NO872881L - Fremgangsmte for bestemmelse av skjult blod i prer av h umant materiale. - Google Patents

Fremgangsmte for bestemmelse av skjult blod i prer av h umant materiale.

Info

Publication number: NO872881L
Authority: NO; Norway
Prior art keywords: approx; preparation; acid; mixture; toluamide
Prior art date: 1986-07-15

Application number

NO872881A

Other languages

English (en)

Norwegian (no)

Other versions

NO872881D0 (no

Inventor

Abraham Ben-Michael

Original Assignee

Savyon Diagnostics Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-07-15

Filing date

1987-07-10

Publication date

1988-01-18

1986-07-15 Priority claimed from IL79417A external-priority patent/IL79417A0/xx

1987-07-10 Application filed by Savyon Diagnostics Ltd filed Critical Savyon Diagnostics Ltd

1987-07-10 Publication of NO872881D0 publication Critical patent/NO872881D0/no

1988-01-18 Publication of NO872881L publication Critical patent/NO872881L/no

Links

239000008280 blood Substances 0.000 title claims abstract description 27
210000004369 blood Anatomy 0.000 title claims abstract description 27
238000000034 method Methods 0.000 title claims abstract description 18
239000000463 material Substances 0.000 title claims abstract description 11
238000002360 preparation method Methods 0.000 claims abstract description 63
239000007788 liquid Substances 0.000 claims abstract description 20
150000001875 compounds Chemical class 0.000 claims abstract description 11
239000002738 chelating agent Substances 0.000 claims abstract description 10
230000000087 stabilizing effect Effects 0.000 claims abstract description 9
239000000010 aprotic solvent Substances 0.000 claims abstract description 7
239000003125 aqueous solvent Substances 0.000 claims abstract description 6
150000002978 peroxides Chemical class 0.000 claims abstract description 6
-1 using stable Substances 0.000 claims abstract description 5
239000000126 substance Substances 0.000 claims abstract description 3
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 35
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 27
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 26
FZERHIULMFGESH-UHFFFAOYSA-N N-phenylacetamide Chemical compound CC(=O)NC1=CC=CC=C1 FZERHIULMFGESH-UHFFFAOYSA-N 0.000 claims description 22
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 15
CJAOGUFAAWZWNI-UHFFFAOYSA-N 1-n,1-n,4-n,4-n-tetramethylbenzene-1,4-diamine Chemical compound CN(C)C1=CC=C(N(C)C)C=C1 CJAOGUFAAWZWNI-UHFFFAOYSA-N 0.000 claims description 13
FRIBMENBGGCKPD-UHFFFAOYSA-N 3-(2,3-dimethoxyphenyl)prop-2-enal Chemical compound COC1=CC=CC(C=CC=O)=C1OC FRIBMENBGGCKPD-UHFFFAOYSA-N 0.000 claims description 13
229960001413 acetanilide Drugs 0.000 claims description 11
239000000203 mixture Substances 0.000 claims description 11
FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims description 11
229940048086 sodium pyrophosphate Drugs 0.000 claims description 11
235000019818 tetrasodium diphosphate Nutrition 0.000 claims description 11
239000001577 tetrasodium phosphonato phosphate Substances 0.000 claims description 11
HJIAMFHSAAEUKR-UHFFFAOYSA-N (2-hydroxyphenyl)-phenylmethanone Chemical compound OC1=CC=CC=C1C(=O)C1=CC=CC=C1 HJIAMFHSAAEUKR-UHFFFAOYSA-N 0.000 claims description 10
RLFWWDJHLFCNIJ-UHFFFAOYSA-N 4-aminoantipyrine Chemical compound CN1C(C)=C(N)C(=O)N1C1=CC=CC=C1 RLFWWDJHLFCNIJ-UHFFFAOYSA-N 0.000 claims description 10
FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims description 10
OISVCGZHLKNMSJ-UHFFFAOYSA-N 2,6-dimethylpyridine Chemical compound CC1=CC=CC(C)=N1 OISVCGZHLKNMSJ-UHFFFAOYSA-N 0.000 claims description 9
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 9
239000001509 sodium citrate Substances 0.000 claims description 9
HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 claims description 9
229940038773 trisodium citrate Drugs 0.000 claims description 9
MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 claims description 9
FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 claims description 9
235000012141 vanillin Nutrition 0.000 claims description 9
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 8
239000012153 distilled water Substances 0.000 claims description 8
MMAFPMQOIUHLNH-UHFFFAOYSA-N 2-hydroxy-3-methoxybenzenesulfonic acid Chemical compound COC1=CC=CC(S(O)(=O)=O)=C1O MMAFPMQOIUHLNH-UHFFFAOYSA-N 0.000 claims description 7
YRNWIFYIFSBPAU-UHFFFAOYSA-N 4-[4-(dimethylamino)phenyl]-n,n-dimethylaniline Chemical compound C1=CC(N(C)C)=CC=C1C1=CC=C(N(C)C)C=C1 YRNWIFYIFSBPAU-UHFFFAOYSA-N 0.000 claims description 7
239000005725 8-Hydroxyquinoline Substances 0.000 claims description 7
229960003540 oxyquinoline Drugs 0.000 claims description 7
MCJGNVYPOGVAJF-UHFFFAOYSA-N quinolin-8-ol Chemical compound C1=CN=C2C(O)=CC=CC2=C1 MCJGNVYPOGVAJF-UHFFFAOYSA-N 0.000 claims description 7
150000003839 salts Chemical class 0.000 claims description 7
ZBDXDMJVRUZKDX-UHFFFAOYSA-N 10-benzylideneanthracen-9-one Chemical compound C12=CC=CC=C2C(=O)C2=CC=CC=C2C1=CC1=CC=CC=C1 ZBDXDMJVRUZKDX-UHFFFAOYSA-N 0.000 claims description 6
BWZVCCNYKMEVEX-UHFFFAOYSA-N 2,4,6-Trimethylpyridine Chemical compound CC1=CC(C)=NC(C)=C1 BWZVCCNYKMEVEX-UHFFFAOYSA-N 0.000 claims description 6
KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims description 6
XBLVHTDFJBKJLG-UHFFFAOYSA-N Ethyl nicotinate Chemical compound CCOC(=O)C1=CC=CN=C1 XBLVHTDFJBKJLG-UHFFFAOYSA-N 0.000 claims description 6
HXTGGPKOEKKUQO-VQHVLOKHSA-N N-BENZYLIDENEMETHYLAMINE Chemical compound C\N=C\C1=CC=CC=C1 HXTGGPKOEKKUQO-VQHVLOKHSA-N 0.000 claims description 6
UHBGYFCCKRAEHA-UHFFFAOYSA-N P-toluamide Chemical compound CC1=CC=C(C(N)=O)C=C1 UHBGYFCCKRAEHA-UHFFFAOYSA-N 0.000 claims description 6
