NO753230L - - Google Patents

Info

Publication number: NO753230L
Authority: NO; Norway
Prior art keywords: units; mol; active substance; weight; molding compound
Prior art date: 1974-09-24

Application number

NO753230A

Other languages

English (en)

Norwegian (no)

Inventor

G Schoepflin

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-09-24

Filing date

1975-09-23

Publication date

1976-03-25

1975-09-23 Application filed by Schering Ag filed Critical Schering Ag

1976-03-25 Publication of NO753230L publication Critical patent/NO753230L/no

Links

239000013543 active substance Substances 0.000 claims description 49
229920001296 polysiloxane Polymers 0.000 claims description 43
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 40
238000000465 moulding Methods 0.000 claims description 37
150000001875 compounds Chemical class 0.000 claims description 31
229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 22
239000004205 dimethyl polysiloxane Substances 0.000 claims description 20
229910052697 platinum Inorganic materials 0.000 claims description 17
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 16
-1 polydimethylsiloxane Polymers 0.000 claims description 14
239000012876 carrier material Substances 0.000 claims description 12
229920001577 copolymer Polymers 0.000 claims description 9
239000003937 drug carrier Substances 0.000 claims description 8
238000004132 cross linking Methods 0.000 claims description 6
230000007774 longterm Effects 0.000 claims description 4
230000003197 catalytic effect Effects 0.000 claims description 3
229920002554 vinyl polymer Polymers 0.000 claims description 3
239000012907 medicinal substance Substances 0.000 claims 1
239000003814 drug Substances 0.000 description 26
229940079593 drug Drugs 0.000 description 22
235000013870 dimethyl polysiloxane Nutrition 0.000 description 21
239000000203 mixture Substances 0.000 description 21
239000000725 suspension Substances 0.000 description 20
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 19
239000000969 carrier Substances 0.000 description 17
IMONTRJLAWHYGT-ZCPXKWAGSA-N Norethindrone Acetate Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@](C#C)(OC(=O)C)[C@@]1(C)CC2 IMONTRJLAWHYGT-ZCPXKWAGSA-N 0.000 description 13
238000010438 heat treatment Methods 0.000 description 13
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
229960001652 norethindrone acetate Drugs 0.000 description 12
229920001971 elastomer Polymers 0.000 description 11
239000000806 elastomer Substances 0.000 description 11
229960004400 levonorgestrel Drugs 0.000 description 11
WWYNJERNGUHSAO-XUDSTZEESA-N (+)-Norgestrel Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 WWYNJERNGUHSAO-XUDSTZEESA-N 0.000 description 10
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 10
239000000243 solution Substances 0.000 description 10
239000003054 catalyst Substances 0.000 description 9
229920002379 silicone rubber Polymers 0.000 description 9
238000004073 vulcanization Methods 0.000 description 9
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 8
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 8
239000010949 copper Substances 0.000 description 8
239000004480 active ingredient Substances 0.000 description 7
229910052802 copper Inorganic materials 0.000 description 7
TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 6
JNGZXGGOCLZBFB-IVCQMTBJSA-N compound E Chemical compound N([C@@H](C)C(=O)N[C@@H]1C(N(C)C2=CC=CC=C2C(C=2C=CC=CC=2)=N1)=O)C(=O)CC1=CC(F)=CC(F)=C1 JNGZXGGOCLZBFB-IVCQMTBJSA-N 0.000 description 6
239000000377 silicon dioxide Substances 0.000 description 6
235000012239 silicon dioxide Nutrition 0.000 description 6
239000004753 textile Substances 0.000 description 6
BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 description 5
229920000742 Cotton Polymers 0.000 description 5
BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 description 5
239000008186 active pharmaceutical agent Substances 0.000 description 5
229960002568 ethinylestradiol Drugs 0.000 description 5
239000011888 foil Substances 0.000 description 5
238000002513 implantation Methods 0.000 description 5
239000000463 material Substances 0.000 description 5
150000003058 platinum compounds Chemical class 0.000 description 5
238000002360 preparation method Methods 0.000 description 5
229940126062 Compound A Drugs 0.000 description 4
NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 4
238000006243 chemical reaction Methods 0.000 description 4
125000004435 hydrogen atom Chemical group [H]* 0.000 description 4
