NO933341L - Fordindelser mot kreft - Google Patents
Fordindelser mot kreftInfo
- Publication number
- NO933341L NO933341L NO933341A NO933341A NO933341L NO 933341 L NO933341 L NO 933341L NO 933341 A NO933341 A NO 933341A NO 933341 A NO933341 A NO 933341A NO 933341 L NO933341 L NO 933341L
- Authority
- NO
- Norway
- Prior art keywords
- carbon atoms
- alkyl
- alkoxy
- hydroxy
- halogen
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 12
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 125000003545 alkoxy group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- -1 hydroxy- Chemical class 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 2
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 2
- 150000008574 D-amino acids Chemical group 0.000 abstract 1
- 108010016626 Dipeptides Proteins 0.000 abstract 1
- 125000000729 N-terminal amino-acid group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000000278 alkyl amino alkyl group Chemical group 0.000 abstract 1
- 125000006350 alkyl thio alkyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000005242 carbamoyl alkyl group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
- 125000003790 chinazolinyl group Chemical group 0.000 abstract 1
- 125000004966 cyanoalkyl group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000005358 mercaptoalkyl group Chemical group 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 125000003396 thiol group Chemical class [H]S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Kinazolin med formel (I). hvorer hydrogen eller amino,. eller Rer alkyl, alkoksy eller alkyltio som hver har opptil 6 karbonatomer,. eller Rer aryl eller aryloksy, som hver har opptil 10. karbonatomer,. eller R^- er halogen, hydroksy eller merkapto,. ellerer alkyl med opptil 3 karbonatomer som har en eller flere substituenter valgt fra halogen, hydroksy og alkanoylamino, som hver har opptil 6 karbonatomer,. eller Rer alkoksy med opptil 3 karbonatomer som har en eller flere substituenter valgt fra hydroksy og alkoksy med opptil 6 karbonatomer;. er hydrogen eller alkyl, alkenyl, alkynyl, hydroksy-. alkyl, alkoksyalkyl, merkaptoalkyl, alkyltioalkyl, halogen-. alkyl, cyanoalkyl, aminoalkyl, alkylaminoalkyl, dialkyl-. aminoalkyl, alkanoylalkyl, karboksyalkyl, karbamoylalkyl eller alkanoyl, med opptil 6 karbonatomer;. Ar er fenylen eller heterocyklen som er usubstituert eller. som har en eller flere substituenter valgt fra halogen,. cyano, nitro, hydroksy, amino og karbamoyl og alkyl,. alkoksy, halogenalkyl, alkanoylamino og alkoksykarbonyl, som hver har opptil 6 karbonatomer;. i R-er resten av et dipeptid hvori den første, N-terminale aminosyrerest knyttet til karbonylgruppen i COR^ er en L-eller D-aminosyrerest -NHCH(C0H)-A-CO- hvori A er en alkylengruppe med opptil 6 karbonatomer, og den andre aminosyrerest er av en cx-aminosyre som har D-konfigurasjon ved sitt asymmetriske a-karbonatom;. Rer hydroqen eller alkyl med opptil 4 karbonatomer,. Rer hydrogen eller alkyl med opptil 4 karbonatomer; og hver av,og Rer hydrogen eller alkyl eller alkoksy. hver med opptil 4 karbonatomer; eller de er halogen; eller et farmasøytisk akseptabelt salt, ester eller amid ; derav er av terapeutisk verdi, spesielt ved behandling av I kreft.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919105771A GB9105771D0 (en) | 1991-03-19 | 1991-03-19 | Anti-cancer compounds |
| PCT/GB1992/000476 WO1992016512A1 (en) | 1991-03-19 | 1992-03-18 | Anti-cancer compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO933341D0 NO933341D0 (no) | 1993-09-20 |
| NO933341L true NO933341L (no) | 1993-11-18 |
Family
ID=10691801
