NO912541L - Fremgangsmaate for fremstilling og anvendelse av 2,4- og 2,5-substituerte pyridin-n-oksider. - Google Patents

Fremgangsmaate for fremstilling og anvendelse av 2,4- og 2,5-substituerte pyridin-n-oksider.

Info

Publication number: NO912541L
Authority: NO; Norway
Prior art keywords: oxides; substituted pyridine; procedure; preparation; collagen
Prior art date: 1990-06-28

Application number

NO91912541A

Other languages

English (en)

Other versions

NO178026C (no

NO912541D0 (no

NO178026B (no

Inventor

Ekkehard Baader

Martin Bickel

Volkmar Guenzler-Pukall

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-28

Filing date

1991-06-27

Publication date

1991-12-30

1991-06-27 Application filed by Hoechst Ag filed Critical Hoechst Ag

1991-06-27 Publication of NO912541D0 publication Critical patent/NO912541D0/no

1991-12-30 Publication of NO912541L publication Critical patent/NO912541L/no

1995-10-02 Publication of NO178026B publication Critical patent/NO178026B/no

1996-01-10 Publication of NO178026C publication Critical patent/NO178026C/no

Links

102000008186 Collagen Human genes 0.000 abstract 1
108010035532 Collagen Proteins 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
229920001436 collagen Polymers 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000001506 immunosuppresive effect Effects 0.000 abstract 1
230000004060 metabolic process Effects 0.000 abstract 1
ILVXOBCQQYKLDS-UHFFFAOYSA-N pyridine N-oxide Chemical class [O-][N+]1=CC=CC=C1 ILVXOBCQQYKLDS-UHFFFAOYSA-N 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Diabetes (AREA)
Hematology (AREA)
Transplantation (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Obesity (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicinal Preparation (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

NO912541A 1990-06-28 1991-06-27 Analogifremgangsmåte for fremstilling av terapeutisk aktive 2,4- og 2,5-substituerte pyridin-N-oksider NO178026C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4020570A DE4020570A1 (de)	1990-06-28	1990-06-28	2,4- und 2,5-substituierte pyridin-n-oxide, verfahren zu deren herstellung sowie deren verwendung

Publications (4)

Publication Number	Publication Date
NO912541D0 NO912541D0 (no)	1991-06-27
NO912541L true NO912541L (no)	1991-12-30
NO178026B NO178026B (no)	1995-10-02
NO178026C NO178026C (no)	1996-01-10

Family

ID=6409247

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO912541A NO178026C (no)	1990-06-28	1991-06-27	Analogifremgangsmåte for fremstilling av terapeutisk aktive 2,4- og 2,5-substituerte pyridin-N-oksider

Country Status (27)