238000004519 manufacturing process Methods 0.000 description 4
229940126601 medicinal product Drugs 0.000 description 4
IMSSROKUHAOUJS-MJCUULBUSA-N mestranol Chemical compound C1C[C@]2(C)[C@@](C#C)(O)CC[C@H]2[C@@H]2CCC3=CC(OC)=CC=C3[C@H]21 IMSSROKUHAOUJS-MJCUULBUSA-N 0.000 description 4
229960001390 mestranol Drugs 0.000 description 4
239000004971 Cross linker Substances 0.000 description 3
239000002253 acid Substances 0.000 description 3
229940045985 antineoplastic platinum compound Drugs 0.000 description 3
239000007943 implant Substances 0.000 description 3
238000011866 long-term treatment Methods 0.000 description 3
229910052751 metal Inorganic materials 0.000 description 3
239000002184 metal Substances 0.000 description 3
229940053934 norethindrone Drugs 0.000 description 3
VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 description 3
239000004945 silicone rubber Substances 0.000 description 3
239000007787 solid Substances 0.000 description 3
NNJPGOLRFBJNIW-HNNXBMFYSA-N (-)-demecolcine Chemical compound C1=C(OC)C(=O)C=C2[C@@H](NC)CCC3=CC(OC)=C(OC)C(OC)=C3C2=C1 NNJPGOLRFBJNIW-HNNXBMFYSA-N 0.000 description 2
VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 2
229910002621 H2PtCl6 Inorganic materials 0.000 description 2
241001465754 Metazoa Species 0.000 description 2
239000000853 adhesive Substances 0.000 description 2
229930182833 estradiol Natural products 0.000 description 2
229960005309 estradiol Drugs 0.000 description 2
238000000605 extraction Methods 0.000 description 2
238000002347 injection Methods 0.000 description 2
239000007924 injection Substances 0.000 description 2
150000002500 ions Chemical class 0.000 description 2
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
239000011159 matrix material Substances 0.000 description 2
229960004296 megestrol acetate Drugs 0.000 description 2
RQZAXGRLVPAYTJ-GQFGMJRRSA-N megestrol acetate Chemical compound C1=C(C)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 RQZAXGRLVPAYTJ-GQFGMJRRSA-N 0.000 description 2
125000005375 organosiloxane group Chemical group 0.000 description 2
239000002245 particle Substances 0.000 description 2
239000002994 raw material Substances 0.000 description 2
239000011347 resin Substances 0.000 description 2
229920005989 resin Polymers 0.000 description 2
229920006395 saturated elastomer Polymers 0.000 description 2
239000003826 tablet Substances 0.000 description 2
SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
DXPPIEDUBFUSEZ-UHFFFAOYSA-N 6-methylheptyl prop-2-enoate Chemical compound CC(C)CCCCCOC(=O)C=C DXPPIEDUBFUSEZ-UHFFFAOYSA-N 0.000 description 1
239000004342 Benzoyl peroxide Substances 0.000 description 1
OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 1
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
LVHOURKCKUYIGK-RGUJTQARSA-N Dimethisterone Chemical compound C1([C@@H](C)C2)=CC(=O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@](C#CC)(O)[C@@]2(C)CC1 LVHOURKCKUYIGK-RGUJTQARSA-N 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
YNVGQYHLRCDXFQ-XGXHKTLJSA-N Lynestrenol Chemical compound C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 YNVGQYHLRCDXFQ-XGXHKTLJSA-N 0.000 description 1
ICTXHFFSOAJUMG-SLHNCBLASA-N Norethynodrel Chemical compound C1CC(=O)CC2=C1[C@H]1CC[C@](C)([C@](CC3)(O)C#C)[C@@H]3[C@@H]1CC2 ICTXHFFSOAJUMG-SLHNCBLASA-N 0.000 description 1
239000004677 Nylon Substances 0.000 description 1
244000208734 Pisonia aculeata Species 0.000 description 1
239000004952 Polyamide Substances 0.000 description 1
RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 description 1
125000004423 acyloxy group Chemical group 0.000 description 1
230000001070 adhesive effect Effects 0.000 description 1
230000002411 adverse Effects 0.000 description 1
125000000217 alkyl group Chemical group 0.000 description 1
125000004429 atom Chemical group 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
235000019400 benzoyl peroxide Nutrition 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
230000036760 body temperature Effects 0.000 description 1
239000006227 byproduct Substances 0.000 description 1
235000011089 carbon dioxide Nutrition 0.000 description 1
IVFILROKUQKCPB-UHFFFAOYSA-N carbonyl dichloride;platinum Chemical compound [Pt].ClC(Cl)=O IVFILROKUQKCPB-UHFFFAOYSA-N 0.000 description 1
150000001735 carboxylic acids Chemical class 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
239000003610 charcoal Substances 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
239000000356 contaminant Substances 0.000 description 1
