NO864321L - Rensemetode for proteiner. - Google Patents

Rensemetode for proteiner.

Info

Publication number: NO864321L
Authority: NO; Norway
Prior art keywords: tnf; matrix; hydrophobic; purified; protein
Prior art date: 1985-10-30

Application number

NO864321A

Other languages

English (en)

Norwegian (no)

Other versions

NO864321D0 (no

Inventor

Leo Shun-Lee Lin

Wolfgang Helmut Hanisch

Ralph Yamamoto

James William Thomson

Glenn Dorin

Sidney Norman Wolfe

Original Assignee

Cetus Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-10-30

Filing date

1986-10-29

Publication date

1987-05-04

1985-10-30 Priority claimed from US06/792,815 external-priority patent/US4677197A/en

1986-05-22 Priority claimed from US06/866,213 external-priority patent/US4894439A/en

1986-10-29 Application filed by Cetus Corp filed Critical Cetus Corp

1986-10-29 Publication of NO864321D0 publication Critical patent/NO864321D0/no

1987-05-04 Publication of NO864321L publication Critical patent/NO864321L/no

Links

108090000623 proteins and genes Proteins 0.000 title claims description 97
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238000000034 method Methods 0.000 title claims description 78
238000004140 cleaning Methods 0.000 title description 5
230000002209 hydrophobic effect Effects 0.000 claims abstract description 76
108060008682 Tumor Necrosis Factor Proteins 0.000 claims abstract description 63
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239000002158 endotoxin Substances 0.000 claims abstract description 18
238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 claims abstract description 16
239000002510 pyrogen Substances 0.000 claims abstract description 7
241000283973 Oryctolagus cuniculus Species 0.000 claims abstract description 4
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108010039491 Ricin Proteins 0.000 claims abstract 2
239000011159 matrix material Substances 0.000 claims description 88
150000003839 salts Chemical class 0.000 claims description 50
238000000746 purification Methods 0.000 claims description 35
238000005349 anion exchange Methods 0.000 claims description 31
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230000008569 process Effects 0.000 claims description 25
230000003993 interaction Effects 0.000 claims description 23
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BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims description 17
229910052921 ammonium sulfate Inorganic materials 0.000 claims description 17
235000011130 ammonium sulphate Nutrition 0.000 claims description 17
-1 polytetrafluoroethylene Polymers 0.000 claims description 14
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229910052709 silver Inorganic materials 0.000 description 1
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229910052708 sodium Inorganic materials 0.000 description 1
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KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
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KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
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YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Analytical Chemistry (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

NO864321A 1985-10-30 1986-10-29 Rensemetode for proteiner. NO864321L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/792,815 US4677197A (en)	1985-10-30	1985-10-30	Purification method for tumor necrosis factor
US06/866,213 US4894439A (en)	1986-05-22	1986-05-22	N-terminal derivatives of tumor necrosis factor purified by microporous PTFE membranes

Publications (2)

Publication Number	Publication Date
NO864321D0 NO864321D0 (no)	1986-10-29
NO864321L true NO864321L (no)	1987-05-04

Family

ID=27121338

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO864321A NO864321L (no)	1985-10-30	1986-10-29	Rensemetode for proteiner.

Country Status (9)

