NO933450L - Antiarrytmiske og kardiobeskyttende substituerte 1(2H)isokinoliner, fremgangsmåter for deres fremstilling, medikament inneholdende disse og anvendelse derav for fremstilling av et medikament for å bekjempe hjertefeil - Google Patents

Antiarrytmiske og kardiobeskyttende substituerte 1(2H)isokinoliner, fremgangsmåter for deres fremstilling, medikament inneholdende disse og anvendelse derav for fremstilling av et medikament for å bekjempe hjertefeil

Info

Publication number: NO933450L
Authority: NO; Norway
Prior art keywords: isoquinolines; heart failure; hydrogen; antiarrhythmic; medicament
Prior art date: 1992-09-28

Application number

NO933450A

Other languages

English (en)

Other versions

NO180374C (no

NO933450D0 (no

NO180374B (no

Inventor

Bansi Lal

Ramesh Matioram Gidwani

Ramanujam Rajagopalan

Radha Panicker

Chinnakulandai Sankar

Hans-Jochen Lang

Heinrich Christian Englert

Wolfgang Scholz

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-09-28

Filing date

1993-09-27

Publication date

1994-03-29

1993-09-27 Application filed by Hoechst Ag filed Critical Hoechst Ag

1993-09-27 Publication of NO933450D0 publication Critical patent/NO933450D0/no

1994-03-29 Publication of NO933450L publication Critical patent/NO933450L/no

1996-12-30 Publication of NO180374B publication Critical patent/NO180374B/no

1997-04-09 Publication of NO180374C publication Critical patent/NO180374C/no

Links

239000003814 drug Substances 0.000 title abstract 4
206010019280 Heart failures Diseases 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
IOEPOEDBBPRAEI-UHFFFAOYSA-N 1,2-dihydroisoquinoline Chemical class C1=CC=C2CNC=CC2=C1 IOEPOEDBBPRAEI-UHFFFAOYSA-N 0.000 title 1
230000003288 anthiarrhythmic effect Effects 0.000 title 1
239000003416 antiarrhythmic agent Substances 0.000 title 1
230000003293 cardioprotective effect Effects 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 3
150000002431 hydrogen Chemical class 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
-1 nitro, amino Chemical group 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
230000002763 arrhythmic effect Effects 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
229940045200 cardioprotective agent Drugs 0.000 abstract 1
239000012659 cardioprotective agent Substances 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
ZHBWNDXFRPEJJX-UHFFFAOYSA-N n-(diaminomethylidene)isoquinoline-1-carboxamide Chemical class C1=CC=C2C(C(=O)NC(=N)N)=NC=CC2=C1 ZHBWNDXFRPEJJX-UHFFFAOYSA-N 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229940124530 sulfonamide Drugs 0.000 abstract 1
150000003456 sulfonamides Chemical class 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicinal Preparation (AREA)

NO933450A 1992-09-28 1993-09-27 Antiarrytmiske og kardiobeskyttende substituerte 1(2H)isokinoliner og anvendelse derav for fremstilling av et medikament for å bekjempe hjertefeil NO180374C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP92116535		1992-09-28

Publications (4)

Publication Number	Publication Date
NO933450D0 NO933450D0 (no)	1993-09-27
NO933450L true NO933450L (no)	1994-03-29
NO180374B NO180374B (no)	1996-12-30
NO180374C NO180374C (no)	1997-04-09

Family

ID=8210063

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO933450A NO180374C (no)	1992-09-28	1993-09-27	Antiarrytmiske og kardiobeskyttende substituerte 1(2H)isokinoliner og anvendelse derav for fremstilling av et medikament for å bekjempe hjertefeil

Country Status (18)

Country	Link
US (1)	US5416094A (no)
EP (1)	EP0590455B1 (no)
JP (1)	JP3645579B2 (no)
AT (1)	ATE198328T1 (no)
AU (1)	AU662079B2 (no)
CA (1)	CA2107008C (no)
DE (1)	DE69329787T2 (no)
DK (1)	DK0590455T3 (no)
ES (1)	ES2152938T3 (no)
FI (1)	FI103884B (no)
GR (1)	GR3035537T3 (no)
HU (1)	HU218208B (no)
IL (1)	IL107118A (no)
NO (1)	NO180374C (no)
NZ (1)	NZ248761A (no)
PT (1)	PT590455E (no)
TW (1)	TW272189B (no)
ZA (1)	ZA937141B (no)