239000003433 contraceptive agent Substances 0.000 description 1
230000002254 contraceptive effect Effects 0.000 description 1
238000005238 degreasing Methods 0.000 description 1
230000003111 delayed effect Effects 0.000 description 1
229950006690 dimethisterone Drugs 0.000 description 1
229920005645 diorganopolysiloxane polymer Polymers 0.000 description 1
238000001035 drying Methods 0.000 description 1
230000000816 effect on animals Effects 0.000 description 1
230000000694 effects Effects 0.000 description 1
CHNXZKVNWQUJIB-CEGNMAFCSA-N ethisterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 CHNXZKVNWQUJIB-CEGNMAFCSA-N 0.000 description 1
229960000445 ethisterone Drugs 0.000 description 1
ONKUMRGIYFNPJW-KIEAKMPYSA-N ethynodiol diacetate Chemical compound C1C[C@]2(C)[C@@](C#C)(OC(C)=O)CC[C@H]2[C@@H]2CCC3=C[C@@H](OC(=O)C)CC[C@@H]3[C@H]21 ONKUMRGIYFNPJW-KIEAKMPYSA-N 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
239000000945 filler Substances 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
239000004922 lacquer Substances 0.000 description 1
239000008101 lactose Substances 0.000 description 1
230000004807 localization Effects 0.000 description 1
230000005923 long-lasting effect Effects 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
229910021645 metal ion Inorganic materials 0.000 description 1
229960001207 micronized progesterone Drugs 0.000 description 1
239000012778 molding material Substances 0.000 description 1
210000000214 mouth Anatomy 0.000 description 1
229910000510 noble metal Inorganic materials 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
229960001858 norethynodrel Drugs 0.000 description 1
YPVUHOBTCWJYNQ-SLHNCBLASA-N norgesterone Chemical compound C1CC(=O)CC2=C1[C@H]1CC[C@](C)([C@](CC3)(O)C=C)[C@@H]3[C@@H]1CC2 YPVUHOBTCWJYNQ-SLHNCBLASA-N 0.000 description 1
229950011191 norgesterone Drugs 0.000 description 1
229960002831 norgestrienone Drugs 0.000 description 1
GVDMJXQHPUYPHP-FYQPLNBISA-N norgestrienone Chemical compound C1CC(=O)C=C2CC[C@@H]([C@H]3[C@@](C)([C@](CC3)(O)C#C)C=C3)C3=C21 GVDMJXQHPUYPHP-FYQPLNBISA-N 0.000 description 1
229920001778 nylon Polymers 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
229920006136 organohydrogenpolysiloxane Polymers 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
150000002978 peroxides Chemical class 0.000 description 1
239000008177 pharmaceutical agent Substances 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
230000001766 physiological effect Effects 0.000 description 1
150000003057 platinum Chemical class 0.000 description 1
239000002574 poison Substances 0.000 description 1
231100000614 poison Toxicity 0.000 description 1
229920002647 polyamide Polymers 0.000 description 1
229920000728 polyester Polymers 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
229920000131 polyvinylidene Polymers 0.000 description 1
239000000843 powder Substances 0.000 description 1
239000000047 product Substances 0.000 description 1
FLGJKPPXEKYCBY-AKCFYGDASA-N quingestanol acetate Chemical compound C([C@H]1[C@@H]2CC[C@@]([C@]2(CC[C@@H]1[C@H]1CC2)C)(OC(=O)C)C#C)C=C1C=C2OC1CCCC1 FLGJKPPXEKYCBY-AKCFYGDASA-N 0.000 description 1
229950009172 quingestanol acetate Drugs 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
230000003014 reinforcing effect Effects 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
238000009958 sewing Methods 0.000 description 1
238000007493 shaping process Methods 0.000 description 1
239000000741 silica gel Substances 0.000 description 1
229910002027 silica gel Inorganic materials 0.000 description 1
229910052709 silver Inorganic materials 0.000 description 1
239000004332 silver Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
150000003431 steroids Chemical class 0.000 description 1
229920001059 synthetic polymer Polymers 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
QFJIELFEXWAVLU-UHFFFAOYSA-H tetrachloroplatinum(2+) dichloride Chemical compound Cl[Pt](Cl)(Cl)(Cl)(Cl)Cl QFJIELFEXWAVLU-UHFFFAOYSA-H 0.000 description 1
KSBAEPSJVUENNK-UHFFFAOYSA-L tin(ii) 2-ethylhexanoate Chemical compound [Sn+2].CCCCC(CC)C([O-])=O.CCCCC(CC)C([O-])=O KSBAEPSJVUENNK-UHFFFAOYSA-L 0.000 description 1
238000011282 treatment Methods 0.000 description 1
239000002966 varnish Substances 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0039—Devices retained in the uterus for a prolonged period, e.g. intrauterine devices for contraception
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
- A61K9/2036—Silicones; Polysiloxanes

