NO743673L - - Google Patents

Info

Publication number: NO743673L
Authority: NO; Norway
Prior art keywords: dihydro; fish; oxo; carboxylic acid; piperazinyl
Prior art date: 1973-10-13

Application number

NO743673A

Other languages

English (en)

Norwegian (no)

Inventor

M Shimizu

K Kouno

Y Takase

Original Assignee

Dainippon Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1973-10-13

Filing date

1974-10-11

Publication date

1975-05-12

1974-10-11 Application filed by Dainippon Pharmaceutical Co filed Critical Dainippon Pharmaceutical Co

1975-05-12 Publication of NO743673L publication Critical patent/NO743673L/no

Links

241000251468 Actinopterygii Species 0.000 claims description 68
-1 heterocyclic carboxylic acid Chemical class 0.000 claims description 43
239000000203 mixture Substances 0.000 claims description 30
150000001875 compounds Chemical class 0.000 claims description 27
238000000034 method Methods 0.000 claims description 18
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
208000035473 Communicable disease Diseases 0.000 claims description 17
235000005911 diet Nutrition 0.000 claims description 17
239000002253 acid Substances 0.000 claims description 16
230000037213 diet Effects 0.000 claims description 15
231100000252 nontoxic Toxicity 0.000 claims description 15
230000003000 nontoxic effect Effects 0.000 claims description 15
150000003839 salts Chemical class 0.000 claims description 15
239000003814 drug Substances 0.000 claims description 11
235000013305 food Nutrition 0.000 claims description 11
238000011282 treatment Methods 0.000 claims description 11
241000894006 Bacteria Species 0.000 claims description 10
230000000069 prophylactic effect Effects 0.000 claims description 9
239000000725 suspension Substances 0.000 claims description 6
238000007654 immersion Methods 0.000 claims description 5
239000000843 powder Substances 0.000 claims description 5
229940124597 therapeutic agent Drugs 0.000 claims description 5
RCIMBBZXSXFZBV-UHFFFAOYSA-N piromidic acid Chemical compound N1=C2N(CC)C=C(C(O)=O)C(=O)C2=CN=C1N1CCCC1 RCIMBBZXSXFZBV-UHFFFAOYSA-N 0.000 claims description 4
239000008187 granular material Substances 0.000 claims description 3
239000004480 active ingredient Substances 0.000 claims description 2
208000035143 Bacterial infection Diseases 0.000 claims 1
208000022362 bacterial infectious disease Diseases 0.000 claims 1
150000001735 carboxylic acids Chemical class 0.000 claims 1
125000000623 heterocyclic group Chemical group 0.000 claims 1
XVRCWGVHAICWOW-UHFFFAOYSA-N pyrido[2,3-d]pyrimidine-6-carboxylic acid Chemical compound N1=CN=CC2=CC(C(=O)O)=CN=C21 XVRCWGVHAICWOW-UHFFFAOYSA-N 0.000 claims 1
125000004943 pyrimidin-6-yl group Chemical group N1=CN=CC=C1* 0.000 claims 1
235000019688 fish Nutrition 0.000 description 57
241000252229 Carassius auratus Species 0.000 description 13
241000252073 Anguilliformes Species 0.000 description 12
230000000694 effects Effects 0.000 description 11
208000015181 infectious disease Diseases 0.000 description 10
239000003795 chemical substances by application Substances 0.000 description 7
208000010824 fish disease Diseases 0.000 description 7
229940079593 drug Drugs 0.000 description 6
239000013505 freshwater Substances 0.000 description 6
201000010099 disease Diseases 0.000 description 5
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
230000004083 survival effect Effects 0.000 description 5
231100000419 toxicity Toxicity 0.000 description 5
230000001988 toxicity Effects 0.000 description 5
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
244000005700 microbiome Species 0.000 description 4
238000012360 testing method Methods 0.000 description 4
ZAMIZBUROFRJHK-UHFFFAOYSA-N 1-ethenyl-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid Chemical compound C1CN(C)CCN1C1=CC=C2C(=O)C(C(O)=O)=CN(C=C)C2=C1 ZAMIZBUROFRJHK-UHFFFAOYSA-N 0.000 description 3
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
241000607528 Aeromonas hydrophila Species 0.000 description 3
241000252087 Anguilla japonica Species 0.000 description 3
241000604777 Flavobacterium columnare Species 0.000 description 3
241000269908 Platichthys flesus Species 0.000 description 3
239000004098 Tetracycline Substances 0.000 description 3
241000607598 Vibrio Species 0.000 description 3
239000013543 active substance Substances 0.000 description 3
230000000845 anti-microbial effect Effects 0.000 description 3
239000002246 antineoplastic agent Substances 0.000 description 3
244000052616 bacterial pathogen Species 0.000 description 3
229940127089 cytotoxic agent Drugs 0.000 description 3
239000003085 diluting agent Substances 0.000 description 3
239000002609 medium Substances 0.000 description 3
244000000010 microbial pathogen Species 0.000 description 3
238000011160 research Methods 0.000 description 3
229960002180 tetracycline Drugs 0.000 description 3
229930101283 tetracycline Natural products 0.000 description 3
235000019364 tetracycline Nutrition 0.000 description 3
150000003522 tetracyclines Chemical class 0.000 description 3
230000001225 therapeutic effect Effects 0.000 description 3
238000005303 weighing Methods 0.000 description 3
WTNGOWIKHDGXEJ-UHFFFAOYSA-N 1-ethenyl-7-(4-ethylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid Chemical compound C1CN(CC)CCN1C1=CC=C2C(=O)C(C(O)=O)=CN(C=C)C2=C1 WTNGOWIKHDGXEJ-UHFFFAOYSA-N 0.000 description 2
241000607534 Aeromonas Species 0.000 description 2
206010001430 Aeromonas infections Diseases 0.000 description 2
206010002091 Anaesthesia Diseases 0.000 description 2
229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
241001646999 Corallococcus Species 0.000 description 2
241000252233 Cyprinus carpio Species 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
108010010803 Gelatin Proteins 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
241000124008 Mammalia Species 0.000 description 2