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DE4344550A1 (de) *	1993-12-24	1995-06-29	Hoechst Ag	Substituierte 1-Oxo-1,2-dihydro-isochinolinoyl- und 1,1-Dioxo-2H-1,2-benzothiazinoylguanidine, Verfahrenzu ihrer Herstellung, ihre Verwendung als Medikamentt oder Diagnostikum sowie sie enthaltendes Medikamen
DE4412334A1 (de) *	1994-04-11	1995-10-19	Hoechst Ag	Substituierte N-Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4415873A1 (de) *	1994-05-05	1995-11-09	Hoechst Ag	Substituierte bizyklische Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US5627193A (en) *	1995-02-09	1997-05-06	Mitsui Toatsu Chemicals, Inc.	Quinoline-4-carbonylguanidine derivatives, process for producing the same and pharmaceutical preparations containing the compounds
US5874443A (en) *	1995-10-19	1999-02-23	Trega Biosciences, Inc.	Isoquinoline derivatives and isoquinoline combinatorial libraries
JPH11514645A (ja) *	1995-10-19	1999-12-14	トーリーパインズインスティチュートフォーモレキュラースタディーズ	イソキノリン誘導体およびイソキノリン組合せライブラリ
DE19540995A1 (de) *	1995-11-03	1997-05-07	Hoechst Ag	Substituierte Sulfonimidamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19542306A1 (de) *	1995-11-14	1997-05-15	Hoechst Ag	Sulfonylamino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
PL316439A1 (en) *	1995-11-20	1997-05-26	Hoechst Ag	Novel substituted derivatives of benzoyloguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents and pharmaceutic agent as such
DE19546736A1 (de) *	1995-12-14	1997-06-19	Hoechst Ag	Substituierte Chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate
DE19548708A1 (de) *	1995-12-23	1997-06-26	Merck Patent Gmbh	Cyclische Sulfone
US20040122096A1 (en) *	1996-06-03	2004-06-24	Hoechst Aktiengesellschaft	Use of inhibitors of the cellular Na+/H+ exchanger (NHE) for preparing a medicament for normalizing serum lipids
US5916899A (en) *	1996-10-18	1999-06-29	Trega Biosciences, Inc.	Isoquinoline derivatives and isoquinoline combinatorial libraries
US5952328A (en) *	1997-11-12	1999-09-14	Cephalon, Inc.	Benzothiazo and related heterocyclic group-containing cysteine and serine protease inhibitors
WO1998021186A1 (en) *	1996-11-13	1998-05-22	Cephalon, Inc.	Benzothiazo and related heterocyclic group-containing cysteine and serine protease inhibitors
JP2002502414A (ja) *	1997-06-02	2002-01-22	藤沢薬品工業株式会社	細胞中のＮａ▲上＋▼／Ｈ▲上＋▼交換の阻害剤としてのグアニジン誘導体
US6534503B1 (en)	1998-04-28	2003-03-18	Lion Bioscience Ag	Melanocortin receptor-3 ligands to treat sexual dysfunction
WO1999055679A1 (en)	1998-04-28	1999-11-04	Trega Biosciences, Inc.	Isoquinoline compound melanocortin receptor ligands and methods of using same
US6284735B1 (en)	1998-04-28	2001-09-04	Lion Bioscience Ag	HP-3228 and related peptides to treat sexual dysfunction
DE19859727A1 (de) *	1998-12-23	2000-06-29	Aventis Pharma Gmbh	Die Verwendung von Hemmern des Natrium-Wasserstoff-Austauschers zur Herstellung eines Medikaments zur Verhinderung von altersbedingten Organ-Dysfunktionen, altersbedingten Erkrankungen zur Lebensverlängerung
NZ555768A (en) *	2004-12-24	2009-12-24	Astrazeneca Ab	Benzamide derivatives as inhibitors of cytokine mediated disease
WO2007053610A2 (en) *	2005-11-01	2007-05-10	The Regents Of The University Of California	Methods of treating atrial fibrillation wtih pirfenidone
AU2007214709A1 (en) *	2006-02-15	2007-08-23	Sanofi-Aventis	Azacyclyl-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments
WO2008091555A2 (en)	2007-01-22	2008-07-31	Gtx, Inc.	Nuclear receptor binding agents
US9623021B2 (en) *	2007-01-22	2017-04-18	Gtx, Inc.	Nuclear receptor binding agents
US9604931B2 (en)	2007-01-22	2017-03-28	Gtx, Inc.	Nuclear receptor binding agents
US10344002B2 (en)	2016-09-26	2019-07-09	Nusirt Sciences, Inc.	Compositions and methods for treating metabolic disorders
JP7378156B2 (ja) *	2018-04-06	2023-11-13	ザボードオブトラスティーズオブザユニバーシティオブイリノイ	Ｋｅａｐ１／ｎｒｆ２タンパク質間相互作用の１，４－置換イソキノリン阻害剤
KR102605163B1 (ko) *	2021-06-01	2023-11-23	연세대학교 산학협력단	뇌암의 예방 또는 치료용 조성물

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US3780027A (en) *	1970-04-29	1973-12-18	Merck & Co Inc	Anthranilic acid derivatives
DE2818423A1 (de) *	1978-04-27	1979-11-08	Hoechst Ag	Neue isochinolinderivate und verfahren zu ihrer herstellung
DE3013906A1 (de) *	1980-04-11	1981-10-15	C.H. Boehringer Sohn, 6507 Ingelheim	Substituierte (alpha) -aminocarbonyl-l-benzyl-3,4-dihydro-isochinoline, verfahren zu deren herstellung und deren verwendung
DE3233424A1 (de) *	1982-09-09	1984-03-15	Hoechst Ag, 6230 Frankfurt	Isochinolinderivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung
JP2930399B2 (ja) *	1990-10-18	1999-08-03	雪印乳業株式会社	新規イソキノリン誘導体またはその酸付加塩