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Reproductive Health (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Dermatology (AREA)
Neurosurgery (AREA)
Gynecology & Obstetrics (AREA)
Urology & Nephrology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Compositions Of Macromolecular Compounds (AREA)
Materials For Medical Uses (AREA)
Media Introduction/Drainage Providing Device (AREA)

NO753230A 1974-09-24 1975-09-23 NO753230L (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19742445971 DE2445971A1 (de)	1974-09-24	1974-09-24	Arzneimittelwirkstofftraeger ii

Publications (1)

Publication Number	Publication Date
NO753230L true NO753230L (fr)	1976-03-25

Family

ID=5926793

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO753230A NO753230L (fr)	1974-09-24	1975-09-23

Country Status (27)

Country	Link
US (1)	US4012497A (fr)
JP (1)	JPS5161618A (fr)
AT (1)	AT347588B (fr)
AU (1)	AU498204B2 (fr)
BE (1)	BE833762A (fr)
BG (1)	BG27880A3 (fr)
CA (1)	CA1049408A (fr)
CH (1)	CH624580A5 (fr)
DD (1)	DD122197A5 (fr)
DE (1)	DE2445971A1 (fr)
DK (1)	DK143384C (fr)
EG (1)	EG11859A (fr)
ES (1)	ES441203A1 (fr)
FI (1)	FI58871C (fr)
FR (1)	FR2285895A1 (fr)
GB (1)	GB1521505A (fr)
HU (1)	HU175675B (fr)
IE (1)	IE41717B1 (fr)
IL (1)	IL48100A (fr)
IN (1)	IN142359B (fr)
IT (1)	IT1042731B (fr)
NL (1)	NL7511244A (fr)
NO (1)	NO753230L (fr)
PL (1)	PL105375B1 (fr)
SE (1)	SE7510658L (fr)
SU (1)	SU605547A3 (fr)
ZA (1)	ZA756082B (fr)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4155991A (en) *	1974-10-18	1979-05-22	Schering Aktiengesellschaft	Vaginal ring
US4219016A (en) *	1978-12-07	1980-08-26	The Procter & Gamble Company	Vaginal contraceptive
US4191741A (en) *	1978-09-22	1980-03-04	Eli Lilly And Company	Removable drug implant
US4292965A (en) *	1978-12-29	1981-10-06	The Population Council, Inc.	Intravaginal ring
US4200090A (en) *	1979-01-15	1980-04-29	The Procter & Gamble Company	Vaginal contraceptive and method of using
US4264576A (en) *	1979-06-28	1981-04-28	Eli Lilly And Company	Contraceptive methods and compositions
US4479795A (en) *	1979-06-29	1984-10-30	The Procter & Gamble Company	Antimicrobial polymer compositions
US4343788A (en) *	1979-06-29	1982-08-10	The Procter & Gamble Company	Antimicrobial polymer compositions
US4264578A (en) *	1979-07-16	1981-04-28	Eli Lilly And Company	Contraceptive methods and compositions
US4264575A (en) *	1979-07-16	1981-04-28	Eli Lilly And Company	Contraceptive methods and compositions
US4264577A (en) *	1979-08-03	1981-04-28	Eli Lilly And Company	Contraceptive methods and compositions
US4341728A (en) *	1979-12-20	1982-07-27	The Population Council, Inc.	Method for making an IUD with shrinking of a medicated attachment onto a support
US4304226A (en) *	1980-03-03	1981-12-08	The Procter & Gamble Company	Vaginal contraceptive
AU538961B2 (en) *	1980-06-09	1984-09-06	Alex Harvey Industries Limited	Intra-vaginal device
DE3040978A1 (de) *	1980-10-28	1982-05-27	Schering Ag, 1000 Berlin Und 4619 Bergkamen	Vaginalring
EP0076068A3 (fr) *	1981-09-25	1985-05-15	Beecham Group Plc	Compositions vétérinaires intramammaires et méthode pour leur utilisation
NZ200564A (en) *	1982-05-10	1987-03-06	Ahi Operations Ltd	Device for slowly releasing chemicals into body cavities of animals