150000002432 hydroperoxides Chemical class 0.000 claims description 6
MIYKHJXFICMPOJ-UHFFFAOYSA-N n-benzyl-1-phenylmethanimine Chemical compound C=1C=CC=CC=1CN=CC1=CC=CC=C1 MIYKHJXFICMPOJ-UHFFFAOYSA-N 0.000 claims description 6
YQUVCSBJEUQKSH-UHFFFAOYSA-N protochatechuic acid Natural products OC(=O)C1=CC=C(O)C(O)=C1 YQUVCSBJEUQKSH-UHFFFAOYSA-N 0.000 claims description 6
WKOLLVMJNQIZCI-UHFFFAOYSA-N vanillic acid Chemical compound COC1=CC(C(O)=O)=CC=C1O WKOLLVMJNQIZCI-UHFFFAOYSA-N 0.000 claims description 6
TUUBOHWZSQXCSW-UHFFFAOYSA-N vanillic acid Natural products COC1=CC(O)=CC(C(O)=O)=C1 TUUBOHWZSQXCSW-UHFFFAOYSA-N 0.000 claims description 6
OKJFKPFBSPZTAH-UHFFFAOYSA-N (2,4-dihydroxyphenyl)-(4-hydroxyphenyl)methanone Chemical compound C1=CC(O)=CC=C1C(=O)C1=CC=C(O)C=C1O OKJFKPFBSPZTAH-UHFFFAOYSA-N 0.000 claims description 5
GHGZVWOTJDLREY-UHFFFAOYSA-N 2-(1,3-benzoxazol-2-yl)phenol Chemical compound OC1=CC=CC=C1C1=NC2=CC=CC=C2O1 GHGZVWOTJDLREY-UHFFFAOYSA-N 0.000 claims description 5
QDRCGSIKAHSALR-UHFFFAOYSA-N 4-hydroxy-3-methoxybenzene-1-sulfonic acid Chemical compound COC1=CC(S(O)(=O)=O)=CC=C1O QDRCGSIKAHSALR-UHFFFAOYSA-N 0.000 claims description 5
229940057818 guaiacolsulfonic acid Drugs 0.000 claims description 5
ASOKPJOREAFHNY-UHFFFAOYSA-N 1-Hydroxybenzotriazole Chemical compound C1=CC=C2N(O)N=NC2=C1 ASOKPJOREAFHNY-UHFFFAOYSA-N 0.000 claims description 4
SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims description 4
229910000029 sodium carbonate Inorganic materials 0.000 claims description 4
AUHZEENZYGFFBQ-UHFFFAOYSA-N 1,3,5-Me3C6H3 Natural products CC1=CC(C)=CC(C)=C1 AUHZEENZYGFFBQ-UHFFFAOYSA-N 0.000 claims description 3
BZFGKBQHQJVAHS-UHFFFAOYSA-N 2-(trifluoromethyl)pyridine-4-carboxylic acid Chemical compound OC(=O)C1=CC=NC(C(F)(F)F)=C1 BZFGKBQHQJVAHS-UHFFFAOYSA-N 0.000 claims description 3
IDQNBVFPZMCDDN-UHFFFAOYSA-N 2-Amino-4,6-dimethylpyrimidine Chemical compound CC1=CC(C)=NC(N)=N1 IDQNBVFPZMCDDN-UHFFFAOYSA-N 0.000 claims description 3
WOXFMYVTSLAQMO-UHFFFAOYSA-N 2-Pyridinemethanamine Chemical compound NCC1=CC=CC=N1 WOXFMYVTSLAQMO-UHFFFAOYSA-N 0.000 claims description 3
XWKFPIODWVPXLX-UHFFFAOYSA-N 2-methyl-5-methylpyridine Natural products CC1=CC=C(C)N=C1 XWKFPIODWVPXLX-UHFFFAOYSA-N 0.000 claims description 3
WGRPQCFFBRDZFV-UHFFFAOYSA-N 3-methylbenzamide Chemical compound CC1=CC=CC(C(N)=O)=C1 WGRPQCFFBRDZFV-UHFFFAOYSA-N 0.000 claims description 3
LVILGAOSPDLNRM-UHFFFAOYSA-N 4-methylpyrimidine Chemical compound CC1=CC=NC=N1 LVILGAOSPDLNRM-UHFFFAOYSA-N 0.000 claims description 3
ZESWUEBPRPGMTP-UHFFFAOYSA-N 4-nitrobenzamide Chemical compound NC(=O)C1=CC=C([N+]([O-])=O)C=C1 ZESWUEBPRPGMTP-UHFFFAOYSA-N 0.000 claims description 3
QUXLCYFNVNNRBE-UHFFFAOYSA-N 6-methylpyridin-2-amine Chemical compound CC1=CC=CC(N)=N1 QUXLCYFNVNNRBE-UHFFFAOYSA-N 0.000 claims description 3
