NO870747L - Analogifremgangsmte for fremstilling av farmastisk akti ve piperidin derivater. - Google Patents

Analogifremgangsmte for fremstilling av farmastisk akti ve piperidin derivater.

Info

Publication number: NO870747L
Authority: NO; Norway
Prior art keywords: sup; sub; carbon atoms; lower alkyl; integer
Prior art date: 1986-02-26

Application number

NO870747A

Other languages

English (en)

Other versions

NO170484B (no

NO170484C (no

NO870747D0 (no

Inventor

Hitoshi Oinuma

Motosuke Yamanaka

Kazutoshi Miyake

Tomonori Hoshiko

Norio Minami

Tadao Shoji

Yoshiharu Daiku

Kohei Sawada

Kenichi Nomoto

Original Assignee

Eisai Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-02-26

Filing date

1987-02-24

Publication date

1987-08-27

1987-02-24 Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd

1987-02-24 Publication of NO870747D0 publication Critical patent/NO870747D0/no

1987-08-27 Publication of NO870747L publication Critical patent/NO870747L/no

1992-07-13 Publication of NO170484B publication Critical patent/NO170484B/no

1992-10-21 Publication of NO170484C publication Critical patent/NO170484C/no

Links

NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 6
125000004432 carbon atom Chemical group C* 0.000 abstract 6
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
150000001335 aliphatic alkanes Chemical class 0.000 abstract 2
125000003342 alkenyl group Chemical group 0.000 abstract 2
125000002947 alkylene group Chemical group 0.000 abstract 2
206010003119 arrhythmia Diseases 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000004093 cyano group Chemical group *C#N 0.000 abstract 2
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
150000001336 alkenes Chemical class 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
230000006793 arrhythmia Effects 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
-1 piperidine compound Chemical class 0.000 abstract 1
125000003944 tolyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
- C07D211/28—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/10—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 3 and 7, e.g. theobromine

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyrrole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO870747A 1986-02-26 1987-02-24 Analogifremgangsmaate for fremstilling av terapeutisk aktive piperidinderivater NO170484C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP3927086		1986-02-26

Publications (4)

Publication Number	Publication Date
NO870747D0 NO870747D0 (no)	1987-02-24
NO870747L true NO870747L (no)	1987-08-27
NO170484B NO170484B (no)	1992-07-13
NO170484C NO170484C (no)	1992-10-21

Family

ID=12548452

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO870747A NO170484C (no)	1986-02-26	1987-02-24	Analogifremgangsmaate for fremstilling av terapeutisk aktive piperidinderivater

Country Status (15)

