NO914577L - PROCEDURE FOR THE PREPARATION OF HETEROCYCLIC SUBSTITUTED PIPERAZINOALKYLBENZOKSAZINE AND THIAZINE COMPOUNDS - Google Patents

PROCEDURE FOR THE PREPARATION OF HETEROCYCLIC SUBSTITUTED PIPERAZINOALKYLBENZOKSAZINE AND THIAZINE COMPOUNDS

Info

Publication number
NO914577L
NO914577L NO91914577A NO914577A NO914577L NO 914577 L NO914577 L NO 914577L NO 91914577 A NO91914577 A NO 91914577A NO 914577 A NO914577 A NO 914577A NO 914577 L NO914577 L NO 914577L
Authority
NO
Norway
Prior art keywords
lower alkyl
compounds
halogen
carbon atoms
hydrogen
Prior art date
Application number
NO91914577A
Other languages
Norwegian (no)
Other versions
NO914577D0 (en
Inventor
Daniel Jasserand
H Francois Floc
Richard White
Original Assignee
Kali Chemie Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kali Chemie Pharma Gmbh filed Critical Kali Chemie Pharma Gmbh
Publication of NO914577D0 publication Critical patent/NO914577D0/en
Publication of NO914577L publication Critical patent/NO914577L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Forbindelser med den generelle formel I ;-R hvor X betyr oksygen eller svovel, Y betyr oksygen eller svovel, R1 betyr hydrogen eller lavere alkyl. R2 betyr hydrogen, lavere alkyl, halogen, lavere alkoksy, hydroksy, nitro eller tri- fluormetyl, og R3 betyr hydrogen, lavere alkyl, halogen eller lavere alkoksy, eller R2 og R3 er bundet til nabokarbonatomer og betyr til sammen en alkylendioksygruppe med 1-2 karbon- atomer, n står for et helt tall fra O til 4, og R4 står for en umettet, heterosyklisk 6-ring som inneholder l eller 2 nitrogenatomer som ikke er bundet direkte til piperazinringen, som eventuelt kan være substituert med 1-2 substituenter fra gruppen lavere alkyl, lavere alkoksy og halogen, som er bundet til karbonatomer, og syreaddi- sjonssalter derav. Forbindelsene er terapeutisk aktive. Fremstillingen av forbindelsene er beskrevet. Forbindelser med den generelle formel IV iv hvor X betyr oksygen eller svovel, R1 betyr hydrogen eller lavere alkyl, R2' betyr hydrogen, lavere alkyl, halogen, lavere alkoksy, nitro eller trifluor- metyl, R betyr hydrogen, lavere alkyl, halogen eller lavere alkoksy, eller R2' og R er bundet til nabostilte karbon- atomer og betyr til sammen en alkylen- dioksygruppe med 1-2 karbonatomer, og n står for et helt tall fra O til 4, kan anvendes som mellomprodukter ved fremstillingen av forbindelser med formel I.Compounds of the general formula I; -R where X means oxygen or sulfur, Y means oxygen or sulfur, R1 represents hydrogen or lower alkyl. R 2 is hydrogen, lower alkyl, halogen, lower alkoxy, hydroxy, nitro or trifluoromethyl, and R 3 is hydrogen, lower alkyl, halogen or lower alkoxy, or R 2 and R 3 are bonded to neighboring carbon atoms and together represent an alkylenedioxy group having 2 carbon atoms, n represents an integer from 0 to 4, and R4 represents an unsaturated, heterocyclic 6 ring containing 1 or 2 nitrogen atoms not directly bonded to the piperazine ring, which may optionally be substituted by 1-2 substituents from the lower alkyl group, lower alkoxy and halogen bonded to carbon atoms, and acid addition salts thereof. The compounds are therapeutically active. The preparation of the compounds is described. Compounds of the general formula IV iv wherein X means oxygen or sulfur, R1 represents hydrogen or lower alkyl, R2 'represents hydrogen, lower alkyl, halogen, lower alkoxy, nitro or trifluoromethyl, R means hydrogen, lower alkyl, halogen or lower alkoxy, or R 2 'and R are bonded to adjacent carbon atoms and together represent an alkylene dioxide group of 1-2 carbon atoms, and n represents an integer from 0 to 4, can be used as intermediates in the preparation of compounds of formula IN.

