NO833681L - 3-aryl-7-klor-3,4-dihydro-akridin-1,9,(2h,10h)-dion-1-oksimer og -1-hydrazonderivater, deres salter, fremgangsmaate til deres fremstilling, midler som inneholder de og deres anvendelse - Google Patents

3-aryl-7-klor-3,4-dihydro-akridin-1,9,(2h,10h)-dion-1-oksimer og -1-hydrazonderivater, deres salter, fremgangsmaate til deres fremstilling, midler som inneholder de og deres anvendelse

Info

Publication number: NO833681L
Authority: NO; Norway
Prior art keywords: chloro; acridine; dihydro; gives; dione
Prior art date: 1982-10-11

Application number

NO833681A

Other languages

English (en)

Norwegian (no)

Inventor

Erhardt Winkelmann

Walter Duerckheimer

Wolfgang Raether

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-10-11

Filing date

1983-10-10

Publication date

1984-04-12

1982-10-11 Priority claimed from DE19823237649 external-priority patent/DE3237649A1/de

1982-12-24 Priority claimed from DE19823247908 external-priority patent/DE3247908A1/de

1983-10-10 Application filed by Hoechst Ag filed Critical Hoechst Ag

1984-04-12 Publication of NO833681L publication Critical patent/NO833681L/no

Links

238000000034 method Methods 0.000 title claims abstract description 6
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238000002360 preparation method Methods 0.000 title abstract description 8
150000001875 compounds Chemical class 0.000 claims abstract description 25
229910052739 hydrogen Inorganic materials 0.000 claims abstract description 19
239000001257 hydrogen Substances 0.000 claims abstract description 19
239000002253 acid Substances 0.000 claims abstract description 9
150000003863 ammonium salts Chemical class 0.000 claims abstract description 8
229910052757 nitrogen Inorganic materials 0.000 claims abstract description 8
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 7
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract description 7
239000000460 chlorine Substances 0.000 claims abstract description 5
125000004433 nitrogen atom Chemical group N* 0.000 claims abstract description 5
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims abstract description 4
229910052801 chlorine Inorganic materials 0.000 claims abstract description 4
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims abstract description 3
125000004193 piperazinyl group Chemical group 0.000 claims abstract description 3
-1 C 1 -C 4 -alkoxy Chemical group 0.000 claims description 55
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 30
125000004432 carbon atom Chemical group C* 0.000 claims description 14
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 13
125000002947 alkylene group Chemical group 0.000 claims description 12
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238000004519 manufacturing process Methods 0.000 claims description 5
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239000007795 chemical reaction product Substances 0.000 claims description 3
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125000005842 heteroatom Chemical group 0.000 claims description 2
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239000000126 substance Substances 0.000 description 4
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206010023076 Isosporiasis Diseases 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 1
CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 1
GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
241000283973 Oryctolagus cuniculus Species 0.000 description 1
206010034133 Pathogen resistance Diseases 0.000 description 1
241000286209 Phasianidae Species 0.000 description 1
OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
241000282887 Suidae Species 0.000 description 1
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
241000231697 Zelus means Species 0.000 description 1
FLMCNCMHXSWZNT-UHFFFAOYSA-N [2-(diethylamino)ethylamino]thiourea Chemical compound CCN(CC)CCNNC(N)=S FLMCNCMHXSWZNT-UHFFFAOYSA-N 0.000 description 1
239000013543 active substance Substances 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
229910000147 aluminium phosphate Inorganic materials 0.000 description 1
150000001408 amides Chemical class 0.000 description 1
150000001412 amines Chemical class 0.000 description 1
229940058934 aminoquinoline antimalarials Drugs 0.000 description 1
150000005010 aminoquinolines Chemical class 0.000 description 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