US4435180A (en)	1982-05-25	1984-03-06	Alza Corporation	Elastomeric active agent delivery system and method of use
US4563184A (en) *	1983-10-17	1986-01-07	Bernard Korol	Synthetic resin wound dressing and method of treatment using same
FR2560768A1 (fr) *	1984-03-07	1985-09-13	Crb Virbac Sa	Dispositif a liberation programmee
JPS61503003A (ja) *	1984-04-19	1986-12-25	ユニバ−シテイ−　オブ　クイ−ンスランド	避妊方法、避妊用製剤及び避妊具
US4673565A (en) *	1985-05-03	1987-06-16	E. I. Du Pont De Nemours And Company	Pharmaceutical compositions containing hollow fine tubular drug delivery systems
NZ217844A (en) *	1985-10-11	1989-10-27	Sumitomo Pharma	A sustained release pharmaceutical composition containing silicone elastomer and an albumin
US5560922A (en) *	1986-05-30	1996-10-01	Rutgers, The State University Of New Jersey	Transdermal absorption dosage unit using a polyacrylate adhesive polymer and process
FR2611735B1 (fr) *	1987-02-26	1989-06-16	Rhone Poulenc Chimie	Composition elastomere silicone polyaddition contenant de l'iode pour le traitement de l'eau
FR2611733B1 (fr) *	1987-02-26	1989-06-16	Rhone Poulenc Chimie	Composition a base de gomme diorganopolysiloxane contenant de l'iode pour le traitement des eaux
FR2611734B1 (fr) *	1987-02-26	1989-06-16	Rhone Poulenc Chimie	Composition elastomere silicone polycondensation contenant de l'iode pour le traitement des eaux
US5238679A (en) *	1987-02-26	1993-08-24	Rhone-Poulenc Chimie	Diorganopolysiloxane dosage forms for the controlled release of iodine values
US4879304A (en) *	1987-05-01	1989-11-07	Angelini Pharmaceuticals Ltd.	Ophthalmic compositions and process for preparing
HU197519B (en) *	1987-06-22	1989-04-28	Biogal Gyogyszergyar	Process for producing medicine form capable for penetrating through epidermis and suitable for intaking the agent through epidermis by kinetics of zero-grade
DE3727180A1 (de) *	1987-08-14	1989-02-23	Wacker Chemie Gmbh	Waessrige silicondispersionen
US4867968A (en) *	1987-12-29	1989-09-19	Florida-Kansas Health Care, Inc.	Elastomeric composition containing therapeutic agents and articles manufactured therefrom
US5019378A (en) *	1987-12-29	1991-05-28	Cuno, Incorporated	Elastomeric composition containing therapeutic agents and articles manufactured therefrom
US5019601A (en) *	1987-12-29	1991-05-28	Cuno, Incorporated	Elastomeric composition containing therapeutic agents and articles manufactured therefrom
US4879294A (en) *	1988-01-28	1989-11-07	Angelini Pharmaceuticals Ltd.	Opthalmic composition
US4906475A (en) *	1988-02-16	1990-03-06	Paco Pharmaceutical Services	Estradiol transdermal delivery system
JP2590358B2 (ja) *	1988-03-01	1997-03-12	正雄五十嵐	子宮内膜症治療用の子宮内又は膣内投与製剤
DE3838815A1 (de) *	1988-11-17	1990-05-23	Hoechst Ag	Verfahren zum herstellen eines intravaginalen applikationssystems
GB2252497B (en) *	1991-02-04	1995-01-18	Elsimar Metzker Coutinho	Pharmaceutical composition
US5620499A (en) *	1992-12-14	1997-04-15	Farley; James J.	Chemical dispensing device and method
US5505963A (en) *	1993-04-07	1996-04-09	Schwartz Pharma Ag	Slow release pharmaceutical preparation
TWI246928B (en) *	1998-09-10	2006-01-11	Sumitomo Pharma	Long time drug-sustained release preparation
US6787531B1 (en) *	1999-08-31	2004-09-07	Schering Ag	Pharmaceutical composition for use as a contraceptive
