NO803682L - Fremgangsmaate for fremstilling av terapeutisk aktive fenylamino-imidazolin-derivater - Google Patents

Fremgangsmaate for fremstilling av terapeutisk aktive fenylamino-imidazolin-derivater

Info

Publication number: NO803682L
Authority: NO; Norway
Prior art keywords: group; see diagramm; general formula; acid addition; phenylamino
Prior art date: 1979-12-07

Application number

NO803682A

Other languages

English (en)

Other versions

NO151412C (no

NO151412B (no

Inventor

Helmut Staehle

Herbert Koeppe

Werner Kummer

Wolfgang Hoefke

Wolfram Gaida

Walter Kobinger

Christian Lillie

Ludwig Pichler

Original Assignee

Boehringer Sohn Ingelheim

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-12-07

Filing date

1980-12-05

Publication date

1981-06-09

1980-12-05 Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim

1981-06-09 Publication of NO803682L publication Critical patent/NO803682L/no

1984-12-27 Publication of NO151412B publication Critical patent/NO151412B/no

1985-04-10 Publication of NO151412C publication Critical patent/NO151412C/no

Links

238000000034 method Methods 0.000 title abstract 2
SACAEVOKRBNXPN-UHFFFAOYSA-N n-phenyl-4,5-dihydroimidazol-1-amine Chemical class C1=NCCN1NC1=CC=CC=C1 SACAEVOKRBNXPN-UHFFFAOYSA-N 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1
239000002253 acid Substances 0.000 abstract 4
150000003839 salts Chemical class 0.000 abstract 4
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 2
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical compound BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
125000004851 cyclopentylmethyl group Chemical group C1(CCCC1)C* 0.000 abstract 2
125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 abstract 2
125000005394 methallyl group Chemical group 0.000 abstract 2
125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 2
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
239000007795 chemical reaction product Substances 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
150000004820 halides Chemical class 0.000 abstract 1
229910052740 iodine Inorganic materials 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
DZHUQIOYWZHKQP-UHFFFAOYSA-N n-(2,6-dibromo-4-methylphenyl)-4,5-dihydro-1h-imidazol-2-amine Chemical compound BrC1=CC(C)=CC(Br)=C1N=C1NCCN1 DZHUQIOYWZHKQP-UHFFFAOYSA-N 0.000 abstract 1
125000003396 thiol group Chemical group [H]S* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

NO803682A 1979-12-07 1980-12-05 Analogifremgangsmaate for fremstilling av terapeutisk aktive fenylamino-imidazolin-derivater NO151412C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19792949287 DE2949287A1 (de)	1979-12-07	1979-12-07	Neue substituierte 2-phenylamino-imidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben

Publications (3)

Publication Number	Publication Date
NO803682L true NO803682L (no)	1981-06-09
NO151412B NO151412B (no)	1984-12-27
NO151412C NO151412C (no)	1985-04-10

Family

ID=6087857

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO803682A NO151412C (no)	1979-12-07	1980-12-05	Analogifremgangsmaate for fremstilling av terapeutisk aktive fenylamino-imidazolin-derivater

Country Status (12)