229940064982 ethylnicotinate Drugs 0.000 claims description 3
FCQJEPASRCXVCB-UHFFFAOYSA-N flavianic acid Chemical compound C1=C(S(O)(=O)=O)C=C2C(O)=C([N+]([O-])=O)C=C([N+]([O-])=O)C2=C1 FCQJEPASRCXVCB-UHFFFAOYSA-N 0.000 claims description 3
TWBYWOBDOCUKOW-UHFFFAOYSA-N isonicotinic acid Natural products OC(=O)C1=CC=NC=C1 TWBYWOBDOCUKOW-UHFFFAOYSA-N 0.000 claims description 3
NQRLPDFELNCFHW-UHFFFAOYSA-N nitroacetanilide Chemical compound CC(=O)NC1=CC=C([N+]([O-])=O)C=C1 NQRLPDFELNCFHW-UHFFFAOYSA-N 0.000 claims description 3
HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims description 3
FFRYUAVNPBUEIC-UHFFFAOYSA-N quinoxalin-2-ol Chemical compound C1=CC=CC2=NC(O)=CN=C21 FFRYUAVNPBUEIC-UHFFFAOYSA-N 0.000 claims description 3
GFYHSKONPJXCDE-UHFFFAOYSA-N sym-collidine Natural products CC1=CN=C(C)C(C)=C1 GFYHSKONPJXCDE-UHFFFAOYSA-N 0.000 claims description 3
AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 claims description 3
XXUNIGZDNWWYED-UHFFFAOYSA-N 2-methylbenzamide Chemical compound CC1=CC=CC=C1C(N)=O XXUNIGZDNWWYED-UHFFFAOYSA-N 0.000 claims description 2
NULAJYZBOLVQPQ-UHFFFAOYSA-N N-(1-naphthyl)ethylenediamine Chemical compound C1=CC=C2C(NCCN)=CC=CC2=C1 NULAJYZBOLVQPQ-UHFFFAOYSA-N 0.000 claims description 2
239000007853 buffer solution Substances 0.000 claims description 2
150000001451 organic peroxides Chemical class 0.000 claims description 2
WKEDVNSFRWHDNR-UHFFFAOYSA-N salicylanilide Chemical compound OC1=CC=CC=C1C(=O)NC1=CC=CC=C1 WKEDVNSFRWHDNR-UHFFFAOYSA-N 0.000 claims description 2
229950000975 salicylanilide Drugs 0.000 claims description 2
WLHBRQYVZLNQFE-UHFFFAOYSA-N O[S+]1C2=CC=CC=C2N=C1 Chemical compound O[S+]1C2=CC=CC=C2N=C1 WLHBRQYVZLNQFE-UHFFFAOYSA-N 0.000 claims 1
RFTKDSUXTLVWOX-UHFFFAOYSA-N [Na].[Na].[Na].O Chemical compound [Na].[Na].[Na].O RFTKDSUXTLVWOX-UHFFFAOYSA-N 0.000 claims 1
239000002526 disodium citrate Substances 0.000 claims 1
235000019262 disodium citrate Nutrition 0.000 claims 1
CEYULKASIQJZGP-UHFFFAOYSA-L disodium;2-(carboxymethyl)-2-hydroxybutanedioate Chemical compound [Na+].[Na+].[O-]C(=O)CC(O)(C(=O)O)CC([O-])=O CEYULKASIQJZGP-UHFFFAOYSA-L 0.000 claims 1
239000000243 solution Substances 0.000 description 41
238000012360 testing method Methods 0.000 description 27
239000003153 chemical reaction reagent Substances 0.000 description 20
238000003756 stirring Methods 0.000 description 14
238000006243 chemical reaction Methods 0.000 description 9
102000001554 Hemoglobins Human genes 0.000 description 8
108010054147 Hemoglobins Proteins 0.000 description 8
229960001760 dimethyl sulfoxide Drugs 0.000 description 7
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
RWGFKTVRMDUZSP-UHFFFAOYSA-N cumene Chemical compound CC(C)C1=CC=CC=C1 RWGFKTVRMDUZSP-UHFFFAOYSA-N 0.000 description 6