Country	Link
EP (1)	EP0463592B1 (no)
JP (1)	JPH0832687B2 (no)
KR (1)	KR920000724A (no)
CN (1)	CN1038585C (no)
AT (1)	ATE110059T1 (no)
AU (1)	AU636990B2 (no)
BR (1)	BR9102699A (no)
CA (1)	CA2045868A1 (no)
CZ (1)	CZ283782B6 (no)
DE (2)	DE4020570A1 (no)
DK (1)	DK0463592T3 (no)
EG (1)	EG19851A (no)
ES (1)	ES2061118T3 (no)
FI (1)	FI101070B (no)
HR (1)	HRP940701B1 (no)
HU (1)	HU214627B (no)
IE (1)	IE65300B1 (no)
IL (1)	IL98629A (no)
LT (1)	LT3918B (no)
MA (1)	MA22191A1 (no)
MX (1)	MX26415A (no)
MY (1)	MY107573A (no)
NO (1)	NO178026C (no)
NZ (1)	NZ238701A (no)
PT (1)	PT98108B (no)
YU (1)	YU113391A (no)
ZA (1)	ZA914958B (no)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
YU9492A (sh) *	1991-02-05	1995-03-27	Hoechst Ag.	2,4- i 2,5-bis-tetrazolilni piridini i postupak za njihovo dobijanje
CA2085954A1 (en) *	1991-12-24	1993-06-25	Klaus Weidmann	Substituted pyridine n-oxides, processes for their preparation, and their use
TW352384B (en) *	1992-03-24	1999-02-11	Hoechst Ag	Sulfonamido- or sulfonamidocarbonylpyridine-2-carboxamides, process for their preparation and their use as pharmaceuticals
TW222585B (no) *	1992-09-11	1994-04-21	Hoechst Ag
DE4233124A1 (de) *	1992-10-02	1994-04-07	Hoechst Ag	Acylsulfonamido- und Sulfonamidopyridin-2-carbonsäureester sowie ihre Pyridin-N-oxide, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US6451816B1 (en)	1997-06-20	2002-09-17	Klinge Pharma Gmbh	Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression
DE19624704A1 (de) *	1996-06-20	1998-01-08	Klinge Co Chem Pharm Fab	Neue Pyridylalkansäureamide
DE19624659A1 (de)	1996-06-20	1998-01-08	Klinge Co Chem Pharm Fab	Neue Pyridylalken- und Pyridylalkinsäureamide
FR2766187B1 (fr) *	1997-07-17	2000-06-02	Rhone Poulenc Rorer Sa	Derives de pyrazine, leur preparation et les medicaments les contenant
DE19756212A1 (de)	1997-12-17	1999-07-01	Klinge Co Chem Pharm Fab	Neue, mit einem cyclischen Imid substituierte Pyridylalkan-, alken- und -alkincarbonsäureamide
US6903118B1 (en)	1997-12-17	2005-06-07	Klinge Pharma Gmbh	Piperazinyl-substituted pyridylalkane, alkene and alkine carboxamides
DE19756235A1 (de)	1997-12-17	1999-07-01	Klinge Co Chem Pharm Fab	Neue piperidinylsubstituierte Pyridylalkan- alken- und -alkincarbonsäureamide
DE19756261A1 (de)	1997-12-17	1999-07-01	Klinge Co Chem Pharm Fab	Neue arylsubstituierte Pyridylalkan-, alken- und alkincarbonsäureamide
EP1031564A1 (en)	1999-02-26	2000-08-30	Klinge Pharma GmbH	Inhibitors of cellular nicotinamide mononucleotide formation and their use in cancer therapy
DOP2002000332A (es)	2001-02-14	2002-08-30	Warner Lambert Co	Inhibidores de piridina de metaloproteinasas de la matriz
DOP2002000333A (es)	2001-02-14	2002-09-30	Warner Lambert Co	Derivados de acido isoftalico como inhibidores de metaloproteinasas de la matriz
JP2004518723A (ja)	2001-02-14	2004-06-24	ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー	ピリミジンマトリックスメタロプロテイナーゼ阻害剤
US6924276B2 (en)	2001-09-10	2005-08-02	Warner-Lambert Company	Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors
WO2003032999A1 (en)	2001-10-12	2003-04-24	Warner-Lambert Company Llc	Alkyne matrix metalloproteinase inhibitors
US6933298B2 (en)	2001-12-08	2005-08-23	Aventis Pharma Deutschland Gmbh	Pyridine-2,4-dicarboxylic acid diamides and pyrimidine-4,6-dicarboxylic acid diamides and the use thereof for selectively inhibiting collagenases
DE10160357A1 (de) *	2001-12-08	2003-06-18	Aventis Pharma Gmbh	Verwendung von Pyridin-2,4-dicarbonsäurediamiden und Pyrimidin-4,6-dicarbonsäurediamiden zur selektiven Inhibierung von Kollagenasen

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5623987B2 (no) *	1972-02-04	1981-06-03
JPS6052702B2 (ja)	1976-08-27	1985-11-20	中外製薬株式会社	ピリジン誘導体およびその製造方法
JPS57109792A (en) *	1980-12-26	1982-07-08	Banyu Pharmaceut Co Ltd	Penicillin derivative and salt thereof
DE3432094A1 (de)	1984-08-31	1986-03-06	Hoechst Ag, 6230 Frankfurt	Ester der pyridin-2,4- und -2,5- dicarbonsaeure als arzneimittel zur inhibierung der prolin- und lysinhydroxylase
JP2512924B2 (ja) *	1987-01-21	1996-07-03	萬有製薬株式会社	育毛剤
DE3703963A1 (de) *	1987-02-10	1988-08-18	Hoechst Ag	Pyridin-2,4- und 2,,5-dicarbonsaeure-derivate, verfahren zu ihrer herstellung, verwendung derselben, sowie arzneimittel auf basis dieser verbindungen
DE3703959A1 (de)	1987-02-10	1988-08-18	Hoechst Ag	Pyridin-2,4- und 2,5-dicarbonsaeureamide, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen
DE3703962A1 (de)	1987-02-10	1988-08-18	Hoechst Ag	Pyridin-2,4- und 2,5-dicarbonsaeure-derivate, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen
JP2600786B2 (ja) *	1988-04-12	1997-04-16	萬有製薬株式会社	育毛剤
DE3826471A1 (de)	1988-08-04	1990-02-22	Hoechst Ag	Verbessertes verfahren zur herstellung von n,n'-bis(alkoxyalkyl)-pyridin-2,4-dicarbonsaeurediamiden
DE3924093A1 (de)	1989-07-20	1991-02-07	Hoechst Ag	N,n'-bis(alkoxy-alkyl)-pyridin-2,4-dicarbonsaeurediamide, verfahren zu deren herstellung sowie deren verwendung
ZA91291B (en)	1990-01-16	1991-09-25	Hoechst Ag	Di(nitroxyalkyl)amides of pyridine-2,4-and-2,5-dicarboxylic acids,a process for the preparation thereof,and the use thereof

