NO913644L - Fremgangsmaate for fremstilling av terapeutisk aktive aminosyrederivater. - Google Patents

Fremgangsmaate for fremstilling av terapeutisk aktive aminosyrederivater.

Info

Publication number
NO913644L
NO913644L NO91913644A NO913644A NO913644L NO 913644 L NO913644 L NO 913644L NO 91913644 A NO91913644 A NO 91913644A NO 913644 A NO913644 A NO 913644A NO 913644 L NO913644 L NO 913644L
Authority
NO
Norway
Prior art keywords
alkyl
amino acid
acid derivatives
lower alkyl
procedure
Prior art date
Application number
NO91913644A
Other languages
English (en)
Other versions
NO913644D0 (no
Inventor
Keiji Hemmi
Masahiro Neya
Hiroshi Marusawa
Shinya Watanabe
Masashi Hashimoto
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909020305A external-priority patent/GB9020305D0/en
Priority claimed from GB919105580A external-priority patent/GB9105580D0/en
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of NO913644D0 publication Critical patent/NO913644D0/no
Publication of NO913644L publication Critical patent/NO913644L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/80—Antihypertensive peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Det beskrives fremgangsmåte for fremstilling av en forbindelse med formel: RYX-N-CO-YCH-CON-CH-CONH-CH-CH-R OH hvor Ri er R1 er R3 er R4 er X er YI er morfolinokarbonyl, tiomorfolinokarbonyl, heksahydro-lH-azepin-1-ylkarbonyl, oktahydro- azocin-1-ylkarbonyl, piperidinokarbonyl, lavere alkanoyl, dipropylkarbamoyl, tetrahydroisokinolylkarbonyl eller en heterocyklisk gruppe, lavere alkyl, lavere alkyl som kan være substituert med aryl og cyklo(lavere)alkyl, lavere alkyl, lavere alkylen, en enkeltbinding eller -N- R5 hvori R5 er lavere alkyl, og Y2 er -NH- eller -O-, forutsatt at R= er isobutyl, 2-etylbutyl eller lavere alkyl substituert med substituenter valgt fra aryl og cyklo(lavere)- alkyl, 1) når R' er morfolinokarbonyl og Y1 er -N- ; 2) når Ri er morfolinokarbonyl eller tiomorfolinokarbonyl, Y1 er en enkeltbinding og Y* er -0-; eller 3) når Ri er lavere alkanoyl og Y= er -O-, eller salter derav. De nye aminosyrederivatene og deres farmasøytisk akseptable salter, har hemmende virkninger overfor renin og kan finne anvendelse som legemidler.
NO91913644A 1990-09-17 1991-09-16 Fremgangsmaate for fremstilling av terapeutisk aktive aminosyrederivater. NO913644L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909020305A GB9020305D0 (en) 1990-09-17 1990-09-17 New amino acid derivatives,a process for the preparation thereof and pharmaceutical composition comprising the same
GB919105580A GB9105580D0 (en) 1991-03-15 1991-03-15 New amino acid derivatives,a process for the preparation thereof and pharmaceutical composition comprising the same

Publications (2)

Publication Number Publication Date
NO913644D0 NO913644D0 (no) 1991-09-16
NO913644L true NO913644L (no) 1992-03-18

Family

ID=26297665

Family Applications (1)

Application Number Title Priority Date Filing Date
NO91913644A NO913644L (no) 1990-09-17 1991-09-16 Fremgangsmaate for fremstilling av terapeutisk aktive aminosyrederivater.

Country Status (15)

Country Link
US (1) US5491132A (no)
EP (1) EP0476515A1 (no)
JP (2) JP2641823B2 (no)
KR (1) KR920006326A (no)
CN (1) CN1030922C (no)
AU (1) AU646076B2 (no)
CA (1) CA2051455A1 (no)
FI (1) FI914309A7 (no)
HU (1) HUT59419A (no)
IE (1) IE913220A1 (no)
IL (1) IL99389A0 (no)
NO (1) NO913644L (no)
PT (1) PT98984A (no)
RU (1) RU2057124C1 (no)
TW (1) TW212176B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5430022A (en) * 1990-05-14 1995-07-04 Fujisawa Pharmaceutical Co., Ltd. Peptide compound and its preparation
GB9127041D0 (en) * 1991-12-20 1992-02-19 Fujisawa Pharmaceutical Co New use
AU6581194A (en) * 1993-04-28 1994-11-21 Fujisawa Pharmaceutical Co., Ltd. Oral pharmaceutical compositions containing renin inhibitors
GB9313330D0 (en) * 1993-06-28 1993-08-11 Fujisawa Pharmaceutical Co New compound and its preparation
GB2281709B (en) * 1993-09-14 1998-04-08 Fujitsu Ltd Biodegradable resin moulded article
US8883857B2 (en) 2012-12-07 2014-11-11 Baylor College Of Medicine Small molecule xanthine oxidase inhibitors and methods of use

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4668769A (en) * 1985-08-02 1987-05-26 Hoover Dennis J Oxa- and azahomocyclostatine polypeptides
ZA87563B (en) * 1986-02-03 1987-09-30 Squibb & Sons Inc N-heterocyclic alcohol renin inhibitors
GB8707412D0 (en) * 1987-03-27 1987-04-29 Fujisawa Pharmaceutical Co Peptide compounds
US4921855A (en) * 1987-06-22 1990-05-01 Fujisawa Pharmaceutical Co., Ltd. New Histidyl amino acid derivatives, and pharmaceutical composition comprising the same
US5223489A (en) * 1987-06-22 1993-06-29 Ujisawa Pharmaceutical Co., Ltd. Amino acid derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same
US5250517A (en) * 1987-10-06 1993-10-05 Hoffmann-La Roche Inc. Renin inhibiting compounds
CA1329680C (en) * 1987-11-23 1994-05-17 Harold Norris Weller, Iii N-heterocyclic alcohol derivatives
US5256645A (en) * 1988-03-04 1993-10-26 Hoffmann-La Roche Inc. Amino acid derivatives
US4981843A (en) * 1988-04-07 1991-01-01 E. R. Squibb & Sons, Inc. N-heterocyclic alcohol derivatives
EP0391180A3 (de) * 1989-04-04 1991-04-03 F. Hoffmann-La Roche Ag Peptidartige Aminosäurederivate mit reninhemmender Wirkung

Also Published As

Publication number Publication date
HUT59419A (en) 1992-05-28
IL99389A0 (en) 1992-08-18
FI914309A0 (fi) 1991-09-13
FI914309A7 (fi) 1992-03-18
PT98984A (pt) 1992-07-31
HU912979D0 (en) 1992-01-28
US5491132A (en) 1996-02-13
JPH04279570A (ja) 1992-10-05
IE913220A1 (en) 1992-02-25
AU8379091A (en) 1992-03-19
JPH08283244A (ja) 1996-10-29
KR920006326A (ko) 1992-04-27
NO913644D0 (no) 1991-09-16
TW212176B (no) 1993-09-01
RU2057124C1 (ru) 1996-03-27
JP2641823B2 (ja) 1997-08-20
CN1030922C (zh) 1996-02-07
AU646076B2 (en) 1994-02-03
CA2051455A1 (en) 1992-03-18
CN1063691A (zh) 1992-08-19
EP0476515A1 (en) 1992-03-25

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