NO803550L - Kardiotomisk virksomme 5-(pyridinyl)-2(1h)-pyridinoner, og fremgangsmaate til deres fremstilling - Google Patents

Kardiotomisk virksomme 5-(pyridinyl)-2(1h)-pyridinoner, og fremgangsmaate til deres fremstilling

Info

Publication number: NO803550L
Authority: NO; Norway
Prior art keywords: cardiotomic; pyridinones; pyridinyl; procedures; activity
Prior art date: 1979-11-26

Application number

NO803550A

Other languages

English (en)

Other versions

NO154345B (no

NO154345C (no

Inventor

George Yohe Lesher

Richard Everett Philion

Donald Frederick Page

Chester Joseph Opalka

Original Assignee

Sterling Drug Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-11-26

Filing date

1980-11-25

Publication date

1981-05-27

1980-03-28 Priority claimed from US06/135,100 external-priority patent/US4297360A/en

1980-10-20 Priority claimed from US06/198,461 external-priority patent/US4313951A/en

1980-11-25 Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc

1981-05-27 Publication of NO803550L publication Critical patent/NO803550L/no

1986-05-26 Publication of NO154345B publication Critical patent/NO154345B/no

1986-09-03 Publication of NO154345C publication Critical patent/NO154345C/no

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pyridine Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

NO803550A 1979-11-26 1980-11-25 Analogifremgangsmaate for fremstilling av kardiotonisk virksomme 5-(pyridinyl)-2(1h)-pyridinoner. NO154345C (no)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US9750479A	1979-11-26	1979-11-26
US06/135,100 US4297360A (en)	1980-03-28	1980-03-28	5-(Pyridinyl)pyridine-2,3-diamines, preparation thereof and their cardiotonic use
US06/198,461 US4313951A (en)	1979-11-26	1980-10-20	3-Substituted-6-(lower-alkyl)-5-(pyridinyl)-2(1H)-pyridinones, their cardiotonic use and intermediates therefor
US06/204,726 US4312875A (en)	1980-03-28	1980-11-06	5-(Pyridinyl)-6-(lower-alkyl)-2(1H)-pyridinones, 1,2-dihydro-2-oxo-5-(pyridinyl)-6-(lower-alkyl)nicotinic acids and lower-alkyl esters thereof, and cardiotonic use thereof

Publications (3)

Publication Number	Publication Date
NO803550L true NO803550L (no)	1981-05-27
NO154345B NO154345B (no)	1986-05-26
NO154345C NO154345C (no)	1986-09-03

Family

ID=27492921

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO803550A NO154345C (no)	1979-11-26	1980-11-25	Analogifremgangsmaate for fremstilling av kardiotonisk virksomme 5-(pyridinyl)-2(1h)-pyridinoner.
NO85854001A NO156127C (no)	1979-11-26	1985-10-09	1-pyridinyl-2(dialkylamino)-etenylalkylketoner.

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
NO85854001A NO156127C (no)	1979-11-26	1985-10-09	1-pyridinyl-2(dialkylamino)-etenylalkylketoner.

Country Status (20)

