NO791474L - Fremgangsmaate ved fremstilling av substituerte 8-hydroxy-1-fenyl-2,3,4,5-tetrahydro-1h-3-benzazepiner - Google Patents

Fremgangsmaate ved fremstilling av substituerte 8-hydroxy-1-fenyl-2,3,4,5-tetrahydro-1h-3-benzazepiner

Info

Publication number: NO791474L
Authority: NO; Norway
Prior art keywords: phenyl; formula; tetrahydro; benzazepine; compound
Prior art date: 1978-05-08

Application number

NO791474A

Other languages

English (en)

Norwegian (no)

Inventor

Elijah H Gold

Wei Chang

Original Assignee

Scherico Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-05-08

Filing date

1979-05-03

Publication date

1979-11-09

1979-05-03 Application filed by Scherico Ltd filed Critical Scherico Ltd

1979-11-09 Publication of NO791474L publication Critical patent/NO791474L/no

Links

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238000006243 chemical reaction Methods 0.000 claims description 18
239000002253 acid Substances 0.000 claims description 15
150000003839 salts Chemical class 0.000 claims description 13
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 8
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 6
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 6
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239000000460 chlorine Substances 0.000 claims description 6
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230000008569 process Effects 0.000 claims description 6
MEXPXLPUVFBQGJ-UHFFFAOYSA-N 5-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepine Chemical class C1NCCC2=CC=CC=C2C1C1=CC=CC=C1 MEXPXLPUVFBQGJ-UHFFFAOYSA-N 0.000 claims description 5
125000001309 chloro group Chemical group Cl* 0.000 claims description 5
GOTMKOSCLKVOGG-HNNXBMFYSA-N (5s)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol Chemical group C1([C@H]2C3=CC(O)=C(Cl)C=C3CCN(C2)C)=CC=CC=C1 GOTMKOSCLKVOGG-HNNXBMFYSA-N 0.000 claims description 4
SNXWZKKKYZCZRK-UHFFFAOYSA-N 5-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepin-7-ol Chemical class C12=CC(O)=CC=C2CCNCC1C1=CC=CC=C1 SNXWZKKKYZCZRK-UHFFFAOYSA-N 0.000 claims description 4
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238000005984 hydrogenation reaction Methods 0.000 claims description 3
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VOZUARFUPJPSMU-UHFFFAOYSA-N 1-phenyl-2,3-dihydro-1h-3-benzazepine Chemical compound C1NC=CC2=CC=CC=C2C1C1=CC=CC=C1 VOZUARFUPJPSMU-UHFFFAOYSA-N 0.000 claims description 2
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

NO791474A 1978-05-08 1979-05-03 Fremgangsmaate ved fremstilling av substituerte 8-hydroxy-1-fenyl-2,3,4,5-tetrahydro-1h-3-benzazepiner NO791474L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US90362378A	1978-05-08	1978-05-08

Publications (1)

Publication Number	Publication Date
NO791474L true NO791474L (no)	1979-11-09

Family

ID=25417804

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
NO791475A NO791475L (no)	1978-05-08	1979-05-03	Fremgangsmaate ved fremstilling av substituerte 1-fenyl-2,3,4,5-tetrahydro-1h-3-benzazepiner
NO791476A NO791476L (no)	1978-05-08	1979-05-03	Fremgangsmaate ved fremstilling av estere av substituerte 8-hydroxy-1-fenyl-2,3,4,5-tetrahydro-1h-3-benzazepiner
NO791474A NO791474L (no)	1978-05-08	1979-05-03	Fremgangsmaate ved fremstilling av substituerte 8-hydroxy-1-fenyl-2,3,4,5-tetrahydro-1h-3-benzazepiner

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
NO791475A NO791475L (no)	1978-05-08	1979-05-03	Fremgangsmaate ved fremstilling av substituerte 1-fenyl-2,3,4,5-tetrahydro-1h-3-benzazepiner
NO791476A NO791476L (no)	1978-05-08	1979-05-03	Fremgangsmaate ved fremstilling av estere av substituerte 8-hydroxy-1-fenyl-2,3,4,5-tetrahydro-1h-3-benzazepiner

Country Status (8)