Country	Link
US (3)	US4876262A (no)
EP (1)	EP0235752B1 (no)
JP (1)	JPH0780841B2 (no)
KR (1)	KR910002563B1 (no)
CN (1)	CN1019973C (no)
AT (1)	ATE97405T1 (no)
AU (1)	AU599632B2 (no)
CA (1)	CA1317941C (no)
DE (1)	DE3788145T2 (no)
DK (2)	DK93287A (no)
ES (1)	ES2059315T3 (no)
HU (1)	HU199794B (no)
NO (1)	NO170484C (no)
NZ (1)	NZ219401A (no)
PH (1)	PH23283A (no)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
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PH23283A (en) *	1986-02-26	1989-06-30	Eisai Co Ltd	Piperidine derivative, pharmaceutical composition containing the same and method of use thereof
GB8619472D0 (en) *	1986-08-09	1986-09-17	Pfizer Ltd	Anti-arrhythmia agents
GB8710494D0 (en) *	1987-05-02	1987-06-03	Pfizer Ltd	Antiarrhythmic agents
PH25458A (en) *	1987-08-24	1991-07-01	Eisai Co Ltd	Piperidine derivatives, therapeutic, preventive agents
US5093341A (en) *	1987-12-17	1992-03-03	Merrell Dow Pharmaceuticals Inc.	N-aralkyl piperidine derivatives useful as antithrombolytic agents
US5166211A (en) *	1987-12-17	1992-11-24	Merrell Dow Pharmaceuticals Inc.	Method of using 1,4-disubstituted piperidinyl compounds in the treatment of coronary vasospasons and variant angina
DE3835291A1 (de) *	1988-04-19	1989-11-02	Bayer Ag	1,3-disubstituierte pyrrolidine
US4868194A (en) *	1988-09-23	1989-09-19	Merrell Dow Pharmaceuticals Inc.	Imidazole antiarrhythmics
US5006523A (en) *	1989-10-26	1991-04-09	E. R. Squibb & Sons, Inc.	Antiarrhythmic agents: aryl cyanoguanidine potassium channel blockers
US5112824A (en) *	1989-12-08	1992-05-12	Merck & Co., Inc.	Benzofuran compounds as class III antiarrhythmic agents
US5032604A (en) *	1989-12-08	1991-07-16	Merck & Co., Inc.	Class III antiarrhythmic agents
US5215989A (en) *	1989-12-08	1993-06-01	Merck & Co., Inc.	Nitrogen-containing heterocyclic compounds as class III antiarrhythmic agents
US5032598A (en) *	1989-12-08	1991-07-16	Merck & Co., Inc.	Nitrogens containing heterocyclic compounds as class III antiarrhythmic agents
US5206240A (en) *	1989-12-08	1993-04-27	Merck & Co., Inc.	Nitrogen-containing spirocycles
NZ236501A (en) *	1989-12-21	1992-12-23	Merrell Dow Pharma	Piperidine derivatives and antithrombotic compositions
US5292752A (en) *	1989-12-21	1994-03-08	Merrell Dow Pharmaceuticals Inc.	Antithrombotic compounds
US5478846A (en) *	1990-06-07	1995-12-26	Merrell Dow Pharmaceuticals Inc.	1-piperidinyl alkanoylanyl sulfonamides for treatment of cardiac arrhythmia
WO1991018603A1 (en) *	1990-06-07	1991-12-12	Merrell Dow Pharmaceuticals Inc.	1-pyperidinyl alkanoylarylsulfonamide derivatives
CA2115426C (en) *	1991-08-14	2001-09-11	Stanford Salvatore Pelosi Jr.	Novel cyclic ureas useful as antiarrhythmic and antifibrillatory agents
DE69230563T2 (de) *	1991-08-14	2000-09-14	Procter & Gamble Pharmaceuticals, Inc.	Oxazolidinon-derivate mit antiarrhythmischer und antifibrillatorische wirkung
WO1993004061A1 (en) *	1991-08-14	1993-03-04	Procter & Gamble Pharmaceuticals	Novel 4-oxocyclic ureas useful as antiarrhythmic and antifibrillatory agents
US5254689A (en) *	1992-02-25	1993-10-19	American Home Products Corporation	Piperdinyl and piperazinyl derivatives
US5202346A (en) *	1992-02-25	1993-04-13	American Home Products Corporation	Piperidinyl and piperazinyl derivatives
CA2139305A1 (en) *	1992-07-02	1994-01-20	Kohji Kagara	Process for producing pyrrolidine derivative and salt thereof
WO1995000481A1 (en) *	1993-06-23	1995-01-05	Merrell Dow Pharmaceuticals Inc.	Piperidin-1-yl-2,2-dialkylpropanonearylsulfonamide derivatives
US5382587A (en) *	1993-06-30	1995-01-17	Merck & Co., Inc.	Spirocycles
US5403846A (en) *	1993-11-22	1995-04-04	Merck & Co., Inc.	Spirocycles
US5439914A (en) *	1994-02-18	1995-08-08	Merck & Co., Inc.	Spirocycles
KR960007560A (ko) *	1994-08-16	1996-03-22	김정규	신규한 아민 유도체, 그의 제조방법 및 항부정맥제로서의 용도
EP0697407B1 (en)	1994-08-19	1997-06-25	MITSUI TOATSU CHEMICALS, Inc.	Pyrimidinedione derivatives and antiarrhythmic compositions containing same
US5679706A (en) *	1994-09-30	1997-10-21	Bristol-Myers Squibb Company	Combination of a potassium channel activator and an antiarrhythmic agent
US5880128A (en) *	1996-05-08	1999-03-09	Schering Corporation	Carbonyl piperazinyl and piperidinyl compounds
US6083991A (en)	1997-06-04	2000-07-04	University Of Florida Research Foundation, Inc.	Anti-arrhythmic composition and methods of treatment
US6777428B1 (en) *	1999-02-10	2004-08-17	Eli Lilly And Company	5-HT1f agonist
CA2402467C (en)	2000-01-19	2010-03-23	Bayer Aktiengesellschaft	Method for producing heterocyclic compounds
CA2398388A1 (en)	2000-01-20	2001-07-26	Koji Kato	Novel piperidine compound and pharmaceutical thereof
JP2005097120A (ja) *	2000-10-06	2005-04-14	Mochida Pharmaceut Co Ltd	４−ヒドロキシピペリジン誘導体の非潮解性塩
MXPA05011223A (es) *	2003-04-18	2006-01-26	Lilly Co Eli	Compuestos de (piperidiniloxi)fenilo, (piperidiniloxi)piridinilo, (piperidinilsulfanil)fenilo y (piperidinilsulfanil)piridinilo como agonistas 5-htif.
GB0325745D0 (en) *	2003-11-05	2003-12-10	Astrazeneca Ab	Chemical compounds
CN105778896B (zh) *	2016-04-08	2018-01-12	山东大学	苯基（4‑哌啶基）甲酮类hERG钾离子通道的小分子荧光探针
KR102380911B1 (ko)	2016-06-06	2022-03-30	바이엘 크롭사이언스 악티엔게젤샤프트	헤테로사이클릭 화합물의 제조 방법