241001465754 Metazoa Species 0.000 description 2
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 2
206010058667 Oral toxicity Diseases 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
230000037005 anaesthesia Effects 0.000 description 2
239000003242 anti bacterial agent Substances 0.000 description 2
238000003287 bathing Methods 0.000 description 2
230000037396 body weight Effects 0.000 description 2
230000000378 dietary effect Effects 0.000 description 2
238000003113 dilution method Methods 0.000 description 2
238000002474 experimental method Methods 0.000 description 2
229920000159 gelatin Polymers 0.000 description 2
239000008273 gelatin Substances 0.000 description 2
235000019322 gelatine Nutrition 0.000 description 2
235000011852 gelatine desserts Nutrition 0.000 description 2
238000000338 in vitro Methods 0.000 description 2
238000011534 incubation Methods 0.000 description 2
230000000813 microbial effect Effects 0.000 description 2
231100000418 oral toxicity Toxicity 0.000 description 2
230000001717 pathogenic effect Effects 0.000 description 2
230000002265 prevention Effects 0.000 description 2
239000000243 solution Substances 0.000 description 2
239000000126 substance Substances 0.000 description 2
238000010998 test method Methods 0.000 description 2
IRYAYNRNRAHHDH-UHFFFAOYSA-N 1-ethenyl-4-oxo-7-piperazin-1-yl-1,8-naphthyridine-3-carboxylic acid Chemical compound C=1C=C2C(=O)C(C(=O)O)=CN(C=C)C2=NC=1N1CCNCC1 IRYAYNRNRAHHDH-UHFFFAOYSA-N 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
241000972773 Aulopiformes Species 0.000 description 1
241001635206 Conger conger Species 0.000 description 1
241000238424 Crustacea Species 0.000 description 1
241000238557 Decapoda Species 0.000 description 1
239000004375 Dextrin Substances 0.000 description 1
229920001353 Dextrin Polymers 0.000 description 1
241000276457 Gadidae Species 0.000 description 1
229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
241001502129 Mullus Species 0.000 description 1
241001327682 Oncorhynchus mykiss irideus Species 0.000 description 1
241000237502 Ostreidae Species 0.000 description 1
241000606860 Pasteurella Species 0.000 description 1
241001600434 Plectroglyphidodon lacrymatus Species 0.000 description 1
241000520869 Pseudomonas anguilliseptica Species 0.000 description 1
241000277331 Salmonidae Species 0.000 description 1
241000269851 Sarda sarda Species 0.000 description 1
241000168311 Sillago Species 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
NHUHCSRWZMLRLA-UHFFFAOYSA-N Sulfisoxazole Chemical compound CC1=NOC(NS(=O)(=O)C=2C=CC(N)=CC=2)=C1C NHUHCSRWZMLRLA-UHFFFAOYSA-N 0.000 description 1
241001504592 Trachurus trachurus Species 0.000 description 1
241000544286 Vibrio anguillarum Species 0.000 description 1
230000005856 abnormality Effects 0.000 description 1
229910052783 alkali metal Inorganic materials 0.000 description 1
239000004599 antimicrobial Substances 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
239000000440 bentonite Substances 0.000 description 1
229910000278 bentonite Inorganic materials 0.000 description 1
SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
238000009395 breeding Methods 0.000 description 1
230000001488 breeding effect Effects 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
229960005091 chloramphenicol Drugs 0.000 description 1
JNGZXGGOCLZBFB-IVCQMTBJSA-N compound E Chemical compound N([C@@H](C)C(=O)N[C@@H]1C(N(C)C2=CC=CC=C2C(C=2C=CC=CC=2)=N1)=O)C(=O)CC1=CC(F)=CC(F)=C1 JNGZXGGOCLZBFB-IVCQMTBJSA-N 0.000 description 1
238000011161 development Methods 0.000 description 1
235000019425 dextrin Nutrition 0.000 description 1
239000002270 dispersing agent Substances 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
235000013601 eggs Nutrition 0.000 description 1
230000007613 environmental effect Effects 0.000 description 1
235000019441 ethanol Nutrition 0.000 description 1
PLHJDBGFXBMTGZ-WEVVVXLNSA-N furazolidone Chemical compound O1C([N+](=O)[O-])=CC=C1\C=N\N1C(=O)OCC1 PLHJDBGFXBMTGZ-WEVVVXLNSA-N 0.000 description 1
229960001625 furazolidone Drugs 0.000 description 1
230000035876 healing Effects 0.000 description 1
239000001863 hydroxypropyl cellulose Substances 0.000 description 1
235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
238000001802 infusion Methods 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
239000002054 inoculum Substances 0.000 description 1
239000008101 lactose Substances 0.000 description 1
231100000636 lethal dose Toxicity 0.000 description 1
239000007788 liquid Substances 0.000 description 1
239000002075 main ingredient Substances 0.000 description 1
229940098779 methanesulfonic acid Drugs 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
235000020636 oyster Nutrition 0.000 description 1
230000008560 physiological behavior Effects 0.000 description 1
230000003449 preventive effect Effects 0.000 description 1
238000011321 prophylaxis Methods 0.000 description 1
235000019515 salmon Nutrition 0.000 description 1
235000015170 shellfish Nutrition 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
239000007787 solid Substances 0.000 description 1
235000014347 soups Nutrition 0.000 description 1
241000894007 species Species 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
229960000654 sulfafurazole Drugs 0.000 description 1
239000003826 tablet Substances 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
239000007160 ty medium Substances 0.000 description 1
238000005406 washing Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Polymers & Plastics (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Husbandry (AREA)
Food Science & Technology (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Epidemiology (AREA)
Oncology (AREA)
General Chemical & Material Sciences (AREA)
Communicable Diseases (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Farming Of Fish And Shellfish (AREA)

