	2001-02-09
PCT/EP2001/006850 WO2001097788A2 (en)	2000-06-20	2001-06-18	Method of administering bisphosphonates

Publications (3)

Publication Number	Publication Date
NO20026117L NO20026117L (no)	2002-12-19
NO20026117D0 NO20026117D0 (no)	2002-12-19
NO330459B1 true NO330459B1 (no)	2011-04-18

Family

ID=26952565

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20026117A NO330459B1 (no)	2000-06-20	2002-12-19	Anvendelse av zoledronsyre for behandling av tilstander med okt benomsetning

Country Status (24)

Country	Link
US (1)	US8052987B2 (de)
EP (1)	EP1296689B3 (de)
JP (2)	JP4722375B2 (de)
KR (1)	KR100864743B1 (de)
CN (1)	CN1272013C (de)
AT (1)	ATE304856T1 (de)
AU (2)	AU7410901A (de)
BR (1)	BR0111806A (de)
CA (1)	CA2410201C (de)
CY (2)	CY1113740T1 (de)
CZ (1)	CZ301972B6 (de)
DE (1)	DE60113537T3 (de)
DK (1)	DK1296689T3 (de)
ES (2)	ES2394211T3 (de)
HU (1)	HU228400B1 (de)
IL (2)	IL153229A0 (de)
MX (1)	MXPA02012682A (de)
NO (1)	NO330459B1 (de)
NZ (1)	NZ523086A (de)
PL (1)	PL203087B1 (de)
PT (1)	PT1591122E (de)
SK (1)	SK287278B6 (de)
TW (1)	TWI289451B (de)
WO (1)	WO2001097788A2 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20070148228A1 (en) *	1999-02-22	2007-06-28	Merrion Research I Limited	Solid oral dosage form containing an enhancer
US7658938B2 (en)	1999-02-22	2010-02-09	Merrion Reasearch III Limited	Solid oral dosage form containing an enhancer
US8119159B2 (en) *	1999-02-22	2012-02-21	Merrion Research Iii Limited	Solid oral dosage form containing an enhancer
US8052987B2 (en)	2000-06-20	2011-11-08	Novartis Pharmaceuticals Corporation	Method of administering bisphosphonates
EP1192945A3 (de) *	2000-09-21	2004-03-03	Pfizer Products Inc.	Verwendung von einem Östrogen Agonist/Antagonist zur Behandlung von Osteoarthritis
EP1383509A4 (de) *	2001-04-03	2005-10-26	Royal Alexandra Hosp Children	Arzneimittel zur verwendung bei der knochentransplantation
US20050070504A1 (en) *	2001-12-21	2005-03-31	The Procter & Gamble Co.	Risedronate compositions and their methods of use
GB0204756D0 (en) *	2002-02-28	2002-04-17	Novartis Ag	Organic compounds
KR20140021045A (ko) *	2002-05-10	2014-02-19	에프. 호프만-라 로슈 아게	골다공증 치료 및 예방용 비스포스폰산
CA2497353C (en) *	2002-09-16	2012-08-28	Novartis Ag	Method for preventing or reducing secondary fractures after hip fracture
EP1553958A1 (de) *	2002-10-15	2005-07-20	Novartis AG	Verfahren zur verabreichung von bisphosphonaten
NZ536273A (en)	2002-12-20	2007-08-31	Hoffmann La Roche	High dose ibandronate formulation
JPWO2005072746A1 (ja) *	2004-01-30	2007-10-11	アステラス製薬株式会社	Ｐ２ｘ受容体阻害剤
DE602005025977D1 (de) *	2004-08-23	2011-03-03	Teva Pharma	Kristalline form des ibandronat-natriums und herstellungsverfahren dafür
US7709508B2 (en)	2004-12-09	2010-05-04	Merck Sharp & Dohme	Estrogen receptor modulators
KR20070085874A (ko) *	2004-12-09	2007-08-27	머크 앤드 캄파니 인코포레이티드	에스트로겐 수용체 조절제
US8071574B2 (en) *	2005-02-22	2011-12-06	John Dennis Bobyn	Implant improving local bone formation
US7473684B2 (en) *	2005-09-16	2009-01-06	Selamine Limited	Bisphosphonate formulation
WO2007117706A2 (en) *	2006-04-07	2007-10-18	Merrion Research Iii Limited	Solid oral dosage form containing an enhancer
WO2007124274A1 (en) *	2006-04-21	2007-11-01	The Uab Research Foundation	Treating neoplasms
US20080139514A1 (en) *	2006-11-29	2008-06-12	Subhash Pandurang Gore	Diphosphonic acid pharmaceutical compositions
US20100068211A1 (en) *	2008-02-08	2010-03-18	Bateman Ted A	Use of antiresorptive compounds to prevent ionizing radiation-induced activation of osteoclasts and resulting bone loss
CN102046192B (zh) *	2008-05-07	2014-11-19	默里昂研究Ⅲ有限公司	GnRH相关化合物的组合物及制备方法
WO2010099255A1 (en) *	2009-02-25	2010-09-02	Merrion Research Iii Limited	Composition and drug delivery of bisphosphonates
DK2459176T3 (en)	2009-07-31	2017-12-04	Gruenenthal Gmbh	Crystallization process and bioavailability
US20160016982A1 (en)	2009-07-31	2016-01-21	Thar Pharmaceuticals, Inc.	Crystallization method and bioavailability
US9169279B2 (en)	2009-07-31	2015-10-27	Thar Pharmaceuticals, Inc.	Crystallization method and bioavailability
PT2473172E (pt)	2009-09-01	2015-06-25	Univ Duke	Composições de bisfosfonato e métodos para o tratamento de insuficiência cardíaca
US20110182985A1 (en) *	2010-01-28	2011-07-28	Coughlan David C	Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof
WO2011120033A1 (en) *	2010-03-26	2011-09-29	Merrion Research Iii Limited	Pharmaceutical compositions of selective factor xa inhibitors for oral administration
US9340565B2 (en)	2010-11-24	2016-05-17	Thar Pharmaceuticals, Inc.	Crystalline forms
WO2012094598A2 (en)	2011-01-07	2012-07-12	Merrion Research Iii Limited	Pharmaceutical compositions of iron for oral administration
CA2856030A1 (en)	2011-11-16	2013-05-23	Duke University	Bisphosphonate compositions and methods for treating and/or reducing cardiac dysfunction
CN103623465B (zh) *	2013-11-21	2015-12-30	彭江	一种可局部调节成破骨活性的组织工程骨支架及制备方法
US10265384B2 (en)	2015-01-29	2019-04-23	Novo Nordisk A/S	Tablets comprising GLP-1 agonist and enteric coating
US10195218B2 (en)	2016-05-31	2019-02-05	Grunenthal Gmbh	Crystallization method and bioavailability
KR20180115979A (ko) *	2017-04-14	2018-10-24	연세대학교 산학협력단	비스포스포네이트를 포함하는 만성 이식신 기능부전 예방 또는 치료용 조성물
GB201716716D0 (en)	2017-10-12	2017-11-29	Univ Of Hertfordshire Higher Education Corporation	Method for coating particles
WO2020093069A1 (en) *	2018-11-02	2020-05-07	Ampersand Biopharmaceuticals, Inc.	Management of risk of cation overload and electrolyte imbalance with topically applied buffers
KR102049233B1 (ko) *	2019-01-14	2019-11-28	연세대학교 산학협력단	비스포스포네이트를 포함하는 만성 이식신 기능부전 예방 또는 치료용 조성물