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Publication number	Priority date	Publication date	Assignee	Title
US2682544A (en) *	1950-09-27	1954-06-29	Sterling Drug Inc	Aryl-pyridylmethyl alkyl sulfones and their preparation
GB1521932A (en) *	1976-03-08	1978-08-16	Labaz	Sulphonamide derivatives and process for preparing the same
US4244963A (en) *	1979-09-27	1981-01-13	Merck & Co., Inc.	1-[2-(Alkyl and arylsulfonyl)-2-propenyl and propyl] substituted piperidines useful as antimicrobial and antiinflammatory agents
GR71991B (no) *	1980-01-21	1983-08-26	Delalande Sa
ZA825227B (en) *	1981-07-22	1984-03-28	Syntex Inc	Substituted pyrrolidine cardiovascular system regulators antihypertensives
US4544654A (en) *	1984-03-20	1985-10-01	Schering A.G.	Substituted sulfonamidobenzamides, antiarrhythmic agents and compositions thereof
IN163948B (no) *	1986-01-17	1988-12-10	Robins Co Inc A H
PH23283A (en) *	1986-02-26	1989-06-30	Eisai Co Ltd	Piperidine derivative, pharmaceutical composition containing the same and method of use thereof
JP2604837B2 (ja) *	1988-12-01	1997-04-30	川崎重工業株式会社	油圧式回転機械

1987
- 1987-02-04 PH PH34909A patent/PH23283A/en unknown
- 1987-02-18 US US07/016,035 patent/US4876262A/en not_active Expired - Lifetime
- 1987-02-24 NO NO870747A patent/NO170484C/no unknown
- 1987-02-24 DK DK093287A patent/DK93287A/da not_active Application Discontinuation
- 1987-02-25 HU HU87730A patent/HU199794B/hu not_active IP Right Cessation
- 1987-02-25 NZ NZ219401A patent/NZ219401A/xx unknown
- 1987-02-25 CA CA000530571A patent/CA1317941C/en not_active Expired - Fee Related
- 1987-02-25 CN CN87100928A patent/CN1019973C/zh not_active Expired - Fee Related
- 1987-02-25 JP JP62042368A patent/JPH0780841B2/ja not_active Expired - Lifetime
- 1987-02-26 KR KR1019870001676A patent/KR910002563B1/ko not_active Expired
- 1987-02-26 DE DE87102743T patent/DE3788145T2/de not_active Expired - Fee Related
- 1987-02-26 EP EP87102743A patent/EP0235752B1/en not_active Expired - Lifetime
- 1987-02-26 AU AU69513/87A patent/AU599632B2/en not_active Ceased
- 1987-02-26 ES ES87102743T patent/ES2059315T3/es not_active Expired - Lifetime
- 1987-02-26 AT AT87102743T patent/ATE97405T1/de not_active IP Right Cessation
1989
- 1989-09-15 US US07/408,106 patent/US4996215A/en not_active Expired - Fee Related
1990
- 1990-10-09 US US07/594,079 patent/US5118689A/en not_active Expired - Fee Related
1995
- 1995-10-02 DK DK110395A patent/DK110395A/da unknown

