NO331173B1 - Substituerte 1-piperidin-3-yl-4-piperidin-4-yl-piperazinderivater og deres anvendelse som neurokininantagonister. - Google Patents

Substituerte 1-piperidin-3-yl-4-piperidin-4-yl-piperazinderivater og deres anvendelse som neurokininantagonister.

Info

Publication number: NO331173B1
Authority: NO; Norway
Prior art keywords: disorders; piperidin; neurokinin; antagonistic activity; diseases
Prior art date: 2002-12-23

Application number

NO20053598A

Other languages

English (en)

Norwegian (no)

Other versions

NO20053598D0 (no

NO20053598L (no

Inventor

Frans Eduard Janssens

Joseph Elisabeth Leenaerts

Francois Maria Sommen

Benoit Christian Albert Ghislain De Boeck

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-12-23

Filing date

2005-07-22

Publication date

2011-10-24

2005-07-22 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2005-07-22 Publication of NO20053598D0 publication Critical patent/NO20053598D0/no

2005-09-20 Publication of NO20053598L publication Critical patent/NO20053598L/no

2011-10-24 Publication of NO331173B1 publication Critical patent/NO331173B1/no

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Psychiatry (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Obesity (AREA)
Immunology (AREA)
Hematology (AREA)
Diabetes (AREA)
Child & Adolescent Psychology (AREA)
Addiction (AREA)
Rheumatology (AREA)
Anesthesiology (AREA)
Otolaryngology (AREA)
Dermatology (AREA)
Gynecology & Obstetrics (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)

NO20053598A 2002-12-23 2005-07-22 Substituerte 1-piperidin-3-yl-4-piperidin-4-yl-piperazinderivater og deres anvendelse som neurokininantagonister. NO331173B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP0214835		2002-12-23
PCT/EP2003/051035 WO2004056364A1 (en)	2002-12-23	2003-12-17	Substituted 1-piperidin-3-yl-4-piperidin-4-yl-piperazine derivatives and their use as neurokinin antagonists

Publications (3)

Publication Number	Publication Date
NO20053598D0 NO20053598D0 (no)	2005-07-22
NO20053598L NO20053598L (no)	2005-09-20
NO331173B1 true NO331173B1 (no)	2011-10-24

Family

ID=32668701

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20053598A NO331173B1 (no)	2002-12-23	2005-07-22	Substituerte 1-piperidin-3-yl-4-piperidin-4-yl-piperazinderivater og deres anvendelse som neurokininantagonister.

Country Status (23)

Country	Link
US (1)	US7572786B2 (pl)
JP (1)	JP4660198B2 (pl)
KR (1)	KR101049075B1 (pl)
CN (1)	CN100482229C (pl)
AR (1)	AR042653A1 (pl)
AU (1)	AU2003300578B2 (pl)
CA (1)	CA2509088C (pl)
CL (1)	CL2003002722A1 (pl)
DE (1)	DE60317709T2 (pl)
EA (1)	EA008774B1 (pl)
ES (1)	ES2297275T3 (pl)
HR (1)	HRP20050554B1 (pl)
IL (1)	IL169337A (pl)
JO (1)	JO2485B1 (pl)
MX (1)	MXPA05006888A (pl)
MY (1)	MY134383A (pl)
NO (1)	NO331173B1 (pl)
NZ (1)	NZ541036A (pl)
PA (1)	PA8593201A1 (pl)
PL (1)	PL214705B1 (pl)
TW (1)	TWI327916B (pl)
UA (1)	UA83474C2 (pl)
WO (1)	WO2004056364A1 (pl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MY141736A (en) *	2002-10-08	2010-06-15	Elanco Animal Health Ireland	Substituted 1,4-di-piperidin-4-yi-piperazine derivatives and their use as neurokinin antagonists
AU2005234596B8 (en)	2004-04-13	2011-06-16	Incyte Holdings Corporation	Piperazinylpiperidine derivatives as chemokine receptor antagonists
GB0417702D0 (en) *	2004-08-09	2004-09-08	Merck Sharp & Dohme	New uses
DE602006016244D1 (de) *	2005-03-08	2010-09-30	Janssen Pharmaceutica Nv	Diazaspiro-ä4,4ü-nonanderivate als neurokinin-(nk1)-antagonisten
CN105209436B (zh) *	2013-03-15	2019-02-01	南洋理工大学	3-哌啶酮化合物及其作为神经激肽-1(nk1)受体拮抗剂的用途
EP3915560A1 (en)	2014-06-25	2021-12-01	Emory University	Methods of managing conditioned fear with neurokinin receptor antagonists