Country	Link
AT (1)	AT379387B (no)
CH (1)	CH649535A5 (no)
DE (1)	DE3044568A1 (no)
DK (1)	DK151799C (no)
ES (1)	ES507620A0 (no)
FI (1)	FI76564C (no)
FR (2)	FR2470124B1 (no)
GB (2)	GB2065642B (no)
GR (1)	GR71608B (no)
HK (2)	HK31189A (no)
IE (1)	IE50632B1 (no)
IL (2)	IL61501A (no)
IT (1)	IT1148740B (no)
LU (1)	LU82957A1 (no)
MX (1)	MX155904A (no)
NL (2)	NL192202C (no)
NO (2)	NO154345C (no)
NZ (1)	NZ195564A (no)
PT (1)	PT72106B (no)
SE (1)	SE442398B (no)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4305948A (en) *	1980-12-22	1981-12-15	Sterling Drug Inc.	N-Hydroxy-1,2-dihydro-2-oxo-5-(pyridinyl)-nicotinimidamide and their cardiotonic use
US4465686A (en) *	1981-09-08	1984-08-14	Sterling Drug Inc.	5-(Hydroxy- and/or amino-phenyl)-6-(lower-alkyl)-2-(1H)-pyridinones, their cardiotonic use and preparation
FR2529891A1 (fr) *	1982-07-12	1984-01-13	Nativelle Sa Ets	Derives du pyridyl-3 alcoxy-5 pyrazole, procede de preparation et application en therapeutique
IL69407A (en) *	1982-08-23	1987-10-20	Warner Lambert Co	2(1h)-pyridinones,their preparation and pharmaceutical compositions containing them
IL70169A0 (en) *	1982-11-18	1984-02-29	Sterling Drug Inc	2(1h)-pyridinones,their preparation and pharmaceutical compositions containing them
GB8414220D0 (en) *	1984-06-04	1984-07-11	Sterwin Ag	Medicaments in unit dose form
ES2072015T3 (es) *	1990-08-21	1995-07-01	Upjohn Co	Derivados del acido bisfosfonico como agente anti-artritico.
CZ403592A3 (en) *	1992-02-20	1993-12-15	Hoechst Ag	Arylcarbonylaminoalkyldihydrooxopyridines, process of their preparation and their use
US7772188B2 (en)	2003-01-28	2010-08-10	Ironwood Pharmaceuticals, Inc.	Methods and compositions for the treatment of gastrointestinal disorders
CA2591413A1 (en) *	2004-12-16	2006-06-22	Vertex Pharmaceuticals Incorporated	Pyrid-2-ones useful as inhibitors of tec family protein kinases for the treatment of inflammatory, proliferative and immunologically-mediated diseases
WO2007056457A2 (en)	2005-11-09	2007-05-18	Combinatorx, Incorporated	Methods, compositions, and kits for the treatment of medical conditions
EP2527360B1 (en)	2007-06-04	2015-10-28	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2810951B1 (en)	2008-06-04	2017-03-15	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP3241839B1 (en)	2008-07-16	2019-09-04	Bausch Health Ireland Limited	Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
ES2664873T3 (es)	2011-03-01	2018-04-23	Synergy Pharmaceuticals Inc.	Proceso de preparación de agonistas de guanilato ciclasa C
CN104023725B (zh)	2011-08-16	2019-04-26	卡迪欧拉有限公司	控释制剂
WO2013106547A1 (en)	2012-01-10	2013-07-18	President And Fellows Of Harvard College	Beta-cell replication promoting compounds and methods of their use
US9545446B2 (en)	2013-02-25	2017-01-17	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase and their uses
CA2905435A1 (en)	2013-03-15	2014-09-25	Synergy Pharmaceuticals Inc.	Compositions useful for the treatment of gastrointestinal disorders
CA2905438A1 (en)	2013-03-15	2014-09-25	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase and their uses
SI3004138T1 (sl)	2013-06-05	2024-07-31	Bausch Health Ireland Limited	Ultra čisti agonisti gvanilat ciklaze C, postopek za njihovo pripravo in uporabo
KR102456567B1 (ko)	2013-08-09	2022-10-19	알데릭스, 인코포레이티드	인산염 수송을 억제하기 위한 화합물 및 방법
JP2018500365A (ja)	2014-12-22	2018-01-11	カーディオラピーティーワイリミテッド	治療方法
WO2020237096A1 (en)	2019-05-21	2020-11-26	Ardelyx, Inc.	Combination for lowering serum phosphate in a patient

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4072746A (en) *	1975-10-14	1978-02-07	Sterling Drug Inc.	3-Amino-5-(pyridinyl)-2(1H)-pyridinones
US4004012A (en) *	1975-10-14	1977-01-18	Sterling Drug Inc.	3-Cyano-5-(pyridinyl)-2(1H)-pyridinones