230000000740 bleeding effect Effects 0.000 description 5
238000009534 blood test Methods 0.000 description 5
210000003608 fece Anatomy 0.000 description 5
239000007787 solid Substances 0.000 description 5
239000002250 absorbent Substances 0.000 description 4
230000002745 absorbent Effects 0.000 description 4
230000000694 effects Effects 0.000 description 3
QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 2
230000002378 acidificating effect Effects 0.000 description 2
239000012736 aqueous medium Substances 0.000 description 2
OHDRQQURAXLVGJ-HLVWOLMTSA-N azane;(2e)-3-ethyl-2-[(e)-(3-ethyl-6-sulfo-1,3-benzothiazol-2-ylidene)hydrazinylidene]-1,3-benzothiazole-6-sulfonic acid Chemical compound [NH4+].[NH4+].S/1C2=CC(S([O-])(=O)=O)=CC=C2N(CC)C\1=N/N=C1/SC2=CC(S([O-])(=O)=O)=CC=C2N1CC OHDRQQURAXLVGJ-HLVWOLMTSA-N 0.000 description 2
238000004090 dissolution Methods 0.000 description 2
238000002575 gastroscopy Methods 0.000 description 2
238000004519 manufacturing process Methods 0.000 description 2
239000002609 medium Substances 0.000 description 2
238000002156 mixing Methods 0.000 description 2
238000012986 modification Methods 0.000 description 2
230000004048 modification Effects 0.000 description 2
238000012216 screening Methods 0.000 description 2
239000002904 solvent Substances 0.000 description 2
210000002700 urine Anatomy 0.000 description 2
230000010736 Chelating Activity Effects 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
PAYRUJLWNCNPSJ-UHFFFAOYSA-N N-phenyl amine Natural products NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 description 1
206010028980 Neoplasm Diseases 0.000 description 1
GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
239000000654 additive Substances 0.000 description 1
238000013019 agitation Methods 0.000 description 1
HFACYLZERDEVSX-UHFFFAOYSA-N benzidine Chemical compound C1=CC(N)=CC=C1C1=CC=C(N)C=C1 HFACYLZERDEVSX-UHFFFAOYSA-N 0.000 description 1
201000011510 cancer Diseases 0.000 description 1
238000001514 detection method Methods 0.000 description 1
238000011161 development Methods 0.000 description 1
238000003745 diagnosis Methods 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
238000001035 drying Methods 0.000 description 1
230000002708 enhancing effect Effects 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
238000005470 impregnation Methods 0.000 description 1
239000011159 matrix material Substances 0.000 description 1
239000000376 reactant Substances 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
238000013112 stability test Methods 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
239000012085 test solution Substances 0.000 description 1
238000004448 titration Methods 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
- G01N33/721—Haemoglobin
- G01N33/725—Haemoglobin using peroxidative activity