JP2006500115A (ja)	2000-11-16	2006-01-05	マイクロスフエリツクス・エル・エル・シー	密封小線源治療用の可撓性および／または弾性シードまたはストランド
IL157771A0 (en) *	2001-03-27	2004-03-28	Galen Chemicals Ltd	Intravaginal drug delivery devices for the administration of an antimicrobial agent
EP1494646B2 (fr) *	2002-03-27	2017-10-04	Warner Chilcott (Ireland) Limited	Dispositifs d'apport par voie vaginale d'un medicament present dans une matrice
ES2335008T3 (es) *	2003-04-24	2010-03-18	Jagotec Ag	Comprimido con nucleo coloreado.
WO2006026844A1 (fr) *	2004-09-09	2006-03-16	Biolab Sanus Farmacêutica Ltda.	Composition hormonale a liberation differee a base de polyorganosiloxanes ou d'ethylene-acetate de vinyle, son procede de fabrication
US7862552B2 (en) *	2005-05-09	2011-01-04	Boston Scientific Scimed, Inc.	Medical devices for treating urological and uterine conditions
PT2049123E (pt)	2006-08-03	2013-03-06	Horizon Pharma Ag	Tratamento de doença reumatóide com glucocorticóide de libertação retardada
US20090269403A1 (en) *	2008-04-24	2009-10-29	Shaked Ze Ev	Oral contraceptive dosage forms and methods of making such dosage forms
US20100040671A1 (en) *	2008-08-12	2010-02-18	Ahmed Salah U	Intravaginal Devices With a Rigid Support, Methods of Making, and Uses Thereof
US8420153B2 (en) *	2008-09-19	2013-04-16	Mentor Worldwide Llc	Coating with antimicrobial agents
US8419793B2 (en) *	2008-09-19	2013-04-16	Mentor Worldwide Llc	Coating with antimicrobial agents
EP2391369A1 (fr) *	2009-01-26	2011-12-07	Nitec Pharma AG	Traitement de l'asthme par glucocorticoïde à libération retardée
EP2566535A4 (fr) *	2010-05-03	2013-12-18	Izhar Halahmi	Dispositif d'administration d'un agent bioactif
US8580294B2 (en)	2010-10-19	2013-11-12	International Partnership For Microbicides	Platinum-catalyzed intravaginal rings
US10137031B2 (en)	2013-11-14	2018-11-27	International Partnership For Microbicides, Inc.	Combination therapy intravaginal rings
KR20170021929A (ko) *	2014-06-28	2017-03-02	라보라토리오스 안드로마코 에스.에이.	조산 예방에 유용한 지속적, 서방성, 및 연속 방출의 프로게스테론 함유 원형 결찰 페서리
WO2016028774A1 (fr)	2014-08-19	2016-02-25	The Regents Of The University Of California	Implants pour l'administration localisée de médicament et procédés pour les utiliser
US11344526B2 (en)	2020-03-20	2022-05-31	The Regents Of The University Of California	Implantable drug delivery devices for localized drug delivery
US11338119B2 (en) *	2020-03-20	2022-05-24	The Regents Of The University Of California	Implantable drug delivery devices for localized drug delivery
US11173291B2 (en) *	2020-03-20	2021-11-16	The Regents Of The University Of California	Implantable drug delivery devices for localized drug delivery
CA3171976A1 (fr)	2020-03-20	2021-09-23	Carlos Schuler	Dispositifs implantables d'administration de medicament pour administration localisee de medicament
AU2024339675A1 (en) *	2023-09-13	2026-04-30	Shenyang Xinghua Pharmaceutical Technology Co., Ltd	Pharmaceutical composition, drug-loaded rod core, implant, preparation method therefor, and use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3279996A (en) *	1962-08-28	1966-10-18	Jr David M Long	Polysiloxane carrier for controlled release of drugs and other agents
US3545439A (en) *	1968-01-04	1970-12-08	Upjohn Co	Medicated devices and methods
US3920805A (en) *	1971-12-09	1975-11-18	Upjohn Co	Pharmaceutical devices and method

