NO915065L - Nye spirofuranderivater - Google Patents
Nye spirofuranderivaterInfo
- Publication number
- NO915065L NO915065L NO91915065A NO915065A NO915065L NO 915065 L NO915065 L NO 915065L NO 91915065 A NO91915065 A NO 91915065A NO 915065 A NO915065 A NO 915065A NO 915065 L NO915065 L NO 915065L
- Authority
- NO
- Norway
- Prior art keywords
- oxadiazol
- alkenyl
- chr
- amino
- alkyl
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000004505 1,2,4-oxadiazol-5-yl group Chemical group O1N=CN=C1* 0.000 abstract 1
- -1 3-amino-1,2,4-oxadiazol-5-yl Chemical group 0.000 abstract 1
- 206010008748 Chorea Diseases 0.000 abstract 1
- 206010026749 Mania Diseases 0.000 abstract 1
- 102000014415 Muscarinic acetylcholine receptor Human genes 0.000 abstract 1
- 108050003473 Muscarinic acetylcholine receptor Proteins 0.000 abstract 1
- 206010036631 Presenile dementia Diseases 0.000 abstract 1
- 206010039966 Senile dementia Diseases 0.000 abstract 1
- 206010043118 Tardive Dyskinesia Diseases 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 206010003230 arteritis Diseases 0.000 abstract 1
- 125000001231 benzoyloxy group Chemical group C(C1=CC=CC=C1)(=O)O* 0.000 abstract 1
- 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 208000012601 choreatic disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Forbindelser med generell formel (I), \ X (CH2)n <CH2>m (D t der R1 representerer hydrogen eller alkyl Cj^; R2 representerer hydrogen, alkyl C-^, alkenyl C3_6 eller alkenyl C3_6; n og m er hele tall fra l til 3, forutsatt at n + m - 4, og en av X og Y representerer CH£ og den andre representerer CHR3, C - CHR4 eller C - NR5, der R3 representerer NR6R7, NR8R9, C02R10, 3- metyl-l,2,4-oksadiazol-5-yl eller 3-amino- 1,2,4-oksadiazol-5-yl, R4 representerer alkanoyl C.,, eller COOR11, og R5 representerer OR12, alkanoyloksy C ,, benzoyloksy, Cl_6 alkanoylamino eller (aminokarbonyl)amino, R6 representerer C]L_6 alkanoyl eller C._, alkoksykarbo- nyl, og R7, R8, R9, R10, R11 og R12 representerer hydrogen eller CI_A alkyl, og salter og solvater derav, og ,jeres salter er nyttige som farmasøytika, særlig som sentralmuskarinisk acetylcholinreseptorer. Forbindelse ne er derfor velegnde i behandling av sykdommer slik som presenil og senil dementia, Huntingston's chorea, tardiv dyskinesl, hyperkinesl, mani og Tourette-. syndrom, og også som analgetiske midler til anvendelse l behandling av alvorlige smertefulle tilstander slik som reumatisme, arteritt og terminal sykdom.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/369,324 US5075317A (en) | 1989-06-21 | 1989-06-21 | Spirofurane derivatives |
| PCT/US1990/003351 WO1990015804A1 (en) | 1989-06-21 | 1990-06-20 | Novel spirofurane derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO915065D0 NO915065D0 (no) | 1991-12-20 |
| NO915065L true NO915065L (no) | 1992-02-07 |
Family
ID=26781507
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO91915065A NO915065L (no) | 1989-06-21 | 1991-12-20 | Nye spirofuranderivater |
Country Status (1)
| Country | Link |
|---|---|
| NO (1) | NO915065L (no) |
-
1991
- 1991-12-20 NO NO91915065A patent/NO915065L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO915065D0 (no) | 1991-12-20 |
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