NO933503L - Dicytostelium dipeptidylaminopeptidase - Google Patents

Dicytostelium dipeptidylaminopeptidase

Info

Publication number
NO933503L
NO933503L NO933503A NO933503A NO933503L NO 933503 L NO933503 L NO 933503L NO 933503 A NO933503 A NO 933503A NO 933503 A NO933503 A NO 933503A NO 933503 L NO933503 L NO 933503L
Authority
NO
Norway
Prior art keywords
ddap
enzyme
dap
peptides
methods
Prior art date
Application number
NO933503A
Other languages
English (en)
Other versions
NO933503D0 (no
Inventor
Paul Robert Atkinson
Matthew Dale Hilton
Peter Karl Lambooy
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO933503D0 publication Critical patent/NO933503D0/no
Publication of NO933503L publication Critical patent/NO933503L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/485—Exopeptidases (3.4.11-3.4.19)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/11—Aminopeptidases (3.4.11)
    • C12Y304/11005—Prolyl aminopeptidase (3.4.11.5)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification
    • Y10S435/815—Enzyme separation or purification by sorption

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Diabetes (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Escalators And Moving Walkways (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Detergent Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Polyamides (AREA)
  • Chemical Or Physical Treatment Of Fibers (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Purification Treatments By Anaerobic Or Anaerobic And Aerobic Bacteria Or Animals (AREA)
  • Noodles (AREA)
  • Fats And Perfumes (AREA)

Abstract

En ny dipeptidylamlnopeptldase isolert fra den cellulære slimsoppen Dictyostellum dlscodeum. Det nye DÅP enzymet, dDAP utviser en aktivitet som lingner noe på både DAP-I og DAP-III, men er veldig forskjellig fra disse enzymene l fysiske og andre enzymatiske karakter- trekk. Fremgangsmåte for anvendelse av dDAP enzymet for å fjerne dlpeptider fra N-terminusen til rekombinant produserte forløperproteiner eller peptider er også beskrevet. Fremgangsmåter for isolering og rensning av dDAP enzymet fra kulturer av D. siscodeum er også beskrevet.
NO933503A 1992-10-01 1993-09-30 Dicytostelium dipeptidylaminopeptidase NO933503L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95553992A 1992-10-01 1992-10-01

Publications (2)

Publication Number Publication Date
NO933503D0 NO933503D0 (no) 1993-09-30
NO933503L true NO933503L (no) 1994-04-05

Family

ID=25496954

Family Applications (1)

Application Number Title Priority Date Filing Date
NO933503A NO933503L (no) 1992-10-01 1993-09-30 Dicytostelium dipeptidylaminopeptidase

Country Status (26)

