NO903640L - Fremgangsmaate for fremstilling av 2-(rs)-substituerte 2,3-dihydro-5-oksy-4,6,7-trimetylbenzofuraner. - Google Patents

Fremgangsmaate for fremstilling av 2-(rs)-substituerte 2,3-dihydro-5-oksy-4,6,7-trimetylbenzofuraner.

Info

Publication number: NO903640L
Authority: NO; Norway
Prior art keywords: benzofuranes; dihydro; oxy; trimethyl; substituted
Prior art date: 1989-08-18

Application number

NO90903640A

Other languages

English (en)

Other versions

NO175819C (no

NO175819B (no

NO903640D0 (no

Inventor

Mario Brufani

Stefano Ceccarelli

Patrizia De Vellis

Patrizia Giannetti

Agnese Paesano

Romolo Scuri

Sergio Zanarella

Original Assignee

Foscama Biomed Chim Farma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-08-18

Filing date

1990-08-17

Publication date

1991-02-19

1990-08-17 Application filed by Foscama Biomed Chim Farma filed Critical Foscama Biomed Chim Farma

1990-08-17 Publication of NO903640D0 publication Critical patent/NO903640D0/no

1991-02-19 Publication of NO903640L publication Critical patent/NO903640L/no

1994-09-05 Publication of NO175819B publication Critical patent/NO175819B/no

1994-12-14 Publication of NO175819C publication Critical patent/NO175819C/no

Links

230000002253 anti-ischaemic effect Effects 0.000 abstract 1
239000003963 antioxidant agent Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
239000002516 radical scavenger Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/12—Mucolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Toxicology (AREA)
Biochemistry (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Furan Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Fats And Perfumes (AREA)

NO903640A 1989-08-18 1990-08-17 Analogifremgangsmåte for fremstilling av terapeutisk aktive 2-(RS)-substituerte 2,3-dihydro-5-oksy-4,6,7-trimetylbenzofuraner NO175819C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT8921532A IT1231341B (it)	1989-08-18	1989-08-18	2,3 diidro 5 ossi 4,6,7 trimetilbenzofurani 2 (rs) sostituiti, utili come farmaci antiossidanti con proprieta' mucoregolatrici e antiischemiche.

Publications (4)

Publication Number	Publication Date
NO903640D0 NO903640D0 (no)	1990-08-17
NO903640L true NO903640L (no)	1991-02-19
NO175819B NO175819B (no)	1994-09-05
NO175819C NO175819C (no)	1994-12-14

Family

ID=11183207

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO903640A NO175819C (no)	1989-08-18	1990-08-17	Analogifremgangsmåte for fremstilling av terapeutisk aktive 2-(RS)-substituerte 2,3-dihydro-5-oksy-4,6,7-trimetylbenzofuraner

Country Status (21)

Country	Link
US (1)	US5114966A (no)
EP (1)	EP0413668B1 (no)
JP (1)	JP2931056B2 (no)
KR (1)	KR0167553B1 (no)
CN (1)	CN1032135C (no)
AT (1)	ATE131164T1 (no)
AU (1)	AU634570B2 (no)
CA (1)	CA2023522A1 (no)
CS (1)	CS277503B6 (no)
DE (1)	DE69023980T2 (no)
DK (1)	DK0413668T3 (no)
ES (1)	ES2080821T3 (no)
FI (1)	FI92198C (no)
GR (1)	GR3019030T3 (no)
HU (1)	HU207059B (no)
IT (1)	IT1231341B (no)
NO (1)	NO175819C (no)
NZ (1)	NZ234934A (no)
PT (1)	PT95037B (no)
RU (1)	RU2068845C1 (no)
ZA (1)	ZA906266B (no)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0550292A1 (en) *	1992-01-02	1993-07-07	Merrell Dow Pharmaceuticals Inc.	Tissue protective tocopherol analogs
EP0560568A3 (en) *	1992-03-13	1994-06-29	Takeda Chemical Industries Ltd	Hydroquinone derivatives and intermediates for production thereof
US5510373A (en) *	1992-04-06	1996-04-23	Merrell Pharmaceuticals Inc.	Cardioprotective agents
US5721233A (en) *	1992-04-06	1998-02-24	Merrell Pharmaceuticals Inc.	Derivatives of 2,3-dihydro benzofuranols
WO1993020057A1 (en) *	1992-04-06	1993-10-14	Merrell Dow Pharmaceuticals Inc.	Novel derivatives of 2,3-dihydro-2,2,4,6,7-pentaalkyl-5-benzofuranols
US5545660A (en) *	1992-04-07	1996-08-13	Merrell Pharmaceuticals Inc.	Hydrazide derivatives of 3,4-dihydro-2H-1-benzopyrans
IT1256264B (it) *	1992-12-31	1995-11-29	Lifegroup Spa	N-acilderivati di idrossiammine dotati di attivita' scavenger ed utilizzabili nelle patologie acute e croniche correlate a fenomeni di perossidazione ed infiammazione
WO1995029906A1 (en) *	1994-04-28	1995-11-09	Meiji Milk Products Co., Ltd.	Benzofuran derivative and use thereof
FR2720395B1 (fr) *	1994-05-31	1996-06-28	Oreal	Nouveaux composés de la famille des benzohétérocycles.
US6150402A (en) *	1994-08-15	2000-11-21	Loma Linda University Medical Center	Natriuretic compounds
US5798356A (en) *	1995-08-07	1998-08-25	Alcon Laboratories, Inc.	Angiostatic compounds
US6048891A (en)	1998-12-17	2000-04-11	Loma Linda University Medical Center	Use of γ-tocopherol and its oxidative metabolite LLU-α in the treatment of natriuretic disease
US7078541B2 (en) *	2002-02-07	2006-07-18	Galileo Pharmaceuticals, Inc.	Benzofuran derivatives
US6653346B1 (en)	2002-02-07	2003-11-25	Galileo Pharmaceuticals, Inc.	Cytoprotective benzofuran derivatives
CN107056707B (zh) *	2017-01-23	2019-08-23	温州医科大学	一种3,4,5-三甲氧基苯类化合物及其在制备抗氧化药物中的应用
JP7033824B1 (ja) *	2021-06-28	2022-03-11	株式会社ディスコ	単結晶ダイヤモンドの製造方法および単結晶ダイヤモンド