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US594329A (en) *		1897-11-23		Socket or collet
DE3232959A1 (de)	1982-09-04	1984-03-08	Hoechst Ag, 6230 Frankfurt	Substituierte benzolsulfonsaeureester, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
EP0381296B1 (de)	1984-04-30	1994-11-30	THE PROCTER & GAMBLE COMPANY	Ausrüstung für die Verwendung bei der Behandlung von Osteoporose
US4812311A (en)	1984-12-21	1989-03-14	The Procter & Gamble Company	Kit for use in the treatment of osteoporosis
US4812304A (en)	1984-12-21	1989-03-14	The Procter & Gamble Company	Treatment of osteoporosis
US4822609A (en)	1984-12-21	1989-04-18	The Procter & Gamble Company	Treatment of osteoporosis
US4761406A (en)	1985-06-06	1988-08-02	The Procter & Gamble Company	Regimen for treating osteoporosis
DE10199052I1 (de)	1986-11-21	2002-01-10	Novartis Ag	Neue substituierte Alkandiphosphonsaeuren
CZ282889B6 (cs)	1991-12-17	1997-11-12	Procter And Gamble Pharmaceuticals, Inc.	Použití difosfonátů a parathormonu pro výrobu léčiva, které se používá pro léčení osteoporosy
HUT70210A (en)	1992-06-30	1995-09-28	Procter & Gamble Pharma	Use of phosphonates for the treatment of osteoporosis
AU670337B2 (en)	1992-11-30	1996-07-11	Novartis Ag	Use of certain methanebisphosphonic acid derivatives in fracture healing
EP0600834A1 (de)	1992-11-30	1994-06-08	Ciba-Geigy Ag	Verwendung von Methanbiphosphonsäurederivaten zur Herstellung eines Arzneimittels zur Behandlung von Knochenbrüchen
US5366965A (en)	1993-01-29	1994-11-22	Boehringer Mannheim Gmbh	Regimen for treatment or prophylaxis of osteoporosis
GB9408775D0 (en)	1994-05-04	1994-06-22	Ciba Geigy Ag	Use of certain methanebisphosphonic acid derivatives to prevent prothesis loosening and prothesis migration
CN1157566A (zh)	1994-09-09	1997-08-20	普罗克特和甘保尔公司	用于骨质疏松症的膦酸盐类和甲状旁腺激素
EP0779812A4 (de)	1994-09-09	1997-09-10	Procter & Gamble	Verfahren zur behandlung von osteoporose unter verwendung von knochenaktiven phosphonaten und parathormon
PT854724E (pt)	1995-09-29	2005-08-31	Novartis Ag	Metodo de tratar a doenca navicular em cavalos
US5735810A (en)	1996-06-14	1998-04-07	Becton Dickinson And Company	Device for the iontophoretic administration of bisphosphonates
US5730715A (en)	1996-06-14	1998-03-24	Becton Dickinson And Company	Method for the iontophoretic administration of bisphosphonates
SE9702401D0 (sv)	1997-06-19	1997-06-19	Astra Ab	Pharmaceutical use
EP0998292B1 (de)	1997-07-22	2001-11-21	Merck & Co., Inc. (a New Jersey corp.)	Methoden zur verhinderung von knochenresorption
US6015801A (en) *	1997-07-22	2000-01-18	Merck & Co., Inc.	Method for inhibiting bone resorption
US6432932B1 (en)	1997-07-22	2002-08-13	Merck & Co., Inc.	Method for inhibiting bone resorption
US5994329A (en)	1997-07-22	1999-11-30	Merck & Co., Inc.	Method for inhibiting bone resorption
FI109088B (fi) *	1997-09-19	2002-05-31	Leiras Oy	Tabletti ja menetelmä sen valmistamiseksi
SE9703691D0 (sv) *	1997-10-10	1997-10-10	Astra Ab	Pharmaceutical compositions
IT1296495B1 (it)	1997-11-21	1999-06-25	Prodotti Antibiotici Spa	Impiego di bisfosfonati nella preparazione di forme farmaceutiche per somministrazione intramuscolare
GB2336311A (en)	1998-04-15	1999-10-20	Merck & Co Inc	Bisphosphonate Dosing Regimen
CA2308532C (en)	1999-05-12	2005-11-29	Gador S.A.	Use of bisphosphonates for the treatment of osteogenesis imperfecta
DK1178810T3 (da) *	1999-05-21	2005-07-11	Novartis Ag	Anvendelse af bisphosphonsyrer til behandling af angiogenese
US20010044427A1 (en)	1999-12-20	2001-11-22	Sidney Mazel	Pharmaceutical kit
GB0012209D0 (en)	2000-05-19	2000-07-12	Novartis Ag	Organic compounds
US8052987B2 (en)	2000-06-20	2011-11-08	Novartis Pharmaceuticals Corporation	Method of administering bisphosphonates

