NO930776L - Tetrahydropyrimidin-derivater - Google Patents

Tetrahydropyrimidin-derivater

Info

Publication number
NO930776L
NO930776L NO93930776A NO930776A NO930776L NO 930776 L NO930776 L NO 930776L NO 93930776 A NO93930776 A NO 93930776A NO 930776 A NO930776 A NO 930776A NO 930776 L NO930776 L NO 930776L
Authority
NO
Norway
Prior art keywords
hydrogen
amino
alkyl group
aryl
treatment
Prior art date
Application number
NO93930776A
Other languages
English (en)
Other versions
NO930776D0 (no
Inventor
Ralf Plate
Original Assignee
Akzo Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nv filed Critical Akzo Nv
Publication of NO930776D0 publication Critical patent/NO930776D0/no
Publication of NO930776L publication Critical patent/NO930776L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/12—Nitrogen atoms not forming part of a nitro radical
    • C07D239/14—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to said nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Tetrahydropyrimidin-derivat med formel I hvor R, er hydrogen; R2 er hydrogen, en lavere-alkyl-gruppe, eller lavere acyl; eller RI og R2 tilsammen representerer en binding; R3 er hydrogen, en lavere-hydrokarbon-gruppe eventuelt substi- tuert med halogen, CN, aryl eller COR7; Ri er hydrogen, en lavere-al}:(en) ylgruppe eller aryl; R5 er hydrogen, amino, lavere-alkyl-substituert amino, eller en lavere-alkyl-gruppe; og Ri er hydrogen eller metyl; Rr er amino, lavere-alkyl-substituert amino eller en lavere- alkyl-gruppe; eller et farmasøytisk tilfredsstillende salt derav. Forbindelsene har muskarin-egenskaper og kan anvendes for behandling av oppfattelsesforstyrrelser og for behandling av kolinerge mangler.
NO93930776A 1992-03-04 1993-03-03 Tetrahydropyrimidin-derivater NO930776L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP92200622 1992-03-04

Publications (2)

Publication Number Publication Date
NO930776D0 NO930776D0 (no) 1993-03-03
NO930776L true NO930776L (no) 1993-09-06

Family

ID=8210467

Family Applications (1)

Application Number Title Priority Date Filing Date
NO93930776A NO930776L (no) 1992-03-04 1993-03-03 Tetrahydropyrimidin-derivater

Country Status (11)

Country Link
US (1) US5470856A (no)
EP (1) EP0559279A1 (no)
JP (1) JPH05339245A (no)
KR (1) KR930019640A (no)
AU (1) AU661107B2 (no)
CA (1) CA2090170A1 (no)
FI (1) FI930934A7 (no)
MX (1) MX9301178A (no)
NO (1) NO930776L (no)
NZ (1) NZ247037A (no)
ZA (1) ZA931109B (no)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19612504C2 (de) * 1996-03-29 2003-10-23 Boehringer Ingelheim Kg Neue Wirkstoffkompositionen
DK0891978T3 (da) * 1997-07-18 2002-07-01 Hoffmann La Roche 5H-Thiazol(3,2-a)pyrimidinderivativer
WO2011085406A1 (en) * 2010-01-11 2011-07-14 Mithridion, Inc. Compounds and compositions for cognition-enhancement, methods of making, and methods of treating
WO2012033956A1 (en) 2010-09-08 2012-03-15 Mithridion, Inc. Cognition enhancing compounds and compositions, methods of making, and methods of treating

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4786648A (en) * 1986-12-08 1988-11-22 Warner-Lambert Company O-substituted tetrahydropyridine oxime cholinergic agents
IT1231237B (it) * 1987-09-21 1991-11-26 Angeli Inst Spa Derivati eterociclici
IL97266A0 (en) * 1990-03-06 1992-05-25 Warner Lambert Co Azabicyclo and azacyclo oximes and amines,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
NZ247037A (en) 1995-10-26
FI930934L (fi) 1993-09-05
FI930934A7 (fi) 1993-09-05
MX9301178A (es) 1993-09-01
NO930776D0 (no) 1993-03-03
US5470856A (en) 1995-11-28
JPH05339245A (ja) 1993-12-21
AU3393293A (en) 1993-09-09
EP0559279A1 (en) 1993-09-08
FI930934A0 (fi) 1993-03-03
ZA931109B (en) 1993-09-22
AU661107B2 (en) 1995-07-13
CA2090170A1 (en) 1993-09-05
KR930019640A (ko) 1993-10-18

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