1974
- 1974-09-24 DE DE19742445971 patent/DE2445971A1/de active Pending
1975
- 1975-08-27 IN IN1660/CAL/75A patent/IN142359B/en unknown
- 1975-09-10 EG EG540/75A patent/EG11859A/xx active
- 1975-09-12 IL IL48100A patent/IL48100A/xx unknown
- 1975-09-15 BG BG030981A patent/BG27880A3/xx unknown
- 1975-09-18 IE IE2049/75A patent/IE41717B1/en unknown
- 1975-09-22 AU AU85064/75A patent/AU498204B2/en not_active Expired
- 1975-09-22 DD DD188480A patent/DD122197A5/xx unknown
- 1975-09-22 AT AT724275A patent/AT347588B/de not_active IP Right Cessation
- 1975-09-23 ES ES441203A patent/ES441203A1/es not_active Expired
- 1975-09-23 GB GB38945/75A patent/GB1521505A/en not_active Expired
- 1975-09-23 CH CH1229875A patent/CH624580A5/de not_active IP Right Cessation
- 1975-09-23 HU HU75SCHE537A patent/HU175675B/hu unknown
- 1975-09-23 NO NO753230A patent/NO753230L/no unknown
- 1975-09-23 IT IT27536/75A patent/IT1042731B/it active
- 1975-09-23 SE SE7510658A patent/SE7510658L/xx unknown
- 1975-09-23 FI FI752660A patent/FI58871C/fi not_active IP Right Cessation
- 1975-09-23 US US05/616,001 patent/US4012497A/en not_active Expired - Lifetime
- 1975-09-23 SU SU752174604A patent/SU605547A3/ru active
- 1975-09-24 BE BE160326A patent/BE833762A/fr unknown
- 1975-09-24 DK DK428175A patent/DK143384C/da active
- 1975-09-24 FR FR7529205A patent/FR2285895A1/fr active Granted
- 1975-09-24 ZA ZA00756082A patent/ZA756082B/xx unknown
- 1975-09-24 CA CA236,245A patent/CA1049408A/fr not_active Expired
- 1975-09-24 NL NL7511244A patent/NL7511244A/xx not_active Application Discontinuation
- 1975-09-24 PL PL1975183556A patent/PL105375B1/pl unknown
- 1975-09-25 JP JP50115955A patent/JPS5161618A/ja active Pending