2001
- 2001-06-18 US US10/311,942 patent/US8052987B2/en not_active Expired - Lifetime
- 2001-06-18 CZ CZ20024134A patent/CZ301972B6/cs not_active IP Right Cessation
- 2001-06-18 DK DK01940580T patent/DK1296689T3/da active
- 2001-06-18 DE DE60113537T patent/DE60113537T3/de not_active Expired - Lifetime
- 2001-06-18 ES ES05012711T patent/ES2394211T3/es not_active Expired - Lifetime
- 2001-06-18 PT PT50127117T patent/PT1591122E/pt unknown
- 2001-06-18 EP EP01940580A patent/EP1296689B3/de not_active Expired - Lifetime
- 2001-06-18 MX MXPA02012682A patent/MXPA02012682A/es active IP Right Grant
- 2001-06-18 AU AU7410901A patent/AU7410901A/xx active Pending
- 2001-06-18 BR BR0111806-4A patent/BR0111806A/pt not_active Application Discontinuation
- 2001-06-18 SK SK1808-2002A patent/SK287278B6/sk not_active IP Right Cessation
- 2001-06-18 IL IL15322901A patent/IL153229A0/xx active IP Right Review Request
- 2001-06-18 KR KR1020027017283A patent/KR100864743B1/ko not_active Expired - Lifetime
- 2001-06-18 NZ NZ523086A patent/NZ523086A/en not_active IP Right Cessation
- 2001-06-18 AT AT01940580T patent/ATE304856T1/de active
- 2001-06-18 PL PL358224A patent/PL203087B1/pl unknown
- 2001-06-18 ES ES01940580T patent/ES2247123T7/es active Active
- 2001-06-18 JP JP2002503265A patent/JP4722375B2/ja not_active Expired - Lifetime
- 2001-06-18 HU HU0301164A patent/HU228400B1/hu active Protection Beyond IP Right Term
- 2001-06-18 CA CA2410201A patent/CA2410201C/en not_active Expired - Lifetime
- 2001-06-18 WO PCT/EP2001/006850 patent/WO2001097788A2/en not_active Ceased
- 2001-06-18 CN CNB018113680A patent/CN1272013C/zh not_active Ceased
- 2001-06-18 AU AU2001274109A patent/AU2001274109B2/en not_active Expired
- 2001-06-20 TW TW090114964A patent/TWI289451B/zh not_active IP Right Cessation
2002
- 2002-12-02 IL IL153229A patent/IL153229A/en active IP Right Grant
- 2002-12-19 NO NO20026117A patent/NO330459B1/no not_active IP Right Cessation
2005
- 2005-05-31 JP JP2005159852A patent/JP5005188B2/ja not_active Expired - Lifetime
2012
- 2012-12-14 CY CY20121101222T patent/CY1113740T1/el unknown
2013
- 2013-03-22 CY CY2013011C patent/CY2013011I1/el unknown

