NO844423L - 11-substituerte 5h,11h-pyrrolo(2,1-c)(1,4)benzoksazepin, fremgangsmaate til dets fremstilling samt anvendelse som legemiddel - Google Patents

11-substituerte 5h,11h-pyrrolo(2,1-c)(1,4)benzoksazepin, fremgangsmaate til dets fremstilling samt anvendelse som legemiddel

Info

Publication number: NO844423L
Authority: NO; Norway
Prior art keywords: compound; formula; give; pyrrolo; piperidin
Prior art date: 1983-11-07

Application number

NO844423A

Other languages

English (en)

Norwegian (no)

Inventor

Richard C Effland

Larry Davis

Kevin J Kapples

Original Assignee

Hoechst Roussel Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-11-07

Filing date

1984-11-06

Publication date

1985-05-08

1984-11-06 Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma

1985-05-08 Publication of NO844423L publication Critical patent/NO844423L/no

Links

238000002360 preparation method Methods 0.000 title claims description 12
238000000034 method Methods 0.000 title claims description 8
150000001875 compounds Chemical class 0.000 claims description 120
239000007787 solid Substances 0.000 claims description 119
ZCXLTWVZYXBHJS-UHFFFAOYSA-N 1,2-benzoxazepine Chemical compound O1N=CC=CC2=CC=CC=C12 ZCXLTWVZYXBHJS-UHFFFAOYSA-N 0.000 claims description 39
-1 cyano, hydroxy, cyclohexyl Chemical group 0.000 claims description 37
238000006243 chemical reaction Methods 0.000 claims description 34
125000000217 alkyl group Chemical group 0.000 claims description 29
239000000460 chlorine Substances 0.000 claims description 29
229910052739 hydrogen Inorganic materials 0.000 claims description 25
239000001257 hydrogen Substances 0.000 claims description 24
229910052736 halogen Inorganic materials 0.000 claims description 12
150000002367 halogens Chemical class 0.000 claims description 12
125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 claims description 10
239000002253 acid Substances 0.000 claims description 8
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 8
150000003839 salts Chemical class 0.000 claims description 8
125000001424 substituent group Chemical group 0.000 claims description 8
238000007327 hydrogenolysis reaction Methods 0.000 claims description 7
125000004093 cyano group Chemical group *C#N 0.000 claims description 6
125000002541 furyl group Chemical group 0.000 claims description 6
125000001544 thienyl group Chemical group 0.000 claims description 6
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 5
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims description 4
WTDHULULXKLSOZ-UHFFFAOYSA-N Hydroxylamine hydrochloride Chemical compound Cl.ON WTDHULULXKLSOZ-UHFFFAOYSA-N 0.000 claims description 4
239000003849 aromatic solvent Substances 0.000 claims description 4
238000004519 manufacturing process Methods 0.000 claims description 4
239000002798 polar solvent Substances 0.000 claims description 4
LJCZNYWLQZZIOS-UHFFFAOYSA-N 2,2,2-trichlorethoxycarbonyl chloride Chemical compound ClC(=O)OCC(Cl)(Cl)Cl LJCZNYWLQZZIOS-UHFFFAOYSA-N 0.000 claims description 3
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 3
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125000003545 alkoxy group Chemical group 0.000 claims description 3
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239000011230 binding agent Substances 0.000 claims description 3
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 3
229910052794 bromium Inorganic materials 0.000 claims description 3
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ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 claims description 3
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DGTNSSLYPYDJGL-UHFFFAOYSA-N phenyl isocyanate Chemical compound O=C=NC1=CC=CC=C1 DGTNSSLYPYDJGL-UHFFFAOYSA-N 0.000 claims description 3
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239000002244 precipitate Substances 0.000 description 25
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VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 16
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239000012280 lithium aluminium hydride Substances 0.000 description 11
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IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 10
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CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 8
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229910000104 sodium hydride Inorganic materials 0.000 description 7
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Neurology (AREA)
Public Health (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO844423A 1983-11-07 1984-11-06 11-substituerte 5h,11h-pyrrolo(2,1-c)(1,4)benzoksazepin, fremgangsmaate til dets fremstilling samt anvendelse som legemiddel NO844423L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/549,098 US4608374A (en)	1983-11-07	1983-11-07	11-substituted 5H,11H-pyrrolo[2,1-c][1,4]benzoxazepines as antipsychotic and analgesic agents