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1281325C (en) *	1984-06-20	1991-03-12	Patrice C. Belanger	Benzofuran derivatives
JP2855340B2 (ja) *	1988-06-10	1999-02-10	武田薬品工業株式会社	２―置換クマラン誘導体
JP2855341B2 (ja) *	1988-06-10	1999-02-10	武田薬品工業株式会社	新規２―置換クマラン誘導体
IT1229482B (it) *	1988-08-01	1991-09-03	Foscama Biomed Chim Farma	Acidi (rs) 2 (2,3 diidro 5 idrossi 4,6,7 trimetilbenzofuranil) acetico e 2 (2,3 diidro 5 acilossi 4,6,7 trimetilbenzofuranil) acetici e loro esteri, utili come farmaci mucoregolatori ed antiischemici.

1989
- 1989-08-18 IT IT8921532A patent/IT1231341B/it active
1990
- 1990-08-06 US US07/562,731 patent/US5114966A/en not_active Expired - Lifetime
- 1990-08-08 ZA ZA906266A patent/ZA906266B/xx unknown
- 1990-08-13 FI FI903994A patent/FI92198C/fi not_active IP Right Cessation
- 1990-08-16 AT AT90830376T patent/ATE131164T1/de not_active IP Right Cessation
- 1990-08-16 CS CS904023A patent/CS277503B6/cs unknown
- 1990-08-16 NZ NZ234934A patent/NZ234934A/en unknown
- 1990-08-16 EP EP90830376A patent/EP0413668B1/en not_active Expired - Lifetime
- 1990-08-16 DE DE69023980T patent/DE69023980T2/de not_active Expired - Fee Related
- 1990-08-16 DK DK90830376.1T patent/DK0413668T3/da active
- 1990-08-16 ES ES90830376T patent/ES2080821T3/es not_active Expired - Lifetime
- 1990-08-17 HU HU905062A patent/HU207059B/hu unknown
- 1990-08-17 CA CA002023522A patent/CA2023522A1/en not_active Abandoned
- 1990-08-17 PT PT95037A patent/PT95037B/pt not_active IP Right Cessation
- 1990-08-17 NO NO903640A patent/NO175819C/no unknown
- 1990-08-17 RU SU904830922A patent/RU2068845C1/ru active
- 1990-08-17 JP JP2217977A patent/JP2931056B2/ja not_active Expired - Lifetime
- 1990-08-18 KR KR1019900012708A patent/KR0167553B1/ko not_active Expired - Fee Related
- 1990-08-18 CN CN90107001A patent/CN1032135C/zh not_active Expired - Fee Related
- 1990-08-22 AU AU61280/90A patent/AU634570B2/en not_active Ceased
1996
- 1996-02-21 GR GR960400432T patent/GR3019030T3/el unknown