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MY110227A (en)	1991-08-12	1998-03-31	Ciba Geigy Ag	1-acylpiperindine compounds.
NZ321575A (en) *	1995-10-30	1999-05-28	Janssen Pharmaceutica Nv	1-(1,2-disubstituted piperidinyl)-4- substituted piperazine derivatives
TW531537B (en) *	1995-12-27	2003-05-11	Janssen Pharmaceutica Nv	1-(1,2-disubstituted piperidinyl)-4-substituted piperidine derivatives
FR2791346B3 (fr) *	1999-03-25	2001-04-27	Sanofi Sa	Nouveaux derives de morpholine, procede pour leur preparation et compositions pharmaceutiques les contenant
WO2001030348A1 (en) *	1999-10-25	2001-05-03	Janssen Pharmaceutica N.V.	Use of substance p antagonists for influencing the circadian timing system
GB0025354D0 (en) *	2000-10-17	2000-11-29	Glaxo Group Ltd	Chemical compounds
GB2368098B (en)	2000-10-20	2004-09-15	Gw Pharmaceuticals Ltd	Secure dispensing of materials
US6642226B2 (en)	2001-02-06	2003-11-04	Hoffman-La Roche Inc.	Substituted phenyl-piperidine methanone compounds
JP4389478B2 (ja) *	2002-05-29	2009-12-24	田辺三菱製薬株式会社	新規ピペリジン誘導体
MY141736A (en) *	2002-10-08	2010-06-15	Elanco Animal Health Ireland	Substituted 1,4-di-piperidin-4-yi-piperazine derivatives and their use as neurokinin antagonists
WO2004056772A1 (en) *	2002-12-23	2004-07-08	Janssen Pharmaceutica N.V.	Substituted 1,4-di-piperidin-4-yl-piperazine derivatives and their use as tachykinin antagonists
KR20060006098A (ko) *	2003-06-10	2006-01-18	얀센 파마슈티카 엔.브이.	오피오이드 진통제와 배합된 치환된1,4-디-피페리딘-4-일-피페라진 유도체 및 오피오이드계치료와 관련된 통증 및 부작용 치료용으로 이들의 용도

