NO790319L - Fremgangsmaate ved fremstilling av monorden - Google Patents

Fremgangsmaate ved fremstilling av monorden

Info

Publication number: NO790319L
Authority: NO; Norway
Prior art keywords: monorder; nutrient solution; approx; procedures; manufacturing
Prior art date: 1978-02-01

Application number

NO790319A

Other languages

English (en)

Norwegian (no)

Inventor

Gary Jim Calton

Marlin Alwine Espenshade

Original Assignee

Grace W R & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-02-01

Filing date

1979-01-31

Publication date

1979-08-02

1979-01-31 Application filed by Grace W R & Co filed Critical Grace W R & Co

1979-08-02 Publication of NO790319L publication Critical patent/NO790319L/no

Links

238000000034 method Methods 0.000 title claims description 17
238000004519 manufacturing process Methods 0.000 title claims description 4
235000015097 nutrients Nutrition 0.000 claims description 11
239000000284 extract Substances 0.000 claims description 5
239000002904 solvent Substances 0.000 claims description 5
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical class N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 4
239000000178 monomer Substances 0.000 claims description 4
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical class [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 2
229910052799 carbon Inorganic materials 0.000 claims description 2
229910052500 inorganic mineral Chemical class 0.000 claims description 2
239000011707 mineral Chemical class 0.000 claims description 2
229910052757 nitrogen Inorganic materials 0.000 claims description 2
150000003839 salts Chemical class 0.000 claims description 2
238000000638 solvent extraction Methods 0.000 claims description 2
238000002955 isolation Methods 0.000 claims 1
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 9
241000754833 Pochonia chlamydosporia Species 0.000 description 6
239000002609 medium Substances 0.000 description 5
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
238000000855 fermentation Methods 0.000 description 4
230000004151 fermentation Effects 0.000 description 4
229920001817 Agar Polymers 0.000 description 3
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
239000008272 agar Substances 0.000 description 3
238000000605 extraction Methods 0.000 description 3
239000001965 potato dextrose agar Substances 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
241000233866 Fungi Species 0.000 description 2
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
238000010521 absorption reaction Methods 0.000 description 2
239000002518 antifoaming agent Substances 0.000 description 2
238000004821 distillation Methods 0.000 description 2
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
239000000741 silica gel Substances 0.000 description 2
229910002027 silica gel Inorganic materials 0.000 description 2
239000000126 substance Substances 0.000 description 2
239000000725 suspension Substances 0.000 description 2
239000006150 trypticase soy agar Substances 0.000 description 2
PAWQVTBBRAZDMG-UHFFFAOYSA-N 2-(3-bromo-2-fluorophenyl)acetic acid Chemical compound OC(=O)CC1=CC=CC(Br)=C1F PAWQVTBBRAZDMG-UHFFFAOYSA-N 0.000 description 1
DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 description 1
239000004375 Dextrin Substances 0.000 description 1
229920001353 Dextrin Polymers 0.000 description 1
241000223198 Humicola Species 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
241000364057 Peoria Species 0.000 description 1
XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
240000004808 Saccharomyces cerevisiae Species 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
239000002250 absorbent Substances 0.000 description 1
230000002745 absorbent Effects 0.000 description 1
KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 description 1
PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
150000001413 amino acids Chemical class 0.000 description 1
BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
229910052921 ammonium sulfate Inorganic materials 0.000 description 1
239000001166 ammonium sulphate Substances 0.000 description 1
235000011130 ammonium sulphate Nutrition 0.000 description 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
238000007664 blowing Methods 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
239000013078 crystal Substances 0.000 description 1
235000019425 dextrin Nutrition 0.000 description 1
239000008121 dextrose Substances 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
238000009826 distribution Methods 0.000 description 1
239000003480 eluent Substances 0.000 description 1
238000010828 elution Methods 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
235000013305 food Nutrition 0.000 description 1
239000011521 glass Substances 0.000 description 1
239000008103 glucose Substances 0.000 description 1
235000001727 glucose Nutrition 0.000 description 1
239000001963 growth medium Substances 0.000 description 1
FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
238000011081 inoculation Methods 0.000 description 1
239000002054 inoculum Substances 0.000 description 1
239000008101 lactose Substances 0.000 description 1
239000007788 liquid Substances 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
230000005291 magnetic effect Effects 0.000 description 1
235000013372 meat Nutrition 0.000 description 1
230000008018 melting Effects 0.000 description 1
238000002844 melting Methods 0.000 description 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
235000010755 mineral Nutrition 0.000 description 1
239000000203 mixture Substances 0.000 description 1
VYGYNVZNSSTDLJ-HKCOAVLJSA-N monorden Natural products CC1CC2OC2C=C/C=C/C(=O)CC3C(C(=CC(=C3Cl)O)O)C(=O)O1 VYGYNVZNSSTDLJ-HKCOAVLJSA-N 0.000 description 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
AECPBJMOGBFQDN-YMYQVXQQSA-N radicicol Chemical compound C1CCCC(=O)C[C@H]2[C@H](Cl)C(=O)CC(=O)[C@H]2C(=O)O[C@H](C)C[C@H]2O[C@@H]21 AECPBJMOGBFQDN-YMYQVXQQSA-N 0.000 description 1
229930192524 radicicol Natural products 0.000 description 1
238000012827 research and development Methods 0.000 description 1
241000894007 species Species 0.000 description 1
230000003595 spectral effect Effects 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
230000003068 static effect Effects 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
235000013619 trace mineral Nutrition 0.000 description 1
239000011573 trace mineral Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Compounds Of Unknown Constitution (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Epoxy Compounds (AREA)

