NO932982L - STABLE SALTS OF (+) - (1S, 2R) -2 - ((N- (2-HYDROXYLAMINO-2-OXOETHYL) -N-METHYLAMINO) CARBONYL) CYCLOHEXAN-1-CARBOXYLIC ACID ACID AND PREPARING PROCESS FOR THE PREPARATION OF PREPARATION THEREOF - Google Patents

STABLE SALTS OF (+) - (1S, 2R) -2 - ((N- (2-HYDROXYLAMINO-2-OXOETHYL) -N-METHYLAMINO) CARBONYL) CYCLOHEXAN-1-CARBOXYLIC ACID ACID AND PREPARING PROCESS FOR THE PREPARATION OF PREPARATION THEREOF

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Publication number
NO932982L
NO932982L NO93932982A NO932982A NO932982L NO 932982 L NO932982 L NO 932982L NO 93932982 A NO93932982 A NO 93932982A NO 932982 A NO932982 A NO 932982A NO 932982 L NO932982 L NO 932982L
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NO
Norway
Prior art keywords
preparation
hydroxylamino
oxoethyl
methylamino
carboxylic acid
Prior art date
Application number
NO93932982A
Other languages
Norwegian (no)
Other versions
NO932982D0 (en
Inventor
Raffaello Giorgi
Alessandro Subissi
Luigi Turbanti
Original Assignee
Lab Guidoti Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI913448A external-priority patent/IT1252708B/en
Application filed by Lab Guidoti Spa filed Critical Lab Guidoti Spa
Publication of NO932982D0 publication Critical patent/NO932982D0/en
Publication of NO932982L publication Critical patent/NO932982L/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Salter av (+)-(lS,2R)-2-[[N-(2-hydroksylamlno-2- oksoetyl )-N-metyl-amino]karboyl]cykloheksan-l-karbok- sylsyre med metaller og organiske baser, representert ved generell formel (I) hvor R og R' dersom de er sammen representerer en blvalent kation valgt fra kalsium, etylendiamin og andre farmasøytisk akseptable kationer eller organiske baser, eller dersom R' - H+, er R natrium, kalium, en imidazolgruppe, lysin, cholln, dietanolamin, arginin eller hlstidln, har ACE-inhibi- torlsk aktivitet og er derfor nyttig som aktive ingredienser l antlhypertensive medikamenter. Frem- gangsmåten for fremstilling derav omfatter fortrinnsvis omsetning av utgangssyren, beskyttet med en benzyl- gruppe, med et egnet hydrat, karbonat eller oranlsk base i hydrogeneringsbetlngelser i nærvær av en hydrogeneringskatalysator.Salts of (+) - (1S, 2R) -2 - [[N- (2-hydroxylamino-2-oxoethyl) -N-methylamino] carboyl] cyclohexane-1-carboxylic acid with metals and organic bases, represented by general formula (I) wherein R and R 'if combined represent a covalent cation selected from calcium, ethylenediamine and other pharmaceutically acceptable cations or organic bases, or if R' - H +, R is sodium, potassium, an imidazole group, lysine , choline, diethanolamine, arginine or hilidylin, have ACE inhibitory activity and are therefore useful as active ingredients in antihypertensive drugs. The process of preparing them preferably comprises reacting the starting acid, protected with a benzyl group, with a suitable hydrate, carbonate or orange base in hydrogenation conditions in the presence of a hydrogenation catalyst.

NO93932982A 1991-12-23 1993-08-20 STABLE SALTS OF (+) - (1S, 2R) -2 - ((N- (2-HYDROXYLAMINO-2-OXOETHYL) -N-METHYLAMINO) CARBONYL) CYCLOHEXAN-1-CARBOXYLIC ACID ACID AND PREPARING PROCESS FOR THE PREPARATION OF PREPARATION THEREOF NO932982L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI913448A IT1252708B (en) 1991-12-23 1991-12-23 STABLE SALTS OF (+) - (1R, 2S) -2 ((N- (2-HYDROXYLAMINE-2-OSSOETHL) -N-METHYLAMINE) CARBONYL) CYCLOHEXAN-1-CARBOXYL, ACE INHIBITIVE ACTIVITY, PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
PCT/EP1992/002903 WO1993013056A1 (en) 1991-12-23 1992-12-12 Stable salts of (+)-(1s,2r)-2-[[n-(2-hydroxylamino-2-oxoethyl)-n-methyl-amino]carbonyl]cyclohexane-1-carboxylic acid, process for their preparation and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
NO932982D0 NO932982D0 (en) 1993-08-20
NO932982L true NO932982L (en) 1993-09-28

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Family Applications (1)

Application Number Title Priority Date Filing Date
NO93932982A NO932982L (en) 1991-12-23 1993-08-20 STABLE SALTS OF (+) - (1S, 2R) -2 - ((N- (2-HYDROXYLAMINO-2-OXOETHYL) -N-METHYLAMINO) CARBONYL) CYCLOHEXAN-1-CARBOXYLIC ACID ACID AND PREPARING PROCESS FOR THE PREPARATION OF PREPARATION THEREOF

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NO (1) NO932982L (en)

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Publication number Publication date
NO932982D0 (en) 1993-08-20

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