1990
- 1990-06-28 DE DE4020570A patent/DE4020570A1/de not_active Withdrawn
1991
- 1991-06-22 AT AT91110343T patent/ATE110059T1/de not_active IP Right Cessation
- 1991-06-22 DK DK91110343.0T patent/DK0463592T3/da active
- 1991-06-22 ES ES91110343T patent/ES2061118T3/es not_active Expired - Lifetime
- 1991-06-22 DE DE59102547T patent/DE59102547D1/de not_active Expired - Fee Related
- 1991-06-22 EP EP91110343A patent/EP0463592B1/de not_active Expired - Lifetime
- 1991-06-26 CZ CS911959A patent/CZ283782B6/cs not_active IP Right Cessation
- 1991-06-26 NZ NZ238701A patent/NZ238701A/en unknown
- 1991-06-26 FI FI913118A patent/FI101070B/fi active IP Right Grant
- 1991-06-26 MY MYPI91001142A patent/MY107573A/en unknown
- 1991-06-26 EG EG39291A patent/EG19851A/xx active
- 1991-06-26 IL IL9862991A patent/IL98629A/en not_active IP Right Cessation
- 1991-06-27 BR BR919102699A patent/BR9102699A/pt not_active Application Discontinuation
- 1991-06-27 NO NO912541A patent/NO178026C/no not_active IP Right Cessation
- 1991-06-27 MX MX2641591A patent/MX26415A/es unknown
- 1991-06-27 IE IE225391A patent/IE65300B1/en unknown
- 1991-06-27 MA MA22469A patent/MA22191A1/fr unknown
- 1991-06-27 CA CA002045868A patent/CA2045868A1/en not_active Abandoned
- 1991-06-27 HU HU912158A patent/HU214627B/hu not_active IP Right Cessation
- 1991-06-27 CN CN91104308A patent/CN1038585C/zh not_active Expired - Fee Related
- 1991-06-27 YU YU113391A patent/YU113391A/sh unknown
- 1991-06-27 AU AU79356/91A patent/AU636990B2/en not_active Ceased
- 1991-06-27 JP JP3156562A patent/JPH0832687B2/ja not_active Expired - Lifetime
- 1991-06-27 PT PT98108A patent/PT98108B/pt not_active IP Right Cessation
- 1991-06-27 ZA ZA914958A patent/ZA914958B/xx unknown
- 1991-06-28 KR KR1019910010858A patent/KR920000724A/ko not_active Withdrawn
1993
- 1993-11-12 LT LTIP1464A patent/LT3918B/lt not_active IP Right Cessation
1994
- 1994-10-19 HR HRP-1133/91A patent/HRP940701B1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
ZA914958B (en)	1992-03-25
LT3918B (en)	1996-04-25
ES2061118T3 (es)	1994-12-01
PT98108B (pt)	1998-12-31
PT98108A (pt)	1993-06-30
AU7935691A (en)	1992-01-02
BR9102699A (pt)	1992-02-04
IL98629A0 (en)	1992-07-15
FI101070B (fi)	1998-04-15
DK0463592T3 (da)	1994-12-19
AU636990B2 (en)	1993-05-13
IL98629A (en)	1996-05-14
IE912253A1 (en)	1992-01-01
ATE110059T1 (de)	1994-09-15
FI913118A0 (fi)	1991-06-26
HU214627B (hu)	1998-04-28
NO178026C (no)	1996-01-10
MA22191A1 (fr)	1991-12-31
CN1038585C (zh)	1998-06-03
NO912541D0 (no)	1991-06-27
CZ283782B6 (cs)	1998-06-17
KR920000724A (ko)	1992-01-29
NZ238701A (en)	1994-06-27
LTIP1464A (en)	1995-05-25
EP0463592A1 (de)	1992-01-02
DE4020570A1 (de)	1992-01-02
MX26415A (es)	1993-05-01
HUT59104A (en)	1992-04-28
HRP940701B1 (en)	1999-08-31
MY107573A (en)	1996-04-30
CN1057649A (zh)	1992-01-08
EP0463592B1 (de)	1994-08-17
EG19851A (en)	1996-10-31
HU912158D0 (en)	1991-12-30
CS195991A3 (en)	1992-02-19
NO178026B (no)	1995-10-02
HRP940701A2 (en)	1997-02-28
CA2045868A1 (en)	1991-12-29
DE59102547D1 (de)	1994-09-22
JPH0832687B2 (ja)	1996-03-29
FI913118L (fi)	1991-12-29
JPH04230264A (ja)	1992-08-19
IE65300B1 (en)	1995-10-18
YU113391A (sh)	1995-10-03

