NO331480B1 - Farmasoytiske sammensetninger med kontrollert frigivelse - Google Patents

Farmasoytiske sammensetninger med kontrollert frigivelse Download PDF

Info

Publication number: NO331480B1
Authority: NO; Norway
Prior art keywords: component; rivastigmine; coating; film; solution
Prior art date: 1999-09-29

Application number

NO20021452A

Other languages

English (en)

Norwegian (no)

Other versions

NO20021452L (no

NO20021452D0 (no

Inventor

Satish Chandra Khanna

Jorg Ogorka

Oskar Kalb

Rajen Shah

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-09-29

Filing date

2002-03-22

Publication date

2012-01-16

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10861819&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO331480(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-03-22 Application filed by Novartis Ag filed Critical Novartis Ag

2002-03-22 Publication of NO20021452L publication Critical patent/NO20021452L/no

2002-03-22 Publication of NO20021452D0 publication Critical patent/NO20021452D0/no

2012-01-16 Publication of NO331480B1 publication Critical patent/NO331480B1/no

Links

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238000013270 controlled release Methods 0.000 title description 7
XSVMFMHYUFZWBK-NSHDSACASA-N Rivastigmine Chemical compound CCN(C)C(=O)OC1=CC=CC([C@H](C)N(C)C)=C1 XSVMFMHYUFZWBK-NSHDSACASA-N 0.000 claims abstract description 56
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235000019800 disodium phosphate Nutrition 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
238000007922 dissolution test Methods 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
229940088679 drug related substance Drugs 0.000 description 1
238000010410 dusting Methods 0.000 description 1
230000000694 effects Effects 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
229940108366 exelon Drugs 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
150000004665 fatty acids Chemical class 0.000 description 1
150000002191 fatty alcohols Chemical class 0.000 description 1
239000000945 filler Substances 0.000 description 1
239000007941 film coated tablet Substances 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
238000005243 fluidization Methods 0.000 description 1
235000003599 food sweetener Nutrition 0.000 description 1
239000012458 free base Substances 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
239000000499 gel Substances 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
239000008103 glucose Substances 0.000 description 1
125000005456 glyceride group Chemical group 0.000 description 1
229920000591 gum Polymers 0.000 description 1
229920006158 high molecular weight polymer Polymers 0.000 description 1
229930195733 hydrocarbon Natural products 0.000 description 1
150000002430 hydrocarbons Chemical class 0.000 description 1
239000010514 hydrogenated cottonseed oil Substances 0.000 description 1
230000007062 hydrolysis Effects 0.000 description 1
238000006460 hydrolysis reaction Methods 0.000 description 1
235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
239000012729 immediate-release (IR) formulation Substances 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
230000000968 intestinal effect Effects 0.000 description 1
UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Inorganic materials [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 1
235000013980 iron oxide Nutrition 0.000 description 1
VBMVTYDPPZVILR-UHFFFAOYSA-N iron(2+);oxygen(2-) Chemical class [O-2].[Fe+2] VBMVTYDPPZVILR-UHFFFAOYSA-N 0.000 description 1
FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical class O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 1
235000010494 karaya gum Nutrition 0.000 description 1
239000000231 karaya gum Substances 0.000 description 1
229940039371 karaya gum Drugs 0.000 description 1
150000002632 lipids Chemical class 0.000 description 1
239000012907 medicinal substance Substances 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 description 1
239000012184 mineral wax Substances 0.000 description 1
235000019426 modified starch Nutrition 0.000 description 1
229910052901 montmorillonite Inorganic materials 0.000 description 1
210000003097 mucus Anatomy 0.000 description 1
GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
239000003921 oil Substances 0.000 description 1
235000019198 oils Nutrition 0.000 description 1
239000002357 osmotic agent Substances 0.000 description 1
239000012188 paraffin wax Substances 0.000 description 1
230000000149 penetrating effect Effects 0.000 description 1
230000035515 penetration Effects 0.000 description 1
PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 1
230000035699 permeability Effects 0.000 description 1
239000000049 pigment Substances 0.000 description 1
229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 1
229920001281 polyalkylene Polymers 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
229920001282 polysaccharide Polymers 0.000 description 1
239000005017 polysaccharide Substances 0.000 description 1
150000004804 polysaccharides Chemical class 0.000 description 1
229920002689 polyvinyl acetate Polymers 0.000 description 1
239000011118 polyvinyl acetate Substances 0.000 description 1
239000004800 polyvinyl chloride Substances 0.000 description 1
239000001253 polyvinylpolypyrrolidone Substances 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
229920001592 potato starch Polymers 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
235000021251 pulses Nutrition 0.000 description 1
238000000746 purification Methods 0.000 description 1
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
229940081974 saccharin Drugs 0.000 description 1
235000019204 saccharin Nutrition 0.000 description 1
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
239000012047 saturated solution Substances 0.000 description 1
239000000741 silica gel Substances 0.000 description 1
229910002027 silica gel Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
239000001632 sodium acetate Substances 0.000 description 1
235000017281 sodium acetate Nutrition 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
239000004317 sodium nitrate Substances 0.000 description 1
235000010344 sodium nitrate Nutrition 0.000 description 1
239000008279 sol Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
238000005563 spheronization Methods 0.000 description 1
238000001694 spray drying Methods 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008107 starch Substances 0.000 description 1
229940012831 stearyl alcohol Drugs 0.000 description 1
239000001384 succinic acid Substances 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
230000002522 swelling effect Effects 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
239000004408 titanium dioxide Substances 0.000 description 1
238000004448 titration Methods 0.000 description 1
LDHQCZJRKDOVOX-UHFFFAOYSA-N trans-crotonic acid Natural products CC=CC(O)=O LDHQCZJRKDOVOX-UHFFFAOYSA-N 0.000 description 1
150000003626 triacylglycerols Chemical class 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
229920006163 vinyl copolymer Polymers 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
239000001993 wax Substances 0.000 description 1
238000005303 weighing Methods 0.000 description 1
229940100445 wheat starch Drugs 0.000 description 1
229920001221 xylan Polymers 0.000 description 1
150000004823 xylans Chemical class 0.000 description 1
UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Emergency Medicine (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO20021452A 1999-09-29 2002-03-22 Farmasoytiske sammensetninger med kontrollert frigivelse NO331480B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9923045.0A GB9923045D0 (en)	1999-09-29	1999-09-29	New oral formulations
PCT/EP2000/009455 WO2001022944A1 (fr)	1999-09-29	2000-09-27	Formulations orales a liberation controlee

