NO831652L - Antigenisk peptidforbindelse. - Google Patents

Antigenisk peptidforbindelse.

Info

Publication number: NO831652L
Authority: NO; Norway
Prior art keywords: antigenic; peptide; amino acid; peptid; connection
Prior art date: 1981-09-21

Application number

NO831652A

Other languages

English (en)

Norwegian (no)

Inventor

Erwin Goldberg

Original Assignee

Univ Northwestern

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-09-21

Filing date

1983-05-10

Publication date

1983-05-10

1983-05-10 Application filed by Univ Northwestern filed Critical Univ Northwestern

1983-05-10 Publication of NO831652L publication Critical patent/NO831652L/no

Links

230000000890 antigenic effect Effects 0.000 title claims description 12
108090000765 processed proteins & peptides Proteins 0.000 claims description 18
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 4
ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 3
150000001875 compounds Chemical class 0.000 claims description 2
WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 2
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 2
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 2
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 2
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
229960003136 leucine Drugs 0.000 claims 2
150000008575 L-amino acids Chemical group 0.000 claims 1
ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 1
239000004395 L-leucine Substances 0.000 claims 1
239000004472 Lysine Substances 0.000 claims 1
235000003704 aspartic acid Nutrition 0.000 claims 1
OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 1
239000004220 glutamic acid Substances 0.000 claims 1
235000013922 glutamic acid Nutrition 0.000 claims 1
ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 1
235000004554 glutamine Nutrition 0.000 claims 1
235000018977 lysine Nutrition 0.000 claims 1
229960004452 methionine Drugs 0.000 claims 1
150000001413 amino acids Chemical group 0.000 description 11
235000001014 amino acid Nutrition 0.000 description 9
230000035558 fertility Effects 0.000 description 5
238000000034 method Methods 0.000 description 5
108010028554 LDL Cholesterol Proteins 0.000 description 4
102000004196 processed proteins & peptides Human genes 0.000 description 4
125000001433 C-terminal amino-acid group Chemical group 0.000 description 3
102100031357 L-lactate dehydrogenase C chain Human genes 0.000 description 3
230000015572 biosynthetic process Effects 0.000 description 3
125000006239 protecting group Chemical group 0.000 description 3
238000003786 synthesis reaction Methods 0.000 description 3
229960000814 tetanus toxoid Drugs 0.000 description 3
108090000790 Enzymes Proteins 0.000 description 2
102000004190 Enzymes Human genes 0.000 description 2
CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 2
108010044467 Isoenzymes Proteins 0.000 description 2
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 2
125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 description 2
DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 2
239000000427 antigen Substances 0.000 description 2
230000008878 coupling Effects 0.000 description 2
238000010168 coupling process Methods 0.000 description 2
238000005859 coupling reaction Methods 0.000 description 2
238000005516 engineering process Methods 0.000 description 2
230000004720 fertilization Effects 0.000 description 2
230000001900 immune effect Effects 0.000 description 2
238000010255 intramuscular injection Methods 0.000 description 2
239000007927 intramuscular injection Substances 0.000 description 2
235000005772 leucine Nutrition 0.000 description 2
235000006109 methionine Nutrition 0.000 description 2
229930182817 methionine Natural products 0.000 description 2
239000000243 solution Substances 0.000 description 2
238000012360 testing method Methods 0.000 description 2
210000001550 testis Anatomy 0.000 description 2
150000003573 thiols Chemical class 0.000 description 2
229960005486 vaccine Drugs 0.000 description 2
LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Substances CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 description 1
FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 description 1
HJBUBXIDMQBSQW-UHFFFAOYSA-N 4-(4-diazoniophenyl)benzenediazonium Chemical compound C1=CC([N+]#N)=CC=C1C1=CC=C([N+]#N)C=C1 HJBUBXIDMQBSQW-UHFFFAOYSA-N 0.000 description 1
SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
102000003855 L-lactate dehydrogenase Human genes 0.000 description 1
108700023483 L-lactate dehydrogenases Proteins 0.000 description 1
241000124008 Mammalia Species 0.000 description 1
102000007079 Peptide Fragments Human genes 0.000 description 1
108010033276 Peptide Fragments Proteins 0.000 description 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
241000251539 Vertebrata <Metazoa> Species 0.000 description 1
230000003509 anti-fertility effect Effects 0.000 description 1
102000036639 antigens Human genes 0.000 description 1
108091007433 antigens Proteins 0.000 description 1
238000013459 approach Methods 0.000 description 1
239000011324 bead Substances 0.000 description 1
125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
239000012050 conventional carrier Substances 0.000 description 1
229920001577 copolymer Polymers 0.000 description 1
238000010511 deprotection reaction Methods 0.000 description 1
238000000502 dialysis Methods 0.000 description 1
MYRTYDVEIRVNKP-UHFFFAOYSA-N divinylbenzene Substances C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 description 1
229940116441 divinylbenzene Drugs 0.000 description 1
230000000694 effects Effects 0.000 description 1
239000012530 fluid Substances 0.000 description 1
238000002523 gelfiltration Methods 0.000 description 1
229910000042 hydrogen bromide Inorganic materials 0.000 description 1
230000003053 immunization Effects 0.000 description 1
238000002649 immunization Methods 0.000 description 1
238000009169 immunotherapy Methods 0.000 description 1
230000001939 inductive effect Effects 0.000 description 1
230000036512 infertility Effects 0.000 description 1
208000000509 infertility Diseases 0.000 description 1
231100000535 infertility Toxicity 0.000 description 1
239000012836 macromolecular constituent Substances 0.000 description 1
238000013507 mapping Methods 0.000 description 1
239000000203 mixture Substances 0.000 description 1
210000003101 oviduct Anatomy 0.000 description 1
238000010647 peptide synthesis reaction Methods 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
235000018102 proteins Nutrition 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
239000000376 reactant Substances 0.000 description 1
230000001850 reproductive effect Effects 0.000 description 1
238000011160 research Methods 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 1
238000007086 side reaction Methods 0.000 description 1
239000007790 solid phase Substances 0.000 description 1
238000010532 solid phase synthesis reaction Methods 0.000 description 1
238000012916 structural analysis Methods 0.000 description 1
230000002194 synthesizing effect Effects 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Biophysics (AREA)
Microbiology (AREA)
Biomedical Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Engineering & Computer Science (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO831652A 1981-09-21 1983-05-10 Antigenisk peptidforbindelse. NO831652L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US1981/001271 WO1983001062A1 (en)	1981-09-21	1981-09-21	Antigenic peptide compound