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO933341A NO933341L (no) | 1991-03-19 | 1993-09-20 | Fordindelser mot kreft |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5444061A (no) |
| EP (1) | EP0509643A1 (no) |
| JP (1) | JPH06505974A (no) |
| AU (1) | AU655970B2 (no) |
| CA (1) | CA2106583A1 (no) |
| CZ (1) | CZ195393A3 (no) |
| FI (1) | FI934106A7 (no) |
| GB (2) | GB9105771D0 (no) |
| HU (1) | HUT67177A (no) |
| IE (1) | IE920853A1 (no) |
| IL (1) | IL101281A0 (no) |
| MX (1) | MX9201183A (no) |
| NO (1) | NO933341L (no) |
| NZ (1) | NZ242023A (no) |
| SK (1) | SK100993A3 (no) |
| TW (1) | TW203608B (no) |
| WO (1) | WO1992016512A1 (no) |
| ZA (1) | ZA921985B (no) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9205907D0 (en) * | 1992-03-18 | 1992-04-29 | Cancer Res Inst Royal | Anti-cancer compounds |
| GB9223352D0 (en) * | 1992-11-06 | 1992-12-23 | Ici Plc | Tricyclic compounds |
| GB9408936D0 (en) * | 1994-05-05 | 1994-06-22 | Cancer Res Inst | Anti-cancer compounds |
| IL123164A (en) * | 1995-08-30 | 2001-03-19 | Searle & Co | Meta-guanidine urea thiourea or azacyclic amino benzoic acid derivatives and pharmaceutical compositions containing them |
| GB9904275D0 (en) | 1999-02-24 | 1999-04-21 | Cancer Res Campaign Tech | Anti-cancer compounds |
| US7671200B2 (en) | 1999-10-27 | 2010-03-02 | Cytokinetics, Inc. | Quinazolinone KSP inhibitors |
| US6545004B1 (en) * | 1999-10-27 | 2003-04-08 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
| US7230000B1 (en) | 1999-10-27 | 2007-06-12 | Cytokinetics, Incorporated | Methods and compositions utilizing quinazolinones |
| JP2005529076A (ja) * | 2002-02-15 | 2005-09-29 | サイトキネティクス・インコーポレーテッド | キナゾリノンの合成 |
| RU2004135554A (ru) * | 2002-05-09 | 2006-01-20 | Цитокинетикс, Инк. (Us) | Пиримидиноны, композиции на их основе и способы их использования |
| EP1553931A4 (en) | 2002-05-09 | 2006-08-30 | Cytokinetics Inc | COMPOUNDS, COMPOSITIONS AND METHODS |
| EP1513820A4 (en) * | 2002-05-23 | 2006-09-13 | Cytokinetics Inc | COMPOUNDS, COMPOSITIONS AND METHODS |
| CA2489367A1 (en) * | 2002-06-14 | 2003-12-24 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| US20030236430A1 (en) * | 2002-06-21 | 2003-12-25 | Allen David Robert | Preparation of protected amino acids |
| EP1537089A4 (en) | 2002-07-23 | 2008-04-16 | Cytokinetics Inc | CONNECTIONS, COMPOSITIONS AND PROCEDURES |
| WO2004018058A2 (en) * | 2002-08-21 | 2004-03-04 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| WO2004034972A2 (en) * | 2002-09-30 | 2004-04-29 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| WO2005041888A2 (en) * | 2003-11-03 | 2005-05-12 | Cytokinetics, Inc. | Pyrimidin-4-one compounds, compositions and methods |
| JP2007510660A (ja) * | 2003-11-07 | 2007-04-26 | サイトキネティクス・インコーポレーテッド | 化合物、組成物及び方法 |
| EP1692112A4 (en) * | 2003-12-08 | 2008-09-24 | Cytokinetics Inc | COMPOUNDS, COMPOSITIONS, AND METHODS |
| JP5693950B2 (ja) | 2007-04-11 | 2015-04-01 | メルク エ カンパニー | １８ｆ標識葉酸 |
| KR102431436B1 (ko) | 2014-08-29 | 2022-08-10 | 테스 파마 에스.알.엘. | α-아미노-β-카복시뮤콘산 세미알데히드 데카복실라제의 억제제 |
| WO2020051424A1 (en) | 2018-09-07 | 2020-03-12 | Pic Therapeutics | Eif4e inhibitors and uses thereof |
| TW202146393A (zh) | 2020-03-03 | 2021-12-16 | 美商皮克醫療公司 | Eif4e抑制劑及其用途 |
| US12157732B2 (en) | 2021-08-25 | 2024-12-03 | PIC Therapeutics, Inc. | eIF4E inhibitors and uses thereof |
| CA3229560A1 (en) | 2021-08-25 | 2023-03-02 | Christopher L. Vandeusen | Eif4e inhibitors and uses thereof |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3069468D1 (en) * | 1979-12-19 | 1984-11-22 | Nat Res Dev | Quinazoline derivatives, processes for their preparation, compositions containing them and their use as anti-cancer agents |
