NO874852L - Farmasoeytiske blandinger. - Google Patents

Info

Publication number

NO874852L

NO874852L NO874852A NO874852A NO874852L NO 874852 L NO874852 L NO 874852L NO 874852 A NO874852 A NO 874852A NO 874852 A NO874852 A NO 874852A NO 874852 L NO874852 L NO 874852L

Authority

NO

Norway

Prior art keywords

insulin

particles

coating

lipid

mixture according

Prior art date

1986-03-21

Links

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• Global Dossier
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• 239000000203 mixture Substances 0.000 title claims description 121
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 566
• 102000004877 Insulin Human genes 0.000 claims description 289
• 108090001061 Insulin Proteins 0.000 claims description 289
• 229940125396 insulin Drugs 0.000 claims description 280
• 239000002245 particle Substances 0.000 claims description 213
• 238000000576 coating method Methods 0.000 claims description 163
• 238000002360 preparation method Methods 0.000 claims description 163
• 239000011248 coating agent Substances 0.000 claims description 161
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 111
• 150000002632 lipids Chemical class 0.000 claims description 110
• 239000002775 capsule Substances 0.000 claims description 106
• 239000000463 material Substances 0.000 claims description 87
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 52
• 102000004190 Enzymes Human genes 0.000 claims description 50
• 108090000790 Enzymes Proteins 0.000 claims description 50
• 229940088598 enzyme Drugs 0.000 claims description 50
• 235000018102 proteins Nutrition 0.000 claims description 42
• 102000004169 proteins and genes Human genes 0.000 claims description 42
• 108090000623 proteins and genes Proteins 0.000 claims description 42
• 238000000034 method Methods 0.000 claims description 41
• UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 38
• 230000002366 lipolytic effect Effects 0.000 claims description 36
• -1 polyethylene Polymers 0.000 claims description 35
• 239000003833 bile salt Substances 0.000 claims description 34
• 210000004051 gastric juice Anatomy 0.000 claims description 34
• 102000004895 Lipoproteins Human genes 0.000 claims description 32
• 108090001030 Lipoproteins Proteins 0.000 claims description 32
• 239000000499 gel Substances 0.000 claims description 32
• 238000009505 enteric coating Methods 0.000 claims description 29
• 239000002702 enteric coating Substances 0.000 claims description 29
• 235000012000 cholesterol Nutrition 0.000 claims description 26
• 230000027455 binding Effects 0.000 claims description 25
• 206010012601 diabetes mellitus Diseases 0.000 claims description 25
• 102000019280 Pancreatic lipases Human genes 0.000 claims description 22
• 108050006759 Pancreatic lipases Proteins 0.000 claims description 22
• 229940116369 pancreatic lipase Drugs 0.000 claims description 22
• 239000011230 binding agent Substances 0.000 claims description 20
• 235000014113 dietary fatty acids Nutrition 0.000 claims description 20
• 239000000194 fatty acid Substances 0.000 claims description 20
• 229930195729 fatty acid Natural products 0.000 claims description 20
• 239000004094 surface-active agent Substances 0.000 claims description 20
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• 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 19
• 235000017557 sodium bicarbonate Nutrition 0.000 claims description 19
• 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 19
• DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 18
• 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 18
• 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 18
• 102000004882 Lipase Human genes 0.000 claims description 17
• 108090001060 Lipase Proteins 0.000 claims description 17
• 239000004367 Lipase Substances 0.000 claims description 17
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• 239000003795 chemical substances by application Substances 0.000 claims description 17
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• 239000002202 Polyethylene glycol Substances 0.000 claims description 16
• 229920001223 polyethylene glycol Polymers 0.000 claims description 16
• 239000011247 coating layer Substances 0.000 claims description 15
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
• 150000001875 compounds Chemical class 0.000 claims description 14
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• 230000005484 gravity Effects 0.000 claims description 13
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• 239000002532 enzyme inhibitor Substances 0.000 claims description 11
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• QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 11
• 239000007787 solid Substances 0.000 claims description 11
• ILWRPSCZWQJDMK-UHFFFAOYSA-N triethylazanium;chloride Chemical compound Cl.CCN(CC)CC ILWRPSCZWQJDMK-UHFFFAOYSA-N 0.000 claims description 11
• AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims description 10
• ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims description 10
• 230000015572 biosynthetic process Effects 0.000 claims description 10
• GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 10
• LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims description 10
• JQWAHKMIYCERGA-UHFFFAOYSA-N (2-nonanoyloxy-3-octadeca-9,12-dienoyloxypropoxy)-[2-(trimethylazaniumyl)ethyl]phosphinate Chemical compound CCCCCCCCC(=O)OC(COP([O-])(=O)CC[N+](C)(C)C)COC(=O)CCCCCCCC=CCC=CCCCCC JQWAHKMIYCERGA-UHFFFAOYSA-N 0.000 claims description 9
• WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 9
• LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 9
• QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 9
• WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims description 9
• 239000005642 Oleic acid Substances 0.000 claims description 9
• ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 9
• QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 9
• ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 9
• 239000003381 stabilizer Substances 0.000 claims description 9
• RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 claims description 8
• QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 claims description 8
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 8
• 108091005804 Peptidases Proteins 0.000 claims description 8
• 229920002584 Polyethylene Glycol 6000 Polymers 0.000 claims description 8
• 229920001800 Shellac Polymers 0.000 claims description 8
• 239000002518 antifoaming agent Substances 0.000 claims description 8
• 150000001840 cholesterol esters Chemical class 0.000 claims description 8
• JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 8
• 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 8
• LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 8
• 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 8
• QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 8
• ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 claims description 8
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• 229920002678 cellulose Polymers 0.000 claims description 7
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• OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 7
• 235000021317 phosphate Nutrition 0.000 claims description 7
• 150000003904 phospholipids Chemical class 0.000 claims description 7
• 229940093429 polyethylene glycol 6000 Drugs 0.000 claims description 7
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• 150000003626 triacylglycerols Chemical class 0.000 claims description 7
• WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 claims description 6
• REYJJPSVUYRZGE-UHFFFAOYSA-N Octadecylamine Chemical compound CCCCCCCCCCCCCCCCCCN REYJJPSVUYRZGE-UHFFFAOYSA-N 0.000 claims description 6
• ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 6
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• 235000019419 proteases Nutrition 0.000 claims description 6
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• CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 claims description 5
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• NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims description 5
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• WZHCOOQXZCIUNC-UHFFFAOYSA-N cyclandelate Chemical compound C1C(C)(C)CC(C)CC1OC(=O)C(O)C1=CC=CC=C1 WZHCOOQXZCIUNC-UHFFFAOYSA-N 0.000 claims description 5
• 229960000729 cyclandelate Drugs 0.000 claims description 5
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