NO860890L - Oralt preparat mot tannstein. - Google Patents

Oralt preparat mot tannstein. Download PDF

Info

Publication number: NO860890L
Authority: NO; Norway
Prior art keywords: approx; oral; preparation according; oral preparation; preparation
Prior art date: 1985-03-11

Application number

NO860890A

Other languages

English (en)

Norwegian (no)

Inventor

Abdul Gaffar

Original Assignee

Colgate Palmolive Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-03-11

Filing date

1986-03-10

Publication date

1986-09-12

1985-03-11 Priority claimed from US06/710,876 external-priority patent/US4590064A/en

1986-03-10 Application filed by Colgate Palmolive Co filed Critical Colgate Palmolive Co

1986-09-12 Publication of NO860890L publication Critical patent/NO860890L/no

Links

238000002360 preparation method Methods 0.000 title claims description 72
-1 alkali metal salt Chemical class 0.000 claims description 30
239000003795 chemical substances by application Substances 0.000 claims description 24
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 23
150000001875 compounds Chemical class 0.000 claims description 19
239000000606 toothpaste Substances 0.000 claims description 18
208000006558 Dental Calculus Diseases 0.000 claims description 17
229940034610 toothpaste Drugs 0.000 claims description 16
239000002324 mouth wash Substances 0.000 claims description 14
229940051866 mouthwash Drugs 0.000 claims description 14
208000002925 dental caries Diseases 0.000 claims description 13
239000000499 gel Substances 0.000 claims description 12
230000015572 biosynthetic process Effects 0.000 claims description 11
210000000214 mouth Anatomy 0.000 claims description 11
238000000034 method Methods 0.000 claims description 10
150000003839 salts Chemical class 0.000 claims description 10
239000002253 acid Substances 0.000 claims description 9
230000002401 inhibitory effect Effects 0.000 claims description 9
239000000463 material Substances 0.000 claims description 9
238000005498 polishing Methods 0.000 claims description 9
PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 9
KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 8
229910052783 alkali metal Inorganic materials 0.000 claims description 7
239000006071 cream Substances 0.000 claims description 7
229940091249 fluoride supplement Drugs 0.000 claims description 7
239000007788 liquid Substances 0.000 claims description 7
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
235000003599 food sweetener Nutrition 0.000 claims description 6
239000000843 powder Substances 0.000 claims description 6
239000003765 sweetening agent Substances 0.000 claims description 6
XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 claims description 4
239000000796 flavoring agent Substances 0.000 claims description 4
239000011775 sodium fluoride Substances 0.000 claims description 4
235000013024 sodium fluoride Nutrition 0.000 claims description 4
229960004711 sodium monofluorophosphate Drugs 0.000 claims description 4
AGFRRGYVNWGNLX-UHFFFAOYSA-N O.O.O.O.O.O.[Na].[Na].[Na] Chemical compound O.O.O.O.O.O.[Na].[Na].[Na] AGFRRGYVNWGNLX-UHFFFAOYSA-N 0.000 claims description 2
235000019634 flavors Nutrition 0.000 claims description 2
238000004519 manufacturing process Methods 0.000 claims 1
229910052588 hydroxylapatite Inorganic materials 0.000 description 17
XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 17
239000000243 solution Substances 0.000 description 17
239000000126 substance Substances 0.000 description 15
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 10
230000000694 effects Effects 0.000 description 10
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
239000001506 calcium phosphate Substances 0.000 description 8
239000013078 crystal Substances 0.000 description 8
XUYJLQHKOGNDPB-UHFFFAOYSA-N phosphonoacetic acid Chemical compound OC(=O)CP(O)(O)=O XUYJLQHKOGNDPB-UHFFFAOYSA-N 0.000 description 8
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 8
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 7
239000000203 mixture Substances 0.000 description 7
235000011010 calcium phosphates Nutrition 0.000 description 6