| GB8513754D0 (en) * | 1985-05-31 | 1985-07-03 | Jones T R | Anti-cancer quinazoline derivatives |
| US4746659A (en) * | 1985-12-30 | 1988-05-24 | Sri International | Diastereomers of 10-alkyl-10-deazaminopterins and process for preparing the same |
| US5187167A (en) * | 1986-03-27 | 1993-02-16 | Imperial Chemical Industries Plc | Pharmaceutical compositions comprising quinazolin-4-one derivatives |
| GB8607683D0 (en) * | 1986-03-27 | 1986-04-30 | Ici Plc | Anti-tumor agents |
| GB8625019D0 (en) * | 1986-10-18 | 1986-11-19 | Wellcome Found | Compounds |
| GB8707053D0 (en) * | 1987-03-25 | 1987-04-29 | Ici Plc | Anti-tumour agents |
| US4767761A (en) * | 1987-11-04 | 1988-08-30 | Dana-Farber Cancer Institute, Inc. | Ornithine derivatives and their use as methotrexate-resistant cell inhibitors |
| GB8727737D0 (en) * | 1987-11-26 | 1987-12-31 | Ici Plc | Antitumour agents |
| GB8809978D0 (en) * | 1988-04-27 | 1988-06-02 | Ici Plc | Anti-tumour agents |
| US5252573A (en) * | 1988-12-15 | 1993-10-12 | Imperial Chemical Industries Plc | Anti-tumor agents |
| GB8829296D0 (en) * | 1988-12-15 | 1989-01-25 | Ici Plc | Anti-tumour compounds |
| US4996207A (en) * | 1990-01-18 | 1991-02-26 | Nair Madhavan G | Three new non-polyglutamatable deazaaminopterins |
| DE69111891T2 (de) * | 1990-05-17 | 1996-04-04 | Smith & Nephew United Inc | Elektrisch leitender und adstringierender Film sowie filmbildende Zusammensetzung zur Verwendung auf der Haut. |
| ZA913730B (en) * | 1990-05-30 | 1992-02-26 | Ici Plc | Anti-tumor compounds |
-
1991
- 1991-03-19 GB GB919105771A patent/GB9105771D0/en active Pending
-
1992
- 1992-03-18 JP JP4506050A patent/JPH06505974A/ja active Pending
- 1992-03-18 ZA ZA921985A patent/ZA921985B/xx unknown
- 1992-03-18 IE IE085392A patent/IE920853A1/en unknown
- 1992-03-18 MX MX9201183A patent/MX9201183A/es unknown
- 1992-03-18 AU AU13716/92A patent/AU655970B2/en not_active Expired - Fee Related
- 1992-03-18 IL IL101281A patent/IL101281A0/xx unknown
- 1992-03-18 CA CA002106583A patent/CA2106583A1/en not_active Abandoned
- 1992-03-18 GB GB9205906A patent/GB2253849B/en not_active Expired - Fee Related
- 1992-03-18 SK SK1009-93A patent/SK100993A3/sk unknown
- 1992-03-18 EP EP92302304A patent/EP0509643A1/en not_active Withdrawn
- 1992-03-18 HU HU9302636A patent/HUT67177A/hu unknown
- 1992-03-18 WO PCT/GB1992/000476 patent/WO1992016512A1/en not_active Ceased
- 1992-03-18 US US08/122,473 patent/US5444061A/en not_active Expired - Fee Related
- 1992-03-19 CZ CS931953A patent/CZ195393A3/cs unknown
- 1992-04-27 TW TW081103276A patent/TW203608B/zh active
- 1992-05-18 NZ NZ242023A patent/NZ242023A/en unknown
-
1993
- 1993-09-20 FI FI934106A patent/FI934106A7/fi not_active Application Discontinuation
- 1993-09-20 NO NO933341A patent/NO933341L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CZ195393A3 (en) | 1994-07-13 |
| EP0509643A1 (en) | 1992-10-21 |
| IE920853A1 (en) | 1992-09-23 |
| GB9205906D0 (en) | 1992-04-29 |
| JPH06505974A (ja) | 1994-07-07 |
| WO1992016512A1 (en) | 1992-10-01 |
| ZA921985B (en) | 1993-09-20 |
| MX9201183A (es) | 1994-06-30 |
| AU655970B2 (en) | 1995-01-19 |
| US5444061A (en) | 1995-08-22 |
| FI934106A0 (fi) | 1993-09-20 |
| CA2106583A1 (en) | 1992-09-20 |
| HUT67177A (en) | 1995-02-28 |
| TW203608B (no) | 1993-04-11 |
| GB2253849B (en) | 1995-01-18 |
| SK100993A3 (en) | 1994-08-10 |
| IL101281A0 (en) | 1992-11-15 |
| NO933341D0 (no) | 1993-09-20 |
| FI934106A7 (fi) | 1993-11-18 |
| GB9105771D0 (en) | 1991-05-01 |
| GB2253849A (en) | 1992-09-23 |
| NZ242023A (en) | 1993-12-23 |
| AU1371692A (en) | 1992-10-21 |
| HU9302636D0 (en) | 1993-12-28 |
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