1993
- 1993-09-20 DE DE69329787T patent/DE69329787T2/de not_active Expired - Lifetime
- 1993-09-20 AT AT93115081T patent/ATE198328T1/de not_active IP Right Cessation
- 1993-09-20 DK DK93115081T patent/DK0590455T3/da active
- 1993-09-20 ES ES93115081T patent/ES2152938T3/es not_active Expired - Lifetime
- 1993-09-20 EP EP93115081A patent/EP0590455B1/en not_active Expired - Lifetime
- 1993-09-20 PT PT93115081T patent/PT590455E/pt unknown
- 1993-09-24 NZ NZ248761A patent/NZ248761A/en unknown
- 1993-09-24 US US08/126,200 patent/US5416094A/en not_active Expired - Lifetime
- 1993-09-24 FI FI934185A patent/FI103884B/fi active
- 1993-09-27 ZA ZA937141A patent/ZA937141B/xx unknown
- 1993-09-27 HU HU9302725A patent/HU218208B/hu not_active IP Right Cessation
- 1993-09-27 JP JP23996693A patent/JP3645579B2/ja not_active Expired - Fee Related
- 1993-09-27 CA CA002107008A patent/CA2107008C/en not_active Expired - Lifetime
- 1993-09-27 NO NO933450A patent/NO180374C/no unknown
- 1993-09-27 AU AU48659/93A patent/AU662079B2/en not_active Ceased
- 1993-09-27 IL IL107118A patent/IL107118A/en not_active IP Right Cessation
- 1993-10-14 TW TW082108497A patent/TW272189B/zh active
2001
- 2001-03-09 GR GR20010400378T patent/GR3035537T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
ZA937141B (en)	1994-05-18
AU662079B2 (en)	1995-08-17
FI103884B1 (fi)	1999-10-15
HU218208B (hu)	2000-06-28
ES2152938T3 (es)	2001-02-16
NZ248761A (en)	1995-04-27
HU9302725D0 (en)	1993-12-28
IL107118A0 (en)	1993-12-28
US5416094A (en)	1995-05-16
NO180374C (no)	1997-04-09
DK0590455T3 (da)	2001-01-22
GR3035537T3 (en)	2001-06-29
JPH06211799A (ja)	1994-08-02
CA2107008A1 (en)	1994-03-29
DE69329787D1 (de)	2001-02-01
TW272189B (no)	1996-03-11
DE69329787T2 (de)	2001-06-13
CA2107008C (en)	2004-11-16
AU4865993A (en)	1994-04-14
NO933450D0 (no)	1993-09-27
JP3645579B2 (ja)	2005-05-11
HUT70149A (en)	1995-09-28
EP0590455A1 (en)	1994-04-06
ATE198328T1 (de)	2001-01-15
FI934185A0 (fi)	1993-09-24
FI103884B (fi)	1999-10-15
NO180374B (no)	1996-12-30
PT590455E (pt)	2001-04-30
EP0590455B1 (en)	2000-12-27
IL107118A (en)	1998-06-15
FI934185L (fi)	1994-03-29

Publication	Publication Date	Title
NO180374C (no)	1997-04-09	Antiarrytmiske og kardiobeskyttende substituerte 1(2H)isokinoliner og anvendelse derav for fremstilling av et medikament for å bekjempe hjertefeil
AU6358986A (en)	1987-04-09	New quinazoline derivatives and a process for their production
AU635575B2 (en)	1993-03-25	4- and 6-carbamates related to physostigmine, a process and intermediates for their preparation and their use as medicaments
HUT40101A (en)	1986-11-28	Process for producing quinolin-carboxylic acid derivatives and pharmaceutical compositions containing them as active agents
AU626740B2 (en)	1992-08-06	Aminocarbonylcarbamates related to physostigmine, a process for their preparation and their use as medicaments
HU9201887D0 (en)	1992-08-28	Process for the production of //aralkyl-piperidine-4-yl/-methyl/-2a,3,4,5-tetrahydro-1-/2h/-acenaphtylene-1-on derivatives and of medical preparations containing them as active agents
HUT37797A (en)	1986-02-28	Process for production of tetrahydro-tieno-piridinderivatives and medical preparatives containing of such compounds
HUT45518A (en)	1988-07-28	Process for producing 1,5-benzothiazepine derivatives and pharmaceutics comprising these compounds
DK0570850T3 (da)	1997-06-16	Benzo(b)thiophen-3-yl-piperaziner, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler
AU590748B2 (en)	1989-11-16	Benzo(C)-1,5-naphthyridines, a process and intermediates for their preparation and their use as medicaments
EP0386044A4 (en)	1992-04-15	Hypoglycaemic peptides