1980
- 1980-11-17 IL IL61501A patent/IL61501A/xx not_active IP Right Cessation
- 1980-11-17 NZ NZ195564A patent/NZ195564A/xx unknown
- 1980-11-18 MX MX9577A patent/MX155904A/es unknown
- 1980-11-24 FI FI803652A patent/FI76564C/fi not_active IP Right Cessation
- 1980-11-24 IE IE2430/80A patent/IE50632B1/en not_active IP Right Cessation
- 1980-11-24 NL NL8006399A patent/NL192202C/nl not_active IP Right Cessation
- 1980-11-25 PT PT72106A patent/PT72106B/pt unknown
- 1980-11-25 FR FR8024998A patent/FR2470124B1/fr not_active Expired
- 1980-11-25 SE SE8008252A patent/SE442398B/sv not_active IP Right Cessation
- 1980-11-25 IT IT26218/80A patent/IT1148740B/it active
- 1980-11-25 NO NO803550A patent/NO154345C/no unknown
- 1980-11-25 DK DK501180A patent/DK151799C/da not_active IP Right Cessation
- 1980-11-26 GR GR63461A patent/GR71608B/el unknown
- 1980-11-26 AT AT0578080A patent/AT379387B/de not_active IP Right Cessation
- 1980-11-26 DE DE19803044568 patent/DE3044568A1/de active Granted
- 1980-11-26 GB GB8037856A patent/GB2065642B/en not_active Expired
- 1980-11-26 CH CH8783/80A patent/CH649535A5/fr not_active IP Right Cessation
- 1980-11-26 LU LU82957A patent/LU82957A1/fr unknown
1981
- 1981-12-01 ES ES507620A patent/ES507620A0/es active Granted
1983
- 1983-06-10 GB GB08315983A patent/GB2131421B/en not_active Expired
- 1983-09-28 IL IL69847A patent/IL69847A0/xx unknown
1984
- 1984-10-25 FR FR8416357A patent/FR2553767B1/fr not_active Expired
1985
- 1985-10-09 NO NO85854001A patent/NO156127C/no unknown
1989
- 1989-04-13 HK HK311/89A patent/HK31189A/xx not_active IP Right Cessation
1990
- 1990-10-11 HK HK830/90A patent/HK83090A/xx not_active IP Right Cessation
1997
- 1997-07-24 NL NL970028C patent/NL970028I2/nl unknown

Also Published As

Publication number	Publication date
DK151799B (da)	1988-01-04
HK31189A (en)	1989-04-21
DK501180A (da)	1981-05-27
FR2470124B1 (fr)	1986-12-19
GB2131421B (en)	1985-06-26
NL8006399A (nl)	1981-06-16
FI803652L (fi)	1981-05-27
NL970028I2 (nl)	1998-03-02
NO854001L (no)	1981-05-27
SE8008252L (sv)	1981-05-27
IE50632B1 (en)	1986-05-28
IE802430L (en)	1981-05-26
PT72106B (fr)	1981-09-29
DK151799C (da)	1988-06-20
SE442398B (sv)	1985-12-23
PT72106A (fr)	1980-12-01
IL61501A (en)	1984-06-29
AT379387B (de)	1985-12-27
IT1148740B (it)	1986-12-03
IT8026218A0 (it)	1980-11-25
FR2553767B1 (fr)	1987-01-16
NZ195564A (en)	1983-09-30
NO154345B (no)	1986-05-26
FI76564C (fi)	1988-11-10
ES8301920A1 (es)	1982-11-16
NO154345C (no)	1986-09-03
ES507620A0 (es)	1982-11-16
IL61501A0 (en)	1981-05-20
FR2553767A1 (fr)	1985-04-26
GB2065642B (en)	1984-04-04
NO156127B (no)	1987-04-21
FI76564B (fi)	1988-07-29
DE3044568C2 (no)	1990-11-29
MX155904A (es)	1988-05-23
NL192202C (nl)	1997-03-04
FR2470124A1 (fr)	1981-05-29
NL970028I1 (nl)	1997-10-01
NO156127C (no)	1987-07-29
ATA578080A (de)	1985-05-15
CH649535A5 (fr)	1985-05-31
GB2131421A (en)	1984-06-20
HK83090A (en)	1990-10-19
LU82957A1 (fr)	1981-06-04
DE3044568A1 (de)	1981-08-27
NL192202B (nl)	1996-11-01
GB2065642A (en)	1981-07-01
GB8315983D0 (en)	1983-07-13
IL69847A0 (en)	1983-12-30
GR71608B (no)	1983-06-17

