NO903564L - Fremgangsmaate for fremstilling av 4-substituerte 17beta-(cyklopropylamino)androst-5-en-3beta-ol-derivater. - Google Patents

Fremgangsmaate for fremstilling av 4-substituerte 17beta-(cyklopropylamino)androst-5-en-3beta-ol-derivater.

Info

Publication number: NO903564L
Authority: NO; Norway
Prior art keywords: androst; cyclopropylamino; substituted; 17beta; 3beta
Prior art date: 1989-08-15

Application number

NO90903564A

Other languages

English (en)

Norwegian (no)

Other versions

NO903564D0 (no

Inventor

Michael Richard Angelastro

Thomas Robert Blohm

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-08-15

Filing date

1990-08-14

Publication date

1991-02-18

1990-08-14 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1990-08-14 Publication of NO903564D0 publication Critical patent/NO903564D0/no

1991-02-18 Publication of NO903564L publication Critical patent/NO903564L/no

Links

-1 CYCLOPROPYLAMINO Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
LYFPAZBMEUSVNA-UHFFFAOYSA-N (10R)-3c-Hydroxy-10r.13c-dimethyl-(8cH.9tH.14tH)-Delta5-tetradecahydro-1H-cyclopenta[a]phenanthren Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCCC1(C)CC2 LYFPAZBMEUSVNA-UHFFFAOYSA-N 0.000 abstract 1
LYFPAZBMEUSVNA-DYKIIFRCSA-N (3s,8s,9s,10r,13s,14s)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-ol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CCC[C@@]1(C)CC2 LYFPAZBMEUSVNA-DYKIIFRCSA-N 0.000 abstract 1
239000003098 androgen Substances 0.000 abstract 1
230000001419 dependent effect Effects 0.000 abstract 1
150000002081 enamines Chemical class 0.000 abstract 1
150000004678 hydrides Chemical class 0.000 abstract 1
150000002466 imines Chemical class 0.000 abstract 1
230000003637 steroidlike Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO90903564A 1989-08-15 1990-08-14 Fremgangsmaate for fremstilling av 4-substituerte 17beta-(cyklopropylamino)androst-5-en-3beta-ol-derivater. NO903564L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/394,025 US4966898A (en)	1989-08-15	1989-08-15	4-substituted 17β-(cyclopropylamino)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors

Publications (2)

Publication Number	Publication Date
NO903564D0 NO903564D0 (no)	1990-08-14
NO903564L true NO903564L (no)	1991-02-18

Family

ID=23557240

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO90903564A NO903564L (no)	1989-08-15	1990-08-14	Fremgangsmaate for fremstilling av 4-substituerte 17beta-(cyklopropylamino)androst-5-en-3beta-ol-derivater.

Country Status (20)