NO743673A 1973-10-13 1974-10-11 NO743673L (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP11500673A JPS5647166B2 (fr)	1973-10-13	1973-10-13

Publications (1)

Publication Number	Publication Date
NO743673L true NO743673L (fr)	1975-05-12

Family

ID=14651943

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO743673A NO743673L (fr)	1973-10-13	1974-10-11

Country Status (9)

Country	Link
US (1)	US3981999A (fr)
JP (1)	JPS5647166B2 (fr)
CA (1)	CA1052698A (fr)
DE (1)	DE2448564C3 (fr)
FR (1)	FR2247245B1 (fr)
GB (1)	GB1465993A (fr)
IE (1)	IE39940B1 (fr)
IT (1)	IT1022820B (fr)
NO (1)	NO743673L (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH03250178A (ja) *	1990-02-27	1991-11-07	Tostem Corp	ドアの吊車装置
CA2318580A1 (fr) *	1998-01-23	1999-07-29	Mark L. Nelson	Composes pharmaceutiquement actifs et procedes d'utilisation correspondants
US7334538B1 (en) *	2004-07-27	2008-02-26	Aquascience Research Group, Inc.	Topical medicants for aquatic animals

1973
- 1973-10-13 JP JP11500673A patent/JPS5647166B2/ja not_active Expired
1974
- 1974-10-08 IE IE2086/74A patent/IE39940B1/xx unknown
- 1974-10-10 US US05/513,824 patent/US3981999A/en not_active Expired - Lifetime
- 1974-10-10 GB GB4400074A patent/GB1465993A/en not_active Expired
- 1974-10-11 IT IT28352/74A patent/IT1022820B/it active
- 1974-10-11 CA CA211,264A patent/CA1052698A/fr not_active Expired
- 1974-10-11 DE DE2448564A patent/DE2448564C3/de not_active Expired
- 1974-10-11 NO NO743673A patent/NO743673L/no unknown
- 1974-10-14 FR FR7434486A patent/FR2247245B1/fr not_active Expired

Also Published As

Publication number	Publication date
FR2247245B1 (fr)	1978-07-28
DE2448564B2 (de)	1979-04-05
US3981999A (en)	1976-09-21
DE2448564A1 (de)	1975-06-19
JPS5064415A (fr)	1975-05-31
CA1052698A (fr)	1979-04-17
DE2448564C3 (de)	1979-11-22
IT1022820B (it)	1978-04-20
IE39940B1 (en)	1979-01-31
FR2247245A1 (fr)	1975-05-09
JPS5647166B2 (fr)	1981-11-07
GB1465993A (en)	1977-03-02
AU7418774A (en)	1976-04-15
IE39940L (en)	1975-04-13

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