Country Link
US (2) US5565349A (no)
EP (2) EP0595476B1 (no)
JP (1) JP3550409B2 (no)
KR (1) KR100291528B1 (no)
CN (1) CN1060212C (no)
AT (1) ATE211169T1 (no)
AU (1) AU669735B2 (no)
BR (1) BR9303949A (no)
CA (1) CA2107279A1 (no)
CZ (2) CZ286950B6 (no)
DE (1) DE69331371T2 (no)
DK (1) DK0595476T3 (no)
ES (1) ES2169036T3 (no)
FI (1) FI934305L (no)
HU (1) HU219771B (no)
IL (1) IL107123A (no)
MX (1) MX9306021A (no)
MY (1) MY113378A (no)
NO (1) NO933503L (no)
NZ (1) NZ248810A (no)
PL (1) PL176930B1 (no)
PT (1) PT595476E (no)
RU (1) RU2096455C1 (no)
TW (1) TW257792B (no)
UA (1) UA27718C2 (no)
ZA (1) ZA937243B (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5573923A (en) * 1993-12-22 1996-11-12 Eli Lilly And Company Method for removing N-terminal dipeptides from precursor polypeptides with immobilized dipeptidylaminopeptidase from dictyostelium discoideum
US5614379A (en) * 1995-04-26 1997-03-25 Eli Lilly And Company Process for preparing anti-obesity protein
AU6388499A (en) * 1998-09-21 2000-04-10 Eli Lilly And Company Production of soluble recombinant trypsinogen analogs
US6794159B1 (en) 1999-04-30 2004-09-21 Pharmacia Corporation Method of removing n-terminal alanine residues from polypeptides with aeromonas aminopeptidase
US6743600B1 (en) 1999-04-30 2004-06-01 Monsanto Technologies Llc Method of removing N-terminal alanine residues from polypeptides with Aeromonas aminopeptidase
EP1411062A4 (en) * 2001-07-26 2006-09-13 Ajinomoto Kk PROCESS FOR PREPARING DIPEPTIDE, PEPTIDESYNTHASE USED THEREFOR AND METHOD FOR PRODUCING PEPTIDESYNTHASE
PL211754B1 (pl) * 2002-07-26 2012-06-29 Ajinomoto Kk Enzym tworzący peptyd, mikroorganizm i sposób wytwarzania dipeptydu
EP2298906B1 (en) * 2002-07-26 2014-01-08 Ajinomoto Co., Inc. Novel peptide-forming enzyme gene
US8129139B2 (en) 2009-07-13 2012-03-06 Allergan, Inc. Process for obtaining botulinum neurotoxin
EP2536749A1 (en) * 2010-02-17 2012-12-26 Elona Biotechnologies Methods for preparing human growth hormone
US11427814B2 (en) 2019-03-26 2022-08-30 Encodia, Inc. Modified cleavases, uses thereof and related kits
AU2020247918B2 (en) * 2019-03-26 2022-06-30 Encodia, Inc. Modified cleavases, uses thereof and related kits

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK55685A (da) * 1985-02-07 1986-08-08 Nordisk Gentofte Enzym eller enzymkompleks med proteolytisk aktivitet
DE3519218A1 (de) * 1985-05-29 1986-12-04 Boehringer Mannheim Gmbh, 6800 Mannheim H(pfeil abwaerts)2(pfeil abwaerts)o(pfeil abwaerts)2(pfeil abwaerts)-bildende sarcosinoxidase, ihre herstellung und verwendung
US4894439A (en) * 1986-05-22 1990-01-16 Cetus Corporation N-terminal derivatives of tumor necrosis factor purified by microporous PTFE membranes
US5177003A (en) * 1987-04-16 1993-01-05 Phillips Petroleum Company Flavored protein products derived from Candida utilis
US4929700A (en) * 1987-04-16 1990-05-29 Cetus Corporation Production of purified, biologically active, bacterially produced recombinant human CSF-1
US5075222A (en) * 1988-05-27 1991-12-24 Synergen, Inc. Interleukin-1 inhibitors
JPH023698A (ja) * 1988-06-20 1990-01-09 Denki Kagaku Kogyo Kk ヒトリンホトキシンに対するモノクローナル抗体及びそれら抗体を産生するハイブリドーマ、並びにそれら抗体を用いたヒトリンホトキシンの精製方法、測定方法及び測定試薬
US5208218A (en) * 1988-09-19 1993-05-04 Ludwig Institute For Cancer Research T cell growth factor glycoproteins
US5175251A (en) * 1989-05-04 1992-12-29 Sri International Antimetastatic peptides with laminin activity
US5179196A (en) * 1989-05-04 1993-01-12 Sri International Purification of proteins employing ctap-iii fusions
US5126249A (en) * 1989-05-09 1992-06-30 Eli Lilly And Company Enzymatic removal of a protein amino-terminal sequence
US5173409A (en) * 1989-12-08 1992-12-22 Ecogen Inc. Recovery of bt endotoxin protein from lysed cell mixtures