238000004090 dissolution Methods 0.000 description 6
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 5
229910000389 calcium phosphate Inorganic materials 0.000 description 5
235000014113 dietary fatty acids Nutrition 0.000 description 5
239000000194 fatty acid Substances 0.000 description 5
229930195729 fatty acid Natural products 0.000 description 5
239000000600 sorbitol Substances 0.000 description 5
239000002562 thickening agent Substances 0.000 description 5
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 4
229920000663 Hydroxyethyl cellulose Polymers 0.000 description 4
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
230000001580 bacterial effect Effects 0.000 description 4
239000002585 base Substances 0.000 description 4
230000001680 brushing effect Effects 0.000 description 4
238000006243 chemical reaction Methods 0.000 description 4
210000003298 dental enamel Anatomy 0.000 description 4
239000000551 dentifrice Substances 0.000 description 4
150000004665 fatty acids Chemical class 0.000 description 4
235000019447 hydroxyethyl cellulose Nutrition 0.000 description 4
239000002245 particle Substances 0.000 description 4
229910052708 sodium Inorganic materials 0.000 description 4
239000011734 sodium Substances 0.000 description 4
AQMNWCRSESPIJM-UHFFFAOYSA-M sodium metaphosphate Chemical compound [Na+].[O-]P(=O)=O AQMNWCRSESPIJM-UHFFFAOYSA-M 0.000 description 4
239000007787 solid Substances 0.000 description 4
239000004094 surface-active agent Substances 0.000 description 4
239000000080 wetting agent Substances 0.000 description 4
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
239000004354 Hydroxyethyl cellulose Substances 0.000 description 3
241001465754 Metazoa Species 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
229930006000 Sucrose Natural products 0.000 description 3
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 3
150000001340 alkali metals Chemical class 0.000 description 3
229910052782 aluminium Inorganic materials 0.000 description 3
239000011575 calcium Substances 0.000 description 3
229910052791 calcium Inorganic materials 0.000 description 3
239000001768 carboxy methyl cellulose Substances 0.000 description 3
125000002091 cationic group Chemical group 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
239000008119 colloidal silica Substances 0.000 description 3
239000007859 condensation product Substances 0.000 description 3
235000005911 diet Nutrition 0.000 description 3
230000037213 diet Effects 0.000 description 3
239000004615 ingredient Substances 0.000 description 3
230000005764 inhibitory process Effects 0.000 description 3
OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 3
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
239000000047 product Substances 0.000 description 3
230000002829 reductive effect Effects 0.000 description 3
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 3
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 3
ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 3
229960002799 stannous fluoride Drugs 0.000 description 3
239000005720 sucrose Substances 0.000 description 3
239000008399 tap water Substances 0.000 description 3
235000020679 tap water Nutrition 0.000 description 3
LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 2
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 2
241000894006 Bacteria Species 0.000 description 2
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
BACYUWVYYTXETD-UHFFFAOYSA-N N-Lauroylsarcosine Chemical compound CCCCCCCCCCCC(=O)N(C)CC(O)=O BACYUWVYYTXETD-UHFFFAOYSA-N 0.000 description 2
229910019142 PO4 Inorganic materials 0.000 description 2
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
241000700159 Rattus Species 0.000 description 2
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
229920002125 Sokalan® Polymers 0.000 description 2
YSMRWXYRXBRSND-UHFFFAOYSA-N TOTP Chemical compound CC1=CC=CC=C1OP(=O)(OC=1C(=CC=CC=1)C)OC1=CC=CC=C1C YSMRWXYRXBRSND-UHFFFAOYSA-N 0.000 description 2
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