Publications (3)

Publication Number	Publication Date
NO20021452L NO20021452L (no)	2002-03-22
NO20021452D0 NO20021452D0 (no)	2002-03-22
NO331480B1 true NO331480B1 (no)	2012-01-16

Family

ID=10861819

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20021452A NO331480B1 (no)	1999-09-29	2002-03-22	Farmasoytiske sammensetninger med kontrollert frigivelse

Country Status (31)

Country	Link
US (2)	US20060246101A1 (fr)
EP (1)	EP1216032B1 (fr)
JP (1)	JP2003510268A (fr)
KR (2)	KR100661441B1 (fr)
CN (1)	CN1213737C (fr)
AR (1)	AR025792A1 (fr)
AT (1)	ATE384517T1 (fr)
AU (1)	AU769646B2 (fr)
BR (1)	BR0014440A (fr)
CA (1)	CA2379595A1 (fr)
CO (1)	CO5210867A1 (fr)
CY (1)	CY1107923T1 (fr)
CZ (1)	CZ301455B6 (fr)
DE (1)	DE60037897T2 (fr)
DK (1)	DK1216032T3 (fr)
EC (1)	ECSP003685A (fr)
ES (1)	ES2299438T3 (fr)
GB (1)	GB9923045D0 (fr)
HU (1)	HUP0202744A3 (fr)
IL (2)	IL148908A0 (fr)
MY (1)	MY128759A (fr)
NO (1)	NO331480B1 (fr)
NZ (1)	NZ517335A (fr)
PE (1)	PE20010568A1 (fr)
PL (1)	PL200822B1 (fr)
PT (1)	PT1216032E (fr)
RU (1)	RU2281758C2 (fr)
SK (1)	SK286651B6 (fr)
TR (1)	TR200200683T2 (fr)
WO (1)	WO2001022944A1 (fr)
ZA (1)	ZA200202369B (fr)