Also Published As

Publication number Publication date
KR940009329A (ko) 1994-05-20
HU9302773D0 (en) 1994-01-28
HUT70299A (en) 1995-09-28
PT595476E (pt) 2002-06-28
MX9306021A (es) 1994-05-31
MY113378A (en) 2002-02-28
DE69331371D1 (de) 2002-01-31
US5565349A (en) 1996-10-15
NO933503D0 (no) 1993-09-30
IL107123A (en) 1998-07-15
EP0595476A3 (en) 1994-07-06
AU669735B2 (en) 1996-06-20
DE69331371T2 (de) 2002-08-14
IL107123A0 (en) 1993-12-28
HU219771B (hu) 2001-07-30
ES2169036T3 (es) 2002-07-01
RU2096455C1 (ru) 1997-11-20
PL176930B1 (pl) 1999-08-31
FI934305A0 (fi) 1993-09-30
TW257792B (no) 1995-09-21
PL300537A1 (en) 1994-04-05
JP3550409B2 (ja) 2004-08-04
FI934305A7 (fi) 1994-04-02
UA27718C2 (uk) 2000-10-16
US5565330A (en) 1996-10-15
CN1085253A (zh) 1994-04-13
KR100291528B1 (ko) 2001-06-01
NZ248810A (en) 1994-12-22
EP1094118A1 (en) 2001-04-25
CN1060212C (zh) 2001-01-03
EP0595476A2 (en) 1994-05-04
CA2107279A1 (en) 1994-04-02
ATE211169T1 (de) 2002-01-15
CZ287066B6 (cs) 2000-08-16
ZA937243B (en) 1995-03-29
BR9303949A (pt) 1994-04-05
FI934305L (fi) 1994-04-02
JPH06197759A (ja) 1994-07-19
DK0595476T3 (da) 2002-02-11
CZ203393A3 (en) 1994-04-13
EP0595476B1 (en) 2001-12-19
CZ286950B6 (en) 2000-08-16
AU4871993A (en) 1994-04-14

Similar Documents

Publication Publication Date Title
Franks et al. Cyclic GMP stimulation and inhibition of cyclic AMP phosphodiesterase from thymic lymphocytes
PT673427E (pt) Processo para imobilizar enzimas na parede celular de uma celula microbiana atraves da producao de uma proteina de fusao
DK1121135T3 (da) Præparater af beta-glucaner og specifikke immunglobuliner
ES8202362A1 (es) Procedimiento para preparar un acido desoxi-ribonucleico (adn) recombinante
DE68924775D1 (de) Verwendungen viraler enzyme.
YU45871B (sh) Polipeptid sa humanim imunointerferonskim (ifn-gama) svojstvima
DE69434612D1 (de) Monoklonale Antikörper gegen recombinantes Stratum Corneum chymotryptisches Enzym (SCCE)
YU47100B (sh) Mikrobiološki postupak za proizvodnju ciklosporinskog kompleksa ili njegovih komponenti
DK0470136T3 (da) Terapeutisk middel
GB9825421D0 (en) Process for oxidising terpenes
Komiyama et al. Inhibitory effects of phosphoramidon on neutral metalloendopeptidases and its application on affinity chromatography
NZ304570A (en) Neurone-restrictive silencer factor proteins, nucleic acids and antibodies thereto
AU2002354696A1 (en) Method for purifying an enzyme, a purified enzyme produced thereby, and use of this enzyme
DK0677116T3 (da) Fremgangsmåde til fremstilling af immunosuppressive midler og en ny mikroorganismeart til anvendelse deri
ES360055A1 (es) Un procedimiento para obtener preparados en enzimas proteo-liticas.
NO924576L (no) Kloning og ekspresjon av gener som koder for arabinan-nedbrytende enzymer av sopp-opprinnelse
AU621810B2 (en) Amylolytic enzymes producing microorganisms, constructed by recombinant DNA technology and their use for fermentation processes
ATE131066T1 (de) Mittel zur hemmung von hiv-proteasen.
MY113378A (en) Dictyostelium dipeptidylaminopeptidase
MX9407877A (es) Sustrato de cultivo solido que incluye cebada.
NO180643C (no) Alkalisk pullulanase Y med <alfa>-amylaseaktivitet og en biologisk renkultur av Bacillus sp. mikroorganisme som produserer denne
KR890008166A (ko) 융합 단백질의 선택적 분해 방법
PT1007647E (pt) Expressao de ingap em niveis elevados
Ito et al. Studies on the bacterial formation of a peptide antibiotic, colistin: part I. On the enyzmatic inactivation of colistin by Bacillus colistinus
CA2172954A1 (en) Enzyme and its use in preparing (s)-pipecolic acid

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application