2003
- 2003-12-15 JO JO2003173A patent/JO2485B1/en active
- 2003-12-17 UA UAA200505307A patent/UA83474C2/uk unknown
- 2003-12-17 KR KR1020057009752A patent/KR101049075B1/ko not_active Expired - Fee Related
- 2003-12-17 WO PCT/EP2003/051035 patent/WO2004056364A1/en not_active Ceased
- 2003-12-17 US US10/540,045 patent/US7572786B2/en not_active Expired - Fee Related
- 2003-12-17 MX MXPA05006888A patent/MXPA05006888A/es active IP Right Grant
- 2003-12-17 CA CA2509088A patent/CA2509088C/en not_active Expired - Fee Related
- 2003-12-17 ES ES03813610T patent/ES2297275T3/es not_active Expired - Lifetime
- 2003-12-17 PL PL376075A patent/PL214705B1/pl unknown
- 2003-12-17 DE DE60317709T patent/DE60317709T2/de not_active Expired - Lifetime
- 2003-12-17 HR HRP20050554AA patent/HRP20050554B1/hr not_active IP Right Cessation
- 2003-12-17 AU AU2003300578A patent/AU2003300578B2/en not_active Ceased
- 2003-12-17 CN CNB2003801070088A patent/CN100482229C/zh not_active Expired - Fee Related
- 2003-12-17 JP JP2004561502A patent/JP4660198B2/ja not_active Expired - Fee Related
- 2003-12-17 EA EA200501040A patent/EA008774B1/ru not_active IP Right Cessation
- 2003-12-17 NZ NZ541036A patent/NZ541036A/en not_active IP Right Cessation
- 2003-12-19 PA PA20038593201A patent/PA8593201A1/es unknown
- 2003-12-19 MY MYPI20034910A patent/MY134383A/en unknown
- 2003-12-22 TW TW092136344A patent/TWI327916B/zh not_active IP Right Cessation
- 2003-12-22 CL CL200302722A patent/CL2003002722A1/es unknown
- 2003-12-22 AR ARP030104779A patent/AR042653A1/es unknown
2005
- 2005-06-21 IL IL169337A patent/IL169337A/en not_active IP Right Cessation
- 2005-07-22 NO NO20053598A patent/NO331173B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
IL169337A0 (en)	2007-07-04
DE60317709T2 (de)	2008-10-30
DE60317709D1 (de)	2008-01-03
CN1728999A (zh)	2006-02-01
AU2003300578A1 (en)	2004-07-14
CL2003002722A1 (es)	2005-04-08
PL376075A1 (pl)	2005-12-12
AU2003300578B2 (en)	2009-06-04
JP2006512348A (ja)	2006-04-13
EA008774B1 (ru)	2007-08-31
IL169337A (en)	2011-07-31
US7572786B2 (en)	2009-08-11
PA8593201A1 (es)	2004-07-26
JP4660198B2 (ja)	2011-03-30
AR042653A1 (es)	2005-06-29
KR101049075B1 (ko)	2011-07-15
CA2509088A1 (en)	2004-07-08
CN100482229C (zh)	2009-04-29
NO20053598D0 (no)	2005-07-22
ES2297275T3 (es)	2008-05-01
HRP20050554A2 (en)	2006-06-30
KR20050085217A (ko)	2005-08-29
PL214705B1 (pl)	2013-09-30
WO2004056364A1 (en)	2004-07-08
MXPA05006888A (es)	2005-08-16
CA2509088C (en)	2012-01-24
EA200501040A1 (ru)	2005-12-29
UA83474C2 (uk)	2008-07-25
US20060252747A1 (en)	2006-11-09
TW200503715A (en)	2005-02-01
TWI327916B (en)	2010-08-01
MY134383A (en)	2007-12-31
HK1087924A1 (zh)	2006-10-27
NZ541036A (en)	2007-07-27
NO20053598L (no)	2005-09-20
JO2485B1 (en)	2009-01-20
HRP20050554B1 (hr)	2014-02-28

Legal Events

Date	Code	Title	Description
2016-08-15	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
MY141736A (en)	2010-06-15	Substituted 1,4-di-piperidin-4-yi-piperazine derivatives and their use as neurokinin antagonists
TW200500359A (en)	2005-01-01	Substituted 1-piperidin-4-yl-4-pyrrolidin-3-yl-piperazine derivatives and their use as neurokinin antagonists
KR101791273B1 (ko)	2017-10-27	Ｎａｄｐｈ 옥시다아제 억제제로서 피라졸린 디온 유도체
DE60312042D1 (de)	2007-04-05	Substituierte 1-piperidin-4-yl-4-azetidin-3-yl-piperazinderivate und deren verwendung als neurokininantagonisten
JP5567599B2 (ja)	2014-08-06	ポリ（ａｄｐ−リボース）ポリメラーゼ（ｐａｒｐ）阻害剤
NO20071660L (no)	2007-06-15	Nye pyridinonderivater og deres anvendelse som positive allosteriske modulatorer av MGLUR2-reseptorer
CN101790374A (zh)	2010-07-28	Kcnq钾通道开放剂用于减轻多巴胺能系统受到干扰的障碍或病症的症状或治疗这种障碍或病症的用途
NO20083500L (no)	2008-09-02	1,4-disubstituerte 3-cyano-pyridonderivater og deres anvendelse som positiv-allosteriske modulatorer av mGluR2 receptorer
MXPA05010055A (es)	2005-11-23	Derivados de 2-fenoxi- y 2-fenil-sulfomamida con actividad antagonista del ccr3, para el tratamiento del asma y otros desordenes inflamatorios o inmunologicos.
JP2001503774A (ja)	2001-03-21	５―ｈｔ▲下１ｆ▼アゴニスト
AU2007214128B2 (en)	2012-05-17	Use of KCNQ-openers for treating or reducing the symptoms of schizophrenia
TW200604198A (en)	2006-02-01	Substituted diaza-spiro-[4.5]-decane derivatives and their use as neurokinin antagonists
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MY134383A (en)	2007-12-31	Substituted 1-piperidin-3-yl-4-piperidin-4-yl-piperazine derivatives and their use as neurokinin antagonists
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