Country	Link
EP (1)	EP0220966A3 (da)
AU (1)	AU6449586A (da)
CA (1)	CA1286843C (da)
DK (1)	DK520086A (da)
FI (1)	FI864412L (da)
IL (1)	IL80448A (da)
MX (1)	MX166995B (da)
NO (1)	NO864321L (da)
NZ (1)	NZ218103A (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4689401A (en) *	1986-03-06	1987-08-25	Cetus Corporation	Method of recovering microbially produced recombinant ricin toxin a chain
JPS62298536A (ja) *	1986-06-17	1987-12-25	Green Cross Corp:The	生理活性物質の自動精製方法および自動精製装置
US4771128A (en) *	1986-10-10	1988-09-13	Cetus Corporation	Method of purifying toxin conjugates using hydrophobic interaction chromatography
US4808314A (en) *	1987-09-18	1989-02-28	Scripps Clinic And Research Foundation	Method for reducing bacterial endotoxin contamination in solutions of macromolecules
PT88783B (pt) *	1987-10-23	1993-01-29	Smithkline Beckman Corp	Processo de purificacao de proteina t4 soluvel e de producao da mesma
CA1341379C (en) *	1988-04-28	2002-07-23	Welfide Corporation	Purified antithrombin-iii and methods of producing the same
LT3062B (en)	1992-09-03	1994-10-25	Fermentas Biotech Inst	Method for preparing recombinant human tumour necrolysis factor-alpha
US7642340B2 (en) *	2003-03-31	2010-01-05	Xencor, Inc.	PEGylated TNF-α variant proteins
CN121226565A (zh) *	2025-12-03	2025-12-30	上海银诺医药技术有限公司	一种依苏帕格鲁肽α的纯化方法及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0155549B1 (en) *	1984-03-06	1991-03-20	Dainippon Pharmaceutical Co., Ltd.	Dna encoding human tumor necrosis factor and human tumor necrosis factor polypeptide
AU589919B2 (en) *	1984-10-15	1989-10-26	Cetus Corp	Human tumor necrosis factor
EP0205038A1 (en) *	1985-05-29	1986-12-17	Suntory Limited	Polypeptide, process for preparing it, microorganism and pharmaceutical use

1986
- 1986-09-24 CA CA000518943A patent/CA1286843C/en not_active Expired - Fee Related
- 1986-10-29 MX MX026926A patent/MX166995B/es unknown
- 1986-10-29 AU AU64495/86A patent/AU6449586A/en not_active Abandoned
- 1986-10-29 NZ NZ218103A patent/NZ218103A/xx unknown
- 1986-10-29 NO NO864321A patent/NO864321L/no unknown
- 1986-10-29 IL IL80448A patent/IL80448A/xx not_active IP Right Cessation
- 1986-10-29 FI FI864412A patent/FI864412L/fi not_active Application Discontinuation
- 1986-10-30 DK DK520086A patent/DK520086A/da unknown
- 1986-10-30 EP EP86308484A patent/EP0220966A3/en not_active Withdrawn

Also Published As

Publication number	Publication date
DK520086D0 (da)	1986-10-30
DK520086A (da)	1987-05-01
FI864412A0 (fi)	1986-10-29
NZ218103A (en)	1988-10-28
CA1286843C (en)	1991-07-23
AU6449586A (en)	1987-05-07
EP0220966A2 (en)	1987-05-06
FI864412A7 (fi)	1987-05-01
FI864412L (fi)	1987-05-01
EP0220966A3 (en)	1989-08-23
NO864321D0 (no)	1986-10-29
IL80448A0 (en)	1987-01-30
MX166995B (es)	1993-02-19
IL80448A (en)	1991-01-31

Publication	Publication Date	Title
US4894439A (en)	1990-01-16	N-terminal derivatives of tumor necrosis factor purified by microporous PTFE membranes
ES2293662T3 (es)	2008-03-16	Purificacion de neurotrofinas.
KR101520105B1 (ko)	2015-05-21	재조합 단백질의 리폴딩
Gentry et al.	1988	Molecular events in the processing of recombinant type 1 pre-pro-transforming growth factor beta to the mature polypeptide
Hansson et al.	1994	Single–Step Recovery of a Secreted Recombinant Protein by Expanded Bed Adsorption
JP3843373B2 (ja)	2006-11-08	ポリペプチドの精製法
JP2007302679A6 (ja)	2008-03-06	ニューロトロフィンの精製
WO1998021234A9 (en)	1998-10-01	Purification of neurotrophins
EP0210846B1 (en)	1992-03-11	Method for extracting protein with organic acid
WO1991015504A1 (en)	1991-10-17	Method to purify basic fibroblast growth factor
NO864321L (no)	1987-05-04	Rensemetode for proteiner.
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