Country	Link
US (1)	US4966898A (de)
EP (1)	EP0413270B1 (de)
JP (1)	JP2879703B2 (de)
KR (1)	KR910004649A (de)
CN (1)	CN1050196A (de)
AT (1)	ATE137761T1 (de)
AU (1)	AU628209B2 (de)
CA (1)	CA2023012C (de)
DD (1)	DD299650A5 (de)
DE (1)	DE69026881T2 (de)
ES (1)	ES2088928T3 (de)
FI (1)	FI95804C (de)
HU (1)	HUT55029A (de)
IE (1)	IE72516B1 (de)
IL (1)	IL95358A (de)
NO (1)	NO903564L (de)
NZ (1)	NZ234856A (de)
PH (1)	PH27098A (de)
PT (1)	PT94993B (de)
ZA (1)	ZA906308B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4966897A (en) *	1989-08-15	1990-10-30	Merrell Dow Pharmaceuticals Inc.	4-substituted 17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors
US5604213A (en) *	1992-03-31	1997-02-18	British Technology Group Limited	17-substituted steroids useful in cancer treatment
CZ287434B6 (en) *	1992-03-31	2000-11-15	British Tech Group	Use of steroids, substituted in position 17, steroids functioning as carcinostatics and pharmaceutical preparation containing thereof
TW369521B (en) *	1993-09-17	1999-09-11	Smithkline Beecham Corp	Androstenone derivative
US5541322A (en) *	1994-10-14	1996-07-30	Glaxo Wellcome Inc.	Synthesis of 6-azaandrostenones
US6365597B1 (en)	1996-02-14	2002-04-02	Aventis Pharmaceuticals Inc.	4-aza steroids
RU2291863C2 (ru) *	2000-06-09	2007-01-20	Байер Кропсайенс С.А.	Способ получения пестицидных соединений
JP3753971B2 (ja)	2000-11-17	2006-03-08	武田薬品工業株式会社	新規イミダゾール誘導体、その製造法および用途
DE60144246D1 (de)	2000-11-20	2011-04-28	Takeda Pharmaceutical	Imidazolderivate, verfahren zu deren herstellung und deren verwendung
AU2002221080A1 (en)	2000-12-08	2002-06-18	Masami Kusaka	Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparingthe same and use thereof
US20080051380A1 (en)	2006-08-25	2008-02-28	Auerbach Alan H	Methods and compositions for treating cancer
UY32730A (es)	2009-06-26	2011-01-31	Novartis Ag	Inhibidores de cyp17
JP2011098893A (ja) *	2009-11-04	2011-05-19	Sumitomo Chemical Co Ltd	テストステロンの生合成を抑制するための化合物の使用およびその化合物
KR101926320B1 (ko)	2010-08-04	2018-12-06	펠피큐어 파마슈티걸즈 아이엔씨	전립선 암종의 치료를 위한 병용 요법
EP2627648A1 (de)	2010-09-16	2013-08-21	Novartis AG	17a-HYDROXYLASE-C17, 20-LYASE-INHIBITOREN
MX359399B (es)	2011-04-28	2018-09-27	Novartis Ag	Inhibidores de 17alfa-hidroxilasa/c17-20-liasa.
WO2014158875A1 (en)	2013-03-14	2014-10-02	Pellficure Pharmaceuticals Inc.	Novel therapy for prostate carcinoma
CA2960750A1 (en)	2014-09-12	2016-03-17	Pellficure Pharmaceuticals, Inc.	Compositions and methods for treatment of prostate carcinoma
MX2019001224A (es)	2016-07-29	2019-06-03	Janssen Pharmaceutica Nv	Metodos para tratar el cancer de prostata.
WO2018080933A1 (en)	2016-10-24	2018-05-03	Pellficure Pharmaceuticals Inc.	Pharmaceutical compositions of 5-hydroxy-2-methylnaphthalene-1, 4-dione

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3107254A (en) *	1960-10-05	1963-10-15	Upjohn Co	17beta-dialkylamino-17-cyanosteroids and their 17alpha-alkyl, alkylene and alkyne derivatives
US3097200A (en) *	1962-01-03	1963-07-09	Syntex Corp	17-aminoandrostanes
NL302932A (de) *	1962-12-31
ZA882717B (en) *	1987-04-22	1988-10-17	Merrell Dow Pharmaceuticals Inc.	17beta-(cyclopropylamino)-androst-5-eb-3beta-ol and related compounds useful as c17-20 lyase inhibitors
US4966897A (en) *	1989-08-15	1990-10-30	Merrell Dow Pharmaceuticals Inc.	4-substituted 17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors

1989
- 1989-08-15 US US07/394,025 patent/US4966898A/en not_active Expired - Fee Related
1990
- 1990-08-09 JP JP2209389A patent/JP2879703B2/ja not_active Expired - Fee Related
- 1990-08-09 ZA ZA906308A patent/ZA906308B/xx unknown
- 1990-08-09 AU AU60877/90A patent/AU628209B2/en not_active Ceased
- 1990-08-09 CA CA002023012A patent/CA2023012C/en not_active Expired - Fee Related
- 1990-08-10 DE DE69026881T patent/DE69026881T2/de not_active Expired - Fee Related
- 1990-08-10 NZ NZ234856A patent/NZ234856A/en unknown
- 1990-08-10 ES ES90115391T patent/ES2088928T3/es not_active Expired - Lifetime
- 1990-08-10 AT AT90115391T patent/ATE137761T1/de not_active IP Right Cessation
- 1990-08-10 EP EP90115391A patent/EP0413270B1/de not_active Expired - Lifetime
- 1990-08-13 IL IL9535890A patent/IL95358A/en not_active IP Right Cessation
- 1990-08-14 HU HU905004A patent/HUT55029A/hu unknown
- 1990-08-14 IE IE294290A patent/IE72516B1/en not_active IP Right Cessation
- 1990-08-14 KR KR1019900012533A patent/KR910004649A/ko not_active Ceased
- 1990-08-14 PT PT94993A patent/PT94993B/pt not_active IP Right Cessation
- 1990-08-14 NO NO90903564A patent/NO903564L/no unknown
- 1990-08-15 FI FI904035A patent/FI95804C/fi not_active IP Right Cessation
- 1990-08-15 DD DD90343476A patent/DD299650A5/de unknown
- 1990-08-15 PH PH41034A patent/PH27098A/en unknown
- 1990-08-15 CN CN90107580A patent/CN1050196A/zh active Pending

