NO842254L - Triazol (2,3-c)(1,3)benzodiazepiner, fremgangsmaate til deres fremstilling, farmasoeytiske preparater som inneholder disse forbindelser, samt deres terapeutiske anvendelse - Google Patents

Triazol (2,3-c)(1,3)benzodiazepiner, fremgangsmaate til deres fremstilling, farmasoeytiske preparater som inneholder disse forbindelser, samt deres terapeutiske anvendelse

Info

Publication number: NO842254L
Authority: NO; Norway
Prior art keywords: alkyl; carbamoyl; alkoxy; sulfamoyl; hydroxy
Prior art date: 1983-06-06

Application number

NO842254A

Other languages

English (en)

Other versions

NO162070C (no

NO162070B (no

Inventor

Isidoros Vlattas

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-06-06

Filing date

1984-06-05

Publication date

1984-12-07

1984-06-05 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1984-12-07 Publication of NO842254L publication Critical patent/NO842254L/no

1989-07-24 Publication of NO162070B publication Critical patent/NO162070B/no

1989-11-01 Publication of NO162070C publication Critical patent/NO162070C/no

Links

150000001875 compounds Chemical class 0.000 title abstract 8
238000000034 method Methods 0.000 title abstract 2
QWENRTYMTSOGBR-UHFFFAOYSA-N 1H-1,2,3-Triazole Chemical compound C=1C=NNN=1 QWENRTYMTSOGBR-UHFFFAOYSA-N 0.000 title 1
229940049706 benzodiazepine Drugs 0.000 title 1
150000001557 benzodiazepines Chemical class 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 20
-1 carbamoyl- Chemical group 0.000 abstract 18
229910052739 hydrogen Inorganic materials 0.000 abstract 9
239000001257 hydrogen Substances 0.000 abstract 9
125000003545 alkoxy group Chemical group 0.000 abstract 8
229910052736 halogen Inorganic materials 0.000 abstract 8
150000002367 halogens Chemical class 0.000 abstract 8
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 6
150000002431 hydrogen Chemical group 0.000 abstract 6
150000003839 salts Chemical class 0.000 abstract 5
125000002861 (C1-C4) alkanoyl group Chemical group 0.000 abstract 4
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 4
125000004414 alkyl thio group Chemical group 0.000 abstract 4
125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 abstract 4
125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 abstract 4
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 abstract 4
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 2
125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 abstract 2
SXIFAEWFOJETOA-UHFFFAOYSA-N 4-hydroxy-butyl Chemical group [CH2]CCCO SXIFAEWFOJETOA-UHFFFAOYSA-N 0.000 abstract 2
150000001204 N-oxides Chemical class 0.000 abstract 2
229910052783 alkali metal Inorganic materials 0.000 abstract 2
150000001340 alkali metals Chemical class 0.000 abstract 2
125000005153 alkyl sulfamoyl group Chemical group 0.000 abstract 2
125000002947 alkylene group Chemical group 0.000 abstract 2
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 2
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 2
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Pulmonology (AREA)
Immunology (AREA)
Psychiatry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

NO842254A 1983-06-06 1984-06-05 Analogifremgangsmaate til fremstilling av terapeutisk aktive triazol(2,3-c) (1,3)benzodiazepiner. NO162070C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US50132883A	1983-06-06	1983-06-06

Publications (3)

Publication Number	Publication Date
NO842254L true NO842254L (no)	1984-12-07
NO162070B NO162070B (no)	1989-07-24
NO162070C NO162070C (no)	1989-11-01

Family

ID=23993078

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO842254A NO162070C (no)	1983-06-06	1984-06-05	Analogifremgangsmaate til fremstilling av terapeutisk aktive triazol(2,3-c) (1,3)benzodiazepiner.

Country Status (17)

Country	Link
EP (1)	EP0129509B1 (no)
JP (1)	JPS606689A (no)
AT (1)	ATE45740T1 (no)
AU (1)	AU574075B2 (no)
CA (1)	CA1215044A (no)
DD (1)	DD220310A5 (no)
DE (1)	DE3479499D1 (no)
DK (1)	DK276484A (no)
ES (1)	ES8506713A1 (no)
FI (1)	FI78098C (no)
GR (1)	GR82058B (no)
HU (1)	HU190930B (no)
IL (1)	IL72015A (no)
NO (1)	NO162070C (no)
NZ (1)	NZ208373A (no)
PT (1)	PT78687A (no)
ZA (1)	ZA844186B (no)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL84093A (en) *	1986-10-09	1992-09-06	Ciba Geigy Ag	Aralkyl-4h-1,2,4-triazole derivatives,their preparation and pharmaceutical compositions containing them
DE19824673A1 (de) *	1998-05-26	1999-12-02	Schering Ag	Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3539573A (en) *	1967-03-22	1970-11-10	Jean Schmutz	11-basic substituted dibenzodiazepines and dibenzothiazepines
US4076823A (en) *	1977-08-18	1978-02-28	E. R. Squibb & Sons, Inc.	Triazolo-2,4-benzodiazepines
US4192803A (en) *	1978-09-15	1980-03-11	American Cyanamid Company	5H-Pyrrolo[2,1-c][1,4]benzodiazepine derivatives
FI824170L (fi) *	1981-12-07	1983-06-08	Ciba Geigy Ag	Imidazobensodiazepiner, foerfarande foer deras framstaellning, dessa foereningar innehaollande farmaceutiska preparat och deras anvaendning