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AR040682A1 (es)	2002-07-25	2005-04-13	Pharmacia Corp	Forma de dosificacion una vez al dia de pramipexol
EA200700388A1 (ru) *	2004-08-13	2007-08-31	Бёрингер Ингельхайм Интернациональ Гмбх	Композиция пеллеты пролонгированного высвобождения, содержащая прамипексол или его фармацевтически приемлемую соль, способ её изготовления и её применение
HRP20100682T4 (hr)	2004-08-13	2014-08-01	Boehringer Ingelheim International Gmbh	Formulacija tablete produljenog oslobađanja koja sadrži pramipeksol ili njegovu farmaceutski prihvatljivu sol, postupak njezine priprave i uporaba
JP2008525313A (ja) *	2004-12-27	2008-07-17	エーザイ・アール・アンド・ディー・マネジメント株式会社	抗痴呆薬の安定化方法
GB0606562D0 (en) *	2006-03-31	2006-05-10	Novartis Ag	Organic compounds
CN101797236B (zh) *	2010-03-23	2012-05-23	西南大学	重酒石酸卡巴拉汀口腔崩解片及其制备方法
AU2011305572B2 (en)	2010-09-20	2016-08-04	Diane Goll	Microencapsulation process and product
KR101990951B1 (ko)	2015-04-27	2019-06-20	주식회사 네비팜	리바스티그민 함유 서방출 의약조성물
CN106000294B (zh) *	2016-07-04	2019-04-30	三峡大学	一种高膨胀低收缩率膨润土及制备方法
CN115192538B (zh) *	2022-08-02	2023-09-15	沈阳信康药物研究有限公司	一种压制包衣型硝苯地平缓释片及其制备方法

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SE8404467D0 (sv) *	1984-09-06	1984-09-06	Ferrosan Ab	Controlled-release medical preparations
IL74497A (en) *	1985-03-05	1990-02-09	Proterra Ag	Pharmaceutical compositions containing phenyl carbamate derivatives and certain phenyl carbamate derivatives
DE3805744C2 (de) *	1987-03-04	1999-09-23	Novartis Ag	Phenylcarbamate zur Hemmung der Acetylcholinesterase
HU201906B (en) *	1987-03-04	1991-01-28	Sandoz Ag	Process for producing phenyl-carbamate derivative and acid additional salts and pharmaceutical compositions containing them
IL91398A (en) *	1988-08-30	1994-05-30	Pfizer	Pharmaceutical delivery device comprising active substance surrounded by asymmetric membrane
US4984807A (en) *	1990-01-12	1991-01-15	Baruch Shiryon	Board game
US5229131A (en) *	1990-02-05	1993-07-20	University Of Michigan	Pulsatile drug delivery system
JPH0794379B2 (ja) *	1990-08-07	1995-10-11	ファイザー・インコーポレーテッド	放出製剤における界面重合膜の使用方法
US5407686A (en) *	1991-11-27	1995-04-18	Sidmak Laboratories, Inc.	Sustained release composition for oral administration of active ingredient
US5260069A (en) *	1992-11-27	1993-11-09	Anda Sr Pharmaceuticals Inc.	Pulsatile particles drug delivery system
US5358502A (en) *	1993-02-25	1994-10-25	Pfizer Inc	PH-triggered osmotic bursting delivery devices
ATE195252T1 (de) *	1993-04-23	2000-08-15	Novartis Erfind Verwalt Gmbh	Wirkstoffabgabevorrichtung mit gesteuerter freigabe
US5500227A (en) *	1993-11-23	1996-03-19	Euro-Celtique, S.A.	Immediate release tablet cores of insoluble drugs having sustained-release coating
US5962535A (en) *	1997-01-17	1999-10-05	Takeda Chemical Industries, Ltd.	Composition for alzheimer's disease
IL128043A (en) *	1997-05-30	2004-08-31	Osmotica Corp	Multi-layered osmotic device for controlled delivery of active agents
GB9711643D0 (en) *	1997-06-05	1997-07-30	Janssen Pharmaceutica Nv	Glass thermoplastic systems
WO1999001121A1 (fr) *	1997-07-01	1999-01-14	Pfizer Inc.	Sels de sertraline et formes posologiques de sertraline, a liberation prolongee
SE9704870D0 (sv) *	1997-12-22	1997-12-22	Astra Ab	New pharmaceutical formulation I
BR9914251A (pt) *	1998-10-01	2001-06-19	Novartis Ag	Formulações orais de liberação sustentada
US6632451B2 (en) *	1999-06-04	2003-10-14	Dexcel Pharma Technologies Ltd.	Delayed total release two pulse gastrointestinal drug delivery system