Country	Link
EP (1)	EP0030616B1 (no)
JP (1)	JPS5692274A (no)
AT (1)	ATE5818T1 (no)
AU (1)	AU533756B2 (no)
DE (2)	DE2949287A1 (no)
DK (1)	DK521680A (no)
ES (1)	ES497480A0 (no)
FI (1)	FI69068C (no)
IE (1)	IE50485B1 (no)
IL (1)	IL61637A (no)
NO (1)	NO151412C (no)
ZA (1)	ZA807611B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4461904A (en) *	1981-11-20	1984-07-24	Alcon Laboratories, Inc.	2-(Trisubstituted phenylimino)-imidazolines
US4515800A (en) *	1981-11-20	1985-05-07	Icilio Cavero	Method of lowering intraocular pressure using phenylimino-imidazoles
US4644007A (en) *	1981-11-20	1987-02-17	Alcon Laboratories, Inc.	3-chloro-4-(4,5-dihydro-1H-imidazo-2-yl)-amino-5-alkylbenzoic acids, esters, salts, compositions and methods
US4517199A (en) *	1981-11-20	1985-05-14	Alcon Laboratories, Inc.	Method for lowering intraocular pressure using phenylimino-imidazoles
HU192986B (en) *	1984-05-23	1987-08-28	Egyt Gyogyszervegyeszeti Gyar	Process for production of imidasodiline derivatives
DE19514579A1 (de)	1995-04-20	1996-10-24	Boehringer Ingelheim Kg	Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT285599B (de) *	1968-06-21	1970-11-10	Boehringer Sohn Ingelheim	Verfahren zur Herstellung von neuen trisubstituierten 2-Arylaminoimidazolinen und ihren Salzen
BE759048A (fr) *	1969-11-17	1971-05-17	Boehringer Sohn Ingelheim	Nouvelles n-aminoalcoyl-arylamino-imidazolines-(2) substituees et procedes pour les fabriquer
DE2259160A1 (de) *	1972-12-02	1974-06-06	Boehringer Sohn Ingelheim	Neue substituierte 2-phenylaminoimidazoline, deren saeureadditionssalze und verfahren zur herstellung derselben sowie ihre verwendung als arzneimittel
DE2523103C3 (de) *	1975-05-24	1979-11-29	C.H. Boehringer Sohn, 6507 Ingelheim	Substituierte 2-[N-Progargyl-N-(2-chlorphenyl)amino] -imidazoline-^), deren Säureadditionssalze, Verfahren zu ihrer Herstellung und deren Verwendung
DE2636732A1 (de) *	1976-08-14	1978-02-16	Boehringer Sohn Ingelheim	Neue substituierte 2-phenylamino- imidazoline- (2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben

1979
- 1979-12-07 DE DE19792949287 patent/DE2949287A1/de not_active Withdrawn
1980
- 1980-11-03 DE DE8080106725T patent/DE3066104D1/de not_active Expired
- 1980-11-03 EP EP80106725A patent/EP0030616B1/de not_active Expired
- 1980-11-03 AT AT80106725T patent/ATE5818T1/de not_active IP Right Cessation
- 1980-12-05 IE IE2555/80A patent/IE50485B1/en unknown
- 1980-12-05 NO NO803682A patent/NO151412C/no unknown
- 1980-12-05 AU AU65136/80A patent/AU533756B2/en not_active Ceased
- 1980-12-05 FI FI803799A patent/FI69068C/fi not_active IP Right Cessation
- 1980-12-05 DK DK521680A patent/DK521680A/da not_active Application Discontinuation
- 1980-12-05 JP JP17196380A patent/JPS5692274A/ja active Pending
- 1980-12-05 ZA ZA00807611A patent/ZA807611B/xx unknown
- 1980-12-05 IL IL61637A patent/IL61637A/xx unknown
- 1980-12-05 ES ES497480A patent/ES497480A0/es active Granted

Also Published As

Publication number	Publication date
DK521680A (da)	1981-06-08
IE50485B1 (en)	1986-04-30
FI803799L (fi)	1981-06-08
EP0030616B1 (de)	1984-01-11
ATE5818T1 (de)	1984-01-15
DE3066104D1 (en)	1984-02-16
JPS5692274A (en)	1981-07-25
DE2949287A1 (de)	1981-06-11
AU533756B2 (en)	1983-12-08
FI69068B (fi)	1985-08-30
NO151412C (no)	1985-04-10
EP0030616A1 (de)	1981-06-24
AU6513680A (en)	1981-06-18
IL61637A (en)	1984-11-30
IE802555L (en)	1981-06-07
ES8201978A1 (es)	1982-01-01
IL61637A0 (en)	1981-01-30
ES497480A0 (es)	1982-01-01
FI69068C (fi)	1985-12-10
ZA807611B (en)	1982-08-25
NO151412B (no)	1984-12-27

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