Country	Link
EP (3)	EP0005300A1 (da)
JP (3)	JPS54145687A (da)
AU (2)	AU4668779A (da)
DK (3)	DK184679A (da)
FI (3)	FI791426A7 (da)
IL (3)	IL57213A (da)
NO (3)	NO791475L (da)
ZA (3)	ZA792043B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4284556A (en) *	1980-01-31	1981-08-18	Smithkline Corporation	7,8-Amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
CA1234110A (en) *	1983-08-12	1988-03-15	Joel G. Berger	Benzazepine derivatives, pharmaceutical compositions containing them and processes for the preparation of such compounds and compositions
US5015639A (en) *	1987-03-27	1991-05-14	Schering Corporation	Substituted benzazepines, their preparation and pharmaceutical compositions containing them
GB8800891D0 (en) *	1988-01-15	1988-02-17	Lilly Industries Ltd	Pharmaceutical compounds
DK107688D0 (da) *	1988-03-01	1988-03-01	Novo Industri As	Carbaminsyreestere af substituerede 7-hydroxy-2,3,4,5-tetrahydro-1h-3-benzazepiner
DK325188D0 (da) *	1988-06-15	1988-06-15	Novo Industri As	Hidtil ukendte benzazepinderivater
US4861771A (en) *	1989-01-27	1989-08-29	Smithkline Beckman Corporation	Carbamates of 6-chloro-7,8-dihydroxy-1-(4'-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine as prodrugs
DK67489D0 (da) *	1989-02-14	1989-02-14	Novo Industri As	Nye benzazepinderivater
US5276992A (en) *	1992-06-29	1994-01-11	Daiwa Seiko, Inc.	Lure
AU2001271018A1 (en) *	2000-07-04	2002-01-14	Takeda Chemical Industries Ltd.	Gpr14 antagonist

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1118688A (en) *	1967-02-17	1968-07-03	Scherico Ltd	Novel benzazepines and process for making same
CA974989A (en) *	1968-03-11	1975-09-23	Wallace And Tiernan Inc.	Process for preparing 1,2,4,5-tetrahydro-3h,3-benzazepines and products obtained thereby
US4160765A (en) *	1976-11-17	1979-07-10	Smithkline Corporation	Method for 6-bromination of 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds
DE2658450C3 (de) *	1976-12-23	1979-06-21	Kukident Kurt Krisp Kg, 6940 Weinheim	Reinigungstablette zum selbsttätigen Reinigen von Zahnprothesen in wäßriger Lösung sowie Verfahren zu ihrer Her-

1979
- 1979-04-27 ZA ZA792043A patent/ZA792043B/xx unknown
- 1979-04-27 ZA ZA792044A patent/ZA792044B/xx unknown
- 1979-04-27 ZA ZA792042A patent/ZA792042B/xx unknown
- 1979-05-02 EP EP79200209A patent/EP0005300A1/en not_active Withdrawn
- 1979-05-02 EP EP79200207A patent/EP0005298A1/en not_active Withdrawn
- 1979-05-02 EP EP79200208A patent/EP0005299A1/en not_active Withdrawn
- 1979-05-03 FI FI791426A patent/FI791426A7/fi not_active Application Discontinuation
- 1979-05-03 NO NO791475A patent/NO791475L/no unknown
- 1979-05-03 NO NO791476A patent/NO791476L/no unknown
- 1979-05-03 FI FI791425A patent/FI791425A7/fi not_active Application Discontinuation
- 1979-05-03 FI FI791424A patent/FI791424A7/fi not_active Application Discontinuation
- 1979-05-03 NO NO791474A patent/NO791474L/no unknown
- 1979-05-04 IL IL57213A patent/IL57213A/xx unknown
- 1979-05-04 IL IL57215A patent/IL57215A0/xx unknown
- 1979-05-04 AU AU46687/79A patent/AU4668779A/en not_active Abandoned
- 1979-05-04 JP JP5516579A patent/JPS54145687A/ja active Pending
- 1979-05-04 JP JP5516779A patent/JPS54145689A/ja active Pending
- 1979-05-04 DK DK184679A patent/DK184679A/da unknown
- 1979-05-04 JP JP5516679A patent/JPS54145688A/ja active Pending
- 1979-05-04 AU AU46685/79A patent/AU4668579A/en not_active Abandoned
- 1979-05-04 DK DK184579A patent/DK184579A/da unknown
- 1979-05-04 DK DK184779A patent/DK184779A/da not_active Application Discontinuation
- 1979-05-04 IL IL57214A patent/IL57214A0/xx unknown

Also Published As

Publication number	Publication date
EP0005300A1 (en)	1979-11-14
IL57213A (en)	1983-06-15
NO791476L (no)	1979-11-09
DK184679A (da)	1979-11-09
JPS54145688A (en)	1979-11-14
EP0005299A1 (en)	1979-11-14
AU4668779A (en)	1979-11-29
FI791426A7 (fi)	1981-01-01
IL57215A0 (en)	1979-09-30
IL57213A0 (en)	1979-09-30
AU4668579A (en)	1979-11-29
ZA792043B (en)	1980-05-28
EP0005298A1 (en)	1979-11-14
NO791475L (no)	1979-11-09
FI791425A7 (fi)	1981-01-01
ZA792042B (en)	1980-05-28
DK184579A (da)	1979-11-09
DK184779A (da)	1979-11-09
IL57214A0 (en)	1979-09-30
JPS54145687A (en)	1979-11-14
JPS54145689A (en)	1979-11-14
ZA792044B (en)	1980-05-28
FI791424A7 (fi)	1981-01-01

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JPS6365663B2 (da)	1988-12-16
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