1999
- 1999-09-29 GB GBGB9923045.0A patent/GB9923045D0/en not_active Ceased
2000
- 2000-09-27 CA CA002379595A patent/CA2379595A1/fr not_active Abandoned
- 2000-09-27 TR TR2002/00683T patent/TR200200683T2/xx unknown
- 2000-09-27 BR BR0014440-1A patent/BR0014440A/pt not_active Application Discontinuation
- 2000-09-27 KR KR1020027004024A patent/KR100661441B1/ko not_active Expired - Fee Related
- 2000-09-27 EP EP00971290A patent/EP1216032B1/fr not_active Expired - Lifetime
- 2000-09-27 SK SK413-2002A patent/SK286651B6/sk not_active IP Right Cessation
- 2000-09-27 AU AU10197/01A patent/AU769646B2/en not_active Ceased
- 2000-09-27 PL PL354075A patent/PL200822B1/pl not_active IP Right Cessation
- 2000-09-27 ES ES00971290T patent/ES2299438T3/es not_active Expired - Lifetime
- 2000-09-27 JP JP2001526156A patent/JP2003510268A/ja active Pending
- 2000-09-27 WO PCT/EP2000/009455 patent/WO2001022944A1/fr not_active Ceased
- 2000-09-27 AT AT00971290T patent/ATE384517T1/de active
- 2000-09-27 RU RU2002109236/15A patent/RU2281758C2/ru not_active IP Right Cessation
- 2000-09-27 PT PT00971290T patent/PT1216032E/pt unknown
- 2000-09-27 KR KR1020057018185A patent/KR20050100710A/ko not_active Ceased
- 2000-09-27 NZ NZ517335A patent/NZ517335A/en not_active IP Right Cessation
- 2000-09-27 CZ CZ20021028A patent/CZ301455B6/cs not_active IP Right Cessation
- 2000-09-27 CN CNB008134529A patent/CN1213737C/zh not_active Expired - Fee Related
- 2000-09-27 AR ARP000105065A patent/AR025792A1/es unknown
- 2000-09-27 IL IL14890800A patent/IL148908A0/xx unknown
- 2000-09-27 CO CO00073349A patent/CO5210867A1/es not_active Application Discontinuation
- 2000-09-27 DE DE60037897T patent/DE60037897T2/de not_active Expired - Lifetime
- 2000-09-27 DK DK00971290T patent/DK1216032T3/da active
- 2000-09-27 PE PE2000001020A patent/PE20010568A1/es not_active Application Discontinuation
- 2000-09-27 HU HU0202744A patent/HUP0202744A3/hu unknown
- 2000-09-28 EC EC2000003685A patent/ECSP003685A/es unknown
- 2000-09-28 MY MYPI20004521A patent/MY128759A/en unknown
2002
- 2002-03-22 NO NO20021452A patent/NO331480B1/no not_active IP Right Cessation
- 2002-03-25 ZA ZA200202369A patent/ZA200202369B/en unknown
- 2002-03-26 IL IL148908A patent/IL148908A/en not_active IP Right Cessation
2006
- 2006-06-30 US US11/479,020 patent/US20060246101A1/en not_active Abandoned
2008
- 2008-04-17 CY CY20081100432T patent/CY1107923T1/el unknown
2010
- 2010-10-27 US US12/913,399 patent/US20110038897A1/en not_active Abandoned

Also Published As

Publication number	Publication date
PL200822B1 (pl)	2009-02-27
CA2379595A1 (fr)	2001-04-05
CZ301455B6 (cs)	2010-03-10
JP2003510268A (ja)	2003-03-18
KR20050100710A (ko)	2005-10-19
ECSP003685A (es)	2002-05-23
MY128759A (en)	2007-02-28
IL148908A0 (en)	2002-09-12
NO20021452L (no)	2002-03-22
GB9923045D0 (en)	1999-12-01
PE20010568A1 (es)	2001-05-29
DK1216032T3 (da)	2008-06-02
DE60037897D1 (de)	2008-03-13
ATE384517T1 (de)	2008-02-15
BR0014440A (pt)	2002-06-18
EP1216032B1 (fr)	2008-01-23
ZA200202369B (en)	2002-12-24
DE60037897T2 (de)	2008-12-24
AR025792A1 (es)	2002-12-11
SK286651B6 (sk)	2009-03-05
CN1376058A (zh)	2002-10-23
ES2299438T3 (es)	2008-06-01
HUP0202744A2 (hu)	2003-01-28
CY1107923T1 (el)	2013-09-04
CN1213737C (zh)	2005-08-10
EP1216032A1 (fr)	2002-06-26
AU1019701A (en)	2001-04-30
NZ517335A (en)	2003-10-31
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Publication	Publication Date	Title
JP4012689B2 (ja)	2007-11-21	新規徐放性経口製剤
US20110038897A1 (en)	2011-02-17	Oral controlled release formulations
WO2011039686A1 (fr)	2011-04-07	Formes pharmaceutiques orales à libération prolongée de latrépirdine
RU2286766C2 (ru)	2006-11-10	Новые композиции пролонгированного действия для перорального введения
MXPA01002365A (en)	2001-11-21	New sustained release oral formulations
ZA200101932B (en)	2002-06-26	New sustained release oral formulations