230000037396 body weight Effects 0.000 description 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
229910052794 bromium Inorganic materials 0.000 description 1
239000006172 buffering agent Substances 0.000 description 1
KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
239000002775 capsule Substances 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
230000000973 chemotherapeutic effect Effects 0.000 description 1
235000013330 chicken meat Nutrition 0.000 description 1
125000000068 chlorophenyl group Chemical group 0.000 description 1
235000015165 citric acid Nutrition 0.000 description 1
SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 1
239000002270 dispersing agent Substances 0.000 description 1
239000000975 dye Substances 0.000 description 1
239000003995 emulsifying agent Substances 0.000 description 1
BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
150000002170 ethers Chemical class 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
239000000945 filler Substances 0.000 description 1
229910052731 fluorine Inorganic materials 0.000 description 1
239000011737 fluorine Substances 0.000 description 1
239000001530 fumaric acid Substances 0.000 description 1
150000008282 halocarbons Chemical class 0.000 description 1
XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
229910052740 iodine Inorganic materials 0.000 description 1
125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
239000004310 lactic acid Substances 0.000 description 1
235000014655 lactic acid Nutrition 0.000 description 1
239000007788 liquid Substances 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
239000011976 maleic acid Substances 0.000 description 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
239000000203 mixture Substances 0.000 description 1
125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 description 1
229910017604 nitric acid Inorganic materials 0.000 description 1
NRYJIKFQAFBQJF-UHFFFAOYSA-N o-(2-morpholin-4-ylethyl)hydroxylamine Chemical compound NOCCN1CCOCC1 NRYJIKFQAFBQJF-UHFFFAOYSA-N 0.000 description 1
PYXHZSPWJIANNK-UHFFFAOYSA-N o-(2-pyrrolidin-1-ylethyl)hydroxylamine Chemical compound NOCCN1CCCC1 PYXHZSPWJIANNK-UHFFFAOYSA-N 0.000 description 1
235000006408 oxalic acid Nutrition 0.000 description 1
FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
UNEIHNMKASENIG-UHFFFAOYSA-N para-chlorophenylpiperazine Chemical compound C1=CC(Cl)=CC=C1N1CCNCC1 UNEIHNMKASENIG-UHFFFAOYSA-N 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
235000011007 phosphoric acid Nutrition 0.000 description 1
229910052698 phosphorus Inorganic materials 0.000 description 1
239000011574 phosphorus Substances 0.000 description 1
230000000704 physical effect Effects 0.000 description 1
239000000843 powder Substances 0.000 description 1
BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
230000035484 reaction time Effects 0.000 description 1
229960004889 salicylic acid Drugs 0.000 description 1
150000007659 semicarbazones Chemical class 0.000 description 1
239000004334 sorbic acid Substances 0.000 description 1
235000010199 sorbic acid Nutrition 0.000 description 1
229940075582 sorbic acid Drugs 0.000 description 1
125000000547 substituted alkyl group Chemical group 0.000 description 1
239000003826 tablet Substances 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical compound C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
125000003944 tolyl group Chemical group 0.000 description 1
ZAMCTDDIJFNXOH-UHFFFAOYSA-N tributylazanium;acetate Chemical compound CC(O)=O.CCCCN(CCCC)CCCC ZAMCTDDIJFNXOH-UHFFFAOYSA-N 0.000 description 1
230000007306 turnover Effects 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/06—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/08—Nitrogen atoms
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO833681A 1982-10-11 1983-10-10 3-aryl-7-klor-3,4-dihydro-akridin-1,9,(2h,10h)-dion-1-oksimer og -1-hydrazonderivater, deres salter, fremgangsmaate til deres fremstilling, midler som inneholder de og deres anvendelse NO833681L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19823237649 DE3237649A1 (de)	1982-10-11	1982-10-11	3-aryl-7-chlor-10-hydroxy-3,4-dihydro-acridin-1,9-(2h, 10h)-dion-1-oxime und -1-hydrazonderivate, deren salze, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung
DE19823247908 DE3247908A1 (de)	1982-12-24	1982-12-24	3-aryl-7-chlor-3,4-dihydro-acridin-1,9-(2h,-10h)-dion-1-oxime und -1-hydrazonderivate, deren salze, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung

Publications (1)

Publication Number	Publication Date
NO833681L true NO833681L (no)	1984-04-12

Family

ID=25805046

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO833681A NO833681L (no)	1982-10-11	1983-10-10	3-aryl-7-klor-3,4-dihydro-akridin-1,9,(2h,10h)-dion-1-oksimer og -1-hydrazonderivater, deres salter, fremgangsmaate til deres fremstilling, midler som inneholder de og deres anvendelse

Country Status (17)

Country	Link
US (1)	US4593027A (fr)
EP (1)	EP0106284B1 (fr)
AU (1)	AU561449B2 (fr)
CA (1)	CA1217491A (fr)
DE (1)	DE3372094D1 (fr)
DK (1)	DK465583A (fr)
ES (1)	ES8405616A1 (fr)
FI (1)	FI833651A7 (fr)
GR (1)	GR78732B (fr)
HU (1)	HU190854B (fr)
IL (1)	IL69941A (fr)
JO (1)	JO1266B1 (fr)
MA (1)	MA19925A1 (fr)
NO (1)	NO833681L (fr)
NZ (1)	NZ205906A (fr)
PH (1)	PH19108A (fr)
PT (1)	PT77476B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4626540A (en) *	1983-11-08	1986-12-02	Warner-Lambert Company	Substituted 1-amino-4-nitro-acridinones and methods of treating bacterial infections and leukemia with them
IN164921B (fr) *	1986-07-22	1989-07-08	Hoechst India
US5180717A (en) *	1988-08-16	1993-01-19	The Upjohn Company	Bivalent ligands effective for blocking ACAT enzyme for lowering plasma triglycerides and for elevating HDL cholesterol
US5268388A (en) *	1988-12-27	1993-12-07	E. I. Du Pont De Nemours And Company	Substituted semicarbazone arthropodicides
US5182303A (en) *	1988-12-27	1993-01-26	E. I. Du Pont De Nemours And Company	Substituted semicarbazone arthropodicides
US5859028A (en) *	1997-04-28	1999-01-12	Potomax Limited Partnership	Carotenoid synthesis inhibiting herbicides and fatty acid synthesis inhibiting oxime herbicides as anti-Apicomplexa protozoan parasite agents
WO2007101710A1 (fr) *	2006-03-09	2007-09-13	Cenix Bioscience Gmbh	Utilisation d'inhibiteurs de protéines de la classe des récepteurs éboueurs dans le traitement de maladies infectieuses
EP2121681B1 (fr)	2007-01-11	2015-04-15	Critical Outcome Technologies, Inc.	Composés et méthode de traitement un cancer
EP2225226B1 (fr)	2007-12-26	2016-08-17	Critical Outcome Technologies, Inc.	Composés et leur utilisation dans un procédé pour le traitement du cancer
EP3023426A1 (fr)	2008-07-17	2016-05-25	Critical Outcome Technologies, Inc.	Composés inhibiteurs à base de thiosemicarbazone et procédés de traitement du cancer
US8987272B2 (en)	2010-04-01	2015-03-24	Critical Outcome Technologies Inc.	Compounds and method for treatment of HIV

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2880210A (en) *		1959-03-31		Acridine n-oxides
US3184452A (en) *		1965-05-18		New aminoalkoxy compounds and process for theik manufacture
NL132832C (fr) *	1961-05-26
US3577558A (en) *	1968-04-15	1971-05-04	Sterling Drug Inc	1-aminoalkylamino-4-alkoxymethylthioxanthene derivatives
DE1811409A1 (de) *	1968-11-28	1970-06-18	Bayer Ag	Mittel zur Bekaempfung von Insekten,Milben,Hasenartigen und Nagetieren
DE2337474C2 (de) *	1973-07-24	1982-01-21	Hoechst Ag, 6000 Frankfurt	Chemotherapeutisch wirksame Tetrahydroacridone, Verfahren zu ihrer Herstellung und sie enthaltende Mittel
DE2651084A1 (de) *	1976-11-09	1978-12-14	Hoechst Ag	Basisch substituirte o-(2-hydroxypropyl) -aldoxime, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE2748333A1 (de) *	1977-10-28	1979-05-03	Hoechst Ag	Mittel gegen malaria
US4178451A (en) *	1978-07-13	1979-12-11	E. R. Squibb & Sons, Inc.	3-(Substituted hydrazino)benzisothiazole-1,1-dioxides
US4266062A (en) *	1978-09-18	1981-05-05	Mcneilab, Inc.	(1-Methyl-2-pyridinylidene) derivatives of guanidine
US4447427A (en) *	1979-01-04	1984-05-08	The United States Of America As Represented By The Secretary Of The Army	Method for treating bacterial infections with 2-acetyl- and 2-propionylpyridine thiosemicarbazones
US4291034A (en) *	1980-03-20	1981-09-22	Warner Lambert Company	7-Chloro-3-substituted aryl-3,4-dihydro-1,9(2H,10H) and 10 hydroxy acridinedioneimines having antimalarial activity
US4440771A (en) *	1982-02-12	1984-04-03	The United States Of America As Represented By The Secretary Of The Army	2-Acetyl quinoline thiosemicarbazones useful in treatment of gonorrhea, malaria or bacterial infections