1984
- 1984-05-29 DE DE8484810264T patent/DE3479499D1/de not_active Expired
- 1984-05-29 EP EP84810264A patent/EP0129509B1/de not_active Expired
- 1984-05-29 AT AT84810264T patent/ATE45740T1/de not_active IP Right Cessation
- 1984-06-04 FI FI842228A patent/FI78098C/fi not_active IP Right Cessation
- 1984-06-04 CA CA000455776A patent/CA1215044A/en not_active Expired
- 1984-06-04 DK DK276484A patent/DK276484A/da not_active Application Discontinuation
- 1984-06-04 PT PT78687A patent/PT78687A/pt not_active IP Right Cessation
- 1984-06-04 GR GR74912A patent/GR82058B/el unknown
- 1984-06-04 IL IL72015A patent/IL72015A/xx unknown
- 1984-06-05 ES ES533135A patent/ES8506713A1/es not_active Expired
- 1984-06-05 HU HU842181A patent/HU190930B/hu unknown
- 1984-06-05 AU AU29106/84A patent/AU574075B2/en not_active Ceased
- 1984-06-05 NZ NZ208373A patent/NZ208373A/en unknown
- 1984-06-05 ZA ZA844186A patent/ZA844186B/xx unknown
- 1984-06-05 DD DD84263805A patent/DD220310A5/de not_active IP Right Cessation
- 1984-06-05 NO NO842254A patent/NO162070C/no unknown
- 1984-06-06 JP JP59114697A patent/JPS606689A/ja active Granted

Also Published As

Publication number	Publication date
ES533135A0 (es)	1985-08-01
ES8506713A1 (es)	1985-08-01
EP0129509A3 (en)	1985-09-11
FI842228A0 (fi)	1984-06-04
ZA844186B (en)	1985-02-27
IL72015A (en)	1987-12-31
EP0129509B1 (de)	1989-08-23
ATE45740T1 (de)	1989-09-15
DE3479499D1 (en)	1989-09-28
GR82058B (no)	1984-12-13
NO162070C (no)	1989-11-01
JPS606689A (ja)	1985-01-14
NZ208373A (en)	1987-02-20
DD220310A5 (de)	1985-03-27
HU190930B (en)	1986-12-28
PT78687A (en)	1984-07-01
IL72015A0 (en)	1984-10-31
AU2910684A (en)	1984-12-13
CA1215044A (en)	1986-12-09
HUT34488A (en)	1985-03-28
AU574075B2 (en)	1988-06-30
DK276484A (da)	1984-12-07
DK276484D0 (da)	1984-06-04
FI842228A7 (fi)	1984-12-07
FI78098B (fi)	1989-02-28
JPH0354669B2 (no)	1991-08-20
EP0129509A2 (de)	1984-12-27
NO162070B (no)	1989-07-24
FI78098C (fi)	1989-06-12

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JO1351B1 (en)	1986-11-30	Chemical compounds
WO1999042465A3 (en)	1999-09-30	Sulphonamide derivatives being 5-ht6 receptor antagonists and process for their preparation
DE3264861D1 (en)	1985-08-29	Modified d-retro cyclic hexapeptide somatostatin analogs, process for their preparation and pharmaceutical compositions containing them
NO801866L (no)	1980-12-22	Pyrazolokinoliner, fremgangsmaate til deres fremstilling, farmasoeytiske preparater inneholdende disse forbindelser, samt deres terapeutiske anvendelse
AU2413995A (en)	1996-02-09	Bicyclic amidine derivatives as inhibitors of nitric oxide synthetase
IE872646L (en)	1988-04-03	7-((meta-substituted) phenylglycine)¹1-carba-1-dethiacephalosporins
NO842254L (no)	1984-12-07	Triazol (2,3-c)(1,3)benzodiazepiner, fremgangsmaate til deres fremstilling, farmasoeytiske preparater som inneholder disse forbindelser, samt deres terapeutiske anvendelse
GB8823475D0 (en)	1988-11-16	Chemical compounds
IE880306L (en)	1988-08-05	Pyridopyrroloquinolines and intermediates thereof
DK210387D0 (da)	1987-04-24	Heterocykliske forbindelser og fremgangsmaade til deres fremstilling samt farmaceutiske midler indeholdende disse
ES8307812A1 (es)	1983-08-01	Un procedimiento para la preparacion de nuevos amidin derivados del acido clavulawilo.
GR3023653T3 (en)	1997-09-30	N(1) substituted pyrazino Ä2,3-cÜ-1,2,6-thiadiazine 2,2-dioxides and their use as pharmaceuticals