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Hematology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Cell Biology (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)

NO872881A 1986-07-15 1987-07-10 Fremgangsmte for bestemmelse av skjult blod i prer av h umant materiale. NO872881L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IL79417A IL79417A0 (en)	1986-07-15	1986-07-15	Liquid stable chemical compositions for the determination of pseudo-peroxidases
IL82840A IL82840A0 (en)	1986-07-15	1987-06-10	Method and compositions for the determination of occult blood

Publications (2)

Publication Number	Publication Date
NO872881D0 NO872881D0 (no)	1987-07-10
NO872881L true NO872881L (no)	1988-01-18

Family

ID=26321565

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO872881A NO872881L (no)	1986-07-15	1987-07-10	Fremgangsmte for bestemmelse av skjult blod i prer av h umant materiale.

Country Status (4)

Country	Link
EP (1)	EP0253548A3 (da)
DK (1)	DK360587A (da)
IL (1)	IL82840A0 (da)
NO (1)	NO872881L (da)

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Publication number	Priority date	Publication date	Assignee	Title
WO1990002339A1 (en) *	1988-08-16	1990-03-08	Cetus Corporation	Stable indicator solutions for detection of peroxidatic activity
US5182213A (en) *	1991-03-18	1993-01-26	Miles Inc.	Method for detecting the presence of peroxidatively active substance in basic media
US5447868A (en) *	1993-09-14	1995-09-05	Propper Manufacturing Co. Inc.	Method, reagent and kit for the detection of fecal occult blood
DE19544150C2 (de) *	1995-11-16	2002-06-13	Seramun Diagnostica Gmbh	Stabile 3,3',5,5'-Tetramethylbenzidin-Lösungen
WO1997035030A1 (en) *	1996-03-22	1997-09-25	Stc Technologies, Inc.	A solution-based assay for peroxidatively-active substances in bodily fluids
US5885789A (en) *	1997-03-20	1999-03-23	Stc Technologies Incorporated	Solution-based assay for peroxidatively-active substances in bodily fluids
US9631558B2 (en)	2012-01-03	2017-04-25	United Technologies Corporation	Geared architecture for high speed and small volume fan drive turbine
US9239012B2 (en)	2011-06-08	2016-01-19	United Technologies Corporation	Flexible support structure for a geared architecture gas turbine engine
US9410608B2 (en)	2011-06-08	2016-08-09	United Technologies Corporation	Flexible support structure for a geared architecture gas turbine engine
US9133729B1 (en)	2011-06-08	2015-09-15	United Technologies Corporation	Flexible support structure for a geared architecture gas turbine engine
US10287914B2 (en)	2012-01-31	2019-05-14	United Technologies Corporation	Gas turbine engine with high speed low pressure turbine section and bearing support features
US10125693B2 (en)	2012-04-02	2018-11-13	United Technologies Corporation	Geared turbofan engine with power density range
EP3467272A1 (en) *	2013-06-03	2019-04-10	United Technologies Corporation	Geared architecture for high speed and small volume fan drive turbine

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0108526A3 (en) *	1982-11-01	1984-07-11	Beckman Instruments, Inc.	Method and reagent for the determination of peroxide and precursors thereof
CA1216215A (en) *	1983-03-01	1987-01-06	Henry J. Wells	Peroxidase activity detection composition
DE3311887A1 (de) *	1983-03-31	1984-12-20	Byk-Mallinckrodt Chemische Produkte Gmbh, 6057 Dietzenbach	Verfahren zur bestimmung der peroxidase-aktivitaet durch endverduennungstitration und mittel zur durchfuehrung des verfahrens
US4447542A (en) *	1983-04-04	1984-05-08	Miles Laboratories, Inc.	Analytical test composition, device and method for the determination of peroxidatively active substances
US4615982A (en) *	1984-12-11	1986-10-07	Lawrence Paul J	Fecal occult blood test
EP0196743A3 (en) *	1985-01-31	1988-10-19	Savyon Diagnostics Ltd.	Stable chemical compositions containing chromogenic materials and peroxides, and method for obtaining them

1987
- 1987-06-10 IL IL82840A patent/IL82840A0/xx unknown
- 1987-07-06 EP EP87305957A patent/EP0253548A3/en not_active Withdrawn
- 1987-07-10 NO NO872881A patent/NO872881L/no unknown
- 1987-07-10 DK DK360587A patent/DK360587A/da not_active Application Discontinuation

Also Published As

Publication number	Publication date
IL82840A0 (en)	1987-12-20
DK360587A (da)	1988-01-16
EP0253548A3 (en)	1989-07-12
EP0253548A2 (en)	1988-01-20
NO872881D0 (no)	1987-07-10
DK360587D0 (da)	1987-07-10

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NO872881L - Fremgangsmte for bestemmelse av skjult blod i prer av h umant materiale. - Google Patents