Also Published As

Publication number	Publication date
NO903564D0 (no)	1990-08-14
EP0413270A2 (de)	1991-02-20
KR910004649A (ko)	1991-03-29
JP2879703B2 (ja)	1999-04-05
JPH0383998A (ja)	1991-04-09
CA2023012C (en)	2001-07-03
FI95804B (fi)	1995-12-15
IE902942A1 (en)	1991-02-27
PT94993B (pt)	1997-07-31
AU6087790A (en)	1991-02-21
DE69026881T2 (de)	1996-09-12
ZA906308B (en)	1991-06-26
HUT55029A (en)	1991-04-29
FI95804C (fi)	1996-03-25
DE69026881D1 (de)	1996-06-13
CA2023012A1 (en)	1991-02-16
EP0413270B1 (de)	1996-05-08
ATE137761T1 (de)	1996-05-15
DD299650A5 (de)	1992-04-30
PH27098A (en)	1993-02-26
AU628209B2 (en)	1992-09-10
CN1050196A (zh)	1991-03-27
EP0413270A3 (en)	1992-05-20
HU905004D0 (en)	1991-01-28
IE72516B1 (en)	1997-04-23
NZ234856A (en)	1992-08-26
IL95358A0 (en)	1991-06-30
IL95358A (en)	1995-03-30
ES2088928T3 (es)	1996-10-01
FI904035A0 (fi)	1990-08-15
PT94993A (pt)	1991-04-18
US4966898A (en)	1990-10-30

Publication	Publication Date	Title
NO903564L (no)	1991-02-18	Fremgangsmaate for fremstilling av 4-substituerte 17beta-(cyklopropylamino)androst-5-en-3beta-ol-derivater.
NO881746L (no)	1988-10-24	Fremgangsmaate for fremstilling av 17beta-(cyclopropylamino)androst-5-en-3beta-ol og beslektede forbindelser.
ATE108453T1 (de)	1994-07-15	Benzopyridopiperidin, -piperidyliden und - piperazin-verbindungen, zusammensetzungen, methoden zur herstellung und verwendung.
NO903565D0 (no)	1990-08-14	Fremgangsmaate for fremstilling av 4-substituerte 17beta-(cyklopropyl)androst-5-en-3beta-ol-derivater.
DK0564350T3 (da)	1997-12-15	3, 5-di-tert-butyl-4-hydroxyflavoner, fremgangsmåde til deres fremstilling og farmaceutiske sammensætninger med antioxidant- og anti-vasokonstriktorisk virkning
NO168892C (no)	1992-04-15	Analogifremgangsmaate ved fremstilling av terapeutisk aktive 17beta-(cyclopropyloxy)androst-5-en-3beta-ol-derivater
EP0319962A3 (de)	1990-08-22	Piperidinyl-Methanol-Derivate zur Behandlung von Angstzuständen
IL111580A (en)	1999-10-28	Use of melatonin derivatives in the preparation of pharmaceutical compositions for use in treating sleep disorders
ATE71099T1 (de)	1992-01-15	Calcium-4,6-dioxo-4h-pyrano(3,2-g>-chinolin-2,8 dicarboxylat-derivat, verfahren zu seiner herstellung und dieses enthaltende zusammensetzungen.
ATE157670T1 (de)	1997-09-15	Digitoxigenin und dihydrodigitoxigenin 3-beta- derivate und pharmazeutische präparate davon, zur behandlung von hypertonie
EP0402857A3 (de)	1991-10-09	Verwendung von 17-beta-Cyclopropylaminoandrosten-Derivaten