NO913211L - Nytt monoklonalt antistoff mot nytt antigen knyttet til menneske-tumorer. - Google Patents

Nytt monoklonalt antistoff mot nytt antigen knyttet til menneske-tumorer.

Info

Publication number
NO913211L
NO913211L NO91913211A NO913211A NO913211L NO 913211 L NO913211 L NO 913211L NO 91913211 A NO91913211 A NO 91913211A NO 913211 A NO913211 A NO 913211A NO 913211 L NO913211 L NO 913211L
Authority
NO
Norway
Prior art keywords
new
antigen
tumors
monoclonal antibody
announced
Prior art date
Application number
NO91913211A
Other languages
English (en)
Other versions
NO913211D0 (no
Inventor
Karl Erik Hellstroem
Ingegerd Hellstroem
Hans Marquardt
Yoshitaka Yoneyama
Original Assignee
Oncogen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncogen filed Critical Oncogen
Publication of NO913211D0 publication Critical patent/NO913211D0/no
Publication of NO913211L publication Critical patent/NO913211L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/828—Cancer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Den foreliggende oppfinnelse vedrører et nytt monoklonalt antistoff som binder seg sterkt til et proteinantigen knyttet til mennesketumorer, inkludert karcinomer i kolon, bryst, ovarium og lunger, såvel som melanomer og sarcomer. Antistoffet binder seg til normale menneskeceller i en mye mindre grad enn til tumorceller. Antistoffet finner anvendelse både i diagnos-tiske metoder slik som påvisning av ondartete celler knyttet til tumorer og i terapeutiske metoder for behandling av mennesker med tumorer. Også beskrevet er et nytt 100.000 dalton glyko-proteinantigen funnet på celleoverflaten av mennesketumorceller. Den aminoterminale aminosyresekvens for dette antigen er (I), hvor X representer en ikke-identifisert aminosyre.
NO91913211A 1989-02-17 1991-08-16 Nytt monoklonalt antistoff mot nytt antigen knyttet til menneske-tumorer. NO913211L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/312,640 US5134075A (en) 1989-02-17 1989-02-17 Monoclonal antibody to novel antigen associated with human tumors
PCT/US1990/000407 WO1990009197A1 (en) 1989-02-17 1990-01-23 Novel monoclonal antibody to novel antigen associated with human tumors

Publications (2)

Publication Number Publication Date
NO913211D0 NO913211D0 (no) 1991-08-16
NO913211L true NO913211L (no) 1991-08-16

Family

ID=23212367

Family Applications (1)

Application Number Title Priority Date Filing Date
NO91913211A NO913211L (no) 1989-02-17 1991-08-16 Nytt monoklonalt antistoff mot nytt antigen knyttet til menneske-tumorer.

Country Status (16)

Country Link
US (1) US5134075A (no)
EP (1) EP0458878B1 (no)
JP (1) JPH04503307A (no)
KR (1) KR910700077A (no)
AT (1) ATE142108T1 (no)
AU (1) AU629617B2 (no)
CA (1) CA2010253A1 (no)
DE (1) DE69028388D1 (no)
DK (1) DK0458878T3 (no)
FI (1) FI913891A7 (no)
GR (1) GR1000454B (no)
IL (1) IL93156A (no)
NO (1) NO913211L (no)
NZ (1) NZ232554A (no)
PT (1) PT93167B (no)
WO (1) WO1990009197A1 (no)

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Also Published As

Publication number Publication date
PT93167A (pt) 1990-08-31
US5134075A (en) 1992-07-28
NO913211D0 (no) 1991-08-16
GR1000454B (el) 1992-07-30
NZ232554A (en) 1993-01-27
AU5150890A (en) 1990-09-05
FI913891A0 (fi) 1991-08-16
KR910700077A (ko) 1991-03-13
FI913891A7 (fi) 1991-08-16
IL93156A (en) 1995-07-31
DE69028388D1 (de) 1996-10-10
DK0458878T3 (da) 1996-09-23
WO1990009197A1 (en) 1990-08-23
EP0458878A1 (en) 1991-12-04
EP0458878A4 (en) 1992-04-08
AU629617B2 (en) 1992-10-08
IL93156A0 (en) 1990-11-05
GR900100121A (en) 1991-06-28
ATE142108T1 (de) 1996-09-15
CA2010253A1 (en) 1990-08-17
JPH04503307A (ja) 1992-06-18
EP0458878B1 (en) 1996-09-04
PT93167B (pt) 1996-03-29

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