Publications (1)

Publication Number	Publication Date
NO844423L true NO844423L (no)	1985-05-08

Family

ID=24191656

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO844423A NO844423L (no)	1983-11-07	1984-11-06	11-substituerte 5h,11h-pyrrolo(2,1-c)(1,4)benzoksazepin, fremgangsmaate til dets fremstilling samt anvendelse som legemiddel

Country Status (19)

Country	Link
US (1)	US4608374A (de)
EP (2)	EP0144729B1 (de)
JP (1)	JPS60115590A (de)
KR (1)	KR850003893A (de)
AT (1)	ATE47856T1 (de)
AU (2)	AU582553B2 (de)
CA (1)	CA1267893A (de)
DE (1)	DE3480399D1 (de)
DK (1)	DK527984A (de)
ES (4)	ES8608524A1 (de)
FI (1)	FI78103C (de)
GR (1)	GR80839B (de)
HU (1)	HU193233B (de)
IL (1)	IL73434A0 (de)
NO (1)	NO844423L (de)
NZ (1)	NZ210100A (de)
PH (1)	PH21257A (de)
PT (1)	PT79457B (de)
ZA (1)	ZA848655B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4758559A (en) *	1986-01-21	1988-07-19	Ciba-Geigy Corporation	Pyrrolo[1,2-a] [4,1]benzoxazepine derivatives useful as calmodulin and histamine inhibitors
US4794110A (en) *	1987-07-20	1988-12-27	Hoechst-Roussel Pharmaceuticals, Inc.	5-Aryl-11-substituted-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepined as analgesic and hypotensive agents
US4865764A (en) *	1987-07-20	1989-09-12	Hoechst-Roussel Pharmaceuticals, Inc.	5-aryl-11-substituted-5H,11H-pyrrolo[2,1-][1,4]benzoxazepines as hypotensive agents
US4812450A (en) *	1987-07-30	1989-03-14	Hoechst-Roussel Pharmaceuticals Inc.	Spiro((piperidine-pyrrolidine- or hexahydroazepinyl substituted) pyrrolo(2,1-C) (1,4)benzoxazepines)
US5015637A (en) *	1990-05-25	1991-05-14	Hoechst-Roussel Pharmaceutical Inc.	Pyrido[3,4-b]pyrrolo[1,2-e][1,4,5]oxadiazepines
GB9418326D0 (en) *	1994-09-12	1994-11-02	Lilly Industries Ltd	Pharmaceutical compounds
GB2308362A (en) *	1995-12-19	1997-06-25	Lilly Industries Ltd	Pharmaceutical indole derivatives
CA2450073C (en)	2001-07-25	2017-08-29	Biomarin Pharmaceutical Inc.	Compositions and methods for modulating blood-brain barrier transport
JP4400441B2 (ja)	2004-12-14	2010-01-20	三菱電機株式会社	半導体装置
EP2671508B1 (de)	2005-04-28	2020-09-16	Proteus Digital Health, Inc.	Pharma-Informatiksystem
JP2010503710A (ja)	2006-09-18	2010-02-04	ラプトールファーマシューティカルインコーポレイテッド	受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置
GB0711776D0 (en) *	2007-06-18	2007-07-25	Syngenta Participations Ag	Substituted aromatic heterocyclic compounds as fungicides
ES2919563T3 (es)	2009-02-20	2022-07-27	Enhanx Biopharm Inc	Sistema de administración de medicamentos a base de glutatión
KR20180114970A (ko)	2009-05-06	2018-10-19	라보라토리 스킨 케어, 인크.	활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120077778A1 (en)	2010-09-29	2012-03-29	Andrea Bourdelais	Ladder-Frame Polyether Conjugates

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4045448A (en) *	1976-02-26	1977-08-30	American Hoechst Corporation	Pyrrolo[2,1-c][1,4]benzoxazepine and benzoxazocine derivatives
US4029672A (en) *	1976-02-26	1977-06-14	American Hoechst Corporation	Aminoalkylpyrrolobenzoxazalkanes
US4053599A (en) *	1976-02-26	1977-10-11	American Hoechst Corporation	Piperazionalkylpyrrolobenzoxazalkanes
US4169095A (en) *	1977-01-19	1979-09-25	American Hoechst Corporation	Process for preparing aminoalkylpyrrolobenzoxazalkanes
US4169094A (en) *	1977-01-19	1979-09-25	American Hoechst Corporation	Process for preparing aminoalkylpyrrolobenzoxazalkanes
US4263438A (en) *	1977-09-13	1981-04-21	Pfizer Inc.	3-[2,4-(Disubstituted)-phenyl]azacycloalkanones as analgesics
US4208417A (en) *	1978-06-29	1980-06-17	Pharmindustrie	Indole derivatives and their use as anxiolytics
GR73560B (de) *	1979-02-24	1984-03-15	Pfizer
CA1211437A (en) *	1981-08-12	1986-09-16	Rene Borer	Benzazepines