HFIGWKOFZLNOQK-UHFFFAOYSA-K [O-]P([O-])(=O)OP(=O)([O-])O.[Ca+2].[Na+] Chemical class [O-]P([O-])(=O)OP(=O)([O-])O.[Ca+2].[Na+] HFIGWKOFZLNOQK-UHFFFAOYSA-K 0.000 description 2
125000001931 aliphatic group Chemical group 0.000 description 2
125000000129 anionic group Chemical group 0.000 description 2
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
150000001720 carbohydrates Chemical class 0.000 description 2
235000014633 carbohydrates Nutrition 0.000 description 2
125000004432 carbon atom Chemical group C* 0.000 description 2
230000001013 cariogenic effect Effects 0.000 description 2
239000011248 coating agent Substances 0.000 description 2
238000000576 coating method Methods 0.000 description 2
DGTVXEHQMSJRPE-UHFFFAOYSA-M difluorophosphinate Chemical compound [O-]P(F)(F)=O DGTVXEHQMSJRPE-UHFFFAOYSA-M 0.000 description 2
239000012153 distilled water Substances 0.000 description 2
229920001971 elastomer Polymers 0.000 description 2
150000002222 fluorine compounds Chemical class 0.000 description 2
235000013355 food flavoring agent Nutrition 0.000 description 2
239000003906 humectant Substances 0.000 description 2
238000005470 impregnation Methods 0.000 description 2
238000000338 in vitro Methods 0.000 description 2
238000001727 in vivo Methods 0.000 description 2
238000011835 investigation Methods 0.000 description 2
229940094522 laponite Drugs 0.000 description 2
XCOBTUNSZUJCDH-UHFFFAOYSA-B lithium magnesium sodium silicate Chemical compound [Li+].[Li+].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Na+].[Na+].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3 XCOBTUNSZUJCDH-UHFFFAOYSA-B 0.000 description 2
GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 description 2
125000005341 metaphosphate group Chemical group 0.000 description 2
238000002156 mixing Methods 0.000 description 2
229910000403 monosodium phosphate Inorganic materials 0.000 description 2
235000019799 monosodium phosphate Nutrition 0.000 description 2
239000003921 oil Substances 0.000 description 2
235000019198 oils Nutrition 0.000 description 2
239000010452 phosphate Substances 0.000 description 2
235000021317 phosphate Nutrition 0.000 description 2
229920001451 polypropylene glycol Polymers 0.000 description 2
229910052700 potassium Inorganic materials 0.000 description 2
239000011591 potassium Substances 0.000 description 2
NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 description 2
239000002243 precursor Substances 0.000 description 2
230000000069 prophylactic effect Effects 0.000 description 2
230000009467 reduction Effects 0.000 description 2
239000005060 rubber Substances 0.000 description 2
239000002002 slurry Substances 0.000 description 2
AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 2
235000019614 sour taste Nutrition 0.000 description 2
238000003756 stirring Methods 0.000 description 2
230000009747 swallowing Effects 0.000 description 2
230000000699 topical effect Effects 0.000 description 2
238000011282 treatment Methods 0.000 description 2
239000000052 vinegar Substances 0.000 description 2
235000021419 vinegar Nutrition 0.000 description 2
238000005406 washing Methods 0.000 description 2
BHHYHSUAOQUXJK-UHFFFAOYSA-L zinc fluoride Chemical compound F[Zn]F BHHYHSUAOQUXJK-UHFFFAOYSA-L 0.000 description 2
JLPAMKUIIFHLBH-UHFFFAOYSA-N 1,2-dihydroxypropane-1-sulfonic acid Chemical compound CC(O)C(O)S(O)(=O)=O JLPAMKUIIFHLBH-UHFFFAOYSA-N 0.000 description 1
OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
RPZANUYHRMRTTE-UHFFFAOYSA-N 2,3,4-trimethoxy-6-(methoxymethyl)-5-[3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxyoxane;1-[[3,4,5-tris(2-hydroxybutoxy)-6-[4,5,6-tris(2-hydroxybutoxy)-2-(2-hydroxybutoxymethyl)oxan-3-yl]oxyoxan-2-yl]methoxy]butan-2-ol Chemical compound COC1C(OC)C(OC)C(COC)OC1OC1C(OC)C(OC)C(OC)OC1COC.CCC(O)COC1C(OCC(O)CC)C(OCC(O)CC)C(COCC(O)CC)OC1OC1C(OCC(O)CC)C(OCC(O)CC)C(OCC(O)CC)OC1COCC(O)CC RPZANUYHRMRTTE-UHFFFAOYSA-N 0.000 description 1
SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
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LFJJOPDNPVFCNZ-UHFFFAOYSA-N 2-[hexadecanoyl(methyl)amino]acetic acid Chemical class CCCCCCCCCCCCCCCC(=O)N(C)CC(O)=O LFJJOPDNPVFCNZ-UHFFFAOYSA-N 0.000 description 1