Also Published As

Publication number	Publication date
FI58871C (fi)	1981-05-11
EG11859A (en)	1978-03-29
CA1049408A (fr)	1979-02-27
SE7510658L (sv)	1976-03-25
ZA756082B (en)	1976-09-29
ES441203A1 (es)	1977-03-16
BE833762A (fr)	1976-03-24
FI752660A7 (fr)	1976-03-25
PL105375B1 (pl)	1979-10-31
DK428175A (da)	1976-03-25
IN142359B (fr)	1977-06-25
JPS5161618A (fr)	1976-05-28
PL183556A1 (en)	1978-04-24
DK143384B (da)	1981-08-17
ATA724275A (de)	1978-05-15
DD122197A5 (fr)	1976-09-20
SU605547A3 (ru)	1978-04-30
IE41717L (en)	1976-03-24
HU175675B (hu)	1980-09-28
BG27880A3 (bg)	1980-01-15
FR2285895B1 (fr)	1980-05-09
IT1042731B (it)	1980-01-30
NL7511244A (nl)	1976-03-26
DE2445971A1 (de)	1976-04-08
IE41717B1 (en)	1980-03-12
IL48100A (en)	1979-01-31
AU8506475A (en)	1977-03-31
DK143384C (da)	1981-12-14
IL48100A0 (en)	1975-11-25
AU498204B2 (en)	1979-02-22
CH624580A5 (fr)	1981-08-14
GB1521505A (en)	1978-08-16
FR2285895A1 (fr)	1976-04-23
AT347588B (de)	1979-01-10
US4012497A (en)	1977-03-15
FI58871B (fi)	1981-01-30

Publication	Publication Date	Title
FI58871C (fi)	1981-05-11	Laekemedelsbaerare innehaollande en siloxanelastomer
US4230686A (en)	1980-10-28	Drug excipient of silicone rubber
US3887699A (en)	1975-06-03	Biodegradable polymeric article for dispensing drugs
US3991766A (en)	1976-11-16	Controlled release of medicaments using polymers from glycolic acid
CN1184957C (zh)	2005-01-19	用于给药睾酮和睾酮前体的阴道内给药装置
KR101592615B1 (ko)	2016-02-05	자궁내 시스템
US4012496A (en)	1977-03-15	Vaginal ring
DE69003347T2 (de)	1994-02-17	Elemente mit protrahierter Wirkstoffabgabe.
TW381024B (en)	2000-02-01	Contraceptive composition in the form of subcutaneous implants of a matrix type and a method for producing them
JP7248614B2 (ja)	2023-03-29	避妊具及び関連した器具
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RU2412693C2 (ru)	2011-02-27	Система доставки
EP2953595A1 (fr)	2015-12-16	Dispositif intravaginal, et procédé de réduction de la vitesse de diffusion d'ingrédients actifs dans ledit dispositif intravaginal
IE42324B1 (en)	1980-07-16	Pharmaceutical preparations containing silicone rubber
WO2020229733A1 (fr)	2020-11-19	Dispositif de libération contrôlée pour cavité buccale
CN113509448A (zh)	2021-10-19	一种可生物降解控释长效植入片及其制备方法
PL90082B1 (fr)	1976-12-31
CN100423792C (zh)	2008-10-08	缓释型睾丸假体及其应用
JP2003221338A (ja)	2003-08-05	子宮腺筋症治療製剤
JPS63203610A (ja)	1988-08-23	複数成分からなるインプラント用の持効性医薬製剤
CN116726370A (zh)	2023-09-12	聚合物微针、微针片及递送系统、制备方法、应用
WO2025054598A2 (fr)	2025-03-13	Implant sous-cutané biodégradable pour l'administration d'agents thérapeutiques d'une manière pulsatile contrôlée ou prolongée
WO2006026844A1 (fr)	2006-03-16	Composition hormonale a liberation differee a base de polyorganosiloxanes ou d'ethylene-acetate de vinyle, son procede de fabrication
Nanjwade et al.	2012	SILICON BASED DRUG DELIVERY SYSTEM
WO2006006054A1 (fr)	2006-01-19	Elaboration d'un systeme polymere biocompatible pour liberation de substance pharmaceutique en application locale, et utilisation de ce systeme