Also Published As

Publication number	Publication date
HUT54669A (en)	1991-03-28
HU905062D0 (en)	1991-01-28
HU207059B (en)	1993-03-01
ES2080821T3 (es)	1996-02-16
GR3019030T3 (en)	1996-05-31
EP0413668A2 (en)	1991-02-20
KR910004588A (ko)	1991-03-29
CN1049499A (zh)	1991-02-27
ZA906266B (en)	1991-05-29
NZ234934A (en)	1992-02-25
US5114966A (en)	1992-05-19
PT95037A (pt)	1991-04-18
DE69023980D1 (de)	1996-01-18
PT95037B (pt)	1997-10-31
FI92198C (fi)	1994-10-10
FI92198B (fi)	1994-06-30
DE69023980T2 (de)	1996-08-01
JPH03236383A (ja)	1991-10-22
AU6128090A (en)	1991-02-21
CN1032135C (zh)	1996-06-26
NO175819C (no)	1994-12-14
NO175819B (no)	1994-09-05
CS277503B6 (en)	1993-03-17
NO903640D0 (no)	1990-08-17
EP0413668A3 (en)	1991-09-11
IT1231341B (it)	1991-11-28
KR0167553B1 (ko)	1999-01-15
ATE131164T1 (de)	1995-12-15
IT8921532A0 (it)	1989-08-18
FI903994A0 (fi)	1990-08-13
EP0413668B1 (en)	1995-12-06
RU2068845C1 (ru)	1996-11-10
DK0413668T3 (da)	1996-04-22
JP2931056B2 (ja)	1999-08-09
CA2023522A1 (en)	1991-02-19
AU634570B2 (en)	1993-02-25
CS402390A3 (en)	1992-01-15

Publication	Publication Date	Title
NO903640D0 (no)	1990-08-17	Fremgangsmaate for fremstilling av 2-(rs)-substituerte 2,3-dihydro-5-oksy-4,6,7-trimetylbenzofuraner.
ATE269290T1 (de)	2004-07-15	Benzoylderivate
DK0623607T3 (da)	1999-04-19	Benzofuranyl- og -thiophenyl-alkancarboxylsyrederivater
DE69524528D1 (de)	2002-01-24	ZNS wirksames (R)-(-)-2-[5-(4-Fluorophenyl)-3-pyridylmethylaminomethyl]chroman
DE69116909D1 (de)	1996-03-21	3,5-Di-tertiärbutyl-4-hydroxyphenylmethylenderivate von 2-substituierten Thiazolidinonen, Oxazolidinonen und Imidazolidinonen als antientzündlich wirkende Mittel
MX20359A (es)	1994-02-28	Derivados de 2-oxindol 3-substituidos.
MX9204190A (es)	1993-01-01	Derivdos de 2-(4-hidroxipiperidino)-1-alcanol como agentes antiisquemicos.
DE69021501D1 (de)	1995-09-14	Anti-entzündende 4-aminophenol-derivate.
ATE179173T1 (de)	1999-05-15	2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy 1,3-propandiol-derivate
NO944406D0 (no)	1994-11-17	Nye 7 se inhibitorer
FI920023A0 (fi)	1992-01-03	Heteroarylpiperazinfoereningar som antipsykotiska aemnen.
ES2090099T3 (es)	1996-10-16	Derivados de piranil-cianoguanidina.
FI902179A0 (fi)	1990-04-30	Elektrodmaettkropp foer anvaendning i vaetskeformiga omgivningar med hoeg temperatur och stark straolning.
IT9019754A0 (it)	1990-03-21	Composizioni farmaceutiche,dietetiche o veterinarie ad attivita' eumetabolica
FI952682A0 (fi)	1995-06-01	Insektisidisiä 5-substituoituja 2,4-diamiinipyrimidiinijohdannaisia
IT8921380A0 (it)	1989-07-28	Composti piperazin piperidinici atti all'impiego come stabilizzanti per materiali organici.
DK0625520T3 (da)	2000-01-31	Thiazolotriazol- og thiazolodiazolderivater med fungicid aktivitet
ATE45856T1 (de)	1989-09-15	Aminoalkanphosphonsaeure und derivate davon als fungizide mittel.
DE3889336D1 (de)	1994-06-01	Alkyltetramethylcyclohexan-derivate und deren verwendung als duftstoffe.
DE58907941D1 (de)	1994-07-28	Substituierte 2-(Halogenmethylthio)-pyrimidin-Derivate.
DE69213049D1 (de)	1996-10-02	Isoquinolinderivate
IT1230056B (it)	1991-09-27	Derivato di 4-(piperidin-1-il) piridina ad attivita' antifibroplastica.
IT9021262A1 (it)	1992-02-10	Derivati 1, 4-benzotiacinici ad attivita' calcio antagonista
IT8622051A1 (it)	1988-04-17	Composizioni farmaceutiche ad attivita' cicatrizzante
ITMI921863A1 (it)	1994-01-30	Derivati 1, 4-benzotiazinici ad attivita' calcio antagonista