NGOZDSMNMIRDFP-UHFFFAOYSA-N 2-[methyl(tetradecanoyl)amino]acetic acid Chemical class CCCCCCCCCCCCCC(=O)N(C)CC(O)=O NGOZDSMNMIRDFP-UHFFFAOYSA-N 0.000 description 1
DDFHBQSCUXNBSA-UHFFFAOYSA-N 5-(5-carboxythiophen-2-yl)thiophene-2-carboxylic acid Chemical compound S1C(C(=O)O)=CC=C1C1=CC=C(C(O)=O)S1 DDFHBQSCUXNBSA-UHFFFAOYSA-N 0.000 description 1
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229940120146 EDTMP Drugs 0.000 description 1
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102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
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235000007297 Gaultheria procumbens Nutrition 0.000 description 1
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UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
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230000002378 acidificating effect Effects 0.000 description 1
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150000001298 alcohols Chemical class 0.000 description 1
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OQZCJRJRGMMSGK-UHFFFAOYSA-M potassium metaphosphate Chemical compound [K+].[O-]P(=O)=O OQZCJRJRGMMSGK-UHFFFAOYSA-M 0.000 description 1
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CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
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239000012488 sample solution Substances 0.000 description 1
108700004121 sarkosyl Proteins 0.000 description 1
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239000000377 silicon dioxide Substances 0.000 description 1
235000012239 silicon dioxide Nutrition 0.000 description 1
239000000344 soap Substances 0.000 description 1
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
239000004299 sodium benzoate Substances 0.000 description 1
229960003885 sodium benzoate Drugs 0.000 description 1
235000010234 sodium benzoate Nutrition 0.000 description 1
235000017550 sodium carbonate Nutrition 0.000 description 1
229940001593 sodium carbonate Drugs 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
229960001790 sodium citrate Drugs 0.000 description 1
235000011083 sodium citrates Nutrition 0.000 description 1
229960001462 sodium cyclamate Drugs 0.000 description 1
229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
UGTZMIPZNRIWHX-UHFFFAOYSA-K sodium trimetaphosphate Chemical compound [Na+].[Na+].[Na+].[O-]P1(=O)OP([O-])(=O)OP([O-])(=O)O1 UGTZMIPZNRIWHX-UHFFFAOYSA-K 0.000 description 1
239000002195 soluble material Substances 0.000 description 1
239000001587 sorbitan monostearate Substances 0.000 description 1
235000011076 sorbitan monostearate Nutrition 0.000 description 1
229940035048 sorbitan monostearate Drugs 0.000 description 1
229910001220 stainless steel Inorganic materials 0.000 description 1
239000010935 stainless steel Substances 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
239000008400 supply water Substances 0.000 description 1
235000019605 sweet taste sensations Nutrition 0.000 description 1
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239000012085 test solution Substances 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
229940078499 tricalcium phosphate Drugs 0.000 description 1
229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
235000019731 tricalcium phosphate Nutrition 0.000 description 1
AZJYLVAUMGUUBL-UHFFFAOYSA-A u1qj22mc8e Chemical group [F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].O=[Si]=O.O=[Si]=O.O=[Si]=O.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3 AZJYLVAUMGUUBL-UHFFFAOYSA-A 0.000 description 1
230000004584 weight gain Effects 0.000 description 1
235000019786 weight gain Nutrition 0.000 description 1
239000000811 xylitol Substances 0.000 description 1
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
235000010447 xylitol Nutrition 0.000 description 1
229960002675 xylitol Drugs 0.000 description 1
UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
GFQYVLUOOAAOGM-UHFFFAOYSA-N zirconium(iv) silicate Chemical compound [Zr+4].[O-][Si]([O-])([O-])[O-] GFQYVLUOOAAOGM-UHFFFAOYSA-N 0.000 description 1

