NO854730L - Mellomprodukter for bruk ved fremstilling av antibakterielt virksomme cefem-forbindelser og fremgangsmaate for deres fremstilling - Google Patents

Mellomprodukter for bruk ved fremstilling av antibakterielt virksomme cefem-forbindelser og fremgangsmaate for deres fremstilling

Info

Publication number
NO854730L
NO854730L NO854730A NO854730A NO854730L NO 854730 L NO854730 L NO 854730L NO 854730 A NO854730 A NO 854730A NO 854730 A NO854730 A NO 854730A NO 854730 L NO854730 L NO 854730L
Authority
NO
Norway
Prior art keywords
intermediates
procedure
manufacture
preparation
antibacterial effective
Prior art date
Application number
NO854730A
Other languages
English (en)
Other versions
NO167293B (no
NO167293C (no
Inventor
Akio Miyake
Masahiro Kondo
Masahiko Fujino
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP1984/000212 external-priority patent/WO1985004879A1/ja
Priority claimed from PCT/JP1984/000270 external-priority patent/WO1985005620A1/ja
Priority claimed from PCT/JP1985/000102 external-priority patent/WO1986005184A1/ja
Publication of NO854730L publication Critical patent/NO854730L/no
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of NO167293B publication Critical patent/NO167293B/no
Publication of NO167293C publication Critical patent/NO167293C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
NO85854730A 1984-04-23 1985-11-26 Mellomprodukter. NO167293C (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/JP1984/000212 WO1985004879A1 (en) 1984-04-23 1984-04-23 Cephem compounds
PCT/JP1984/000270 WO1985005620A1 (fr) 1984-05-25 1984-05-25 Composes cephem
PCT/JP1985/000102 WO1986005184A1 (fr) 1985-03-01 1985-03-01 Composes antibacteriens
NO851538A NO165842C (no) 1984-04-23 1985-04-17 Analogifremgangsmaate for fremstilling av terapeutisk aktive cefem-forbindelser.

Publications (3)

Publication Number Publication Date
NO854730L true NO854730L (no) 1985-10-24
NO167293B NO167293B (no) 1991-07-15
NO167293C NO167293C (no) 1991-10-23

Family

ID=27304399

Family Applications (2)

Application Number Title Priority Date Filing Date
NO851538A NO165842C (no) 1984-04-23 1985-04-17 Analogifremgangsmaate for fremstilling av terapeutisk aktive cefem-forbindelser.
NO85854730A NO167293C (no) 1984-04-23 1985-11-26 Mellomprodukter.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO851538A NO165842C (no) 1984-04-23 1985-04-17 Analogifremgangsmaate for fremstilling av terapeutisk aktive cefem-forbindelser.

Country Status (13)

Country Link
EP (1) EP0160252B1 (no)
JP (1) JPH07103130B2 (no)
KR (2) KR920008945B1 (no)
AU (1) AU580995B2 (no)
CA (1) CA1283096C (no)
DE (2) DE3586547T2 (no)
ES (4) ES8606362A1 (no)
FI (1) FI851592A7 (no)
GR (1) GR850965B (no)
NO (2) NO165842C (no)
NZ (1) NZ211858A (no)
PH (1) PH23134A (no)
PT (1) PT80328B (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH22107A (en) * 1984-06-07 1988-06-01 Takeda Chemical Industries Ltd 3-pyrazolo(1,5-a)pyrdinium cephem compounds
EP0203271B1 (en) * 1985-03-01 1993-05-26 Takeda Chemical Industries, Ltd. Antibacterial compounds, their production and use
ATE89826T1 (de) * 1985-03-01 1993-06-15 Takeda Chemical Industries Ltd Antibakterielle verbindungen, ihre herstellung und verwendung.
US4921851A (en) * 1986-06-09 1990-05-01 Takeda Chemical Industries, Ltd. Cephem compounds, their production and use
JP2519054B2 (ja) * 1986-06-09 1996-07-31 武田薬品工業株式会社 新規セフェム化合物
DE3707019A1 (de) * 1987-03-05 1988-09-15 Hoechst Ag Cephalosporinderivate und verfahren zu ihrer herstellung
US4933334A (en) * 1987-12-04 1990-06-12 Takeda Chemical Industries, Ltd. Antibiotic composition
AU615966B2 (en) * 1987-12-04 1991-10-17 Takeda Chemical Industries Ltd. Crystals of cephem hydrochloride
ATE117690T1 (de) * 1990-03-01 1995-02-15 Takeda Chemical Industries Ltd Imidazopyridazine, ihre herstellung und verwendung.
TW526202B (en) 1998-11-27 2003-04-01 Shionogi & Amp Co Broad spectrum cephem having benzo[4,5-b]pyridium methyl group of antibiotic activity
ES2336917T3 (es) * 2003-04-30 2010-04-19 Trine Pharmaceuticals, Inc. Antibioticos betalactamicos de la clase de los carbacefem.
MX2011004636A (es) 2008-10-31 2011-06-20 Shionogi & Co Cefarosporinas que tienen un grupo catecol.
EP2557082A4 (en) 2010-04-05 2013-08-28 Shionogi & Co CEPHEM COMPOUND COMPRISING A CATÉCHOL GROUP
TWI547496B (zh) 2011-10-04 2016-09-01 葛蘭素集團公司 抗菌化合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4165430A (en) * 1976-03-19 1979-08-21 Glaxo Laboratories Limited Cephalosporins having a 7-carboxy substituted α-etherified oximinoarylacetamido) group
ES511101A0 (es) * 1981-04-03 1983-05-01 Fujisawa Pharmaceutical Co "procedimiento para preparar un nuevo compuesto de cefem".
DE3336757A1 (de) * 1983-10-08 1985-04-25 Hoechst Ag, 6230 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
NO165842B (no) 1991-01-07
AU4170085A (en) 1985-10-31
NZ211858A (en) 1988-08-30
ES8706692A1 (es) 1987-06-16
NO165842C (no) 1991-04-17
NO851538L (no) 1985-10-24
NO167293B (no) 1991-07-15
DE3586547D1 (de) 1993-02-04
DE3586547A1 (no) 1993-02-04
GR850965B (no) 1985-11-25
FI851592L (fi) 1985-10-24
KR850007427A (ko) 1985-12-04
JPS60231684A (ja) 1985-11-18
NO167293C (no) 1991-10-23
ES8606362A1 (es) 1986-04-01
FI851592A0 (fi) 1985-04-22
ES8707245A1 (es) 1987-07-16
PT80328A (en) 1985-05-01
DE3586547T2 (de) 1993-04-15
PT80328B (en) 1987-02-16
EP0160252A3 (en) 1987-01-14
ES557129A0 (es) 1987-12-01
PH23134A (en) 1989-05-11
ES542447A0 (es) 1986-04-01
ES553666A0 (es) 1987-06-16
CA1283096C (en) 1991-04-16
ES549180A0 (es) 1987-07-16
JPH07103130B2 (ja) 1995-11-08
ES8800950A1 (es) 1987-12-01
KR920008945B1 (ko) 1992-10-12
EP0160252A2 (en) 1985-11-06
FI851592A7 (fi) 1985-10-24
AU580995B2 (en) 1989-02-09
KR920008953B1 (ko) 1992-10-12
EP0160252B1 (en) 1992-08-26