Legal Events

Date	Code	Title	Description
2002-01-28	MM1K	Lapsed by not paying the annual fees	Free format text: LAPSED IN DECEMBER 2001

Publication	Publication Date	Title
NO912541D0 (no)	1991-06-27	Fremgangsmaate for fremstilling og anvendelse av 2,4- og 2,5-substituerte pyridin-n-oksider.
FI970357A7 (fi)	1997-03-26	Tyypin II diabeteksen hoitoon käyttökelpoisia bensoksatsoli- ja pyridi inijohdannaisia
NO881697D0 (no)	1988-04-20	Verktoeyenhet, verktoeydeler og fremgangsmaate for sammensetting av delene.
NO990542D0 (no)	1999-02-05	K-252a-derivater og anvendelse av K-252a-derivater
NO931635D0 (no)	1993-05-05	Fremgangsmaate for fremstilling av kinazolin-derivater
DK0461079T3 (da)	1998-02-09	Substituerede phthalider og heterocykliske phthalider
NO885006L (no)	1990-05-10	Fremgangsmaate og anordning for bevegelseskompensering av stigeroer.
NO902750L (no)	1990-12-27	Fremgangsmaate til fremstilling av 3,5,6-substituerte derivater av 1,2-0-isopropyliden-alfa-glukofuranose og mellomprodukter for fremstilling av derivatene.
DE3763215D1 (de)	1990-07-19	Aushaengbares verschwindscharnier fuer schaltschraenke.
DK62288A (da)	1988-08-16	Substituerede 2,6-substituerede pyridinforbindelser og herbicide praeparater indeholdende disse forbindelser
FI925825A7 (fi)	1993-06-25	Substituoidut pyridiini-N-oksidit, menetelmä niiden valmistamiseksi sekä niiden käyttö
DK62388A (da)	1988-08-10	Substituerede 2,6-substituerede pyridinforbindelser og herbicide praeparater indeholdende disse forbindelser
DK210687D0 (da)	1987-04-24	1,5-diphenyl-1h-1,2,4-triazol-3-carboxamidderivat og herbicidt middel indeholdende derivatet
NO904805L (no)	1991-05-07	Fremgangsmaate for fremstilling av antihypertensive og antiarytmiske pyridinderivater.
NO910163L (no)	1991-07-17	Fremgangsmaate for fremstilling og anvendelse av pyridin-2,4- og 2,5-dikarboksylsyredi-(nitroksyalkyl)amid.
DE3860186D1 (de)	1990-07-05	Substituierte 2,3-epoxy-5-cyclohexenonderivate und diese enthaltende fungizide und herbizide.
DE69230003D1 (de)	1999-10-21	Substituierte pyridincarbonsäurederivate als herbizide
MX9200492A (es)	1992-08-01	2,4- y 2,5-bis-tetrazolilpiridinas, procedimiento para su preparacion asi como su empleo como medicamentos.
IT8747886A0 (it)	1987-04-24	Perfezionamento alle cerniere diporte, sportelli e simili
LV10431A (lv)	1995-02-20	2,4- un 2,5-divaizvietoti piridina N-oksidi to iegusanas panemiens un pielietojums
IT218602Z2 (it)	1992-06-23	Dispositivo per l'azionamento automatico, particolarmente di ante di armadi, mobili o similari.
ATE104945T1 (de)	1994-05-15	Alkyltetramethylcyclohexan-derivate und deren verwendung als duftstoffe.
IT213322Z2 (it)	1989-11-13	Controtelaio ripiegabile, per il montaggio di porte e simili