Landscapes

Cosmetics (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

NO860890A 1985-03-11 1986-03-10 Oralt preparat mot tannstein. NO860890L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/710,876 US4590064A (en)	1985-03-11	1985-03-11	Anticalculus oral composition

Publications (1)

Publication Number	Publication Date
NO860890L true NO860890L (no)	1986-09-12

Family

ID=24855906

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO860890A NO860890L (no)	1985-03-11	1986-03-10	Oralt preparat mot tannstein.

Country Status (9)

Country	Link
DK (1)	DK111786A (el)
ES (1)	ES8707858A1 (el)
GR (1)	GR860659B (el)
IT (1)	IT1191257B (el)
MX (1)	MX163304A (el)
NO (1)	NO860890L (el)
PH (1)	PH21815A (el)
SG (1)	SG90991G (el)
ZA (1)	ZA861485B (el)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4059922A (en) *	1976-01-12	1977-11-29	Digiacinto Joseph A	Sprayer hydroponic grower
US4658542A (en) *	1986-02-24	1987-04-21	Holmberg Douglas A	Portable growing system

1986
- 1986-02-27 ZA ZA861485A patent/ZA861485B/xx unknown
- 1986-02-28 MX MX170686A patent/MX163304A/es unknown
- 1986-03-10 IT IT47748/86A patent/IT1191257B/it active
- 1986-03-10 GR GR860659A patent/GR860659B/el unknown
- 1986-03-10 ES ES552850A patent/ES8707858A1/es not_active Expired
- 1986-03-10 NO NO860890A patent/NO860890L/no unknown
- 1986-03-11 PH PH33511A patent/PH21815A/en unknown
- 1986-03-11 DK DK111786A patent/DK111786A/da unknown
1991
- 1991-10-31 SG SG90991A patent/SG90991G/en unknown

Also Published As

Publication number	Publication date
GR860659B (en)	1986-07-14
DK111786A (da)	1986-09-12
DK111786D0 (da)	1986-03-11
IT1191257B (it)	1988-02-24
PH21815A (en)	1988-03-04
SG90991G (en)	1991-12-13
ES552850A0 (es)	1987-09-01
ZA861485B (en)	1987-10-28
IT8647748A0 (it)	1986-03-10
ES8707858A1 (es)	1987-09-01
MX163304A (es)	1992-04-14

Publication	Publication Date	Title
US5180576A (en)	1993-01-19	Anticalculus dentifrices
JP2573685B2 (ja)	1997-01-22	抗歯石口腔用組成物
FI89237B (fi)	1993-05-31	Oral sammansaettning som foerhindrar bildande av tandsten
FI90201B (fi)	1993-09-30	Oraalinen hammaskiven muodostumista ehkäisevä koostumus
US6464963B1 (en)	2002-10-15	Desensitizing dentifrice containing potassium and tin salts
AU630028B2 (en)	1992-10-15	Antibacterial antiplaque anticalculus oral composition
US4808401A (en)	1989-02-28	Anticalculus oral composition
RU2092162C1 (ru)	1997-10-10	Композиция для орального введения, предотвращающая образование камней
EP0329069B1 (en)	1992-05-06	Anticalculus oral composition
US5089255A (en)	1992-02-18	Dental remineralization
US4224308A (en)	1980-09-23	Anticalculus oral composition
IE914446A1 (en)	1992-07-01	Anticalculus oral composition
US4339431A (en)	1982-07-13	Anticalculus oral composition
EP0405682B1 (en)	1994-03-23	Dental remineralization
US4590064A (en)	1986-05-20	Anticalculus oral composition
IE50730B1 (en)	1986-06-25	Non-staining antigingivitis composition
HK1000082B (en)	1997-11-21	Dental remineralization
US4880619A (en)	1989-11-14	Anticalculus oral composition
US4215105A (en)	1980-07-29	Anticalculus oral composition
US6692725B2 (en)	2004-02-17	Composition for oral care
NO860890L (no)	1986-09-12	Oralt preparat mot tannstein.