NO790319A 1978-02-01 1979-01-31 Fremgangsmaate ved fremstilling av monorden NO790319L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/874,207 US4166764A (en)	1978-02-01	1978-02-01	Production of monorden

Publications (1)

Publication Number	Publication Date
NO790319L true NO790319L (no)	1979-08-02

Family

ID=25363230

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO790319A NO790319L (no)	1978-02-01	1979-01-31	Fremgangsmaate ved fremstilling av monorden

Country Status (8)

Country	Link
US (1)	US4166764A (fr)
JP (1)	JPS54163896A (fr)
BE (1)	BE873855A (fr)
CA (1)	CA1109406A (fr)
DK (1)	DK40479A (fr)
FR (1)	FR2416230A1 (fr)
IT (1)	IT1110770B (fr)
NO (1)	NO790319L (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE911915A1 (en) *	1990-06-06	1991-12-18	Sankyo Co	Radicicol derivatives, their preparation and their¹anti-tumor activity
US5650430A (en) *	1990-06-06	1997-07-22	Sankyo Company, Limited	Radicicol derivatives, their preparation and their anti-tumor activity
US5731343A (en) *	1995-02-24	1998-03-24	The Scripps Research Institute	Method of use of radicicol for treatment of immunopathological disorders
EP1315732B1 (fr) *	2000-08-25	2006-06-07	Sloan-Kettering Institute For Cancer Research	Radicicol et monocillin et leurs analogues et leurs utilisations
US20080108694A1 (en) *	2003-12-19	2008-05-08	Samuel J Danishefsky	Novel Macrocycles and Uses Thereof
CN107955802A (zh) *	2017-12-05	2018-04-24	福建农林大学	一种厚垣孢普可尼亚菌固体发酵产孢的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH441623A (de) *	1964-05-20	1967-08-15	Sandoz Ag	Verfahren zur Herstellung neuer Antibiotica
CH516640A (de) *	1969-03-18	1971-12-15	Sandoz Ag	Verfahren zur Herstellung eines neuen Antibioticums

1978
- 1978-02-01 US US05/874,207 patent/US4166764A/en not_active Expired - Lifetime
1979
- 1979-01-02 CA CA318,958A patent/CA1109406A/fr not_active Expired
- 1979-01-29 JP JP830179A patent/JPS54163896A/ja active Pending
- 1979-01-30 IT IT19718/79A patent/IT1110770B/it active
- 1979-01-31 BE BE193202A patent/BE873855A/fr unknown
- 1979-01-31 DK DK40479A patent/DK40479A/da not_active Application Discontinuation
- 1979-01-31 NO NO790319A patent/NO790319L/no unknown
- 1979-02-01 FR FR7902670A patent/FR2416230A1/fr not_active Withdrawn

Also Published As

Publication number	Publication date
IT1110770B (it)	1986-01-06
DK40479A (da)	1979-08-02
JPS54163896A (en)	1979-12-26
BE873855A (fr)	1979-05-16
CA1109406A (fr)	1981-09-22
US4166764A (en)	1979-09-04
IT7919718A0 (it)	1979-01-30
FR2416230A1 (fr)	1979-08-31

Publication	Publication Date	Title
IE893482L (en)	1990-04-28	The glycosidase inhibitor salbostatin, process for its¹preparation, and its use
JPS5910798B2 (ja)	1984-03-12	新しいリフアマイシン類の製造方法
CA1181746A (fr)	1985-01-29	Mycarosyltylactone
US3546073A (en)	1970-12-08	Fusarium fermentation
CA1109406A (fr)	1981-09-22	Production de monorden
CA1079213A (fr)	1980-06-10	Antibiotique et procede de fabrication
US4366247A (en)	1982-12-28	Process for preparing tylactone
US3428526A (en)	1969-02-18	Production of radicicol
US4440857A (en)	1984-04-03	Process for preparing mycarosyltylactone
US2689854A (en)	1954-09-21	Acetopyrrothine and preparation thereof
Venkata Dasu et al.	1999	Studies on production of griseofulvin
US3959468A (en)	1976-05-25	Antibiotic equisetin and method of production
US3701787A (en)	1972-10-31	Preparation of 5,6-dihydro-5-hydroxy-6-propenyl-2-pyrone by fermentation and derivatives thereof
US4362881A (en)	1982-12-07	Tylactone
US3465079A (en)	1969-09-02	Antibiotic sl 1846
US3467579A (en)	1969-09-16	Microbiological process for the production of lycopene
US5397570A (en)	1995-03-14	Antibiotics AB-023 and process for preparing them
US3775433A (en)	1973-11-27	Antimicrobial metabolite s491beta and s491ypsilon and chemical derivatives
US3433710A (en)	1969-03-18	Process for the preparation of 7-chloro-5-hydroxytetracycline
US3701790A (en)	1972-10-31	Antibiotic sphaeropsidin
US4859655A (en)	1989-08-22	Urdamycin G and derivatives thereof, a process for their preparation and their use
US3647776A (en)	1972-03-07	1-hydroxy- and acetyloxy-3-(1-hexenylazoxy)-2-butanone
US3577530A (en)	1971-05-04	Janiemycin
US3555075A (en)	1971-01-12	Novel antifungal agents
US3743635A (en)	1973-07-03	27-demethoxy-27-hydroxyrifamycin derivatives