1983
- 1983-11-07 US US06/549,098 patent/US4608374A/en not_active Expired - Fee Related
1984
- 1984-10-31 HU HU844037A patent/HU193233B/hu not_active IP Right Cessation
- 1984-11-02 EP EP84113181A patent/EP0144729B1/de not_active Expired
- 1984-11-02 DE DE8484113181T patent/DE3480399D1/de not_active Expired
- 1984-11-02 AT AT84113181T patent/ATE47856T1/de not_active IP Right Cessation
- 1984-11-02 EP EP87110724A patent/EP0258612A1/de not_active Withdrawn
- 1984-11-05 IL IL73434A patent/IL73434A0/xx unknown
- 1984-11-05 FI FI844333A patent/FI78103C/fi not_active IP Right Cessation
- 1984-11-05 NZ NZ210100A patent/NZ210100A/xx unknown
- 1984-11-05 ES ES537369A patent/ES8608524A1/es not_active Expired
- 1984-11-05 PH PH31405A patent/PH21257A/en unknown
- 1984-11-05 AU AU35104/84A patent/AU582553B2/en not_active Ceased
- 1984-11-05 GR GR80839A patent/GR80839B/el unknown
- 1984-11-06 CA CA000467151A patent/CA1267893A/en not_active Expired - Lifetime
- 1984-11-06 DK DK527984A patent/DK527984A/da not_active Application Discontinuation
- 1984-11-06 PT PT79457A patent/PT79457B/pt unknown
- 1984-11-06 ZA ZA848655A patent/ZA848655B/xx unknown
- 1984-11-06 JP JP59232553A patent/JPS60115590A/ja active Pending
- 1984-11-06 NO NO844423A patent/NO844423L/no unknown
- 1984-11-07 KR KR1019840006971A patent/KR850003893A/ko not_active Ceased
1985
- 1985-07-30 ES ES545728A patent/ES8707538A1/es not_active Expired
1986
- 1986-01-31 ES ES551522A patent/ES8704950A1/es not_active Expired
- 1986-03-01 ES ES552578A patent/ES8707953A1/es not_active Expired
1989
- 1989-01-18 AU AU28565/89A patent/AU2856589A/en not_active Abandoned

Also Published As

Publication number	Publication date
HUT36127A (en)	1985-08-28
GR80839B (en)	1985-02-26
ES552578A0 (es)	1987-09-16
KR850003893A (ko)	1985-06-29
ES545728A0 (es)	1987-08-01
ES8704950A1 (es)	1987-04-16
AU582553B2 (en)	1989-04-06
CA1267893A (en)	1990-04-17
ES8707538A1 (es)	1987-08-01
FI78103C (fi)	1989-06-12
DK527984A (da)	1985-05-08
PT79457B (en)	1986-11-14
ES537369A0 (es)	1986-06-16
AU3510484A (en)	1985-05-16
PH21257A (en)	1987-08-31
PT79457A (en)	1984-12-01
ES8707953A1 (es)	1987-09-16
ZA848655B (en)	1985-06-26
FI844333A0 (fi)	1984-11-05
DK527984D0 (da)	1984-11-06
IL73434A0 (en)	1985-02-28
ATE47856T1 (de)	1989-11-15
EP0258612A1 (de)	1988-03-09
EP0144729A1 (de)	1985-06-19
FI78103B (fi)	1989-02-28
US4608374A (en)	1986-08-26
FI844333L (fi)	1985-05-08
AU2856589A (en)	1989-07-13
HU193233B (en)	1987-08-28
JPS60115590A (ja)	1985-06-22
NZ210100A (en)	1988-06-30
ES551522A0 (es)	1987-04-16
ES8608524A1 (es)	1986-06-16
DE3480399D1 (en)	1989-12-14
EP0144729B1 (de)	1989-11-08

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