Also Published As

Publication number	Publication date
JPS62281858A (ja)	1987-12-07
EP0235752B1 (en)	1993-11-18
KR910002563B1 (ko)	1991-04-26
US4996215A (en)	1991-02-26
AU599632B2 (en)	1990-07-26
KR870007888A (ko)	1987-09-22
CA1317941C (en)	1993-05-18
NZ219401A (en)	1990-07-26
HUT46675A (en)	1988-11-28
ATE97405T1 (de)	1993-12-15
EP0235752A2 (en)	1987-09-09
US5118689A (en)	1992-06-02
NO170484B (no)	1992-07-13
HU199794B (en)	1990-03-28
US4876262A (en)	1989-10-24
AU6951387A (en)	1987-08-27
CN87100928A (zh)	1987-09-09
NO170484C (no)	1992-10-21
DK110395A (da)	1995-10-02
DE3788145T2 (de)	1994-04-28
CN1019973C (zh)	1993-03-03
EP0235752A3 (en)	1990-07-25
DK93287D0 (da)	1987-02-24
ES2059315T3 (es)	1994-11-16
DK93287A (da)	1987-08-27
PH23283A (en)	1989-06-30
JPH0780841B2 (ja)	1995-08-30
DE3788145D1 (de)	1993-12-23
NO870747D0 (no)	1987-02-24

Publication	Publication Date	Title
NO870747D0 (no)	1987-02-24	Analogifremgangsmaate for fremstilling av farmasoeytisk aktive piperidin-derivater.
GB8711802D0 (en)	1987-06-24	Dithioacetal compounds
NO163855C (no)	1990-08-01	Analogifremgangsmaate for fremstilling av terapeutisk aktive arylcyklobutylalkylaminer.
PL109757B1 (en)	1980-06-30	Method of producing new phenylethylamines
IE891199L (en)	1989-10-18	2-alkyl-3-benzoylbenzofurans and pharmaceutical compositions¹containing them
CA2014521A1 (en)	1990-10-15	2-Substituted N,N'-Ditrimethoxybenzoyl Piperazines, a Preparation Process of the Same and Therapeutic Compositions Containing Them
PT81808A (en)	1986-02-01	A method for the preparation of aminoalkyl substituted urea derivatives and acid addition salts thereof
ATE52506T1 (de)	1990-05-15	Oxabicycloheptan-derivate, pharmazeutische zusammensetzung und verwendung.
DK0420224T3 (da)	1993-04-05	Anthihepatopatisk middel
ATE18761T1 (de)	1986-04-15	Carbamoyloxybenzhydrol-derivate, ihre herstellung und ihre pharmazeutische zusammensetzungen.
FI834793A0 (fi)	1983-12-27	Foerfarande foer framstaellning av piperidinderivat
HUT43817A (en)	1987-12-28	Process for producing hydroxy-alkoxy-4-phenyl-propyl-indol derivatives and pharmaceutical compositions containing them as active agents
ES8801656A1 (es)	1988-02-16	Un procedimiento para la preparacion de un compuesto de quinazolinona.
DK644487A (da)	1988-06-10	Farmaceutisk praeparat indeholdende en 2-oxo-imidazolidinforbindelse
PH23966A (en)	1990-01-23	Imidazoquinozoline compounds as agent for treatment of nephritis
KR920016405A (ko)	1992-09-24	판토텐산 유도체
ATE193204T1 (de)	2000-06-15	Präparat zur behandlung der drogenabhängigkeit
ES509514A0 (es)	1983-01-16	"procedimiento para la preparacion de nuevos 1-(acilamino-arloxi-)2-hidroxi-3-alquinilaminopropanos".

NO870747L - Analogifremgangsmte for fremstilling av farmastisk akti ve piperidin derivater. - Google Patents