1983
- 1983-10-07 CA CA000438636A patent/CA1217491A/fr not_active Expired
- 1983-10-07 EP EP83110035A patent/EP0106284B1/fr not_active Expired
- 1983-10-07 FI FI833651A patent/FI833651A7/fi not_active Application Discontinuation
- 1983-10-07 DE DE8383110035T patent/DE3372094D1/de not_active Expired
- 1983-10-10 DK DK465583A patent/DK465583A/da not_active Application Discontinuation
- 1983-10-10 PH PH29680A patent/PH19108A/en unknown
- 1983-10-10 NO NO833681A patent/NO833681L/no unknown
- 1983-10-10 ES ES526354A patent/ES8405616A1/es not_active Expired
- 1983-10-10 AU AU20004/83A patent/AU561449B2/en not_active Ceased
- 1983-10-10 MA MA20145A patent/MA19925A1/fr unknown
- 1983-10-10 NZ NZ205906A patent/NZ205906A/en unknown
- 1983-10-10 GR GR72653A patent/GR78732B/el unknown
- 1983-10-10 HU HU833500A patent/HU190854B/hu not_active IP Right Cessation
- 1983-10-10 IL IL69941A patent/IL69941A/xx unknown
- 1983-10-10 PT PT77476A patent/PT77476B/pt unknown
- 1983-10-11 JO JO19831266A patent/JO1266B1/en active
- 1983-10-11 US US06/540,647 patent/US4593027A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PT77476B (de)	1986-04-16
ES526354A0 (es)	1984-06-16
FI833651A7 (fi)	1984-04-12
US4593027A (en)	1986-06-03
JO1266B1 (en)	1985-04-20
AU561449B2 (en)	1987-05-07
ES8405616A1 (es)	1984-06-16
DK465583A (da)	1984-04-12
HU190854B (en)	1986-11-28
DK465583D0 (da)	1983-10-10
CA1217491A (fr)	1987-02-03
AU2000483A (en)	1984-04-19
PT77476A (de)	1983-11-01
NZ205906A (en)	1986-06-11
DE3372094D1 (en)	1987-07-23
EP0106284A1 (fr)	1984-04-25
FI833651A0 (fi)	1983-10-07
EP0106284B1 (fr)	1987-06-16
PH19108A (en)	1986-01-06
IL69941A0 (en)	1984-01-31
GR78732B (fr)	1984-10-02
MA19925A1 (fr)	1984-07-01
IL69941A (en)	1988-06-30

Publication	Publication Date	Title
DE69202243T2 (de)	1995-08-31	2,4-Diaminochinazolin-Derivate, um die Antitumorwirkung zu erhöhen.
US3299067A (en)	1967-01-17	2-[1'-(benzyl and phenyl)-4'-piperazinyl]-pyrimidine derivatives
US5328906A (en)	1994-07-12	0-(3-amino-2-hydroxypropyl)-hydroximic acid halides and process for preparing the same
US20020072520A1 (en)	2002-06-13	Sulfonylcarboxamide derivatives, process for their preparation and their use as pharmaceuticals
NO833681L (no)	1984-04-12	3-aryl-7-klor-3,4-dihydro-akridin-1,9,(2h,10h)-dion-1-oksimer og -1-hydrazonderivater, deres salter, fremgangsmaate til deres fremstilling, midler som inneholder de og deres anvendelse
WO1994014780A1 (fr)	1994-07-07	Derives de pyrimidine, de pyridine, de pteridinone et d'indazole utilises comme inhibiteurs enzymatiques
US4232022A (en)	1980-11-04	Heterocyclic compounds
JP2018502146A (ja)	2018-01-25	ビグアニド化合物及びその使用
US5874431A (en)	1999-02-23	Benzazole compounds
Dumas et al.	2002	Synthesis and pharmacological characterization of a potent, orally active p38 kinase inhibitor
US7582655B2 (en)	2009-09-01	Antineoplastic compounds
US5401743A (en)	1995-03-28	Aminoalkyl-substituted 2-amino-5-mercaptothiadiazoles the preparation and use thereof
US3753981A (en)	1973-08-21	4-amino-2-styrylquinazoline compounds
HU191126B (en)	1987-01-28	Process for producing new n-imino-pyridinium-betaine derivatives and pharmaceutical compositions containing them as active agents
CZ288824B6 (cs)	2001-09-12	Deriváty hydroximové kyseliny, farmaceutické prostředky, které je obsahují, způsob jejich přípravy a meziprodukty v tomto způsobu
CS274494B2 (en)	1991-04-11	Method of substituted styrene derivatives preparation
HUP0204282A2 (hu)	2003-06-28	Biszszulfonamidok alkalmazása hiperlipidémia kezelésére vagy megelőzésére alkalmas gyógyászati készítmények előállítására
US3682933A (en)	1972-08-08	Derivatives of benzoxazoline-2-one
US3890323A (en)	1975-06-17	Phenylketone derivatives
US3167556A (en)	1965-01-26	Basic derivatives of anilides
US4011220A (en)	1977-03-08	Pyridazinium compounds and a process for their production
DE3237649A1 (de)	1984-04-12	3-aryl-7-chlor-10-hydroxy-3,4-dihydro-acridin-1,9-(2h, 10h)-dion-1-oxime und -1-hydrazonderivate, deren salze, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung
US2846438A (en)	1958-08-05	Nu-(beta-diethylaminoethyl) isonicotinamide
US4152518A (en)	1979-05-01	Halogenated thiobenzamides
US4610991A (en)	1986-09-09	Antihypertensive pyridylaminobenzamide compounds