Similar Documents

Publication Publication Date Title
DK279780A (da) 2-formyl-3-hydroxy-phenoxyforbindelser deres fremstilling og anvendelse og mellemprodukter anvendelige ved deres fremstilling
DK306885D0 (da) Substituerede benzoatestere af 3-hydroxymorphinaner, deres fremstilling og anvendelse
NO850614L (no) Fremgangsmaate for fremstilling av antibakterielle kinolin- og naftyridin-derivater
DK457781A (da) Bicyclooxyhenylurinstoffer deres fremstilling og anvendelse
FI881223A7 (fi) Menetelmä terapeuttisesti aktiivisten substituoitujen 9-aminotetrahydroakriinien ja niille läheisten yhdisteiden valmistamiseksi
NO803328L (no) Krystallinske borsilikatmaterialer og fremgangsmaate ved fremstilling derav
NO851524L (no) Fremgangsmaate for fremstilling av fenetanolamin-forbindelser
ES546360A0 (es) Procedimiento para la obtencion de poli-hidro piridazo dia- cepinas triacepinas o diazocinas
ZA857081B (en) Composition for the treatment of allergy
NO170924C (no) Fremgangsmaate for fremstilling av zeolitt l
DK407383A (da) Diaminopyrimidiner, fremgangsmaader til deres fremstilling, deres anvendelse og mellemprodukter anvendelige ved forbindelsernes fremstilling
FI854603A7 (fi) Menetelmä ja välituotteet 5-alkyyli-1-fenyyli-2-piperatsino-alkyylipyratsolin-3-oni-yhdisteiden valmistamiseksi.
NO170159C (no) Fortykningsmiddel og anvendelse av dette
NO851330L (no) Fremgangsmaate ved fremstilling av pyrrolidonderivater
DK326085D0 (da) 4-amino-2-phenylquinoliner, deres fremstilling og anvendelse samt ved fremstillingen anvendelige mellemprodukter
NO851638L (no) Fremgangsmaate ved fremstilling av iminothiazolidin-derivater
DK169481A (da) Kobberphthalocyaninpigmenter deres fremstilling og deres anvendelse
NO851059L (no) Fremgangsmaate for fremstilling av 2-oksindol-1-karboks-amider og mellomprodukter for anvendelse ved fremgangsmaaten.
DK318081A (da) Kondenserede as-triazinderivater deres fremstilling og anvendelse
NO170140C (no) Fremgangsmaate for overflatebehandling av materialer med plane overflater
NO168581C (no) Fremgangsmaate ved fremstilling av terapeutisk aktive beta-methylen-thiofenethanaminer
JPS5676459A (en) Cationic compound of haphthalimide* its manufacture and use
NO812937L (no) Fremgangsmaate ved fremstilling av terapeutisk virksomt n-(1-allyl-2-pyrrolidinyl-methyl)-2-methoxy-4-amino-5-methylsulfamoyl-benzamid
ES545117A0 (es) Procedimiento de preparacion de nuevos derivados de acido- 9- u 11-nitroaprovincaminico racemicos y opticamente activos
FI923744A7 (fi) Menetelmä ja välituotteita 6-fluoribentsisotiatsolien valmistamiseksi