NO844176L - Fenoksypropanolaminer - Google Patents

Fenoksypropanolaminer

Info

Publication number
NO844176L
NO844176L NO84844176A NO844176A NO844176L NO 844176 L NO844176 L NO 844176L NO 84844176 A NO84844176 A NO 84844176A NO 844176 A NO844176 A NO 844176A NO 844176 L NO844176 L NO 844176L
Authority
NO
Norway
Prior art keywords
alkyl
optionally
group
see diagramm
mono
Prior art date
Application number
NO84844176A
Other languages
English (en)
Other versions
NO159791C (no
NO159791B (no
Inventor
Leo Alig
Marcel Mueller
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO844176L publication Critical patent/NO844176L/no
Publication of NO159791B publication Critical patent/NO159791B/no
Publication of NO159791C publication Critical patent/NO159791C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
NO84844176A 1983-10-19 1984-10-18 Analogifremgangsmaate ved fremstilling av terapeutisk aktive fenoksypropanolaminer. NO159791C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH568483 1983-10-19
CH428884 1984-09-07

Publications (3)

Publication Number Publication Date
NO844176L true NO844176L (no) 1985-04-22
NO159791B NO159791B (no) 1988-10-31
NO159791C NO159791C (no) 1989-02-08

Family

ID=25695136

Family Applications (1)

Application Number Title Priority Date Filing Date
NO84844176A NO159791C (no) 1983-10-19 1984-10-18 Analogifremgangsmaate ved fremstilling av terapeutisk aktive fenoksypropanolaminer.

Country Status (17)

Country Link
US (1) US5064863A (no)
EP (1) EP0140243B1 (no)
AT (1) ATE38510T1 (no)
AU (1) AU575590B2 (no)
CA (1) CA1262729A (no)
DE (1) DE3475066D1 (no)
DK (1) DK497284A (no)
DO (1) DOP1984004282A (no)
FI (1) FI844082A7 (no)
HU (1) HU200992B (no)
IL (1) IL73239A (no)
MC (1) MC1625A1 (no)
NO (1) NO159791C (no)
NZ (1) NZ209866A (no)
PH (1) PH21479A (no)
PT (1) PT79371B (no)
ZW (1) ZW16684A1 (no)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8418472D0 (en) * 1984-07-19 1984-08-22 Beecham Group Plc Compounds
EP0300290B1 (de) * 1987-07-21 1991-12-18 F. Hoffmann-La Roche Ag Phenoxypropanolamine
GB8801306D0 (en) * 1988-01-21 1988-02-17 Ici Plc Chemical compounds
GB8905336D0 (en) * 1989-03-08 1989-04-19 Ici Plc Chemical compounds
US5177219A (en) * 1992-03-06 1993-01-05 American Home Products Corporation N-phenyl-N'-thienylmethyl-bis-diamino-5-methylene-1,3-dioxane-4,6-dione compounds
US5321036A (en) * 1993-02-10 1994-06-14 Bristol-Myers Squibb Company Thiazole and oxazole-based β3 adrenergic receptor agonists
TW363959B (en) * 1994-03-23 1999-07-11 Sankyo Co Thiazolidine and oxazolidine derivatives, their preparation and their medical use
US5488064A (en) * 1994-05-02 1996-01-30 Bristol-Myers Squibb Company Benzo 1,3 dioxole derivatives
JPH10503507A (ja) * 1994-07-29 1998-03-31 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ベータ３−アドレナリン受容体アゴニストおよびベータ１およびベータ２−アドレナリン受容体アンタゴニストとして有用なアリールオキシおよびアリールチオプロパノールアミン誘導体、およびその医薬組成物
US5726165A (en) * 1994-07-29 1998-03-10 Smithkline Beecham P.L.C. Derivatives of 4-(2-aminoethyl)phenoxymethyl-phosphonic and -phosphinic acid and pharmaceutical and veterinary uses therefor
US5491134A (en) * 1994-09-16 1996-02-13 Bristol-Myers Squibb Company Sulfonic, phosphonic or phosphiniic acid β3 agonist derivatives
ZA967892B (en) * 1995-09-21 1998-03-18 Lilly Co Eli Selective β3 adrenergic agonists.
DE69711519T2 (de) 1996-09-05 2002-10-31 Eli Lilly And Co., Indianapolis Carbazolanaloge als selektive beta3-adrenergische Agonisten
US5808080A (en) * 1996-09-05 1998-09-15 Eli Lilly And Company Selective β3 adrenergic agonists
GB9703492D0 (en) * 1997-02-20 1997-04-09 Smithkline Beecham Plc Novel compounds
UY24949A1 (es) * 1997-04-08 2001-04-30 Smithkline Beecham Corp Compuestos calcilíticos
CO5011072A1 (es) * 1997-12-05 2001-02-28 Lilly Co Eli Etanolaminas pirazinil substituidas como agfonistas de los receptores
AU1572701A (en) * 1999-11-15 2001-05-30 Eli Lilly And Company Treating wasting syndromes with aryloxy propanolamines
US6239313B1 (en) * 2000-02-16 2001-05-29 Council Of Scientific And Industrial Research Process for the solid state synthesis of enantiopure B-aminoalcohols from racemic epoxides
US6653323B2 (en) 2001-11-13 2003-11-25 Theravance, Inc. Aryl aniline β2 adrenergic receptor agonists
TWI249515B (en) 2001-11-13 2006-02-21 Theravance Inc Aryl aniline beta2 adrenergic receptor agonists
US20030229058A1 (en) 2001-11-13 2003-12-11 Moran Edmund J. Aryl aniline beta2 adrenergic receptor agonists
US7317023B2 (en) * 2004-07-21 2008-01-08 Theravance, Inc. Diaryl ether β2 adrenergic receptor agonists