Also Published As

Publication number	Publication date
JP2005247873A (ja)	2005-09-15
CZ20024134A3 (cs)	2003-06-18
HUP0301164A3 (en)	2005-11-28
IL153229A0 (en)	2003-07-06
CA2410201C (en)	2010-10-26
ES2247123T3 (es)	2006-03-01
AU7410901A (en)	2002-01-02
WO2001097788A3 (en)	2002-06-27
CY2013011I2 (el)	2015-08-05
KR100864743B1 (ko)	2008-10-22
ES2394211T3 (es)	2013-01-23
HU228400B1 (en)	2013-03-28
KR20030015283A (ko)	2003-02-20
EP1296689A2 (de)	2003-04-02
DE60113537D1 (de)	2006-02-02
ES2247123T7 (es)	2013-03-01
CA2410201A1 (en)	2001-12-27
DE60113537T2 (de)	2006-06-29
CZ301972B6 (cs)	2010-08-18
CN1620300A (zh)	2005-05-25
US20030181421A1 (en)	2003-09-25
SK287278B6 (sk)	2010-05-07
PT1591122E (pt)	2012-12-12
JP4722375B2 (ja)	2011-07-13
EP1296689B1 (de)	2005-09-21
PL358224A1 (en)	2004-08-09
IL153229A (en)	2007-07-24
NZ523086A (en)	2007-07-27
JP5005188B2 (ja)	2012-08-22
MXPA02012682A (es)	2003-04-25
HK1072539A1 (en)	2005-09-02
ATE304856T1 (de)	2005-10-15
PL203087B1 (pl)	2009-08-31
DE60113537T3 (de)	2013-05-29
EP1296689B3 (de)	2013-02-13
BR0111806A (pt)	2003-05-20
TWI289451B (en)	2007-11-11
CN1272013C (zh)	2006-08-30
AU2001274109B2 (en)	2004-12-23
CY1113740T1 (el)	2015-08-05
US8052987B2 (en)	2011-11-08
WO2001097788A2 (en)	2001-12-27
CY2013011I1 (el)	2015-08-05
NO20026117L (no)	2002-12-19
DK1296689T3 (da)	2005-11-28
NO20026117D0 (no)	2002-12-19
JP2003535889A (ja)	2003-12-02
HUP0301164A2 (hu)	2003-08-28
SK18082002A3 (sk)	2003-08-05

Legal Events

Date	Code	Title	Description
2013-02-18	LC4	Limitation of patent rights - b3 (par. 39b patent act)	Effective date: 20110418
2021-07-12	MK1K	Patent expired

Publication	Publication Date	Title
EP1296689B3 (de)	2013-02-13	Methode zur verabreichung von biphosphonaten
AU2001274109A1 (en)	2002-03-21	Method of administering bisphosphonates
US20050272705A1 (en)	2005-12-08	Method of adminstering bisphosphonates
US5965547A (en)	1999-10-12	Use of certain methanebishosphonic acid derivatives to prevent prosthesis loosening and prosthesis migration
NO322212B1 (no)	2006-08-28	Anvendelse av bisfosfonater ved behandling av myokardial ischemi, osteoartritt, psoriasis, hemangioblastom, hemangiom og smerte
EP1591122B1 (de)	2012-09-26	Methode zur Verabreichung von Biphosphonaten
RU2261100C2 (ru)	2005-09-27	Применение бисфосфоновых кислот для лечения ангиогенеза
HK1072539B (en)	2006-11-24	Use of bisphosphonates in the preparation of a medicment for the treatment of conditings of abnormally increased bone turnover