Publication	Publication Date	Title
NO803550L (no)	1981-05-27	Kardiotomisk virksomme 5-(pyridinyl)-2(1h)-pyridinoner, og fremgangsmaate til deres fremstilling
DK119992A (da)	1992-09-28	Bicycliske, heterocycliske forbindelser og fremgangsmaade til deres fremstilling
DK92378A (da)	1978-09-04	Substituerede phenoxybenzyloxycarbonylderivater fremgangsmaade til deres femstilling og deres anvendelse som insecticider og acaricider
NO813142L (no)	1982-03-17	N-arylbenzamid-derivater og fremgangsmaate for deres fremstilling.
DK154777A (da)	1977-10-10	Substituerede phenoxybenzyloxycarbonylderivater fremgangsmade til deres fremstilling og deres anvendelse som insecticider og acaricider
DK401180A (da)	1981-03-25	Acylerede triazolyl-gamma-fluorpinacolylderivater fremgangsmaader til deres fremstilling og deres anvendelse som fungicider
NL7803165A (nl)	1978-09-27	Nieuwe 7-aminothiazolylaceetamidocefalosporaan- zuuroximverbindingen, werkwijze voor hun berei- ding en farmaceutische preparaten.
NO802027L (no)	1981-01-07	Nye substituerte heterocykliske fenoksyaminer og fremgangsmaate til deres fremstilling
NO780800L (no)	1978-09-12	Azoforbindelser og fremgangsmaate til deres fremstilling
DK582578A (da)	1979-06-30	2,4-thiazolidindion-derivater og fremgangsmaade til deres fremstilling
DK354777A (da)	1978-02-11	N-sulfenylerede oximcarbamater fremgangsmade til deres fremstilling og deres anvendelse som insecticider acaricider og nematodicider
DK111678A (da)	1978-09-15	Enzym-marumer og fremgangsmaade til deres fremstilling
BE868393A (fr)	1978-12-27	3-phenyl-4(1h)pyridones(thiones)5-substituees
DK308878A (da)	1979-02-19	Aminoglyosidderivater og fremgangsmaader til deres fremstilling
NO802138L (no)	1981-03-11	5-(4-pyridinyl)-2(ih)pyridinoner og fremgangsmaate til deres fremstilling
FI803973A7 (fi)	1981-06-27	3-asyyliamino-5-(pyridinyyli)-2(1H)- pyridinoneja sekä niiden valmistus.
NO781560L (no)	1978-11-07	Nye 3,5-disubstituerte-1h-1,2,4-triazolderivater og fremgangsmaate til deres fremstilling
DK132177A (da)	1977-09-28	Oximcarbamater fremgangsmade til deres fremstilling og deres anvendelse som insecticider acaricider og nematodicider
DK24280A (da)	1980-07-23	Spiro-quinolylhydantoiner fremgangsmaade til deres fremstilling og deres anvendelse
NO790564L (no)	1979-08-22	Nye nitrosourinstoff-derivater og fremgangsmaate til deres fremstilling.
NO781159L (no)	1978-10-05	1-(3-(3,4,5-trimetoksyfenoksy)-2-hydroksy-propyl)-4-aryl-piperazinderivater og fremgangsmaate til deres fremstilling
DK258281A (da)	1981-12-14	4-(3-jodpropargyloxy) pyrimidinderivater og fremgangsmaade til deres fremstilling
DK477778A (da)	1979-04-27	17alfa-(3-jodbenzoyloxy)-9alfa-4-pregnen-3,20-dioner deres d-homoanaloge og fremgangsmaade til deres fremstilling og deres anvendelse
ZA807267B (en)	1981-11-25	5-(pyridinyl)-2(1h)-pyridinones,useful as cardiotonic agents and their preparation
NO790280L (no)	1979-07-31	Nye azatianaftalinderivater, fremgangsmaate til deres fremstilling og deres anvendelse