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL301580A (no) * 1962-12-11
US4127675A (en) * 1968-11-12 1978-11-28 Yamanouchi Pharmaceutical Co., Ltd. 4-(Alkylamino-2-hydroxypropoxy)-indenes and method of use
ES373606A1 (es) * 1968-11-18 1972-06-01 Pfizer Un procedimiento para la preparacion de nuevos derivados depropanolamina.
CA956632A (en) * 1969-05-16 1974-10-22 Yoshitomi Pharmaceutical Industries Phenoxy-aminopropanol derivatives
FR2119844B1 (no) * 1970-12-28 1974-03-22 Laroche Navarro Labo
SE388849B (sv) * 1974-02-14 1976-10-18 Haessle Ab Forfarande for framstellning av nya aminer med beta-receptorstimulerande verkan
US4165384A (en) * 1974-11-01 1979-08-21 Aktiebolaget Hassle Amide substituted phenoxy propanol amines
SE402764B (sv) * 1975-06-04 1978-07-17 Haessle Ab Forfarande for framstellning av nya hjertaktiva foreningar
DE2503222A1 (de) * 1975-01-27 1976-07-29 Boehringer Sohn Ingelheim Verfahren zur herstellung von 1-aryl- oxy-3-n-substituierten aminopropanderivaten
FR2330383A1 (fr) * 1975-11-06 1977-06-03 Synthelabo Nouveaux ethers de phenols substitues, leurs sels, leur preparation et les medicaments qui les renferment
DE2645710C2 (de) * 1976-10-09 1985-06-27 Merck Patent Gmbh, 6100 Darmstadt Phenoxy-amino-propanole, Verfahren zu ihrer Herstellung und pharmazeutische Zubereitung
US4263325A (en) * 1977-10-05 1981-04-21 Aktiebolaget Hassle β-Receptor blocking compounds and treatment of cardiovascular disorders therewith
CA1145767A (en) * 1978-07-03 1983-05-03 Jack Mills Phenethanolamines, compositions containing the same, and method for effecting weight control
DE3012012A1 (de) * 1980-03-28 1981-10-08 Beiersdorf Ag, 2000 Hamburg Substituierte 3-aryl-2-cycloalken-1-one und verfahren zu ihrer herstellung
ZW9881A1 (en) * 1980-06-02 1981-12-23 Hoffmann La Roche Substituted phenoxyaminopropanol derivatives
DE3125870C2 (de) * 1980-07-09 1994-09-15 William John Louis 3-Aminopropoxyphenyl Derivate, ihre Herstellung und sie enthaltende Arzneimittel
EP0052963B1 (en) * 1980-11-20 1985-02-20 Beecham Group Plc Secondary amines
IL65541A0 (en) * 1981-05-06 1982-07-30 Haessle Ab Alkylamino-2-propanols,process for their preparation and pharmaceutical preparations containing same
DE3368258D1 (en) * 1982-07-16 1987-01-22 Beecham Group Plc 2-aminoethyl ether derivatives, processes for their preparation and pharmaceutical compositions containing them
ZA835687B (en) * 1982-08-10 1984-03-28 Hoffmann La Roche Novel phenethanolamines
CA1258454A (en) * 1982-08-10 1989-08-15 Leo Alig Phenethanolamines
GB8418472D0 (en) * 1984-07-19 1984-08-22 Beecham Group Plc Compounds

Also Published As

Publication number Publication date
IL73239A0 (en) 1985-01-31
NO159791C (no) 1989-02-08
AU575590B2 (en) 1988-08-04
HU200992B (en) 1990-09-28
DOP1984004282A (es) 1990-03-22
FI844082A0 (fi) 1984-10-17
HUT37743A (en) 1986-02-28
ZW16684A1 (en) 1985-05-15
EP0140243A3 (en) 1986-07-02
DE3475066D1 (de) 1988-12-15
NO159791B (no) 1988-10-31
ATE38510T1 (de) 1988-11-15
CA1262729A (en) 1989-11-07
IL73239A (en) 1989-05-15
MC1625A1 (fr) 1985-09-26
FI844082L (fi) 1985-04-20
PT79371B (en) 1986-11-20
FI844082A7 (fi) 1985-04-20
EP0140243B1 (de) 1988-11-09
PT79371A (en) 1984-11-01
PH21479A (en) 1987-10-28
NZ209866A (en) 1988-07-28
AU3370684A (en) 1985-04-26
US5064863A (en) 1991-11-12
DK497284D0 (da) 1984-10-17
DK497284A (da) 1985-04-20
EP0140243A2 (de) 1985-05-08

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