Publications (1)

Publication Number	Publication Date
NO831652L true NO831652L (no)	1983-05-10

Family

ID=22161441

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO831652A NO831652L (no)	1981-09-21	1983-05-10	Antigenisk peptidforbindelse.

Country Status (7)

Country	Link
EP (1)	EP0088752B1 (da)
JP (1)	JPS58501469A (da)
AU (1)	AU7646981A (da)
DE (1)	DE3173568D1 (da)
DK (1)	DK212083D0 (da)
NO (1)	NO831652L (da)
WO (1)	WO1983001062A1 (da)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4578219A (en) *	1984-10-19	1986-03-25	Northwestern University	Antigenic peptide compound

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4016259A (en) *	1974-07-26	1977-04-05	Research Corporation	Contraceptive polypeptides
DE2602443A1 (de) *	1975-04-04	1976-10-21	Univ California	Biologisch aktive polypeptide
US4290944A (en) *	1980-07-31	1981-09-22	Northwestern University	Antigenic peptide compound

1981
- 1981-09-21 WO PCT/US1981/001271 patent/WO1983001062A1/en not_active Ceased
- 1981-09-21 DE DE8181902712T patent/DE3173568D1/de not_active Expired
- 1981-09-21 EP EP81902712A patent/EP0088752B1/en not_active Expired
- 1981-09-21 JP JP56503235A patent/JPS58501469A/ja active Pending
- 1981-09-21 AU AU76469/81A patent/AU7646981A/en not_active Abandoned
1983
- 1983-05-10 NO NO831652A patent/NO831652L/no unknown
- 1983-05-11 DK DK2120/83A patent/DK212083D0/da unknown

Also Published As

Publication number	Publication date
DK212083A (da)	1983-05-11
DK212083D0 (da)	1983-05-11
EP0088752A1 (en)	1983-09-21
EP0088752A4 (en)	1984-02-09
JPS58501469A (ja)	1983-09-01
DE3173568D1 (en)	1986-03-06
EP0088752B1 (en)	1986-01-22
WO1983001062A1 (en)	1983-03-31
AU7646981A (en)	1983-04-08

Publication	Publication Date	Title
US5110730A (en)	1992-05-05	Human tissue factor related DNA segments
CN1326557C (zh)	2007-07-18	aPL免疫反应性肽和其缀合物以及治疗aPL抗体－介导的疾病的方法
DK175703B1 (da)	2005-01-24	Human vævsfaktor-relaterede DNA-segmenter, polypeptider og antistoffer, hybridomaer, bestemmelsesmetoder, diagnostiske systemer og metoder, isoleringsmetoder og fremstillingsmetoder
NO179164B (no)	1996-05-13	Fremgangsmåte for fremstilling av et immunogenkonjugat
JPH02223599A (ja)	1990-09-05	合成抗原およびその製造方法
US4392997A (en)	1983-07-12	Antigenic peptide compounds
US4290944A (en)	1981-09-22	Antigenic peptide compound
Elsayed et al.	1989	Synthetic allergenic epitopes from the amino-terminal regions of the major allergens of hazel and birch pollen
US4310456A (en)	1982-01-12	Antigenic linear peptide compound
JPH07507924A (ja)	1995-09-07	アンブロシア・アルテミシフォリア由来の主要アレルゲンのｔ細胞エピトープ
US4585587A (en)	1986-04-29	Antigenic peptide compounds
US4353822A (en)	1982-10-12	Antigenic linear peptide compounds
EP0079934B1 (en)	1987-04-29	Antigenic linear peptide compounds
NO831652L (no)	1983-05-10	Antigenisk peptidforbindelse.
US4354967A (en)	1982-10-19	Antigenic linear peptide compound
AU652611B2 (en)	1994-09-01	Analogs of piscine LHRH
US4377516A (en)	1983-03-22	Antigenic linear peptide compounds
US4782136A (en)	1988-11-01	Synthetic peptide compounds producing anitbodies binding to human LDH-C.sub.
EP0378929A2 (en)	1990-07-25	Membrane proteins and peptides of haemophilus influenzae type b
US4578219A (en)	1986-03-25	Antigenic peptide compound
CA1183527A (en)	1985-03-05	Antigenic peptide compound
Boyer et al.	1990	Functional degeneracy of residues in a T cell peptide epitope contributes to its recognition by different T cell hybridomas
WO1997026001A1 (en)	1997-07-24	Proteins and peptides for contraceptive vaccines and fertility diagnosis
CA1181742A (en)	1985-01-29	Antigenic linear peptide compound
CN101362796B (zh)	2011-03-16	附睾蛋白酶抑制蛋白b细胞表位及包含此表位的多重抗原肽