NO91914577A 1990-11-24 1991-11-22 PROCEDURE FOR THE PREPARATION OF HETEROCYCLIC SUBSTITUTED PIPERAZINOALKYLBENZOKSAZINE AND THIAZINE COMPOUNDS NO914577L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4037427A DE4037427A1 (en) 1990-11-24 1990-11-24 HETEROCYCLICALLY SUBSTITUTED PIPERAZINOALKYLBENZAZAZINE AND -THIAZIN COMPOUNDS, AND METHOD FOR THE PRODUCTION THEREOF, AND THE MEDICAMENTS CONTAINING SUCH COMPOUNDS

Publications (2)

Publication Number Publication Date
NO914577D0 NO914577D0 (en) 1991-11-22
NO914577L true NO914577L (en) 1992-05-25

Family

ID=6418854

Family Applications (1)

Application Number Title Priority Date Filing Date
NO91914577A NO914577L (en) 1990-11-24 1991-11-22 PROCEDURE FOR THE PREPARATION OF HETEROCYCLIC SUBSTITUTED PIPERAZINOALKYLBENZOKSAZINE AND THIAZINE COMPOUNDS

Country Status (16)

Country Link
EP (1) EP0488008A1 (en)
JP (1) JPH05140156A (en)
KR (1) KR920009826A (en)
CN (1) CN1062140A (en)
AU (1) AU644496B2 (en)
CA (1) CA2056009A1 (en)
DE (1) DE4037427A1 (en)
FI (1) FI915518L (en)
HU (1) HUT62004A (en)
IE (1) IE914074A1 (en)
IL (1) IL99949A0 (en)
MX (1) MX9102192A (en)
NO (1) NO914577L (en)
PT (1) PT99570A (en)
TW (1) TW218876B (en)
ZA (1) ZA918341B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2667068B1 (en) * 1990-09-26 1994-09-09 Adir NOVEL HETEROCYCLIC ALKYL AMINES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
AU638154B2 (en) * 1990-10-04 1993-06-17 Suntory Limited Benzoxazine derivative and herbicide containing same as an active ingredient
WO1994018195A1 (en) * 1993-02-05 1994-08-18 Yamanouchi Pharmaceutical Co., Ltd. Novel benzoxazine derivative, medicine containing the same, and intermediate therefor
FR2702477B1 (en) * 1993-03-08 1995-04-28 Synthelabo Benzoxazine derivatives, their preparation and their therapeutic application.
FR2755690B1 (en) * 1996-11-08 1998-12-18 Adir NOVEL HETEROCYCLIC AMINOMETHYL DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1244481A (en) * 1967-11-08 1971-09-02 Wyeth John & Brother Ltd Benzothiazine derivatives and the preparation thereof
EP0186310A1 (en) * 1984-11-28 1986-07-02 Takeda Chemical Industries, Ltd. 1,4-Benzothiazine Derivatives, their production and use
EP0233728A1 (en) * 1986-02-11 1987-08-26 Takeda Chemical Industries, Ltd. 1,4-Benzoxazine derivatives their production and use
FR2667068B1 (en) * 1990-09-26 1994-09-09 Adir NOVEL HETEROCYCLIC ALKYL AMINES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

Also Published As

Publication number Publication date
FI915518A0 (en) 1991-11-22
FI915518A7 (en) 1992-05-25
HU913482D0 (en) 1992-01-28
NO914577D0 (en) 1991-11-22
HUT62004A (en) 1993-03-29
FI915518L (en) 1992-05-25
AU644496B2 (en) 1993-12-09
EP0488008A1 (en) 1992-06-03
CN1062140A (en) 1992-06-24
DE4037427A1 (en) 1992-05-27
TW218876B (en) 1994-01-11
IL99949A0 (en) 1992-08-18
CA2056009A1 (en) 1992-05-25
KR920009826A (en) 1992-06-25
IE914074A1 (en) 1992-06-03
AU8809191A (en) 1992-05-28
JPH05140156A (en) 1993-06-08
MX9102192A (en) 1994-08-31
ZA918341B (en) 1992-07-29
PT99570A (en) 1992-10-30

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