NO902261L - Fremgangsmaate ved multipel oksydasjon av steroider og genetisk konstruerte celler for slik bruk. - Google Patents
Fremgangsmaate ved multipel oksydasjon av steroider og genetisk konstruerte celler for slik bruk.Info
- Publication number
- NO902261L NO902261L NO90902261A NO902261A NO902261L NO 902261 L NO902261 L NO 902261L NO 90902261 A NO90902261 A NO 90902261A NO 902261 A NO902261 A NO 902261A NO 902261 L NO902261 L NO 902261L
- Authority
- NO
- Norway
- Prior art keywords
- host cells
- steroids
- cholesterol
- procedure
- progesterone
- Prior art date
Links
- 230000003647 oxidation Effects 0.000 title abstract 4
- 238000007254 oxidation reaction Methods 0.000 title abstract 4
- 150000003431 steroids Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 6
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 abstract 4
- 235000012000 cholesterol Nutrition 0.000 abstract 3
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 abstract 2
- 230000008236 biological pathway Effects 0.000 abstract 2
- 229960000890 hydrocortisone Drugs 0.000 abstract 2
- DBPWSSGDRRHUNT-UHFFFAOYSA-N 17alpha-hydroxy progesterone Natural products C1CC2=CC(=O)CCC2(C)C2C1C1CCC(C(=O)C)(O)C1(C)CC2 DBPWSSGDRRHUNT-UHFFFAOYSA-N 0.000 abstract 1
- 241000193830 Bacillus <bacterium> Species 0.000 abstract 1
- DOMWKUIIPQCAJU-LJHIYBGHSA-N Hydroxyprogesterone caproate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)CCCCC)[C@@]1(C)CC2 DOMWKUIIPQCAJU-LJHIYBGHSA-N 0.000 abstract 1
- 241000235649 Kluyveromyces Species 0.000 abstract 1
- ORNBQBCIOKFOEO-YQUGOWONSA-N Pregnenolone Natural products O=C(C)[C@@H]1[C@@]2(C)[C@H]([C@H]3[C@@H]([C@]4(C)C(=CC3)C[C@@H](O)CC4)CC2)CC1 ORNBQBCIOKFOEO-YQUGOWONSA-N 0.000 abstract 1
- 241000235070 Saccharomyces Species 0.000 abstract 1
- 229940107161 cholesterol Drugs 0.000 abstract 1
- 229950000801 hydroxyprogesterone caproate Drugs 0.000 abstract 1
- ORNBQBCIOKFOEO-QGVNFLHTSA-N pregnenolone Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 ORNBQBCIOKFOEO-QGVNFLHTSA-N 0.000 abstract 1
- 229960000249 pregnenolone Drugs 0.000 abstract 1
- 229960003387 progesterone Drugs 0.000 abstract 1
- 239000000186 progesterone Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Genetisk konstruerte vertsceller er laget som er istand til å utfore samtidige oksidasjoner av steroider, fortrinnsvis den samtidige introduksjonen av 17cx-hydroksyl og C21-hydroksyl-gruppen. Spesielt blir oksidasjonen utfart av celler som har DNA innsatt og som koder for minst to proteiner involvert i den biologiske reaksjonsveien fra kolesterol til hydrocortison. Passende vertsceller omfatter artene Bacillus, Saccharomyces eller Kluyveromyces. De nye vertscellene er velegnet for biokje-miske oksidasjoner av kolesterol, pregnenolon, progesteron og 17a-hydroksy-progesteron, som er intermediære i nevnte biologiske reaksjonsvei.Vertscellene er også anvendbare for den endelige utvikling av et multigensystem for ett-trinn-overf«ringen av kolesterol til hydrocortison.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP88202080 | 1988-09-23 | ||
| PCT/NL1989/000072 WO1990003428A1 (en) | 1988-09-23 | 1989-09-25 | Process for the multiple oxidation of steroids and genetically engineered cells to be used therefor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO902261L true NO902261L (no) | 1990-05-22 |
| NO902261D0 NO902261D0 (no) | 1990-05-22 |
Family
ID=26115333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO902261A NO902261D0 (no) | 1988-09-23 | 1990-05-22 | Fremgangsmaate ved multipel oksydasjon av steroider og genetisk konstruerte celler for slik bruk. |
Country Status (1)
| Country | Link |
|---|---|
| NO (1) | NO902261D0 (no) |
-
1990
- 1990-05-22 NO NO902261A patent/NO902261D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO902261D0 (no) | 1990-05-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |